A photo of Qing Richard Lu.

Qing Richard Lu, PhD


  • Beatrice C. Lampkin Endowed Chair in Cancer Epigenetics
  • Scientific Director, Brain Tumor Center
  • Professor, UC Department of Pediatrics

About

Publications

Selected

EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. Science advances. 2020; 6.

Selected

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Cancer Cell. 2019; 36:302-318.e7.

Selected

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.

Selected

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. Nature Medicine. 2018; 24:338-351.

Selected

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

Selected

lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. He, D; Wang, J; Lu, Y; Deng, Y; Zhao, C; Xu, L; Chen, Y; Hu, Y; Zhou, W; Lu, QR. Neuron. 2017; 93:362-378.

Selected

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Lu, F; Chen, Y; Zhao, C; Wang, H; He, D; Xu, L; Wang, J; He, X; Deng, Y; Lu, EE; et al. Cancer Cell. 2016; 29:669-683.

Selected

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. He, D; Marie, C; Zhao, C; Kim, B; Wang, J; Deng, Y; Clavairoly, A; Frah, M; Wang, H; He, X; et al. Nature Neuroscience. 2016; 19:678-689.

Selected

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. He, X; Zhang, L; Chen, Y; Remke, M; Shih, D; Lu, F; Wang, H; Deng, Y; Yu, Y; Xia, Y; et al. Nature Medicine. 2014; 20:1035-1042.

Selected

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; et al. Cell. 2013; 152:248-261.

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