Experimental Hematology and Cancer Biology

Publications

Agarwal, P; Sampson, A; Hueneman, K; Choi, K; Jakobsen, NA; Uible, E; Ishikawa, C; Yeung, J; Bolanos, L; Zhao, X; Galloway-Pena, J; Byrd, JC; Vyas, P; Starczynowski, DT. Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature. 2025; 642(8066):201-211.

Aggarwal, RK; Sidoli, S; Wang, J; Sahu, S; Sanawar, R; Gupta, V; Aluri, S; Sukrithan, V; Vegivinti, CTR; Zavras, PD; Lafave, LM; Cheng, H; Verma, A; Zou, Y. Smoking-Associated Carcinogen-Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation. Clinical Cancer Research. 2025; 31(4):746-755.

Ahmari, N; Choi, K; Wu, J; Rizvi, TA; Jackson, M; Kershner, LJ; Kim, M-O; Zhang, X; Dombi, E; Shern, J; Hildeman, DA; Ratner, N. Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas. Life Science Alliance. 2025; 8(12).

Anandappa, A; Trivedi, V; Bones, M; Raval, J; Hefner, R; Wooten, A; Bowman, R; Levine, R; Starczynowski, D; Miles, L. RAS G12 and Q61 codon mutations confer distinct disease characteristics in Acute Myeloid Leukemia and exhibit differential response to RAS(ON) inhibitor RMC-7977. Blood. 2025; 146(Supplement 1):3229-3229.

Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. MICRO-TAG enzyme complementation enables quantification of cellular drug-target engagement in temperature series. SLAS Discovery. 2025; 38:100291.

Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. Abstract 5480: Live cell real-time quantification of drug-target engagement for rapid drug discovery. Cancer Research. 2025; 85(8_Supplement_1):5480-5480.

Badar, T; Kumar, M; Kusne, Y; Lasho, T; Foran, J; Murthy, H; Kharfan-Dabaja, M; Chlon, T; Gangat, N; Alkhateeb, H; Ferrer, A; Litzow, M; Al-Kali, A; Patnaik, M. Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients. Blood. 2025; 146(Supplement 1):1442.

Bischoff, LJ; Schrenk, S; Soroko, K; Sherpa, C; Arasu, A; Reynaud, D; Boscolo, E. Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling. Developmental Dynamics. 2025.

Borate, U; Pugh, K; Waller, A; Welkie, RL; Huang, Y; Bewersdorf, JP; Stahl, M; Dezern, AE; Platzbecker, U; Sekeres, MA; Bennett, JM; List, AF; Brunner, AM; Zeidan, AM. Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement. Blood. 2025; 145(13):1369-1381.

Boucher, AA; Dayton, VJ; Pratt, AR; Nassar, NN; Elgammal, Y; Kalfa, TA. Three-generation female cohort with macrocytic anemia and iron overload. American Journal of Hematology. 2025; 100(1):133-138.

Cai, M; Adam, M; Guo, F; Zheng, Y. Abstract 1596: Tumor-derived RAC1A159V gain-of-function mutation promotes an immunosuppressive tumor microenvironment and represses response to immune checkpoint inhibitors. Cancer Research. 2025; 85(8_Supplement_1):1596-1596.

Cai, M; Adam, M; Duan, X; Guo, F; Zheng, Y. Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor. Science Advances. 2025; 11(44):eaea1212.

Chang, X; Li, W; Matsui, S; Huynh, C; Erickson, C; Guo, F; Cederquist, GY; Studer, L; Iwafuchi, M; Shillington, A; Chronis, C; Tchieu, J. ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis. Nature Communications. 2025; 16(1):9010.

Chen, F; Liu, X; Zhong, X; Chen, X; Nicholson, E; Liu, K; Chen, H; Lin, Y; Shu, Y; Zhou, W; Schuurmans, CJ; Lu, QR. Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity. Science Advances. 2025; 11(30):eadw9296.

Chen, Z; Zeng, C; Yang, L; Che, Y; Chen, M; Sau, L; Wang, B; Zhou, K; Chen, Y; Qing, Y; Weng, H; Xiao, G; Deng, X; Chen, J. YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies. Cell. 2025; 188(2):331-351.e30.

Chi, M; Malik, P. An engineered β-globin homology donor reveals insights into β-globin expression and betters HDR. Molecular Therapy. 2025; 33(4):1308-1309.

