Experimental Hematology and Cancer Biology

Publications

Akwii, RG; Sajib, MS; Zahra, FT; Tullar, P; Zabet-Moghaddam, M; Zheng, Y; Silvio Gutkind, J; Doci, CL; Mikelis, CM. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis. 2022; 25:373-396.

Alavattam, KG; Maezawa, S; Andreassen, PR; Namekawa, SH. Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis. Cellular and Molecular Life Sciences. 2022; 79.

Amoah, A; Keller, A; Emini, R; Hoenicka, M; Liebold, A; Vollmer, A; Eiwen, K; Soller, K; Sakk, V; Zheng, Y; et al. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica. 2022; 107:393-402.

Aoyagi, Y; Hayashi, Y; Harada, Y; Choi, K; Matsunuma, N; Sadato, D; Maemoto, Y; Ito, A; Yanagi, S; Starczynowski, DT; et al. Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes. Cancer Discovery. 2022; 12:250-269.

Azhar, M; Kincaid, Z; Kesarwani, M; Ahmed, A; Wunderlich, M; Latif, T; Starczynowski, D; Azam, M. Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Blood Advances. 2022; 6:1186-1192.

Badar, T; Chlon, T. Germline and Somatic Defects in DDX41 and its Impact on Myeloid Neoplasms. Current Hematologic Malignancy Reports. 2022.

Barreyro, L; Sampson, AM; Ishikawa, C; Hueneman, KM; Choi, K; Pujato, MA; Chutipongtanate, S; Wyder, M; Haffey, WD; O'Brien, E; et al. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science Translational Medicine. 2022; 14.

Bartram, J; Filippi, MD. The new metabolic needs of hematopoietic stem cells. Current Opinion in Hematology. 2022; 29:188-193.

Bennett, J; Starczynowski, DT. IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies. Current Opinion in Hematology. 2022; 29:8-19.

Boscolo, E; Pastura, P; Schrenk, S; Goines, J; Kang, R; Pillis, D; Malik, P; Le Cras, TD. NRASQ61R mutation in human endothelial cells causes vascular malformations. Angiogenesis. 2022; 25:331-342.

Cancelas, JA; Genthe, JR; Stolla, M; Rugg, N; Bailey, SL; Nestheide, S; Shaz, B; Mack, S; Schroeder, K; Anani, W; et al. Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage. Transfusion. 2022; 62:1619-1629.

Cancelas, JA; Nestheide, S; Rugg, N; Eckerman, A; Macdonald, VW; Charles, ML; Markstrom, L; Atkinson, AJ; King, MR; Snyder, M; et al. Characterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma. Transfusion. 2022; 62:406-417.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; et al. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14.

Cram, JP; Wu, J; Coover, RA; Rizvi, TA; Chaney, KE; Ravindran, R; Cancelas, JA; Spinner, RJ; Ratner, N. P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. eLife. 2022; 11.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; et al. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge). 2022; 149.

Ehrman, JM; Merchan-Sala, P; Ehrman, LA; Chen, B; Lim, HW; Waclaw, RR; Campbell, K. Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. Journal of Neuroscience. 2022; 42:3344-3364.

Felker, S; Shrestha, A; Bailey, J; Pillis, DM; Siniard, D; Malik, P. Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment. JCI insight. 2022; 7.

Filippi, M. Hungry Hematopoietic Stem Cells during Bacterial Infection: Fatty Acid for Food. 2022; 4.

Filippi, MD. Asymmetric division: the choice of fate for huHSCs. Blood. 2022; 139:1930-1932.

Fishman, H; Madiwale, S; Geron, I; Bari, V; Van Loocke, W; Kirschenbaum, Y; Ganmore, I; Kugler, E; Rein-Gil, A; Friedlander, G; et al. ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells. Blood. 2022; 139:399-412.

González-Muñoz, T; Kim, AR; Ratner, N; Peinado, H. The Need for New Treatments Targeting MPNST: The Potential of Strategies Combining MEK Inhibitors with Antiangiogenic Agents. Clinical Cancer Research. 2022; 28:3185-3195.

Govindarajah, V; Reynaud, D. Role of the hematopoietic stem cells in immunological memory. Current stem cell reports. 2022; 8:35-43.

Hater, N; Iwaniuk, KM; Leifeld, C; Grüten, P; Wiek, C; Raba, K; Zhang, F; Fischer, JC; Andreassen, PR; Hanenberg, H; et al. Identification of new RAD51D-regulating microRNAs that also emerge as potent inhibitors of the Fanconi Anemia/homologous recombination pathways. Human Molecular Genetics. 2022.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Hegde, S; Zheng, Y; Cancelas, JA. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current Opinion in Hematology. 2022.

Intisar, A; Shin, HY; Kim, W; Kang, HG; Kim, MY; Kim, YS; Cho, Y; Mo, YJ; Lim, H; Lee, S; et al. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy. Advanced Science. 2022.

Javier, J; Hinge, A; Bartram, J; Xu, J; Filippi, MD. Transforming growth factor-β signaling modifies the hematopoietic acute inflammatory response to drive bone marrow failure. Haematologica. 2022; 107:1323-1334.

Jones, LQ M; Starczynowski, DT. IKAROS and MENIN in synergy in AML. 2022; 3:528-529.

Kogiso, M; Qi, L; Du, Y; Braun, FK; Zhang, H; Huang, LF; Guo, L; Huang, Y; Teo, WY; Lindsay, H; et al. Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma. Translational Oncology. 2022; 18.

Koh, W; Malik, P; Whitehead, J; Morales, DL S; Hayes, D. Successful use of veno-venous extracorporeal membrane oxygenation for acute chest syndrome in a child with sickle cell disease and SARS-CoV-2. Pediatric Pulmonology. 2022; 57:1096-1099.

Lynch, DR; Stringham, EN; Zhang, B; Balbin-Cuesta, G; Curtis, BR; Palumbo, JS; