Experimental Hematology and Cancer Biology
Lu Lab

Lu Research Lab

Glia cells, myelination, tumorigenesis and cancer neuroscience

Recent studies indicate a convergence between neural developmental processes, neurological disorders and brain tumorigenesis whereby insight into one yields insight into the others. We are interested in understanding how distinct glial cell types (e.g., myelinating oligodendrocytes) and their stem / progenitor cells contribute to neurological diseases and how dysregulated developmental programs play a role in tumorigenesis both in the central (CNS) and peripheral (PNS) nervous systems.

A major focus of our lab is to elucidate the transcriptional, posttranscriptional, epigenetic, and signaling networks that govern development, remyelination, and tumor formation in the CNS and PNS. We have established a series of in vitro and in vivo animal models to understand the mechanisms underlying myelinogenesis and neurodegenerative diseases such as multiple sclerosis and autism spectrum disorder, as well as brain tumorigenesis by using endogenous and patient-derived brain or neural tumor models that recapitulate histological and molecular features of human tumors.

We use cutting-edge molecular and cellular approaches (e.g., single-cell multi-omics, functional genomics, and spatial transcriptomics) to dissect how the genetic, epigenetic, and microenvironment controls brain or neural cancer development, recurrence, and metastasis. Our cross-species genomic analyses of human tumors and developing brain tissue at the single cell resolution coupled with genetic mouse modeling have identified a set of glial progenitor-like cells (e.g., Olig2+ pri-OPCs) and “stem-like’ cells (e.g., transitional cerebellar progenitors) as key in the formation of malignant gliomas and medulloblastoma, respectively, pointing to specific cell lineages as the origin of distinct brain tumors, and potential lineage-specific vulnerabilities for targeting distinct subtypes of brain tumors. We are also investigating the tumor microenvironment control of cancer stem cell fitness, tumor recurrence and metastasis by using lineage-traceable model systems for developing effective immunotherapy.

Current projects in Lu Lab aim to: 

  1. Leverage cutting-edge genomic and multi-omics approaches to dissect the brain tumor cells of origin and underlying molecular and signaling pathways that are hijacked and altered during the evolution of brain cancers including glioblastoma, medulloblastoma, ependymoma, and diffuse midline gliomas (DMG / DIPG) (Luo et al., Nature, 2022; Hu et al., Nature Cell Biology, 2023; Weng et al., Cell Stem Cell, 2019; Zhang et al., Cancer Cell, 2019; Lu et al., Cancer Cell, 2016, He et al., Nature medicine, 2014).
  2. Define transcriptional, signaling, and epigenetic control of myelination and functional nerve regeneration by using in vitro primary neural cell culture, genetically-engineered mice, and pharmacogenomic approaches (Yu et al., Cell, 2013; Wang, et al., Science Advances, 2020; He et al., Nature medicine, 2018; Zhao et al., Dev Cell 2018; He et al., Neuron, 2017; Wang et al., Dev Cell 2017; He et al., Nature Neuroscience, 2016).
  3. Dissect molecular and signaling mechanisms that control Schwann cell myelination in the PNS and the malignant transformation of peripheral nerve sheath tumors (MPNST) by defining the tumor stem-like subpopulation, tumor cell–state evolution and heterogeneity and their regulatory circuitries during NF-to-MPNST transformation (Wu, et al., Science Advances, 2022; Wu et al., Cancer Cell, 2018; Deng et al., Nature communications, 2017; Wu et al., Nature Neuroscience, 2016).

Our research goals comprise dissecting the etiological mechanisms of these neurological diseases and cancers to develop effective therapies respectively through promoting myelin repair and functional nerve regeneration or blocking brain tumorigenesis and recurrence.

Publications

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; et al. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25:323-336.

Luo, Z; Xia, M; Shi, W; Zhao, C; Wang, J; Xin, D; Dong, X; Xiong, Y; Zhang, F; Berry, K; et al. Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022; 612:787-794.

Wu, LM N; Zhang, F; Rao, R; Adam, M; Pollard, K; Szabo, S; Liu, X; Belcher, KA; Luo, Z; Ogurek, S; et al. Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Science Advances. 2022; 8:eabo5442.

Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science Advances. 2020; 6:eaaz6477.

Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019; 36:302-318.e7.

Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019; 24:707-723.e8.

He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature Medicine. 2018; 24:338-351.

Lu, F; Chen, Y; Zhao, C; Wang, H; He, D; Xu, L; Wang, J; He, X; Deng, Y; Lu, EE; et al. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell. 2016; 29:669-683.

He, X; Zhang, L; Chen, Y; Remke, M; Shih, D; Lu, F; Wang, H; Deng, Y; Yu, Y; Xia, Y; et al. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature Medicine. 2014; 20:1035-1042.

Yu, Y; Chen, Y; Kim, B; Wang, H; Zhao, C; He, X; Liu, L; Liu, W; Wu, LM N; Mao, M; et al. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013; 152:248-261.

Lv, X; Lu, Q; Yang, J. Hybrid Endoscopic Submucosal Dissection for Early Gastric Neoplasms: An Ideal Technique?. Clinical Gastroenterology and Hepatology. 2023; 21:2436-2437.

Grote, CW; Mackay, MJ; Lu, Q; Liu, X; Meyer, AR; Wang, J. A whole-joint histopathologic grading system for murine knee osteoarthritis. Journal of Orthopaedic Research. 2023; 41:1407-1418.