Clough, CA; Cunningham, C; Philbrook, SY; Hueneman, KM; Sampson, AM; Choi, K; Greis, KD; Starczynowski, D. Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome. Leukemia. 2025; 39(8):1997-2009.

Davies, SM; Grimley, MS; Shrestha, A; Shova, A; Asnani, M; Kent, M; Sayani, F; Quinn, CT; Niss, O; Lutzko, CM; Witting, S; Latham, T; Bushman, FD; Malik, P. Gene Therapy with Reduced-Intensity Conditioning for Sickle Cell Disease. Transplantation and Cellular Therapy. 2025; 31(2):s2-s3.

Dionisio, LM; Zheng, Y; Cancelas, JA. Redox Control in Platelet Activity and Therapy. Antioxidants. 2025; 14(11).

Duan, H; Zhang, C; Zhang, Z; Wang, X; Zhang, J; Yang, L; He, F; Mao, L; Yang, L; Pan, Z; Pan, D; Yin, F; Xiao, W; Peng, J. Gene therapy with covalently closed-end AAV vector for spinal muscular atrophy. Molecular Therapy. 2025; 33(10):4848-4857.

Fisher, J; Stepanchick, E; Wilson, A; Kida, J; Badar, T; Lasho, T; Kusne, Y; Patnaik, M; Chlon, T. The somatic hotspot mutation of DDX41 (p.R525H) elicits dominant-negative effects upon non-truncating germline variants, explaining similar disease risk as truncating variants. Blood. 2025; 146(Supplement 1):3221-3221.

Fisher, AA; Gonzalez, LS; Cappel, ZR; Grover, KE; Waclaw, RR; Robinson, JE. Dopaminergic encoding of future defensive actions in the mouse nucleus accumbens. PNAS Nexus. 2025; 4(5):pgaf128.

Goda, C; Kulkarni, R; Bustos, Y; Li, W; Rudich, A; Balcioglu, O; Chidester, S; Urs, AP; Karunasiri, M; Al-Marrawi, Y; Viny, AD; Miles, LA; Miller, KE; Dorrance, AM. Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia. Leukemia. 2025; 39(1):51-63.

Gonzalez, LS; Fisher, AA; Grover, KE; Robinson, JE. Examining the role of the photopigment melanopsin in the striatal dopamine response to light. Frontiers in Systems Neuroscience. 2025; 19:1568878.

Gower, M; Li, X; Aguilar-Navarro, AG; Lin, B; Fernandez, M; Edun, G; Nader, M; Rondeau, V; Arruda, A; Tierens, A; Jones, CL; Dolgalev, I; Jahangiri, S; Tikhonova, AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup. Science Translational Medicine. 2025; 17(779):eadr2012.

Grimley, M; Davies, SM; Shrestha, A; Shova, A; Asnani, M; Kent, M; Sayani, F; Quinn, CT; Niss, O; Lutzko, C; Witting, S; Latham, T; Bushman, FD; Malik, P. Lentiviral gene therapy with reduced-intensity conditioning for sickle cell disease: a phase 1/2 trial. Nature Medicine. 2025; 31(7):2204-2212.

Hanenberg, H; Zhang, F; Malev, N; Wiek, C; Klamer, BG; Nassar, N; Hesselbrock, T; Hanenberg, JH; Aeilts, AM; Hentschel, J; Hauke, J; Niederacher, D; Toland, AE; Andreassen, PR. Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points-Based Framework. Clinical Cancer Research. 2025; 31(12):2426-2440.

Hoyt, SB; Finocchio, CJ; Croll, E; Tawa, GJ; Zhang, M; Wang, J; Li, H; Ma, L; Li, K; Zhang, X; Culver-Cochran, AE; Rosenbaum, JS; Starczynowski, DT; Thomas, CJ. IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia. ACS Medicinal Chemistry Letters. 2025; 16(5):887-895.

Hsu, AY; Huang, Q; Pi, X; Fu, J; Raghunathan, K; Ghimire, L; Balasubramanian, A; Xie, X; Yu, H; Loison, F; Thiagarajah, JR; Wu, H; Feng, S; Luo, HR. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025; 188(6):1623-1641.e26.

Ishikawa, C; Barreyro, L; Sampson, AM; Hueneman, KM; Choi, K; Philbrook, SY; Choi, I; Bolanos, LC; Wunderlich, M; Volk, AG; Watowich, SS; Greis, KD; Starczynowski, DT. Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia. Journal of Clinical Investigation. 2025; 135(10).

