Takuji Suzuki, MD, PhD

Member, Translational Pulmonary Science Center, Division of Pulmonary Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3309

Email takuji.suzuki@cchmc.org

Lung innate immunity; macrophage biology
Takuji Suzuki, MD, PhD and his team identified and characterized the clinical presentation, pathogenesis, diagnosis and therapy of hereditary Pulmonary Alveolar Proteinosis (hPAP). They established iPS cells from hPAP patients and developed a novel cell and gene therapy, pulmonary macrophage transplantation (PMT) therapy in mice.

MD: Tohoku University, Sendai, Japan.

PhD: Tohoku University Graduate School of Medicine, Sendai, Japan.

Residency: St. Luke's International Hospital, Tokyo, Japan.

Clinical Fellowship: Tohoku University Hospital, Sendai, Japan.

Research Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Suzuki T. Trapnell BC. Pulmonary Alveolar Proteinosis Syndrome. Clin Chest Med. 2016;37:431-440.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305.

Acciani TH, Suzuki T, Trapnell BC, Le Cras TD. Epidermal growth factor receptor signaling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Clin Exp Allergy. 2016;46:317-328.

Suzuki T, Mayhew C, Sallese A, Chalk C, Carey BC, Malik P, Wood RE, Trapnell BC. Use of Induced Pluripotent Stem Cells To Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis. Am J Respir Crit Care Med. 2014;189:183-193.

Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC. Pulmonary Macrophage Transplantation Therapy. Nature. 2014;514:450-454.

Suzuki T, Mayhew C, Sallese A, Chalk C, Carey BC, Malik P, Wood RE, Trapnell BC*. Use of Induced Pluripotent Stem Cells To Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis. Am J Respir Crit Care Med. 2014;189:183-193.

Suzuki T, Maranda B, Sakagami T, Catellier P, Couture CY, Carey BC, Chalk C, Trapnell BC. Hereditary Pulmonary Alveolar Proteinosis Caused by Recessive CSF2RB mutations. Eur Respir J. 2011;37:201-204.

Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert S, Rubin BK, Katherine Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo, Trapnell BC. Hereditary Pulmonary Alveolar Proteinosis: Pathogenesis, Presentation, Diagnosis, and Therapy. Am J Respir Crit Care Med. 2010;182:1292-1304.

Sakagami T, Uchida K, Suzuki T, Carey BC, Wood RE, Wert SE, Whitsett JA, Trapnell BC, Luisetti M. Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med. 2009;361:2679-2681.

Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, Grabowski G, Carey BC, Stevens C, van der Loo JC, Trapnell BC. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008;205:2703-2710.