I'm a physician-scientist researching innate lung immunity, macrophage biology, interstitial lung diseases, pulmonary alveolar proteinosis and rare lung diseases. The goal of my lab is to develop a novel cell and gene therapy for the treatment of lung diseases, especially for hereditary pulmonary alveolar proteinosis.
During my clinical experiences caring for patients with severe lung diseases, I became interested in pulmonary research. Some of my lab's groundbreaking work includes identifying
and characterizing the clinical presentation, pathogenesis, diagnosis and therapy of hereditary pulmonary alveolar proteinosis (hPAP). We also established induced pluripotent stem (iPS) cells from hPAP patients and developed a novel cell and gene therapy, pulmonary macrophage transplantation (PMT) therapy in mice.
I am honored to have received these awards:
- American Thoracic Society (ATS) Travel Award (2011)
- Annual American Thoracic Society (ATS) Assembly on Pediatrics Scientific Abstract Award (2012)
- ATS Neonatal and Developing Lung Interest Group (NDLIG) Award (2016)
- Japanese Respiratory Society (JRS) Kumagai Award (2019)
I have been a researcher for more than 26 years and began my work at Cincinnati Children's in 2005. My work is published in many well-respected journals, including Nature, The New England Journal of Medicine, The Journal of Experimental Medicine, Blood, American Journal of Respiratory and Critical Care Medicine, The European Respiratory Journal, Journal
of Immunology, American Journal of Respiratory Cell and Molecular Biology, Molecular Therapy, Nature Communications, Stem Cell Reports, Haematologica and Scientific Reports.
Lung innate immunity; macrophage biology
Assistant Professor, UC Department of Pediatrics