Iwata, W; Adachi, Y; West, JJ; Ewald, AJ; Zheng, Y; Wood, LD; Anders, RA; Sesaki, H; Iijima, M. Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix. Cell reports. 2025; 44(12):116649.

Jones, L; Khadaroo, A; Tiwari, R; Choi, K; Adam, M; Wunderlich, M; Stillwell, C; Sexton, C; Seibel, W; Tawa, G; Hoyt, S; Thomas, C; Starczynowski, D. FLT3-F691L confers kinase-independent resistance via Grb2-dependent MAPK signaling in AML. Blood. 2025; 146(Supplement 1):5049-5049.

Khanal, N; Summey, V; Bailey, J; Duan, X; Zheng, Y; Zhu, L; Stringer, K; Rao, M; Banerjee, RK. Development of Mouse-Tumor Model Using Prostate Cancer (PC3) Cell Line for High-Intensity Focused Ultrasound (HIFU) Ablation. Prostate Cancer. 2025; 2025:5678314.

Khot, B; Suriyaarachchi, H; Majumder, T; Nathan, A; Lu, QR; Liu, G. miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance. iScience. 2025; 28(12):114242.

Kiang, KM; Wong, YKH; Sengupta, S; Roussel, MF; Lu, QR. Developmental Origins and Oncogenesis in Medulloblastoma. Annual Review of Neuroscience. 2025; 48(1):85-102.

Kida, J; Fricker, M; Stepanchick, E; Kusne, Y; Badar, T; Lasho, T; Patnaik, M; Chlon, T. The somatic DDX41 hot spot mutation (p.R525H) causes skewed differentiation into plasmacytoid dendritic cells in human iPSC and leukemia models. Blood. 2025; 146(Supplement 1):678-678.

Kida, J; Chlon, TM. Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding. Current Opinion in Hematology. 2025; 32(2):67-76.

Kirstein, A; Ionascu, D; Lamba, MAS; Ruffolo, BM; Crail, KJ; Mascia, AE; Sertorio, MG; Hinrichs, BH; Zender, C; Lehn, MA; Wise-Draper, TM; Perentesis, JP; Zheng, Y; Wells, SI. In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy. Clinical and Translational Radiation Oncology. 2026; 56:101046.

Klaver, YLB; Hoogeman, MS; Lu, QR; Bradley, JD; Choi, JI; Ferris, MJ; Grau, C; Guha, C; Lin, H; Lin, L; Zhou, S; Amos, RA; Hawkins, M; Simone, CB. Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus. International Journal of Radiation Oncology Biology Physics. 2025; 123(1):296-305.

Koo, J; Langenberg, L; Zhao, X; Setchell, KR; Lake, KE; Luebbering, N; Walter, E; Lane, A; Myers, KC; Reynaud, D; Sabulski, A; Teusink-Cross, A; Jodele, S; Davies, SM. Lipid dysregulation after hematopoietic stem cell transplant. Haematologica. 2025.

Krishnan, A; Miles, LA; Challen, GA. Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis. Experimental Hematology. 2025; 148:104816.

Kusne, Y; Badar, T; Lasho, T; Marando, L; Mangaonkar, AA; Finke, C; Foran, JM; Al-Kali, A; Palmer, J; Arana Yi, C; Litzow, MR; Chlon, T; Ferrer, A; Patnaik, MM. Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndrome. British Journal of Haematology. 2025; 206(4):1109-1120.

Largaespada, D; Williams, K; Larsson, A; Keller, B; Stehn, C; Chaney, K; Williams, R; Bhunia, M; Draper, G; Jubenville, T; Hudson, W; Galvin, R; Moertel, C; Ratner, N. DDDR-42. Modeling and Translating Precision Therapies for NF1-Associated Tumors Across the Disease Spectrum. Neuro-Oncology. 2025; 27(Supplement_5):v172-v172.

Lee, JJY; Tao, R; You, Z; Haldipur, P; Erickson, AW; Farooq, H; Hendriske, LD; Abeysundara, N; Richman, CM; Wang, EY; Millen, KJ; Huang, LF; Northcott, PA; Taylor, MD. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip. Nature Genetics. 2025; 57(1):88-102.

Li, J; Bai, J; Pham, VT; Hashimoto, M; Sezaki, M; Shi, Q; Jin, Q; He, C; Armstrong, A; Li, T; Luan, Y; Zeng, H; Andreassen, PR; Huang, G. Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells. Journal of Clinical Investigation. 2025; 135(5).

