Lai Man Natalie Wu, PhD

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Wang, J; Wang, J; Yang, L; Zhao, C; Wu, LN; Xu, L; Zhang, F; Weng, Q; Wegner, M; Lu, QR. Nature Communications. 2020; 11(1):4133.

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. Siems, SB; Jahn, O; Eichel, MA; Kannaiyan, N; Wu, LMN; Sherman, DL; Kusch, K; Hesse, D; Jung, RB; Fledrich, R; Sereda, MW; Rossner, MJ; Brophy, PJ; Werner, HB. eLife. 2020; 9.

Therapeutic targets for malignant peripheralnerve sheath tumors. Wu, LMN; Lu, QR. Future Neurology. 2019; 14(1):fnl7.

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Zhao, C; Dong, C; Frah, M; Deng, Y; Marie, C; Zhang, F; Xu, L; Ma, Z; Dong, X; Lin, Y; Xin, M; Zhou, W; Parras, C; Lu, QR. Developmental Cell. 2018; 45(6):753-768.e8.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LMN; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; Zheng, Y; Xin, M; Ratner, N; Lu, QR. Cancer Cell. 2018; 33(2):292-308.e7.

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination. Deng, Y; Wu, LMN; Bai, S; Zhao, C; Wang, H; Wang, J; Xu, L; Sakabe, M; Zhou, W; Xin, M; Lu, QR. Nature Communications. 2017; 8:15161.

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Wu, LMN; Wang, J; Conidi, A; Zhao, C; Wang, H; Ford, Z; Zhang, L; Zweier, C; Ayee, BG; Maurel, P; Zwijsen, A; Chan, JR; Jankowski, MP; Huylebroeck, D; Lu, QR. Nature Neuroscience. 2016; 19(8):1060-1072.

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LMN; Mao, M; Chan, JR; Wu, J; Lu, QR. Cell. 2013; 152(1-2):248-261.

Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum. Wu, LMN; Williams, A; Delaney, A; Sherman, DL; Brophy, PJ. Current Biology. 2012; 22(20):1957-1961.

Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. Sherman, DL; Wu, LMN; Grove, M; Gillespie, CS; Brophy, PJ. Journal of Neuroscience. 2012; 32(27):9419-9428.