Luo, Z; Lu, R. MDB-05. HUMAN FETAL CEREBELLAR CELL ATLAS INFORMS MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2023; 25:i62.

Lu, R; Luo, Z. MDB-02. NUCLEAR ENVELOPE PHOSPHATASE CTDNEP1 MUTATIONS POTENTIATE AGGRESSIVE MEDULLOBLASTOMA BY TRIGGERING MYC ACTIVATION AND GENOMIC INSTABILITY. Neuro-Oncology. 2023; 25:i61-i62.

Xia, Y; Hua, L; Dai, Z; Han, Y; Du, Y; Zhao, S; Zhou, H; Wang, X; Yan, R; Wang, X; et al. Attenuated post-movement beta rebound reflects psychomotor alterations in major depressive disorder during a simple visuomotor task: a MEG study. BMC Psychiatry. 2023; 23:395.

Lv, X; Luo, R; Lu, Q; Deng, K; Yang, J. Underwater versus conventional endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumors ≤20mm: A systematic review and meta-analysis. Digestive and Liver Disease. 2023; 55:714-720.

Thompson, M; Sakabe, M; Verba, M; Hao, J; Meadows, SM; Lu, QR; Xin, M. PRDM16 regulates arterial development and vascular integrity. Frontiers in Physiology. 2023; 14:1165379.

Zhang, J; Guan, M; Zhou, X; Berry, K; He, X; Lu, QR. Long Noncoding RNAs in CNS Myelination and Disease. The Neuroscientist: reviews at the interface of basic and clinical neurosciences. 2023; 29:287-301.

Tian, S; Zhu, R; Chen, Z; Wang, H; Chattun, MR; Zhang, S; Shao, J; Wang, X; Yao, Z; Lu, Q. Prediction of suicidality in bipolar disorder using variability of intrinsic brain activity and machine learning. Human Brain Mapping. 2023; 44:2767-2777.

Verma, R; Chen, X; Xin, D; Luo, Z; Ogurek, S; Xin, M; Rao, R; Berry, K; Lu, QR. Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer Research. 2023; 83:890-905.

Xia, S; Lu, Q; Wang, Z; Gan, T; Yang, J; Wang, Z. Development and validation of a model to determine the risk of esophageal strictures after endoscopic submucosal dissection for esophageal neoplasms. Surgical Endoscopy: surgical and interventional techniques. 2023; 37:2163-2172.

Wang, J; Grote, CW; Mackay, MJ; Lu, Q; Liu, X; Meyer, AR. A Whole-Joint Histopathologic Grading Scheme For Murine Knee Osteoarthritis. Osteoarthritis and Cartilage. 2023; 31:s317.

Lv, X; Lu, Q; Yang, J. Linked Color Imaging for the Detection of Colorectal Sessile Serrated Lesions. Clinical Gastroenterology and Hepatology. 2023; 21:852.

Zhao, S; Du, Y; Zhang, Y; Wang, X; Xia, Y; Sun, H; Huang, Y; Zou, H; Wang, X; Chen, Z; et al. Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism. Frontiers in Aging Neuroscience. 2023; 15:1106792.

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; et al. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25:323-336.

Tao, P; Dai, Z; Shao, J; Tang, H; Zhang, S; Yao, Z; Lu, Q. Gamma band VMPFC-PreCG.L connection variation after the onset of negative emotional stimuli can predict mania in depressive patients. Journal of Psychiatric Research. 2023; 158:165-171.

Wang, H; Tian, S; Yan, R; Tang, H; Shi, J; Zhu, R; Chen, Y; Han, Y; Chen, Z; Zhou, H; et al. Convergent and divergent cognitive impairment of unipolar and bipolar depression: A magnetoencephalography resting-state study. Journal of Affective Disorders. 2023; 321:8-15.

Xue, L; Shao, J; Wang, H; Wang, X; Zhu, R; Yao, Z; Lu, Q. Shared and unique imaging-derived endo-phenotypes of two typical antidepressant-applicative depressive patients. European Radiology. 2023; 33:645-655.

Lin, J; Tong, X; Li, C; Lu, Q. Expectile Neural Networks for Genetic Data Analysis of Complex Diseases. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2023; 20:352-359.

Xia, Y; Sun, H; Hua, L; Dai, Z; Wang, X; Tang, H; Han, Y; Du, Y; Zhou, H; Zou, H; et al. Spontaneous beta power, motor-related beta power and cortical thickness in major depressive disorder with psychomotor disturbance. NeuroImage-Clinical. 2023; 38:103433.

Dai, Z; Zhang, S; Wang, H; Chen, Z; Zhang, W; Hu, X; Yao, Z; Lu, Q. Hampered gamma oscillations induced by sad emotion underlying suicide attempt in major depressive disorder. Psychiatry and Clinical Neurosciences. 2023; 77:20-29.

Zhang, Y; Shao, J; Wang, X; Pei, C; Zhang, S; Yao, Z; Lu, Q. Partly recovery and compensation in anterior cingulate cortex after SSRI treatment-evidence from multi-voxel pattern analysis over resting state fMRI in depression. Journal of Affective Disorders. 2023; 320:404-412.

Luo, Z; Xia, M; Shi, W; Zhao, C; Wang, J; Xin, D; Dong, X; Xiong, Y; Zhang, F; Berry, K; et al. Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature. 2022; 612:787-794.