Li, W; Xu, M; Cheng, M; Wei, J; Zhu, L; Deng, Y; Guo, F; Bi, F; Liu, M. Current Advances and Future Directions for Sensitizing Gastric Cancer to Immune Checkpoint Inhibitors. Cancer Medicine. 2025; 14(14):e71065.

Li, C; Xie, Q; Ghosh, S; Cao, B; Du, Y; Vo, GV; Huang, TY; Spruck, C; Carpenter, RL; Wang, YA; Lu, QR; Nephew, KP; Shen, J. SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma. JCI Insight. 2025; 10(5).

Li, Q; Liao, Y; Zeng, J; Hu, S; Li, C; Whitsett, JA; Zheng, Y; Luo, F; Xu, C; He, T; Lin, X; Wan, H. KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. 2025; 72(6):663-677.

Lin, S; Kotliar, M; Vallabh, S; Ptasinska, A; Assi, SA; Wunderlich, M; Bonifer, C; Barski, A; Mulloy, JC. Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia. Blood advances. 2025; 9(4):856-861.

Lin, Y; Zheng, Y. Structural Dynamics of Rho GTPases. Journal of Molecular Biology. 2025; 437(3):168919.

Ling, T; O'brien, C; St-Germain, J; Rondeau, V; Shi, M; Berman, JM; Cepa, AK; Saez Raez, P; Wunderlich, M; Carter, K; Hope, K; D'alessandro, A; Raught, B; Jones, CL. Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation. Blood. 2025.

Liu, K; Kang, Z; Yang, M; Chen, F; Xia, M; Dai, W; Zheng, S; Chen, H; Lu, QR; Zhou, W; Lin, Y. The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex. Glia. 2025; 73(1):140-158.

Lucas, C-HG; Gross, AM; Romo, CG; Dehner, CA; Lazar, AJ; Miettinen, M; Pekmezci, M; Quezado, M; Rodriguez, FJ; Stemmer-Rachamimov, A; Viskochil, D; Perry, A. Consensus recommendations for an integrated diagnostic approach to peripheral nerve sheath tumors arising in the setting of Neurofibromatosis Type 1. Neuro-Oncology. 2025; 27(3):616-624.

Luo, Z; Xia, M; Zhang, F; Xin, D; Rao, R; Kiang, KM; Berry, K; Xiong, Y; Liu, H; Lin, Y; Li, H; Taylor, MD; Zhou, W; Lu, QR. CNSC-41. IDENTIFICATION AND VALIDATION OF TRANSITIONAL CEREBELLAR PROGENITORS (TCP) IN THE RHOMBIC LIP OF THE HUMAN FETAL CEREBELLUM. Neuro-Oncology. 2025; 27(Supplement_5):v63-v63.

Mehta, PA; Nelson, A; Loveless, S; Lane, A; Fukuda, T; Teusink-Cross, A; Elder, D; Lagory, D; Miller, E; Cancelas, JA; Edwards, S; Chihanga, T; Wells, SI; Davies, SM. Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia. Blood advances. 2025; 9(8):1927-1939.

Mejía-Ramírez, E; Picazo, PI; Walter, B; Montserrat-Vazquez, S; Affuso, F; Wieser, S; Pezzano, F; Reymond, L; Castillo-Robles, J; Matteini, F; Ruprecht, V; Zheng, Y; Petrone, P; Florian, MC. Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells. Nature Aging. 2025.

Mestre, J; Chaparro-González, L; Granada, I; Mallo, M; Cid, E; Mancini, E; Calvete, O; Risueño, RM; Starczynowski, DT; Solé, F. Integrated cytogenetic and genomic profiling of the MDS-L cell line. Molecular Cytogenetics. 2025; 18(1):11.

Miao, L; Lu, Y; Nusrat, A; Fan, G; Zhang, S; Zhao, L; Wu, C-L; Guo, H; Huyen, TLN; Zheng, Y; Wan, LQ; Zhou, B; Evans, SM; Wu, M. Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Science. 2025; 387(6739):eadd3417.

Miles, LA. Runx2 takes center stage in regulating HSC expansion. Blood. 2025; 146(26):3135-3136.

