Postdoctoral Training: Bioinformatics and System Biology, University of Pennsylvania, Cincinnati Children's Hospital Medical Center
PhD: Genomics, University of Chinese Academy of Sciences, China, 2012
BS: Biotechnology, Ocean University of China, China, 2007
Genetics
Human genomics; biomedical informatics; data science
Expanding Access to Genome Sequencing: Higher Diagnostic Yield in Self-Referred Participants From the CincyKidsSeq Study and Implications for Hybrid Models of Genetic Service Delivery. Clinical Genetics. 2026; 109(4):717-724.
P521: A systematic evaluation of structured electric health record for rare genetic disease detection. Genetics in Medicine Open. 2026; 4:104013.
P509: Redefining access and interpretation in genomic medicine: A hybrid model with systematic variant resolution. Genetics in Medicine Open. 2026; 4:104001.
Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(8):e2316731121.
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 2024; 121(7):e2311854121.
The circadian clock is disrupted in pancreatic cancer. PLoS Genetics. 2023; 19(6):e1010770.
0010 Circadian dysregulation of the cardiopulmonary system in a mouse model of obstructive sleep apnea. Sleep. 2023; 46(Supplement_1):a5-a5.
Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression. PLoS Biology. 2023; 21(5):e3002139.
Integration of genome-scale data identifies candidate sleep regulators. Sleep. 2023; 46(2).
Ontogeny and function of the circadian clock in intestinal organoids. EMBO Journal. 2022; 41(2):e106973.