Sakabe, M; Thompson, M; Chen, N; Verba, M; Hassan, A; Lu, R; Xin, M. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis. eLife. 2022; 11:e74576.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; et al. Chromatin structure predicts survival in glioma patients. Scientific Reports. 2022; 12:8221.

Yan, R; Geng, JT; Huang, YH; Zou, HW; Wang, XM; Xia, Y; Zhao, S; Chen, ZL; Zhou, H; Chen, Y; et al. Aberrant functional connectivity in insular subregions in somatic depression: a resting-state fMRI study. BMC Psychiatry. 2022; 22:146.

Zhang, S; Litvak, V; Tian, S; Dai, Z; Tang, H; Wang, X; Yao, Z; Lu, Q. Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder. European Archives of Psychiatry and Clinical Neuroscience: official organ of the German society for biological psychiatry. 2022; 272:1547-1557.

Lu, Q; Wang, J; Lv, X; Xi, M; Lei, T; Wang, Z; Yang, L; Yang, J. Long-term outcomes of refractory esophageal strictures after endoscopic submucosal dissection of superficial esophageal neoplasms. BMC Gastroenterology. 2022; 22:147.

Kalim, KW; Yang, JQ; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; et al. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for ImmunoTherapy of Cancer. 2022; 10:e004806.

Intisar, A; Shin, HY; Kim, WH; Kang, HG; Kim, MY; Kim, YS; Cho, Y; Mo, YJ; Lim, H; Lee, S; et al. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy. Advanced Science. 2022; 9:e2201358.

Wang, J; Yang, L; Jiang, M; Zhao, C; Liu, X; Berry, K; Waisman, A; Langseth, AJ; Novitch, BG; Bergles, DE; et al. Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:8542-8555.

Liao, Y; Luo, Z; Lin, Y; Chen, H; Chen, T; Xu, L; Orgurek, S; Berry, K; Dzieciatkowska, M; Reisz, JA; et al. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death and Disease. 2022; 13:943.

Wu, LM N; Zhang, F; Rao, R; Adam, M; Pollard, K; Szabo, S; Liu, X; Belcher, KA; Luo, Z; Ogurek, S; et al. Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Science Advances. 2022; 8:eabo5442.

Dong, C; Zhao, C; Chen, X; Berry, K; Wang, J; Zhang, F; Liao, Y; Han, R; Ogurek, S; Xu, L; et al. Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:8373-8392.

Lu, Q; Lv, X; Yang, J. Some Issues Considered for Clip Closure After Endoscopic Resection of Large Serrated Polyps. Clinical Gastroenterology and Hepatology. 2022; 20:2656.

Wang, N; Langfelder, P; Stricos, M; Ramanathan, L; Richman, JB; Vaca, R; Plascencia, M; Gu, X; Zhang, S; Tamai, TK; et al. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022; 110:3318-3338.e9.

Wang, X; Qin, J; Zhu, R; Zhang, S; Tian, S; Sun, Y; Wang, Q; Zhao, P; Tang, H; Wang, L; et al. Predicting Treatment Selections for Individuals with Major Depressive Disorder According to Functional Connectivity Subgroups. Brain Connectivity. 2022; 12:699-710.

Dai, Z; Zhou, H; Zhang, W; Tang, H; Wang, T; Chen, Z; Yao, Z; Lu, Q. Alpha-beta decoupling relevant to inhibition deficits leads to suicide attempt in major depressive disorder. Journal of Affective Disorders. 2022; 314:168-175.

Shao, J; Zhang, Y; Xue, L; Wang, X; Wang, H; Zhu, R; Yao, Z; Lu, Q. Shared and disease-sensitive dysfunction across bipolar and unipolar disorder during depressive episodes: a transdiagnostic study. Neuropsychopharmacology. 2022; 47:1922-1930.

Yi, J; Kim, BW; Shi, X; Zhan, X; Lu, QR; Xuan, Z; Wu, J. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer Research. 2022; 82:2874-2886.

Zou, H; Zhou, H; Yan, R; Yao, Z; Lu, Q. Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms. Frontiers in Neuroscience. 2022; 16:811771.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell Reports. 2022; 40:111072.

Sun, Y; Wang, X; Tian, S; Chen, Z; Wang, H; Xue, L; Yan, R; Yao, Z; Lu, Q. An Investigation into the Association Between Dopamine Receptor D1 Multilocus Genetic Variation, Multiparametric Magnetic Resonance Imaging, and Antidepressant Treatment. Journal of Magnetic Resonance Imaging. 2022; 56:282-290.

Shen, X; Jiang, C; Wen, Y; Li, C; Lu, Q. A Brief Review on Deep Learning Applications in Genomic Studies. 2022; 2:877717.

Wang, J; Lu, Q; Mackay, MJ; Liu, X; Feng, Y; Burton, DC; Asher, MA. Spontaneous Facet Joint Osteoarthritis in NFAT1-Mutant Mice: Age-Dependent Histopathologic Characteristics and Molecular Mechanisms. The Journal of Bone and Joint Surgery. 2022; 104:928-940.

Yan, R; Huang, Y; Shi, J; Zou, H; Wang, X; Xia, Y; Zhao, S; Zhou, H; Chen, Y; Li, X; et al. Alterations of regional spontaneous neuronal activity and corresponding brain circuits related to non-suicidal self-injury in young adults with major depressive disorder. Journal of Affective Disorders. 2022; 305:8-18.