O'brien, C; Nursimulu, N; Tyagi, A; Culp-Hill, R; Arruda, A; Murphy, T; Minden, MD; Kent, A; Stevens, B; Pollyea, DA; Hope, K; Kumar, S; Reisz, JA; D'alessandro, A; Jones, CL. Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia. Blood. 2025; 146(21):2589-2596.

O'brien, C; Jones, CL. Unraveling lipid metabolism for acute myeloid leukemia therapy. Current Opinion in Hematology. 2025; 32(2):77-86.

Peshoff, MM; Zheng, J; Fei, M; Pallegar, PN; Lu, QR; Wu, L-J. TMOD-42. TREM2 modulates glioma-associated microglia and macrophage function in a genetic driver dependent manner. Neuro-Oncology. 2025; 27(Supplement_5):v483-v483.

Pundavela, J; Hall, A; Dinglasan, SA; Choi, K; Rizvi, TA; Trapnell, BC; Wu, J; Ratner, N. Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation. Cancers. 2025; 17(5).

Raut, N; Adlakha, A; Sprague, KL; Rupert, AR; Hofmann, M; Ratner, N; Queme, LF; Jankowski, M. 137 Schwann Cell Glial Cell Line-Derived Neurotrophic Factor Signaling Influences Pain in Neurofibromatosis 1. Journal of Pain. 2025; 29:104935.

Reddoch-Cardenas, KM; Cancelas, JA; Nestheide, S; Rugg, N; Peña, K; Mcintosh, CS; Ferdin, J; Talackine, J; Parker, J; Jensen, LA; Gonzales, R; Hess, JR; Zia, M. Novel anticoagulant-preservative solution maintained the hemostatic function of cold stored whole blood for 56 days. Transfusion. 2025; 65 Suppl 1(Suppl 1):S185-S192.

Roome, RB; Yadav, A; Flores, L; Puarr, AK; Nardini, D; Richardson, A; Waclaw, RR; Arkell, RM; Menon, V; Johnson, JE; Levine, AJ. Ontogeny of the spinal cord dorsal horn. Science. 2026; 391(6781):eadx5781.

Schrenk, S; Sherpa, C; Bischoff, LJ; Cai, Y; Boscolo, E. Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025; 45(12):2243-2260.

Schurer, A; Ilyas, H; Maron, M; Hegde, S; Leyden, M; Roy, I; Hyka, R; Dada, L; Shabanowitz, J; Hunt, D; Belizaire, R; Kitamura, S; Gritsman, K; Shechter, D. TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated Acute Myeloid Leukemia. Blood. 2025; 146(Supplement 1):869-869.

Setayesh, T; Chi, M; Oestreicher, Z; Sakabe, M; Seu, K; Zhu, Z; Kaur, H; Tijani, A; Xin, M; Shova, A; Balla, J; Vandenheuvel, K; Hu, Y-C; Malik, P. A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea. Blood. 2025; 146(1):13-28.

Shrestha, A; Pillis, DM; Felker, S; Chi, M; Wagner, K; Gbotosho, OT; Sieling, J; Shadid, M; Malik, P. Preclinical efficacy of a modified gamma-globin lentivirus gene therapy in Berkeley sickle cell anemia mice and human xenograft models. Molecular Therapy: Methods & Clinical Development. 2025; 33(2):101439.

Soni, UK; Lu, QR. Living on the edge: Uncommitted OPC-like cells drive glioblastoma invasiveness. Developmental Cell. 2025; 60(18):2383-2385.

Sutter, PJ; Walker, MM; Finocchio, CJ; Jiang, J-K; Tawa, GJ; Zhang, X; Xu, X; Shah, P; Gomba, GY; Starczynowski, DT; Thomas, CJ; Hoyt, S. Optimization of IRAK1/4/pan-FLT3 kinase inhibitors as treatments for acute myeloid leukemia. Bioorganic and Medicinal Chemistry Letters. 2025; 129:130355.

Tian, C; Ao, Z; Cerneckis, J; Cai, H; Chen, L; Niu, H; Takayama, K; Kim, J; Shi, Y; Gu, M; Kanekiyo, T; Guo, F. Understanding monocyte-driven neuroinflammation in Alzheimer's disease using human cortical organoid microphysiological systems. Science Advances. 2025; 11(34):eadu2708.

Tweedie, L; Riccetti, MR; Cain, B; Qin, S; Salomone, J; Webb, JA; Riesenberg, A; Ehrman, LA; Waclaw, RR; Kovall, RA; Gebelein, B; Campbell, K. Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects. Disease Models & Mechanisms. 2025; 18(2).

