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Gang Wu, PhD


  • Co-Director of the Bioinformatics, Genetics and Genomics Diagnostic Laboratory, Division of Human Genetics
  • Assistant Professor, UC Department of Pediatrics

About

Postdoctoral Training: Bioinformatics and System Biology, University of Pennsylvania, Cincinnati Children's Hospital Medical Center.

PhD: Genomics, University of Chinese Academy of Sciences, China, 2012.

BS: Biotechnology, Ocean University of China, China, 2007.

Interests

Genetics

Services and Specialties

Human Genetics, Genetics

Interests

Human genomics; biomedical informatics; data science

Research Areas

Human Genetics

Publications

Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes. Yang, Y; Wu, G; Sancar, A; Hogenesch, JB. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2316731121.

Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer. Li, SY; Hammarlund, JA; Wu, G; Lian, JW; Howell, SJ; Clarke, RB; Adamson, AD; Gonçalves, CF; Hogenesch, JB; Anafi, RC; Meng, QJ. Proceedings of the National Academy of Sciences of USA. 2024; 121:e2311854121.

The circadian clock is disrupted in pancreatic cancer. Schwartz, PB; Nukaya, M; Berres, ME; Rubinstein, CD; Wu, G; Hogenesch, JB; Bradfield, CA; Ronnekleiv-Kelly, SM. PLoS Genetics. 2023; 19:e1010770.

Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression. Koritala, BS C; Lee, YY; Gaspar, LS; Bhadri, SS; Su, W; Wu, G; Francey, LJ; Ruben, MD; Gong, MC; Hogenesch, JB; Smith, DF. PLoS Biology. 2023; 21:e3002139.

0010 Circadian dysregulation of the cardiopulmonary system in a mouse model of obstructive sleep apnea. Koritala, B; Lee, YY; Gaspar, LS; Smith, J; Paulose, J; Francey, L; Wu, G; Ruben, M; Smith, D. Sleep. 2023; 46:a5.

Integration of genome-scale data identifies candidate sleep regulators. Lee, YY; Endale, M; Wu, G; Ruben, MD; Francey, LJ; Morris, AR; Choo, NY; Anafi, RC; Smith, DF; Liu, AC; Hogenesch, JB. Sleep. 2023; 46:zsac279.

Ontogeny and function of the circadian clock in intestinal organoids. Rosselot, AE; Park, M; Kim, M; Matsu-Ura, T; Wu, G; Flores, DE; Subramanian, KR; Lee, S; Sundaram, N; Broda, TR; Wells, JM; Hogenesch, JB; Moore, SR; Hong, CI. The EMBO Journal. 2022; 41:e106973.

An in silico genome-wide screen for circadian clock strength in human samples. Wu, G; Ruben, MD; Francey, LJ; Lee, YY; Anafi, RC; Hogenesch, JB. Bioinformatics. 2022; 38:5375-5382.

duper is a null mutation of Cryptochrome 1 in Syrian hamsters. Lee, YY; Cal-Kayitmazbatir, S; Francey, LJ; Bahiru, MS; Hayer, KE; Wu, G; Zeller, MJ; Roberts, R; Speers, J; Koshalek, J; Berres, ME; Bittman, EL; Hogenesch, JB. Proceedings of the National Academy of Sciences of USA. 2022; 119:e2123560119.

Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Zhang, T; Du, X; Gu, Y; Dong, Y; Zhang, W; Yuan, Z; Huang, X; Zou, C; Zhou, Y; Liu, Z; Hogenesch, JB; Zhou, CJ; Zhou, F; Xu, Y. Frontiers in Physiology. 2022; 13:835198.