A photo of James S. Tweddell.

James S. Tweddell, MD

  • Executive Co-Director, Heart Institute
  • Director, Cardiothoracic Surgery, Heart Institute
  • Professor, UC Department of Surgery



Dr. Tweddell leads the Heart Institute’s surgical team providing unparalleled surgical care and innovation for our patients and their families. Over the last 20 years, he built the pediatric cardiothoracic surgery program at the Medical College of Wisconsin, where he held the S. Bert Litwin Chair for Cardiothoracic Surgery position, served as medical director of pediatric cardiothoracic surgery at Children’s Hospital of Wisconsin and professor and chief for the Division of Cardiothoracic Surgery. Dr. Tweddell has an extensive list of vital research contributions, having authored more than 125 peer reviewed articles, published numerous books, chapters, invited reviews and editorials, and serving on multiple editorial boards and national committees.

Dr. Tweddell is the elite surgeon of his generation and has earned a worldwide reputation for outstanding clinical results based on team contributions to his outcomes. He decreased mortality following the Norwood procedure through the use of venous saturation monitoring and afterload reduction. In addition, Dr. Tweddell reduced interstage mortality of a single ventricle patient through the development of a home monitoring program.


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Unethical Studies on Transplantation in Cardiothoracic Surgery Journals. Sade, RM; Carpenter, AJ; D'Amico, TA; Drake, DH; Entwistle, JW; Ray, S; Tweddell, JS. Annals of Thoracic Surgery. 2021; 112:1746-1752.

Unethical studies on transplantation in cardiothoracic surgery journals. Sade, RM; Carpenter, AJ; D'Amico, TA; Drake, DH; Entwistle, JW; Ray, S; Tweddell, JS. Journal of Thoracic and Cardiovascular Surgery. 2021; 162:1647-1653.

Transplantation and Arch Repair in Fontan 3 Years after HeartMate 3: Technical Considerations. Wells, DA; Coghill, M; Szugye, N; Moore, R; Lorts, A; Tweddell, JS; Morales, DL S. Annals of Thoracic Surgery. 2021.

Relationship Between Gestational Age and Outcomes After Congenital Heart Surgery. Savorgnan, F; Elhoff, JJ; Guffey, D; Axelrod, D; Buckley, JR; Gaies, M; Ghanayem, NS; Lasa, JJ; Shekerdemian, L; Tweddell, JS; et al. Annals of Thoracic Surgery. 2021; 112:1509-1516.

Risk of Pediatric Cardiac Surgery Increased in Patients Undergoing Tracheal Surgery During the Same Hospitalization. Riggs, KW; Wells, D; Zafar, F; Morales, DL S; Bryant, R; Tweddell, JS. World journal for pediatric & congenital heart surgery. 2021; 12:730-736.

Socioeconomic Impact on Outcomes During the First Year of Life of Patients with Single Ventricle Heart Disease: An Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Registry. de Loizaga, SR; Schneider, K; Beck, AF; Zang, H; Ollberding, N; Tweddell, JS; Anderson, JB. Pediatric Cardiology. 2021.

The Value of Longitudinal Follow-Up and Linked Registries. Jacobs, JP; Overman, DM; Tweddell, JS. Journal of the American College of Cardiology. 2021; 78:1714-1716.

Digoxin Associated With Greater Transplant-Free Survival in High- vs Low-Risk Interstage Patients. Brown, TN; Brown, DW; Tweddell, JS; Bates, KE; Lannon, CM; Anderson, JB. Annals of Thoracic Surgery. 2021.

A mapping algorithm for International Classification of Diseases 10th Revision codes for congenital heart surgery benchmark procedures. Zafar, F; Allen, P; Bryant, R; Tweddell, JS; Najm, HK; Anderson, BR; Karamlou, T. Journal of Thoracic and Cardiovascular Surgery. 2021.

The Externally-Supported Ross Procedure With Konno Aortoventriculoplasty. Tweddell, JS; O'Donnell, AP. Operative Techniques in Thoracic and Cardiovascular Surgery. 2021; 26:487-509.

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