A photo of Qing Richard Lu.

Beatrice C. Lampkin Endowed Chair in Cancer Epigenetics

Scientific Director, Brain Tumor Center

Professor, UC Department of Pediatrics

513-636-7684

513-636-3549

Biography & Affiliation

Clinical Interests

Neuro-oncology

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Developmental Biology

Science Blog

Cracking the Genetic Code of Malignant Peripheral Nerve Sheath Tumors

Genomics and Development

Cracking the Genetic Code of Malignant Peripheral Nerve Sheath Tumors

Qing Richard Lu, PhD7/3/2019

Shutting Down Glioblastoma at Its Earliest Moments

Cancer

Shutting Down Glioblastoma at Its Earliest Moments

Qing Richard Lu, PhD7/3/2019

Education

BS: Peking Normal University, Beijing, China, 1988.

MS: Rutgers University, Piscataway, NJ, 1993.

PhD: Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 1997.

Postdoctoral Fellow: Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 1997-2002.

Publications

Selected Publication

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Cancer Cell. 2019; 36:302-318.e7.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. Nature Medicine. 2018; 24:338-351.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. He, D; Wang, J; Lu, Y; Deng, Y; Zhao, C; Xu, L; Chen, Y; Hu, Y; Zhou, W; Lu, QR. Neuron. 2017; 93:362-378.

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Lu, F; Chen, Y; Zhao, C; Wang, H; He, D; Xu, L; Wang, J; He, X; Deng, Y; Lu, EE; et al. Cancer Cell. 2016; 29:669-683.

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. He, D; Marie, C; Zhao, C; Kim, B; Wang, J; Deng, Y; Clavairoly, A; Frah, M; Wang, H; He, X; et al. Nature Neuroscience. 2016; 19:678-689.

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Zhang, L; He, X; Liu, L; Jiang, M; Zhao, C; Wang, H; He, D; Zheng, T; Zhou, X; Hassan, A; et al. Developmental Cell. 2016; 36:316-330.

The G protein alpha subunit G alpha(s) is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. He, X; Zhang, L; Chen, Y; Remke, M; Shih, D; Lu, F; Wang, H; Deng, Y; Yu, Y; Xia, Y; et al. Nature Medicine. 2014; 20:1035-1042.

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation. Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; et al. Cell. 2013; 152:248-261.