A photo of Qing Richard Lu.

Beatrice C. Lampkin Endowed Chair in Cancer Epigenetics

Scientific Director, Brain Tumor Center

Professor, UC Department of Pediatrics

513-636-7684

513-636-3549

Biography & Affiliation

Clinical Interests

Neuro-oncology; neurology

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Developmental Biology



Blog Posts

Cracking the Genetic Code of Malignant Peripheral Nerve Sheath Tumors

Genomics and Development

Cracking the Genetic Code of Malignant Peripheral Nerve Sheath Tumors

Qing Richard Lu, PhD7/3/2019

Shutting Down Glioblastoma at Its Earliest Moments

Cancer

Shutting Down Glioblastoma at Its Earliest Moments

Qing Richard Lu, PhD7/3/2019

How CHD8 Mutations Contribute to Autism Spectrum Disorders

Mind Brain Behavior

How CHD8 Mutations Contribute to Autism Spectrum Disorders

Qing Richard Lu, PhD6/30/2019

Education

BS: Peking Normal University, Beijing, China, 1988.

MS: Rutgers University, Piscataway, NJ, 1993.

PhD: Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 1997.

Postdoctoral Fellow: Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 1997-2002.

Publications

Selected Publication

EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. Science advances. 2020; 6.

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Cancer Cell. 2019; 36:302-318.e7.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. Nature Medicine. 2018; 24:338-351.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. He, D; Wang, J; Lu, Y; Deng, Y; Zhao, C; Xu, L; Chen, Y; Hu, Y; Zhou, W; Lu, QR. Neuron. 2017; 93:362-378.

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Lu, F; Chen, Y; Zhao, C; Wang, H; He, D; Xu, L; Wang, J; He, X; Deng, Y; Lu, EE; et al. Cancer Cell. 2016; 29:669-683.

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. He, D; Marie, C; Zhao, C; Kim, B; Wang, J; Deng, Y; Clavairoly, A; Frah, M; Wang, H; He, X; et al. Nature Neuroscience. 2016; 19:678-689.

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. He, X; Zhang, L; Chen, Y; Remke, M; Shih, D; Lu, F; Wang, H; Deng, Y; Yu, Y; Xia, Y; et al. Nature Medicine. 2014; 20:1035-1042.

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; et al. Cell. 2013; 152:248-261.