Lu Lab

Publications

Khot, B; Suriyaarachchi, H; Majumder, T; Nathan, A; Lu, QR; Liu, G. miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance. iScience. 2025; 28(12):114242.

Peshoff, MM; Zheng, J; Fei, M; Pallegar, PN; Lu, QR; Wu, L-J. TMOD-42. TREM2 modulates glioma-associated microglia and macrophage function in a genetic driver dependent manner. Neuro-Oncology. 2025; 27(Supplement_5):v483-v483.

Zhong, X; Triplett, J; Esshaghibayat, A; Lu, R. TMOD-15. Native Histone H3.3K27M Sustains Progenitor Identity and Impairs Differentiation to Rewire Neural Development. Neuro-Oncology. 2025; 27(Supplement_5):v476-v477.

Luo, Z; Xia, M; Zhang, F; Xin, D; Rao, R; Kiang, KM; Berry, K; Xiong, Y; Liu, H; Lin, Y; Li, H; Taylor, MD; Zhou, W; Lu, QR. CNSC-41. IDENTIFICATION AND VALIDATION OF TRANSITIONAL CEREBELLAR PROGENITORS (TCP) IN THE RHOMBIC LIP OF THE HUMAN FETAL CEREBELLUM. Neuro-Oncology. 2025; 27(Supplement_5):v63-v63.

Soni, UK; Lu, QR. Living on the edge: Uncommitted OPC-like cells drive glioblastoma invasiveness. Developmental Cell. 2025; 60(18):2383-2385.

Klaver, YLB; Hoogeman, MS; Lu, QR; Bradley, JD; Choi, JI; Ferris, MJ; Grau, C; Guha, C; Lin, H; Lin, L; Zhou, S; Amos, RA; Hawkins, M; Simone, CB. Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus. International Journal of Radiation Oncology Biology Physics. 2025; 123(1):296-305.

Chen, F; Liu, X; Zhong, X; Chen, X; Nicholson, E; Liu, K; Chen, H; Lin, Y; Shu, Y; Zhou, W; Schuurmans, CJ; Lu, QR. Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity. Science Advances. 2025; 11(30):eadw9296.

Kiang, KM; Wong, YKH; Sengupta, S; Roussel, MF; Lu, QR. Developmental Origins and Oncogenesis in Medulloblastoma. Annual Review of Neuroscience. 2025; 48(1):85-102.

Yang, J-Q; Wang, C; Nayak, RC; Kolla, M; Cai, M; Pujato, M; Zheng, Y; Lu, QR; Guo, F. Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8. Cellular & Molecular Biology Letters. 2025; 30(1):36.

Li, C; Xie, Q; Ghosh, S; Cao, B; Du, Y; Vo, GV; Huang, TY; Spruck, C; Carpenter, RL; Wang, YA; Lu, QR; Nephew, KP; Shen, J. SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma. JCI Insight. 2025; 10(5).

Liu, K; Kang, Z; Yang, M; Chen, F; Xia, M; Dai, W; Zheng, S; Chen, H; Lu, QR; Zhou, W; Lin, Y. The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex. Glia. 2025; 73(1):140-158.

Xin, DE; Luo, Z; Huang, XC; Lu, QR. Single-Cell Multi-omics Analyses of Medulloblastoma. In: Translational Research Methods for Pediatric Brain Tumors. Springer Nature; 2025:1-21.

Tang, H; Shi, J; Zhang, S; Chen, Y; Xiong, T; Wang, X; Chen, Z; Dai, Z; Yao, Z; Lu, Q. Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients. Brain Connectivity. 2024; 14(10):542-549.

Myers, BL; Brayer, KJ; Paez-Beltran, LE; Villicana, E; Keith, MS; Suzuki, H; Newville, J; Anderson, RH; Lo, Y; Mertz, CM; Lu, QR; Bachoo, RM; Johnson, JE; Vue, TY. Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration. Nature Communications. 2024; 15(1):10363.

Tang, H; Xia, Y; Hua, L; Dai, Z; Wang, X; Yao, Z; Lu, Q. Electrophysiological predictors of early response to antidepressants in major depressive disorder. Journal of Affective Disorders. 2024; 365:509-517.

