A photo of Tamara Tilburgs.

Tamara Tilburgs, PhD


  • Member, Division of Immunobiology
  • Assistant Professor, UC Department of Pediatrics

About

Biography

Dr. Tamara Tilburgs obtained her Ph.D. degree in Reproductive Immunology at Leiden University Medical Center, Leiden, Netherlands in the lab of Dr. Frans Claas, where she studied decidual T cell responses in healthy human pregnancies. She conducted a postdoctoral fellowship and held an Instructor position in Dr. Jack Strominger’s laboratory at the Department of Stem Cell and Regenerative Biology at Harvard University, where she focused on the molecular mechanisms of immune tolerance by HLA-G+ extravillous trophoblasts.

Currently, Dr. Tilburgs’ is an Assistant Professor at Cincinnati Children’s Hospital Medical Center, where she investigates how maternal immune cells at the maternal-fetal interface establish tolerance to fetal antigens while at the same time maintaining immunity to viral and bacterial infections. She has published over 25 peer-reviewed papers in the area of reproductive immunology with a more specific scientific production in the field of immune regulatory mechanisms by HLA-G+ extravillous trophoblasts and decidual regulatory T cells as well as decidual NK cell and decidual effector T cell responses to placental and viral antigens.

Publications

Selected

Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Crespo, AC; Mulik, S; Dotiwala, F; Ansara, JA; Sen Santara, S; Ingersoll, K; Ovies, C; Junqueira, C; Tilburgs, T; Strominger, JL; et al. Cell. 2020; 182:1125-1139.e18.

Selected

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Papuchova, H; Meissner, TB; Li, Q; Strominger, JL; Tilburgs, T. Frontiers in Immunology. 2019; 10.

Selected

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Salvany-Celades, M; van der Zwan, A; Benner, M; Setrajcic-Dragos, V; Gomes, HA B; Iyer, V; Norwitz, ER; Strominger, JL; Tilburgs, T. Cell Reports. 2019; 27:2537-2547.e5.

Selected

Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity. van der Zwan, A; Bi, K; Norwitz, ER; Crespo, AC; Claas, FH J; Strominger, JL; Tilburgs, T. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:385-390.

Selected

HLA-G: At the Interface of Maternal-Fetal Tolerance. Ferreira, LM R; Meissner, TB; Tilburgs, T; Strominger, JL. Trends in Immunology. 2017; 38:272-286.

Selected

Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections. Crespo, AC; van der Zwan, A; Ramalho-Santos, J; Strominger, JL; Tilburgs, T. Journal of Reproductive Immunology. 2017; 119:85-90.

Selected

Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Crespo, AC; Strominger, JL; Tilburgs, T. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113:15072-15077.

Selected

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Ferreira, LM R; Meissner, TB; Mikkelsen, TS; Mallard, W; O'Donnell, CW; Tilburgs, T; Gomes, HA B; Camahort, R; Sherwood, RI; Gifford, DK; et al. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113:5364-5369.

Selected

The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface. Tilburgs, T; Evans, JH; Crespo, AC; Strominger, JL. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112:13312-13317.

Selected

CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity. Tilburgs, T; Strominger, JL. American Journal of Reproductive Immunology and Microbiology. 2013; 69:395-407.