A photo of Qing Richard Lu.

Beatrice C. Lampkin Endowed Chair in Cancer Epigenetics

Scientific Director, Brain Tumor Center

Professor, UC Department of Pediatrics

513-636-7684

513-636-3549

My Biography & Research

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Cancer Blood Disease Institute, Experimental Hematology, Cancer and Blood Diseases Institute, Brain Tumor Center, Developmental Biology

My Education

BS: Peking Normal University, Beijing, China, 1988.

MS: Rutgers University, Piscataway, NJ, 1993.

PhD: Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 1997.

Postdoctoral Fellow: Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 1997-2002.

My Publications

Zhang L*, He X*, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones B, Fouladi M, Drissi R, Yang Z, Gustafson WC, Remke M, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Rousse MF, Weiss WA, Lu QR. Single-cell Transcriptomics in Medulloblastoma Reveals Tumor-initiating Progenitors and Oncogenic Cascades During Tumorigenesis and Relapse. Cancer Cell. 2019;36:1-17.

Weng Q, Wang J, Wang J, He D, Cheng Z, Zhang F, Verma R, Xu L, Dong X, He X, Potter A, Zhang L, Zhao C, Xin M, Zhou Q, Aronow BJ, Blackshear PJ, Rich JN, He Q, Zhou W, Suvà, M, Waclaw R, Potter SS, Yu G, Lu QR. Single-cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019;24:707-723. 

Wu LMN, Deng Y, Wang J, Zhao C, Wang JJ, Rao R, Xu L, Zhou W, Choi K, Rizvi TA. Remke M, Rubin JB, Johnson R, Carroll T, Stemmer-Rachamimov AO, Wu J, Zheng Y, Xin M, Ratner N, Lu QR. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer Cell. 2018;33:292-308.

He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw R, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR. A Histone Deacetylase 3-Dependent Pathway Delimits Peripheral Myelin Growth and Functional Regeneration. Nat Medicine. 2018;25:338-351.

He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu Y, Zhou W, Lu QR. lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron. 2017 Jan 18;93(2):362-378.

Lu F, Chen Y, Zhao C, Wang H, He D, Xu L, Wang J, He X, Deng Y, Lu EE, Liu X, Verma R, Bu H, Drissi R, Fouladi M, Stemmer-Rachamimov AO, Burns D, Xin M, Rubin JB, Bahassi EM, Canoll P, Holland EC, Lu QR. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell. 2016; 9;29(5):669-83.

He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR. Chd7 Cooperates with Sox10 and Regulates the Onset of CNS Myelination and Remyelination. Nature Neuroscience. 2016 May;19(5):678-89.


Zhang L*, He X*, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental Cell. 2016 Feb 8;36(3):316-30.

He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister S, Weinstein LS, Pomeroy S, Gilbertson R, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR. The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog driven Medulloblastoma. Nature Medicine. 2014 Sep;20(9):1035-42.

Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu, LM, Mao M, Chan JR, Wu J, Lu QR. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013 Jan 17;152(1-2):248–261.