Wang, H; Zhu, R; Tian, S; Zhang, S; Dai, Z; Shao, J; Xue, L; Yao, Z; Lu, Q. Dynamic connectivity alterations in anterior cingulate cortex associated with suicide attempts in bipolar disorders with a current major depressive episode. Journal of Psychiatric Research. 2022; 149:307-314.

Lu, Q; Lv, X; Yang, J. A few comments about benign esophageal strictures. Gastrointestinal Endoscopy. 2022; 95:1020.

Zhou, H; Zou, H; Dai, Z; Zhao, S; Hua, L; Xia, Y; Han, Y; Yan, R; Tang, H; Huang, Y; et al. Interoception Dysfunction Contributes to the Negative Emotional Bias in Major Depressive Disorder. Frontiers in Psychiatry. 2022; 13:874859.

Lv, X; Lu, Q; Yang, J. Cap-assisted endoscopic full-thickness resection for small gastrointestinal stromal tumors. Gastrointestinal Endoscopy. 2022; 95:810-811.

Grote, CW; Mackay, MJ; Liu, X; Lu, Q; Wang, J. A MODIFIED COMPREHENSIVE GRADING SYSTEM FOR MURINE KNEE OSTEOARTHRITIS: SCORING THE WHOLE JOINT AS AN ORGAN. Osteoarthritis and Cartilage. 2022; 30:s95.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; et al. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-Oncology. 2022; 24:584-597.

Liu, X; Pitner, MA; Baki, PP; Lu, Q; Schroeppel, JP; Wang, J. Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness. Jove-Journal of Visualized Experiments. 2022.

Wang, Q; Tian, S; Zhao, P; Cao, Q; Lu, Q; Yao, Z. Association Between Antidepressant Efficacy and Interactions of Three Core Depression-Related Brain Networks in Major Depressive Disorder. Frontiers in Psychiatry. 2022; 13:862507.

Dai, Z; Shao, J; Zhou, H; Chen, Z; Zhang, S; Wang, H; Jiang, H; Yao, Z; Lu, Q. Disrupted fronto-parietal network and default-mode network gamma interactions distinguishing suicidal ideation and suicide attempt in depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2022; 113:110475.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; et al. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge). 2022; 149:dev200028.

Dai, Z; Pei, C; Zhang, S; Tian, S; Chen, Z; Zhou, H; Lu, Q; Yao, Z. Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response. CNS Neuroscience and Therapeutics. 2022; 28:401-410.

Chen, Z; Zhao, S; Tian, S; Yan, R; Wang, H; Wang, X; Zhu, R; Xia, Y; Yao, Z; Lu, Q. Diurnal mood variation symptoms in major depressive disorder associated with evening chronotype: Evidence from a neuroimaging study. Journal of Affective Disorders. 2022; 298:151-159.

Lv, X; Lu, Q; Sun, Y; Deng, K; Yang, J. Retroflexed view for reexamination of the right colon after forward view examination: Systematic review and meta-analysis. Digestive Endoscopy. 2022; 34:33-42.

Tang, H; Xiong, T; Shi, J; Chen, Y; Liu, X; Zhang, S; Wang, H; Lu, Q; Yao, Z. Global and reflective rumination are related to suicide attempts among patients experiencing major depressive episodes. BMC Psychiatry. 2021; 21:117.

Wu, C; Zhu, J; King, A; Tong, X; Lu, Q; Park, JY; Wang, L; Gao, G; Deng, H; Yang, Y; et al. Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer. Cancer Communications. 2021; 41:1387-1397.

Fan, S; Zhao, Z; Zhang, Y; Yu, H; Zheng, C; Huang, X; Yang, Z; Xing, M; Lu, Q; Luo, Y. Probability calibration-based prediction of recurrence rate in patients with diffuse large B-cell lymphoma. BioData Mining. 2021; 14:38.

Li, Z; Chen, J; Feng, Y; Zhong, S; Tian, S; Dai, Z; Lu, Q; Guan, Y; Shan, Y; Jia, Y. Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study. BMC Psychiatry. 2021; 21:568.

Zhang, M; Wang, J; Zhang, K; Lu, G; Liu, Y; Ren, K; Wang, W; Xin, D; Xu, L; Mao, H; et al. Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature Communications. 2021; 12:5091.

Dai, Z; Zhang, S; Wang, X; Wang, H; Zhou, H; Tian, S; Chen, Z; Lu, Q; Yao, Z. Sub-second transient activated patterns to sad expressions in major depressive disorders discovered via hidden Markov model. Journal of Neuroscience Research. 2021; 99:3250-3260.

Wu, D; Li, C; Lu, Q. Multi-marker genetic association and interaction tests with interval-censored survival outcomes. Genetic Epidemiology. 2021; 45:860-873.

Zhao, S; Xia, Y; Huang, Y; Zou, H; Wang, X; Chen, Z; Zhou, H; Han, Y; Tang, H; Yan, R; et al. The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder. Frontiers in Endocrinology. 2021; 12:779693.

Lin, B; Lu, Q; Ma, H; Yang, J. [Endoscopic Dilation to Treat One Case of Severe Intestinal Stenosis Caused by Endometriosis]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2021; 52:1041-1043.