Uible, EE; Choi, I; Clough, CA; Hassan, A; Anandappa, AJ; Fisher, J; Karki, B; Hueneman, K; Choi, K; Vick, EJ; Pasare, C; Cunningham, JT; Volk, AG; Starczynowski, DT. Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia. Cell Chemical Biology. 2026.

Venkatasubramanian, M; Schwartz, L; Ramachandra, N; Bennett, J; Subramanian, KR; Chen, X; Gordon-Mitchell, S; Fromowitz, A; Pradhan, K; Shechter, D; Grimes, HL; Starczynowski, DT; Verma, A; Salomonis, N. Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias. Science Translational Medicine. 2025; 17(797):eadr1471.

Vick, EJ; Starczynowski, DT. IRAK signaling in cancers: mechanisms, targeting, and clinical implications. Expert Opinion on Investigational Drugs. 2025; 34(10):775-792.

Vick, EJ; Hassan, A; Choi, K; Bennett, J; Muto, T; Clough, CA; Culver-Cochran, AE; Hueneman, K; Bolanos, LC; Wunderlich, M; Klumpp-Thomas, C; Greis, KD; Thomas, CJ; Starczynowski, DT. Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization. Leukemia. 2025; 39(9):2163-2173.

Vick, EJ; Walulik, S; Sampson, A; Hassan, A; Wunderlich, M; Volk, A; Starczynowski, D. The IRAK4 long isoform as widely upregulated in non-splicesome mutated acute myeloid leukemia and as altered by hypomethylating agent therapy. Journal of Clinical Oncology. 2025; 43(16_suppl):6524-6524.

Wang, Y; Xiu, Y; Dong, Q; Zhao, J; Neumbo, K; Miyagi, M; Borcherding, N; Fu, L; De Celis, H; Pintozzi, N; Starczynowski, DT; Zhao, C. TIFAB modulates metabolic pathways in KMT2A::MLLT3-induced AML through HNF4A. Blood advances. 2025; 9(4):844-855.

Wang, X; Zhang, Y; Li, Z; Liu, B; Sakabe, M; Yang, T; Pan, M; Chen, J; Huang, W; Xin, M; Fan, G-C. Abstract 4355964: Probiotic Extracellular Vesicles Stimulate Macrophage Efferocytosis to Limit Ischemia/Reperfusion-Induced Damage by Delivering 5s-rRNA-Derived Short RNA. Circulation. 2025; 152(Suppl_3):a4355964-a4355964.

Weinhaus, B; Homan, S; Kincaid, M; Tadwalkar, A; Gu, X; Kumar, S; Slaughter, A; Zhang, J; Wu, Q; Kofron, JM; Troutman, TD; Defalco, T; Lucas, D. Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells. Nature Communications. 2025; 16(1):4427.

Williams, KB; Larsson, AT; Keller, BJ; Chaney, KE; Williams, RL; Bhunia, MM; Draper, GM; Jubenville, TA; Hudson, WA; Georg, GI; Moertel, CL; Ratner, N; Largaespada, DA. Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors. Molecular Cancer Therapeutics. 2025.

Xin, DE; Luo, Z; Huang, XC; Lu, QR. Single-Cell Multi-omics Analyses of Medulloblastoma. In: Translational Research Methods for Pediatric Brain Tumors. Springer Nature; 2025:1-21.

Xing, Y; Yang, Y; Yang, K; Lu, A; Xing, L; Mackie, K; Guo, F. Intelligent sensing devices and systems for personalized mental health. Med X. 2025; 3(1).

Yang, J; Zheng, Y; Guo, F. Genetic and epigenetic regulation of Treg cells by autism-related CHD8 2064. Journal of Immunology. 2025; 214(Supplement_1).

Yang, Y; Liu, X; Wei, J; Qin, J; Tan, Q; Ji, J; Guo, F; Zheng, Y; Bi, F; Liu, M; Wang, G. In vivo expression of CD3/CD19 bispecific T-cell engager and α-PD-L1-Fc enables effective and durable immunotherapy for CD19+/PD-L1+ leukemia. Leukemia. 2025.

Yang, J-Q; Wang, C; Nayak, RC; Kolla, M; Cai, M; Pujato, M; Zheng, Y; Lu, QR; Guo, F. Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8. Cellular & Molecular Biology Letters. 2025; 30(1):36.

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