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Benjamin Tourdot, PhD

  • Assistant Professor, UC Department of Pediatrics

About

Biography

Clotting disorders, such as heart attacks and strokes, are leading causes of death in the United States. Platelet activation is one of the primary drivers of clot formation. My lab works to understand the mechanisms regulating platelet activation during bleeding and clotting to develop better antiplatelet therapies that can reduce the risk of a clot, but not prolong bleeding.

I have studied platelet biology for more than 12 years and began my career with Cincinnati Children’s in 2020. It is my honor to have received the Pathway to Independence Award (K99/R00) from the National Institutes of Health (NIH) in 2018.

Research Areas

Experimental Hematology and Cancer Biology

Publications

Inflammation, Infection and Venous Thromboembolism. Colling, ME; Tourdot, BE; Kanthi, Y. Circulation Research. 2021; 128:2017-2036.

Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Zaslavsky, A; Adams, M; Cao, X; Yamaguchi, A; Henderson, J; Busch-Østergren, P; Udager, A; Pitchiaya, S; Tourdot, B; Kasputis, T; et al. Thrombosis Research. 2021; 200:64-71.

Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Perry, SC; Horn, T; Tourdot, BE; Yamaguchi, A; Kalyanaraman, C; Conrad, WS; Akinkugbe, O; Holinstat, M; Jacobson, MP; Holman, TR. Biochemistry. 2020; 59:4118-4130.

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. Perry, SC; Kalyanaraman, C; Tourdot, BE; Conrad, WS; Akinkugbe, O; Freedman, JC; Holinstat, M; Jacobson, MP; Holman, TR. Journal of Lipid Research. 2020; 61:1087-1103.

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Freedman, J; Tran, A; Tourdot, BE; Kalyanaraman, C; Perry, S; Holinstat, M; Jacobson, MP; Holman, TR. Biochemistry. 2020; 59:1832-1844.

Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1β-driven venous thrombosis. Yadav, V; Chi, L; Zhao, R; Tourdot, BE; Yalavarthi, S; Jacobs, BN; Banka, A; Liao, H; Koonse, S; Anyanwu, AC; et al. Journal of Clinical Investigation. 2019; 129:2872-2877.

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Green, AR; Freedman, C; Tena, J; Tourdot, BE; Liu, B; Holinstat, M; Holman, TR. Biochemistry. 2018; 57:6726-6734.

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Tourdot, BE; Stoveken, H; Trumbo, D; Yeung, J; Kanthi, Y; Edelstein, LC; Bray, PF; Tall, GG; Holinstat, M. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38:1632-1643.

Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy. Tourdot, BE; Holinstat, M. Trends in Pharmacological Sciences. 2017; 38:1006-1015.

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis. Adili, R; Tourdot, BE; Mast, K; Yeung, J; Freedman, JC; Green, A; Luci, DK; Jadhav, A; Simeonov, A; Maloney, DJ; et al. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017; 37:1828-1839.