Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-Dihpete, implicated with the altered positional specificity of human 15-lipoxygenase-1.
Perry, SC; Horn, T; Tourdot, BE; Yamaguchi, A; Kalyanaraman, C; Conrad, WS; Akinkugbe, O; Holinstat, M; Jacobson, MP; Holman, TR.
Biochemistry.
2020;
59:4118-4130.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5.
Perry, SC; Kalyanaraman, C; Tourdot, BE; Conrad, WS; Akinkugbe, O; Freedman, JC; Holinstat, M; Jacobson, MP; Holman, TR.
Journal of lipid research.
2020;
61:1087-1103.
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Freedman, J; Tran, A; Tourdot, BE; Kalyanaraman, C; Perry, S; Holinstat, M; Jacobson, MP; Holman, TR.
Biochemistry.
2020;
59:1832-1844.
ENTPD-1 disrupts inflammasome IL-1β-driven venous thrombosis.
Yadav, V; Chi, L; Zhao, R; Tourdot, BE; Yalavarthi, S; Jacobs, BN; Banka, A; Liao, H; Koonse, S; Anyanwu, AC; et al.
Journal of Clinical Investigation.
2019;
129:2872-2877.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Green, AR; Freedman, C; Tena, J; Tourdot, BE; Liu, B; Holinstat, M; Holman, TR.
Biochemistry.
2018;
57:6726-6734.
Genetic variant in human PAR (Protease-Activated Receptor) 4 enhances thrombus formation resulting in resistance to antiplatelet therapeutics.
Tourdot, BE; Stoveken, H; Trumbo, D; Yeung, J; Kanthi, Y; Edelstein, LC; Bray, PF; Tall, GG; Holinstat, M.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2018;
38:1632-1643.
Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy.
Tourdot, BE; Holinstat, M.
Trends in Pharmacological Sciences.
2017;
38:1006-1015.
First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis.
Adili, R; Tourdot, BE; Mast, K; Yeung, J; Freedman, JC; Green, A; Luci, DK; Jadhav, A; Simeonov, A; Maloney, DJ; et al.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2017;
37:1828-1839.
12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.
Tourdot, BE; Adili, R; Isingizwe, ZR; Ebrahem, M; Freedman, JC; Holman, TR; Holinstat, M.
Blood Advances.
2017;
1:1124-1131.
12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-γ-linolenic acid, inhibits thrombosis via Gαs signaling in platelets.
Yeung, J; Tourdot, BE; Adili, R; Green, AR; Freedman, CJ; Fernandez-Perez, P; Yu, J; Holman, TR; Holinstat, M.
Arteriosclerosis, Thrombosis, and Vascular Biology.
2016;
36:2068-2077.