Tian, S; Zhu, R; Chattun, MR; Wang, H; Chen, Z; Zhang, S; Shao, J; Wang, X; Yao, Z; Lu, Q. Temporal dynamics alterations of spontaneous neuronal activity in anterior cingulate cortex predict suicidal risk in bipolar II patients. Brain Imaging and Behavior: an international journal. 2021; 15:2481-2491.

Wargent, ET; Ahmad, SJ S; Lu, QR; Kostenis, E; Arch, JR S; Stocker, CJ. Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin. Frontiers in Endocrinology. 2021; 12:698115.

Guo, D; Wang, Y; Cheng, Y; Liao, S; Hu, J; Du, F; Xu, G; Liu, Y; Cai, KQ; Cheung, M; et al. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. The Journal of Experimental Medicine. 2021; 218:e20202350.

Geraldo, LH; Xu, Y; Jacob, L; Pibouin-Fragner, L; Rao, R; Maissa, N; Verreault, M; Lemaire, N; Knosp, C; Lesaffre, C; et al. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. The Journal of Clinical Investigation. 2021; 131:141083.

Zhang, Y; Shao, J; Wang, X; Chen, Z; Liu, H; Pei, C; Zhang, S; Yao, Z; Lu, Q. Functional impairment-based segmentation of anterior cingulate cortex in depression and its relationship with treatment effects. Human Brain Mapping. 2021; 42:4035-4047.

Xue, L; Pei, C; Wang, X; Wang, H; Tian, S; Yao, Z; Lu, Q. Predicting Neuroimaging Biomarkers for Antidepressant Selection in Early Treatment of Depression. Journal of Magnetic Resonance Imaging. 2021; 54:551-559.

Dai, Z; Shen, X; Tian, S; Yan, R; Wang, H; Wang, X; Yao, Z; Lu, Q. Gradually evaluating of suicidal risk in depression by semi-supervised cluster analysis on resting-state fMRI. Brain Imaging and Behavior: an international journal. 2021; 15:2149-2158.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021; 138:221-233.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021; 138:221-233.

Liao, Y; Luo, Z; Deng, Y; Zhang, F; Rao, R; Wang, J; Xu, L; Kumar, SS; Sengupta, S; Dewire-Schottmiller, M; et al. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes. Neuro-Oncology. 2021; 23:1183-1196.

Lei, T; Lu, Q; Yang, J. Re: "Esophageal Foreign Body Management in Children: Can It Wait? " by Esparaz et al. Journal of Laparoendoscopic and Advanced Surgical Techniques - Part A. 2021; 31:710-711.

Zhang, S; Cao, C; Quinn, A; Vivekananda, U; Zhan, S; Liu, W; Sun, B; Woolrich, M; Lu, Q; Litvak, V. Dynamic analysis on simultaneous iEEG-MEG data via hidden Markov model. Neuroimage. 2021; 233:117923.

Zhao, S; Wang, X; Chen, Z; Zhou, H; Han, Y; Tang, H; Yan, R; Yao, Z; Lu, Q. Sex differences in the association between symptom profiles and cognitive functioning in patients with depressive disorder. Journal of Affective Disorders. 2021; 287:1-7.

Ma, T; Chen, H; Lu, Q; Tong, X. Polygenic Risk for Insomnia in Adolescents of Diverse Ancestry. Frontiers in Genetics. 2021; 12:654717.

Zhao, S; Chen, Z; Wang, X; Yao, Z; Lu, Q. Increased prevalence of subclinical hypothyroidism in female hospitalized patients with depression. Endocrine. 2021; 72:479-485.

Wang, J; Lu, Q; Zhang, M; Budden, T. Cartilage-specific NFAT1 overexpression rescues osteoarthritic phenotypes in specific joint tissues of nfat1 knockout mice. Osteoarthritis and Cartilage. 2021; 29:s141.

Yan, H; Lin, B; Lu, Q; Lei, T; Ma, H; Yang, J. Gallbladder bleeding along with cholecystocolonic fistula: a case report. Gastroenterology Report. 2021; 9:81-84.

Sun, Y; Tao, S; Tian, S; Shao, J; Mo, Z; Wang, X; Wang, H; Zhao, P; Chen, Z; Yao, Z; et al. Serotonin 2A receptor polymorphism rs3803189 mediated by dynamics of default mode network: a potential biomarker for antidepressant early response. Journal of Affective Disorders. 2021; 283:130-138.

Luo, Z; Dong, X; Yu, J; Xia, Y; Berry, KP; Rao, R; Xu, L; Xue, P; Chen, T; Lin, Y; et al. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in Cell and Developmental Biology. 2021; 9:634056.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2020102118.

Chen, Z; Tao, S; Zhu, R; Tian, S; Sun, Y; Wang, H; Yan, R; Shao, J; Zhang, Y; Zhang, J; et al. Aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: Bridging RORA gene polymorphism with diurnal mood variation in major depressive disorder. Journal of Psychiatric Research. 2021; 132:123-130.

Wang, J; He, X; Meng, H; Li, Y; Dmitriev, P; Tian, F; Page, JC; Lu, QR; He, Z. Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron. 2020; 108:876-886.e4.

Wang, J; Wang, J; Yang, L; Zhao, C; Wu, LN; Xu, L; Zhang, F; Weng, Q; Wegner, M; Lu, QR. CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature Communications. 2020; 11:4133.

Wang, Z; Xie, Y; Lu, Q; Yan, H; Liu, X; Long, Y; Zhang, X; Yang, J. The impact of albumin infusion on the risk of rebleeding and in-hospital mortality in cirrhotic patients admitted for acute gastrointestinal bleeding: a retrospective study of a single institute. BMC Gastroenterology. 2020; 20:198.

Yang, Y; Chattun, MR; Yan, R; Zhao, K; Chen, Y; Zhu, R; Shi, J; Wang, X; Lu, Q; Yao, Z. Atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters. Brain Imaging and Behavior: an international journal. 2020; 14:2542-2552.

Zhu, R; Tian, S; Wang, H; Jiang, H; Wang, X; Shao, J; Wang, Q; Yan, R; Tao, S; Liu, H; et al. Discriminating Suicide Attempters and Predicting Suicide Risk Using Altered Frontolimbic Resting-State Functional Connectivity in Patients With Bipolar II Disorder. Frontiers in Psychiatry. 2020; 11:597770.

Qiao, J; Tao, S; Wang, X; Shi, J; Chen, Y; Tian, S; Yao, Z; Lu, Q. Brain functional abnormalities in the amygdala subregions is associated with anxious depression. Journal of Affective Disorders. 2020; 276:653-659.

Ueno, M; Nakamura, Y; Nakagawa, H; Niehaus, JK; Maezawa, M; Gu, Z; Kumanogoh, A; Takebayashi, H; Lu, QR; Takada, M; et al. Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury. Cerebral Cortex. 2020; 30:5702-5716.

Chen, Z; Yan, R; Tian, S; Wang, Q; Zhu, R; Wang, X; Zhao, S; Tang, H; Lu, Q; Yao, Z. Characteristics of amplitude of low frequency fluctuations in the frontal lobe in depression patients with different sleep quality and its relationship with memory function. 2020; 29:892-897.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Wang, H; Zhu, R; Dai, Z; Tian, S; Shao, J; Wang, X; Sun, Y; Chen, Z; Li, X; Yao, Z; et al. Aberrant functional connectivity and graph properties in bipolar II disorder with suicide attempts. Journal of Affective Disorders. 2020; 275:202-209.

Wang, J; Lu, QR. Convergent epigenetic regulation of glial plasticity in myelin repair and brain tumorigenesis: A focus on histone modifying enzymes. Neurobiology of Disease. 2020; 144:105040.

Jiang, H; Dai, Z; Lu, Q; Yao, Z. Magnetoencephalography resting-state spectral fingerprints distinguish bipolar depression and unipolar depression. Bipolar Disorders: an international journal of psychiatry and neurosciences. 2020; 22:612-620.

Jiang, H; Zhu, R; Tian, S; Wang, H; Chen, Z; Wang, X; Shao, J; Qin, J; Shi, J; Liu, H; et al. Structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode. Neuropsychopharmacology. 2020; 45:1735-1742.

Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science Advances. 2020; 6:eaaz6477.

Chen, Y; Shi, J; Liu, H; Wang, Q; Chen, X; Tang, H; Yan, R; Yao, Z; Lu, Q. Plasma microRNA Array Analysis Identifies Overexpressed miR-19b-3p as a Biomarker of Bipolar Depression Distinguishing From Unipolar Depression. Frontiers in Psychiatry. 2020; 11:757.

Han, Y; Dai, Z; Ridwan, MC; Lin, P; Zhou, H; Wang, H; Yao, Z; Lu, Q. Connectivity of the Frontal Cortical Oscillatory Dynamics Underlying Inhibitory Control During a Go/No-Go Task as a Predictive Biomarker in Major Depression. Frontiers in Psychiatry. 2020; 11:707.

Parras, C; Marie, C; Zhao, C; Lu, QR. Chromatin remodelers in oligodendroglia. Glia. 2020; 68:1604-1618.

Pei, C; Sun, Y; Zhu, J; Wang, X; Zhang, Y; Zhang, S; Yao, Z; Lu, Q. Ensemble Learning for Early-Response Prediction of Antidepressant Treatment in Major Depressive Disorder. Journal of Magnetic Resonance Imaging. 2020; 52:161-171.

Wang, L; Bi, K; Song, Z; Zhang, Z; Li, K; Kong, Q; Li, X; Lu, Q; Si, T. Disturbed Resting-State Whole-Brain Functional Connectivity of Striatal Subregions in Bulimia Nervosa. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2020; 23:356-365.

Tian, S; Zhang, S; Mo, Z; Chattun, MR; Wang, Q; Wang, L; Zhu, R; Shao, J; Wang, X; Yao, Z; et al. Antidepressants normalize brain flexibility associated with multi-dimensional symptoms in major depressive patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2020; 100:109866.

Jing, L; Cui, Y; Lu, Q; Yu, H. Multiplier method estimates of the population of men who have sex with men: the effect of privacy protection. Journal of Public Health (Oxford). 2020; 42:429-434.

Qiao, J; Tao, S; Wang, X; Yao, Z; Lu, Q. The difference of amplitude of low frequency fluctuation in amygdala subregion and its correlation with clinical characteristics in patients with anxious depression. 2020; 29:400-405.

Tian, S; Sun, Y; Shao, J; Zhang, S; Mo, Z; Liu, X; Wang, Q; Wang, L; Zhao, P; Chattun, MR; et al. Predicting escitalopram monotherapy response in depression: The role of anterior cingulate cortex. Human Brain Mapping. 2020; 41:1249-1260.

