A photo of Lai Man Natalie Wu.

Lai Man Natalie Wu, PhD

  • Assistant Professor, UC Department of Pediatrics


BS: Jacobs University Bremen, Bremen, Germany.

MS: University of Zurich, Zurich, Switzerland.

PhD: University of Edinburgh, Edinburgh, United Kingdom.

Post-doctoral: University of Texas Southwestern Medical Center, Dallas, TX.

Post-doctoral: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.


Molecular basis of neuroblastoma; neural crest-derived cancers; Schwann cell development and tumorigenesis

Research Areas

Experimental Hematology and Cancer Biology



CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Wang, J; Wang, J; Yang, L; Zhao, C; Wu, LN; Xu, L; Zhang, F; Weng, Q; Wegner, M; Lu, QR. Nature Communications. 2020; 11:4133.


Proteome profile of peripheral myelin in healthy mice and in a neuropathy model. Siems, SB; Jahn, O; Eichel, MA; Kannaiyan, N; Wu, LM N; Sherman, DL; Kusch, K; Hesse, D; Jung, RB; Fledrich, R; et al. eLife. 2020; 9:e51406.


Therapeutic targets for malignant peripheralnerve sheath tumors. Wu, LM N; Lu, QR. Future Neurology. 2019; 14:fnl7.


Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Zhao, C; Dong, C; Frah, M; Deng, Y; Marie, C; Zhang, F; Xu, L; Ma, Z; Dong, X; Lin, Y; et al. Developmental Cell. 2018; 45:753-768.e8.


Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.


A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination. Deng, Y; Wu, LM N; Bai, S; Zhao, C; Wang, H; Wang, J; Xu, L; Sakabe, M; Zhou, W; Xin, M; et al. Nature Communications. 2017; 8:15161.


Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Wu, LM N; Wang, J; Conidi, A; Zhao, C; Wang, H; Ford, Z; Zhang, L; Zweier, C; Ayee, BG; Maurel, P; et al. Nature Neuroscience. 2016; 19:1060-1072.


Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; et al. Cell. 2013; 152:248-261.


Increasing internodal distance in myelinated nerves accelerates nerve conduction to a flat maximum. Wu, LM N; Williams, A; Delaney, A; Sherman, DL; Brophy, PJ. Current Biology. 2012; 22:1957-1961.


Drp2 and periaxin form Cajal bands with dystroglycan but have distinct roles in Schwann cell growth. Sherman, DL; Wu, LM N; Grove, M; Stewart Gillespie, C; Brophy, PJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32:9419-9428.