Experimental Hematology and Cancer Biology

Publications

Agarwal, P; Sampson, A; Hueneman, K; Choi, K; Jakobsen, NA; Uible, E; Ishikawa, C; Yeung, J; Bolanos, L; Zhao, X; Galloway-Pena, J; Byrd, JC; Vyas, P; Starczynowski, DT. Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature. 2025; 642:201-211.

Aggarwal, RK; Sidoli, S; Wang, J; Sahu, S; Sanawar, R; Gupta, V; Aluri, S; Sukrithan, V; Vegivinti, CT R; Zavras, PD; LaFave, LM; Cheng, H; Verma, A; Zou, Y. Smoking-Associated Carcinogen-Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation. Clinical Cancer Research. 2025; 31:746-755.

Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. Abstract 5480: Live cell real-time quantification of drug-target engagement for rapid drug discovery. Cancer Research. 2025; 85:5480.

Bedard, MC; Rivera-Cruz, CM; Chihanga, T; VonHandorf, A; Tang, AL; Zender, C; Weirauch, MT; Ferris, R; Wise-Draper, TM; Adam, M; Wells, SI. A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers. Viruses-Basel. 2025; 17:461.

Borate, U; Pugh, K; Waller, A; Welkie, RL; Huang, Y; Bewersdorf, JP; Stahl, M; DeZern, AE; Platzbecker, U; Sekeres, MA; Bennett, JM; List, AF; Brunner, AM; Zeidan, AM. Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement. Blood. 2025; 145:1369-1381.

Boucher, AA; Dayton, VJ; Pratt, AR; Nassar, NN; Elgammal, Y; Kalfa, TA. Three-generation female cohort with macrocytic anemia and iron overload. American Journal of Hematology. 2025; 100:133-138.

Cai, M; Adam, M; Guo, F; Zheng, Y. Abstract 1596: Tumor-derived RAC1A159V gain-of-function mutation promotes an immunosuppressive tumor microenvironment and represses response to immune checkpoint inhibitors. Cancer Research. 2025; 85:1596.

Chen, F; Liu, X; Zhong, X; Chen, X; Nicholson, E; Liu, K; Chen, H; Lin, Y; Shu, Y; Zhou, W; Schuurmans, CJ; Lu, QR. Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity. Science Advances. 2025; 11:eadw9296.

Chen, Z; Zeng, C; Yang, L; Che, Y; Chen, M; Sau, L; Wang, B; Zhou, K; Chen, Y; Qing, Y; Weng, H; Xiao, G; Deng, X; Chen, J. YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies. Cell. 2025; 188:331-351.e30.

Chi, M; Malik, P. An engineered β-globin homology donor reveals insights into β-globin expression and betters HDR. Molecular Therapy. 2025; 33:1308-1309.

Clough, CA; Cunningham, C; Philbrook, SY; Hueneman, KM; Sampson, AM; Choi, K; Greis, KD; Starczynowski, D. Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. Leukemia. 2025; 39:1997-2009.

Davies, SM; Grimley, MS; Shrestha, A; Shova, A; Asnani, M; Kent, M; Sayani, F; Quinn, CT; Niss, O; Lutzko, CM; Witting, S; Latham, T; Bushman, FD; Malik, P. Gene Therapy with Reduced-Intensity Conditioning for Sickle Cell Disease. Transplantation and Cellular Therapy. 2025; 31:s2-s3.

Fisher, AA; Gonzalez, LS; Cappel, ZR; Grover, KE; Waclaw, RR; Robinson, JE. Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens. Editor, Bahar I. PNAS Nexus. 2025; 4:pgaf128.

Goda, C; Kulkarni, R; Bustos, Y; Li, W; Rudich, A; Balcioglu, O; Chidester, S; Urs, AP; Karunasiri, M; Al-Marrawi, Y; Viny, AD; Miles, LA; Miller, KE; Dorrance, AM. Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia. Leukemia. 2025; 39:51-63.

Gonzalez, LS; Fisher, AA; Grover, KE; Robinson, JE. Examining the role of the photopigment melanopsin in the striatal dopamine response to light. Frontiers in Systems Neuroscience. 2025; 19:1568878.

Gower, M; Li, X; Aguilar-Navarro, AG; Lin, B; Fernandez, M; Edun, G; Nader, M; Rondeau, V; Arruda, A; Tierens, A; Jones, CL; Dolgalev, I; Jahangiri, S; Tikhonova, AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup. Science Translational Medicine. 2025; 17:eadr2012.