Chattun, MR; Zhang, S; Chen, Y; Wang, Q; Amdanee, N; Tian, S; Lu, Q; Yao, Z. Caudothalamic dysfunction in drug-free suicidally depressed patients: an MEG study. European Archives of Psychiatry and Clinical Neuroscience: official organ of the German society for biological psychiatry. 2020; 270:217-227.

Berry, K; Wang, J; Richard Lu, Q. Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases. F1000Research. 2020; 9:f1000 faculty rev-105.

Zhou, H; Dai, Z; Hua, L; Jiang, H; Tian, S; Han, Y; Lin, P; Wang, H; Lu, Q; Yao, Z. Decreased Task-Related HRV Is Associated With Inhibitory Dysfunction Through Functional Inter-Region Connectivity of PFC in Major Depressive Disorder. Frontiers in Psychiatry. 2020; 10:989.

Zhao, P; Yan, R; Wang, X; Geng, J; Chattun, MR; Wang, Q; Yao, Z; Lu, Q. Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression. Frontiers in Psychiatry. 2020; 10:994.

Berry, KP; Lu, QR. Chromatin modification and epigenetic control in functional nerve regeneration. Seminars in Cell and Developmental Biology. 2020; 97:74-83.

Weng, Q; Zhao, M; Zheng, J; Yang, L; Xu, Z; Zhang, Z; Wang, J; Wang, J; Yang, B; Lu, QR; et al. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell Death and Differentiation. 2020; 27:130-145.

Zhou, H; Hua, L; Jiang, H; Dai, Z; Han, Y; Lin, P; Wang, H; Lu, Q; Yao, Z. Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression. Neuropsychiatric Disease and Treatment. 2020; 16:235-247.

Lu, Q; Yan, H; Wang, Y; Lei, T; Zhu, L; Ma, H; Yang, J. The role of endoscopic dilation and stents in refractory benign esophageal strictures: a retrospective analysis. BMC Gastroenterology. 2019; 19:95.

Shao, J; Dai, Z; Zhu, R; Wang, X; Tao, S; Bi, K; Tian, S; Wang, H; Sun, Y; Yao, Z; et al. Early identification of bipolar from unipolar depression before manic episode: Evidence from dynamic rfMRI. Bipolar Disorders: an international journal of psychiatry and neurosciences. 2019; 21:774-784.

Tu, Z; Wang, C; Zhao, C; Huang, L; Salomonis, N; Lu, RQ; Zheng, Y. Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells. Blood. 2019; 134:1191.

Rao, R; Zhang, F; Verma, R; Wang, J; Xin, D; Lu, R. TMIC-55. CHARACTERIZATION OF TUMOR-MICROENVIRONMENT INTERACTIONS IN GLIOBLASTOMAS AT THE SINGLE-CELL LEVEL. Neuro-Oncology. 2019; 21:vi259-vi260.

Zhang, L; He, X; Liu, X; Berry, K; Lu, R. PDTM-08. SINGLE-CELL GENOMICS REVEALS TUMOR-INITIATING PROGENITORS AND ONCOGENIC CASCADES DURING TUMORIGENESIS AND RELAPSE IN MEDULLOBLASTOMA. Neuro-Oncology. 2019; 21:vi188.

Verma, R; Lu, R. TMOD-22. LOSS OF PTEN AND TRP53 IN OLIGODENDROCYTE PROGENITORS LEADS TO GLIOMA FORMATION. Neuro-Oncology. 2019; 21:vi267.

Man Natalie Wu, L; Zhang, F; Tian, W; Lu, R. CBMT-20. SINGLE-CELL TRANSCRIPTOMICS RESOLVES CELLULAR HETEROGENEITY AND ONCOGENIC NETWORKS DURING MALIGNANT TRANSFORMATION OF PERIPHERAL NERVE SHEATH TUMORS. Neuro-Oncology. 2019; 21:vi37.

Jiang, H; Hua, L; Dai, Z; Tian, S; Yao, Z; Lu, Q; Popov, T. Spectral fingerprints of facial affect processing bias in major depression disorder. Social Cognitive and Affective Neuroscience. 2019; 14:1233-1242.

Jiang, H; Tian, S; Bi, K; Lu, Q; Yao, Z. Hyperactive frontolimbic and frontocentral resting-state gamma connectivity in major depressive disorder. Journal of Affective Disorders. 2019; 257:74-82.

Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019; 36:302-318.e7.

Wang, L; Bi, K; An, J; Li, M; Li, K; Kong, Q; Li, X; Lu, Q; Si, T. Abnormal structural brain network and hemisphere-specific changes in bulimia nervosa. Translational Psychiatry. 2019; 9:206.

Boshans, LL; Factor, DC; Singh, V; Liu, J; Zhao, C; Mandoiu, I; Lu, QR; Casaccia, P; Tesar, PJ; Nishiyama, A. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in Neuroscience. 2019; 13:829.

Ji, H; Zhou, Y; Zhuang, X; Zhu, Y; Wu, Z; Lu, Y; Li, S; Zeng, Y; Lu, QR; Huo, Y; et al. HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition. Cancer Research. 2019; 79:3676-3688.