Du, Y; Liu, J; Lin, R; Chattun, MR; Gong, W; Hua, L; Tang, H; Han, Y; Lu, Q; Yao, Z. The mediating role of family functioning between childhood trauma and depression severity in major depressive disorder and bipolar disorder. Journal of Affective Disorders. 2024; 365:443-450.

Xin, E; Zhong, X; Huang, C; Lu, R. CSIG-26. TARGETING EPIGENETIC DYSREGULATION AND ADAPTIVE RESISTANCE MECHANISMS IN DIPG/DMG. Neuro-Oncology. 2024; 26(Supplement_8):viii69-viii69.

Myers, B; Brayer, K; Paez-Beltran, L; Keith, M; Suzuki, H; New, J; Anderson, R; Lo, Y; Mertz, C; Kollipara, R; Borromeo, M; Lu, R; Bachoo, R; Johnson, J; Vue, TY. CNSC-46. GLIOBLASTOMA INITIATION, MIGRATION, AND CELL TYPES ARE REGULATED BY CORE BHLH TRANSCRIPTION FACTORS ASCL1 AND OLIG2. Neuro-Oncology. 2024; 26(Supplement_8):viii51-viii51.

Huang, G; Li, Z; Liu, X; Guan, M; Zhou, S; Zhong, X; Zheng, T; Xin, D; Gu, X; Mu, D; Guo, Y; Zhang, L; Zhang, L; Lu, QR; He, X. DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice. Nature Neuroscience. 2024; 27(11):2073-2085.

Klaver, YLB; Hoogeman, MS; Lu, QR; Amos, RA; Hawkins, MA; Simone, CB. Requirements and Study Design for the Next Proton Flash Clinical Trials: An International Multidisciplinary Delphi Consensus. International Journal of Radiation Oncology Biology Physics. 2024; 120(2):s108-s109.

Cui, S; Chen, T; Xin, D; Chen, F; Zhong, X; Dong, C; Chen, X; Chen, H; Zhou, W; Lin, Y; Lu, QR. Zinc-Finger Protein ZFP488 Regulates the Timing of Oligodendrocyte Myelination and Remyelination. Journal of Neuroscience. 2024; 44(39).

Huynh, NPT; Osipovitch, M; Foti, R; Bates, J; Mansky, B; Cano, JC; Benraiss, A; Zhao, C; Lu, QR; Goldman, SA. Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia. Brain. 2024; 147(9):3099-3112.

Schmidt, AL; Kremp, M; Aratake, T; Cui, S; Lin, Y; Zhong, X; Lu, QR; Zhang, C; Qiu, M; Aberle, T; Wegner, M. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. Glia. 2024; 72(7):1304-1318.

Wang, J; Yang, L; Du, Y; Wang, J; Weng, Q; Liu, X; Nicholson, E; Xin, M; Lu, QR. BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination. Journal of Cell Biology. 2024; 223(7).

Kiang, KM; Ahad, L; Zhong, X; Lu, QR. Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer. Trends in Cell Biology. 2024; 34(7):566-577.

Liu, X; Xin, DE; Zhong, X; Zhao, C; Li, Z; Zhang, L; Dourson, AJ; Lee, L; Mishra, S; Bayat, AE; Jankowski, MP; Barton, SK; He, X; Lu, QR. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. 2024; 187(10):2465-2484.e22.

Xin, DE; Liao, Y; Rao, R; Ogurek, S; Sengupta, S; Xin, M; Bayat, AE; Seibel, WL; Graham, RT; Koschmann, C; Lu, QR. Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201. Neuro-Oncology. 2024; 26(4):735-748.

Koschmann, C; Al-Holou, WN; Alonso, MM; Anastas, J; Bandopadhayay, P; Barron, T; Becher, O; Cartaxo, R; Castro, MG; Chung, C; Yadav, VN; Zhang, X; Zhang, Q; Venneti, S. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024; 42(1):1-5.

Lv, X-H; Lu, Q; Yang, J-L. Methodological issues in the evaluation of cold snare endoscopic mucosal resection for colon polyps. Endoscopy. 2024; 56(1):79.

