BS: Jacobs University Bremen, Bremen, Germany.
MS: University of Zurich, Zurich, Switzerland.
PhD: University of Edinburgh, Edinburgh, United Kingdom.
Post-doctoral: University of Texas Southwestern Medical Center, Dallas, TX.
Post-doctoral: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Molecular basis of neuroblastoma; neural crest-derived cancers; Schwann cell development and tumorigenesis
Experimental Hematology and Cancer Biology
CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature Communications. 2020; 11:4133.
Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. eLife. 2020; 9:e51406.
Therapeutic targets for malignant peripheralnerve sheath tumors. Future Neurology. 2019; 14:fnl7.
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Developmental Cell. 2018; 45:753-768.e8.
Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer Cell. 2018; 33:292-308.e7.
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination. Nature Communications. 2017; 8:15161.
Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nature Neuroscience. 2016; 19:1060-1072.
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013; 152:248-261.
Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum. Current Biology. 2012; 22:1957-1961.
Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32:9419-9428.