Postdoctoral Training: Bioinformatics and System Biology, University of Pennsylvania, Cincinnati Children's Hospital Medical Center,
PhD: Genomics, University of Chinese Academy of Sciences, China, 2012,
BS: Biotechnology, Ocean University of China, China, 2007,
Genetics
Human genomics; biomedical informatics; data science
Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(8):e2316731121.
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(7):e2311854121.
The circadian clock is disrupted in pancreatic cancer. PLoS Genetics. 2023; 19(6):e1010770.
0010 Circadian dysregulation of the cardiopulmonary system in a mouse model of obstructive sleep apnea. Sleep. 2023; 46(Supplement_1):a5-a5.
Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression. PLoS Biology. 2023; 21(5):e3002139.
Integration of genome-scale data identifies candidate sleep regulators. Sleep. 2023; 46(2).
Ontogeny and function of the circadian clock in intestinal organoids. EMBO Journal. 2022; 41(2):e106973.
An in silico genome-wide screen for circadian clock strength in human samples. Bioinformatics. 2022; 38(24):5375-5382.
duper is a null mutation of Cryptochrome 1 in Syrian hamsters. Proceedings of the National Academy of Sciences of the United States of America. 2022; 119(18):e2123560119.
Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Frontiers in Physiology. 2022; 13:835198.