Zhang, Q; Du, Y; Bao, C; Hua, L; Yan, R; Dai, Z; Xia, Y; Zou, H; He, C; Sun, H; Lu, Q; Yao, Z. Aberrant high-beta band functional connectivity during reward processing in melancholic major depressive disorder: An MEG study. NeuroImage: Clinical. 2024; 43:103666.

Bao, C; Zhang, Q; He, C; Zou, H; Xia, Y; Yan, R; Hua, L; Wang, X; Lu, Q; Yao, Z. Neural responses to decision-making in suicide attempters with youth major depressive disorder. NeuroImage: Clinical. 2024; 43:103667.

Qiao, J; Tao, S; Sun, Y; Shi, J; Chen, Y; Tian, S; Yao, Z; Lu, Q. The Effects of Variation in the GABAA Receptor Gene on Anxious Depression are Mediated by the Functional Connectivity Between the Amygdala and Middle Frontal Gyrus. Neuropsychiatric Disease and Treatment. 2024; 20:1781-1796.

Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; Tian, W; Zheng, Y. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia. 2023; 37(10):2073-2081.

Talley, MJ; Nardini, D; Ehrman, LA; Lu, QR; Waclaw, RR. Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Development. 2023; 18(1):5.

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O'brien, E; Vancauwenbergh, B; Perentesis, J; Roskin, K; Kornblum, H; Plas, DR; Lu, QR. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports. 2023; 13(1):12433.

Lu, R; Luo, Z. MDB-02. NUCLEAR ENVELOPE PHOSPHATASE CTDNEP1 MUTATIONS POTENTIATE AGGRESSIVE MEDULLOBLASTOMA BY TRIGGERING MYC ACTIVATION AND GENOMIC INSTABILITY. Neuro-Oncology. 2023; 25(Supplement_1):i61-i62.

Luo, Z; Lu, R. MDB-05. HUMAN FETAL CEREBELLAR CELL ATLAS INFORMS MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2023; 25(Supplement_1):i62-i62.

Zhang, J; Guan, M; Zhou, X; Berry, K; He, X; Lu, QR. Long Noncoding RNAs in CNS Myelination and Disease. Neuroscientist. 2023; 29(3):287-301.

Wang, F; Wang, W; Gu, S; Qi, D; Smith, NA; Peng, W; Dong, W; Yuan, J; Zhao, B; Mao, Y; Shapiro, LA; Yi, SS; Wu, E; Huang, JH. Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice. Nature Communications. 2023; 14(1):2186.

Verma, R; Chen, X; Xin, D; Luo, Z; Ogurek, S; Xin, M; Rao, R; Berry, K; Lu, QR. Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer Research. 2023; 83(6):890-905.

Luo, Z; Xin, D; Liao, Y; Berry, K; Ogurek, S; Zhang, F; Zhang, L; Zhao, C; Rao, R; Dong, X; Zhou, W; Weiss, WA; Andreassen, P; Lu, QR. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature Communications. 2023; 14(1):762.

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; Lee, L; Hu, M; Xin, M; Lu, QR. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25(2):323-336.

Thompson, M; Sakabe, M; Verba, M; Hao, J; Meadows, SM; Lu, QR; Xin, M. PRDM16 regulates arterial development and vascular integrity. Frontiers in Physiology. 2023; 14:1165379.

Sakabe, M; Thompson, M; Chen, N; Verba, M; Hassan, A; Lu, R; Xin, M. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis. eLife. 2022; 11.

Berry, K; Ogurek, S; Rao, R; Lu, R. TMIC-47. SINGLE-CELL TRANSCRIPTOMICS REVEALS ANTITUMOR IMMUNE RESPONSES OF PROTON TREATMENT IN GLIOBLASTOMA. Neuro-Oncology. 2022; 24(Supplement_7):vii281-vii282.

Luo, Z; Lu, R. STEM-24. SINGLE-CELL ATLAS OF HUMAN FETAL CEREBELLUM DECODING MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2022; 24(Supplement_7):vii36-vii36.

Wang, J; Yang, L; Jiang, M; Zhao, C; Liu, X; Berry, K; Waisman, A; Langseth, AJ; Novitch, BG; Bergles, DE; Nishiyama, A; Lu, QR. Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination. Journal of Neuroscience. 2022; 42(45):8542-8555.