Grimley, M; Davies, SM; Shrestha, A; Shova, A; Asnani, M; Kent, M; Sayani, F; Quinn, CT; Niss, O; Lutzko, C; Witting, S; Latham, T; Bushman, FD; Malik, P. Lentiviral gene therapy with reduced-intensity conditioning for sickle cell disease: a phase 1/2 trial. Nature Medicine. 2025; 31:2204-2212.

Hanenberg, H; Zhang, F; Malev, N; Wiek, C; Klamer, BG; Nassar, N; Hesselbrock, T; Hanenberg, JH; Aeilts, AM; Hentschel, J; Hauke, J; Niederacher, D; Toland, AE; Andreassen, PR. Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points-Based Framework. Clinical Cancer Research. 2025; 31:2426-2440.

He, X; Hawkins, C; Lawley, L; Phan, TM; Park, I; Joven, N; Zhang, J; Wunderlich, M; Mizukawa, B; Pei, S; Patel, A; VanOudenhove, J; Halene, S; Fang, J. GPR68 supports AML cells through the calcium/calcineurin pro-survival pathway and confers chemoresistance by mediating glucose metabolic symbiosis. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease. 2025; 1871:167565.

Hoyt, SB; Finocchio, CJ; Croll, E; Tawa, GJ; Zhang, M; Wang, J; Li, H; Ma, L; Li, K; Zhang, X; Culver-Cochran, AE; Rosenbaum, JS; Starczynowski, DT; Thomas, CJ. IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia. ACS Medicinal Chemistry Letters. 2025; 16:887-895.

Hsu, AY; Huang, Q; Pi, X; Fu, J; Raghunathan, K; Ghimire, L; Balasubramanian, A; Xie, X; Yu, H; Loison, F; Thiagarajah, JR; Wu, H; Feng, S; Luo, HR. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025; 188:1623-1641.e26.

Ishikawa, C; Barreyro, L; Sampson, AM; Hueneman, KM; Choi, K; Philbrook, SY; Choi, I; Bolanos, LC; Wunderlich, M; Volk, AG; Watowich, SS; Greis, KD; Starczynowski, DT. Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia. The Journal of Clinical Investigation. 2025; 135:e184665.

Kiang, KM; Wong, YK H; Sengupta, S; Roussel, MF; Lu, QR. Developmental Origins and Oncogenesis in Medulloblastoma. Annual Review of Neuroscience. 2025; 48:85-102.

Kida, J; Chlon, TM. Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding. Current Opinion in Hematology. 2025; 32:67-76.

Krishnan, A; Miles, LA; Challen, GA. Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis. Experimental Hematology. 2025; 148:104816.

Kusne, Y; Badar, T; Lasho, T; Marando, L; Mangaonkar, AA; Finke, C; Foran, JM; Al-Kali, A; Palmer, J; Arana Yi, C; Litzow, MR; Chlon, T; Ferrer, A; Patnaik, MM. Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndrome. British Journal of Haematology. 2025; 206:1109-1120.

Lee, JJ Y; Tao, R; You, Z; Haldipur, P; Erickson, AW; Farooq, H; Hendriske, LD; Abeysundara, N; Richman, CM; Wang, EY; Millen, KJ; Huang, LF; Northcott, PA; Taylor, MD. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip. Nature Genetics. 2025; 57:88-102.

Li, C; Xie, Q; Ghosh, S; Cao, B; Du, Y; Vo, GV; Huang, TY; Spruck, C; Carpenter, RL; Wang, YA; Lu, QR; Nephew, KP; Shen, J. SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma. JCI insight. 2025; 10:e186344.

Li, J; Bai, J; Pham, VT; Hashimoto, M; Sezaki, M; Shi, Q; Jin, Q; He, C; Armstrong, A; Li, T; Luan, Y; Zeng, H; Andreassen, PR; Huang, G. Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells. The Journal of Clinical Investigation. 2025; 135:e184069.

Li, Q; Liao, Y; Zeng, J; Hu, S; Li, C; Whitsett, JA; Zheng, Y; Luo, F; Xu, C; He, T; Lin, X; Wan, H. KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. 2025; 72:663-677.

Li, W; Xu, M; Cheng, M; Wei, J; Zhu, L; Deng, Y; Guo, F; Bi, F; Liu, M. Current Advances and Future Directions for Sensitizing Gastric Cancer to Immune Checkpoint Inhibitors. Cancer Medicine. 2025; 14:e71065.

Lin, S; Kotliar, M; Vallabh, S; Ptasinska, A; Assi, SA; Wunderlich, M; Bonifer, C; Barski, A; Mulloy, JC. Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia. Blood Advances. 2025; 9:856-861.

Lin, Y; Zheng, Y. Structural Dynamics of Rho GTPases. Journal of Molecular Biology. 2025; 437:168919.

