Xueguang Sun.

Director of DNA Sequencing and Genotyping Core 1, Division of Human Genetics

Associate Professor, UC Department of Pediatrics


Biography & Affiliation

Research Interests

Next generation sequencing; epigenetics; DNA methylation and hydroxymethylation analysis; assay development

Academic Affiliation

Associate Professor, UC Department of Pediatrics


Human Genetics, Global Health


PhD: Georgia Institute of Technology, Atlanta, GA, 2005.

Post doctorate: Yale University, New Haven, CT, 2008.


Mirror Bisulfite Sequencing: A Method for Single-Base Resolution of Hydroxymethylcytosine. Tan, D; Chung, TH; Sun, X; Jia, X. Analytical Chemistry. 2018; 90:13200-13206.

Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain. Bazov, I; Sarkisyan, D; Kononenko, O; Watanabe, H; Taqi, MM; Stalhandske, L; Verbeek, DS; Mulder, J; Rajkowska, G; Sheedy, D; et al. Cerebral Cortex. 2018; 28:3129-3142.

Transcriptome-Wide Detection of 5-Methylcytosine by Bisulfite Sequencing. Sun, X; Sun, . In: Lusser, Ed. RNA Methylation Methods and Protocols. austria: Humana Press; 2017.

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nature Biotechnology. 2016; 34:726-737.

Practical guidelines and consideration of using RRHP for 5hmC detection. Sun, X; Chung, TH; Tan, D; Kim, A. Epigenomics. 2016; 8:225-235.

Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans. Ashktorab, H; Shakoori, A; Zarnogi, S; Sun, X; Varma, S; Lee, E; Shokrani, B; Laiyemo, AO; Washington, K; Brim, H. Gastroenterology Research and Practice. 2016; 2016:2102674-8.

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. Zhou, J; Yang, L; Zhong, T; Mueller, M; Men, Y; Zhang, N; Xie, J; Giang, K; Chung, H; Sun, X; et al. Nature Communications. 2015; 6.