Liao, Y; Luo, Z; Lin, Y; Chen, H; Chen, T; Xu, L; Orgurek, S; Berry, K; Dzieciatkowska, M; Reisz, JA; D'alessandro, A; Zhou, W; Lu, QR. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death and Disease. 2022; 13(11):943.

Wu, LMN; Zhang, F; Rao, R; Adam, M; Pollard, K; Szabo, S; Liu, X; Belcher, KA; Luo, Z; Ogurek, S; Suva, M; Pratilas, CA; Potter, S; Lu, QR. Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Science Advances. 2022; 8(44):eabo5442.

Dong, C; Zhao, C; Chen, X; Berry, K; Wang, J; Zhang, F; Liao, Y; Han, R; Ogurek, S; Xu, L; Campbell, K; Nakafuku, M; Waclaw, RR; Lu, QR. Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis. Journal of Neuroscience. 2022; 42(44):8373-8392.

Intisar, A; Shin, HY; Kim, W-H; Kang, HG; Kim, MY; Kim, YS; Cho, Y; Mo, YJ; Lim, H; Lee, S; Lu, QR; Lee, Y-I; Kim, MS. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy. Advanced Science. 2022; 9(32):e2201358.

Kalim, KW; Yang, J-Q; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; Jegga, AG; Zheng, Y; Guo, F. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for ImmunoTherapy of Cancer. 2022; 10(11).

Intisar, A; Shin, HY; Kim, W; Kang, HG; Kim, MY; Kim, YS; Cho, Y; Mo, YJ; Lim, H; Lee, S; Lu, QR; Lee, Y; Kim, MS. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy (Adv. Sci. 32/2022) Advanced Science. 2022; 9(32).

Yi, J; Kim, B; Shi, X; Zhan, X; Lu, QR; Xuan, Z; Wu, J. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer Research. 2022; 82(16):2874-2886.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports. 2022; 40(2):111072.

Garrett, MC; Albano, R; Carnwath, T; Shah, S; Woo, D; Lamba, M; Plas, DR; Paranjpe, A; Roskin, K; Zhao, C; Lu, R. Chromatin structure predicts survival in glioma patients. Scientific Reports. 2022; 12(1):8221.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; Lu, QR. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-Oncology. 2022; 24(4):584-597.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; Potter, SS; Waclaw, R; Campbell, K; Nakafuku, M. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development. 2022; 149(5).

Guo, D; Wang, Y; Cheng, Y; Liao, S; Hu, J; Du, F; Xu, G; Liu, Y; Cai, KQ; Cheung, M; Wainwright, BJ; Lu, QR; Zhao, Y; Yang, Z-J. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Journal of Experimental Medicine (JEM). 2021; 218(9).

Zhang, M; Wang, J; Zhang, K; Lu, G; Liu, Y; Ren, K; Wang, W; Xin, D; Xu, L; Mao, H; Mikoshiba, K; Wu, S; Lu, QR; Zhao, X. Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature Communications. 2021; 12(1):5091.

Geraldo, LH; Xu, Y; Jacob, L; Pibouin-Fragner, L; Rao, R; Maissa, N; Verreault, M; Lemaire, N; Knosp, C; Lesaffre, C; Lima, FR; Thomas, J-L; Eichmann, A; Mathivet, T. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. Journal of Clinical Investigation. 2021; 131(16).

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021; 138(3):221-233.

Liao, Y; Luo, Z; Deng, Y; Zhang, F; Rao, R; Wang, J; Xu, L; Kumar, SS; Sengupta, S; Dewire-Schottmiller, M; Berry, K; Garrett, M; Fouladi, M; Drissi, R; Lu, QR. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes. Neuro-Oncology. 2021; 23(7):1183-1196.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, R; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; Azam, M; Tian, W; Lu, QR; Zheng, Y. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118(1).

Luo, Z; Dong, X; Yu, J; Xia, Y; Berry, KP; Rao, R; Xu, L; Xue, P; Chen, T; Lin, Y; Yu, J; Huang, G; Li, H; Zhou, W; Lu, QR. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in Cell and Developmental Biology. 2021; 9:634056.

Wargent, ET; Ahmad, SJS; Lu, QR; Kostenis, E; Arch, JRS; Stocker, CJ. Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin. Frontiers in Endocrinology. 2021; 12:698115.