Liu, K; Kang, Z; Yang, M; Chen, F; Xia, M; Dai, W; Zheng, S; Chen, H; Lu, QR; Zhou, W; Lin, Y. The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex. Glia. 2025; 73:140-158.

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood Advances. 2025; 9:1927-1939.

Miao, L; Lu, Y; Nusrat, A; Fan, G; Zhang, S; Zhao, L; Wu, CL; Guo, H; Huyen, TL N; Zheng, Y; Wan, LQ; Zhou, B; Evans, SM; Wu, M. Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Science. 2025; 387:eadd3417.

Nayak, RC; Emberesh, S; Trump, LR; Wellendorf, AM; Singh, AK; Korkmaz, B; Horwitz, MS; Myers, KC; Kalfa, TA; Lutzko, CM; Cancelas, JA. G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates. The Journal of Clinical Investigation. 2025; 135:e177342.

O'Brien, C; Jones, CL. Unraveling lipid metabolism for acute myeloid leukemia therapy. Current Opinion in Hematology. 2025; 32:77-86.

Pundavela, J; Hall, A; Dinglasan, SA; Choi, K; Rizvi, TA; Trapnell, BC; Wu, J; Ratner, N. Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation. Cancers. 2025; 17:905.

Raut, N; Adlakha, A; Sprague, KL; Rupert, AR; Hofmann, M; Ratner, N; Queme, LF; Jankowski, M. 137 Schwann Cell Glial Cell Line-Derived Neurotrophic Factor Signaling Influences Pain in Neurofibromatosis 1. Journal of Pain. 2025; 29:104935.

Reddoch-Cardenas, KM; Cancelas, JA; Nestheide, S; Rugg, N; Peña, K; McIntosh, CS; Ferdin, J; Talackine, J; Parker, J; Jensen, LA; Gonzales, R; Hess, JR; Zia, M. Novel anticoagulant-preservative solution maintained the hemostatic function of cold stored whole blood for 56 days. Transfusion. 2025; 65 Suppl 1:S185-S192.

Setayesh, T; Chi, M; Oestreicher, Z; Sakabe, M; Seu, K; Zhu, Z; Kaur, H; Tijani, A; Xin, M; Shova, A; Balla, J; VandenHeuvel, K; Hu, YC; Malik, P. A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea. Blood. 2025; 146:13-28.

Shrestha, A; Pillis, DM; Felker, S; Chi, M; Wagner, K; Gbotosho, OT; Sieling, J; Shadid, M; Malik, P. Preclinical efficacy of a modified gamma-globin lentivirus gene therapy in Berkeley sickle cell anemia mice and human xenograft models. Molecular Therapy-Methods & Clinical Development. 2025; 33:101439.

Tweedie, L; Riccetti, MR; Cain, B; Qin, S; Salomone, J; Webb, JA; Riesenberg, A; Ehrman, LA; Waclaw, RR; Kovall, RA; Gebelein, B; Campbell, K. Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects. DMM Disease Models and Mechanisms. 2025; 18:dmm052110.

Venkatasubramanian, M; Schwartz, L; Ramachandra, N; Bennett, J; Subramanian, KR; Chen, X; Gordon-Mitchell, S; Fromowitz, A; Pradhan, K; Shechter, D; Grimes, HL; Starczynowski, DT; Verma, A; Salomonis, N. Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias. Science Translational Medicine. 2025; 17:eadr1471.

Vick, EJ; Walulik, S; Sampson, A; Hassan, A; Wunderlich, M; Volk, A; Starczynowski, D. The IRAK4 long isoform as widely upregulated in non-splicesome mutated acute myeloid leukemia and as altered by hypomethylating agent therapy. Journal of Clinical Oncology. 2025; 43:6524.

Wang, Y; Xiu, Y; Dong, Q; Zhao, J; Neumbo, K; Miyagi, M; Borcherding, N; Fu, L; De Celis, H; Pintozzi, N; Starczynowski, DT; Zhao, C. TIFAB modulates metabolic pathways in KMT2A::MLLT3-induced AML through HNF4A. Blood Advances. 2025; 9:844-855.

Watanabe, H; Song, T; Choi, J; Lee, M; Choi, K; Kim, J; Sherry, B; Diamond, B; Zou, YR; Son, M. Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming. Frontiers in Pharmacology. 2025; 16:1588987.

Yoneyama, Y; Zhang, RR; Maezawa, M; Masaki, H; Kimura, M; Cai, Y; Adam, M; Parameswaran, S; Mizuno, N; Bhadury, J; Nakauchi, H; Potter, SS; Weirauch, MT; Takebe, T. Intercellular mRNA transfer alters the human pluripotent stem cell state. Proceedings of the National Academy of Sciences of USA. 2025; 122:e2413351122.