Lu, Q; Lei, T; Wang, Y; Yan, H; Lin, B; Zhu, L; Ma, H; Yang, J. Development and validation of a model to determine risk of refractory benign esophageal strictures. World Journal of Clinical Cases. 2019; 7:1623-1633.

Rao, R; Verma, R; Wang, J; Lu, QR. Abstract 144: Characterization of glioma subtype-specific macrophage-tumor interactions using single-cell RNA-seq. Cancer Research. 2019; 79:144.

Lu, QR; Qian, L; Zhou, X. Developmental origins and oncogenic pathways in malignant brain tumors. Wiley Interdisciplinary Reviews: Developmental Biology. 2019; 8:e342.

Tian, S; Chattun, MR; Zhang, S; Bi, K; Tang, H; Yan, R; Wang, Q; Yao, Z; Lu, Q. Dynamic community structure in major depressive disorder: A resting-state MEG study. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019; 92:39-47.

Lei, T; Lu, Q; Ma, H; Yang, J. Mo1089 THE ESTABLISHMENT OF RISK-SCORING MODEL FOR COLORECTAL POST-POLYPECTOMY BLEEDING IN AMBULATORY SURGERY UNIT. Gastrointestinal Endoscopy. 2019; 89:ab444.

Lu, Q; Lei, T; Ma, H; Yang, J. Mo1220 DEVELOPMENT AND VALIDATION OF A MODEL TO DETERMINE RISK OF REFRACTORY BENIGN ESOPHAGEAL STRICTURES. Gastrointestinal Endoscopy. 2019; 89:ab471.

Wang, Q; Tian, S; Tang, H; Liu, X; Yan, R; Hua, L; Shi, J; Chen, Y; Zhu, R; Lu, Q; et al. Identification of major depressive disorder and prediction of treatment response using functional connectivity between the prefrontal cortices and subgenual anterior cingulate: A real-world study. Journal of Affective Disorders. 2019; 252:365-372.

Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019; 24:707-723.e8.

Wang, X; Qin, J; Zhu, J; Bi, K; Zhang, S; Yan, R; Zhao, P; Yao, Z; Lu, Q. Rehabilitative compensatory mechanism of hierarchical subnetworks in major depressive disorder: A longitudinal study across multi-sites. European Psychiatry. 2019; 58:54-62.

Yan, R; Tao, S; Liu, H; Chen, Y; Shi, J; Yang, Y; Zhu, R; Yao, Z; Lu, Q. Abnormal Alterations of Regional Spontaneous Neuronal Activity in Inferior Frontal Orbital Gyrus and Corresponding Brain Circuit Alterations: A Resting-State fMRI Study in Somatic Depression. Frontiers in Psychiatry. 2019; 10:267.

Hall, A; Choi, K; Liu, W; Rose, J; Zhao, C; Yu, Y; Na, Y; Cai, Y; Coover, RA; Lin, Y; et al. RUNX represses Pmp22 to drive neurofibromagenesis. Science Advances. 2019; 5:eaau8389.

Wang, J; Feng, Y; Grote, CW; Lu, Q; Haleem, AA. Effect of NFAT1 gene dosage on the progression of posttraumatic osteoarthritis. Osteoarthritis and Cartilage. 2019; 27:s178-s179.

Ou, Z; Ma, Y; Sun, Y; Zheng, G; Wang, S; Xing, R; Chen, X; Han, Y; Wang, J; Lu, QR; et al. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell Reports. 2019; 26:2984-2997.e4.

Yang, L; Kong, Y; Dong, X; Hu, L; Lin, Y; Chen, X; Ni, Q; Lu, Y; Wu, B; Wang, H; et al. Clinical and genetic spectrum of a large cohort of children with epilepsy in China. Genetics in Medicine. 2019; 21:564-571.

Geng, J; Yan, R; Shi, J; Chen, Y; Mo, Z; Shao, J; Wang, X; Yao, Z; Lu, Q. Altered regional homogeneity in patients with somatic depression: A resting-state fMRI study. Journal of Affective Disorders. 2019; 246:498-505.

Yang, Y; Yan, R; Zhu, R; Tao, S; Shi, J; Chen, Y; Liu, X; Lu, Q; Yao, Z. The influence of rs1360780 polymorphism of FK506-binding protein 5 gene on the brain regional homogeneity of resting state fMRI in patients with major depressive disorder. 2019; 28:97-102.

Wu, LM N; Lu, QR. Therapeutic targets for malignant peripheralnerve sheath tumors. Future Neurology. 2019; 14:fnl7.

Zhang, M; Lu, Q; Budden, T; Wang, J. NFAT1 protects articular cartilage against osteoarthritic degradation by directly regulating transcription of specific anabolic and catabolic genes. Bone and Joint Research. 2019; 8:90-100.

Ma, K; Wang, H; Gao, X; Huang, J; Sun, C; Qiao, N; Zhang, H; Lu, Q; Que, X; Li, L; et al. Sleep quality mediating the association of personality traits and quality of life among underground workers and surface workers of Chinese coal mine: A multi-group SEM with latent response variable mediation analysis. Psychiatry Research. 2019; 272:196-205.

Bi, K; Luo, G; Tian, S; Zhang, S; Liu, X; Wang, Q; Lu, Q; Yao, Z. An enriched granger causal model allowing variable static anatomical constraints. NeuroImage-Clinical. 2019; 21:101592.

Contact Us

Join the Lab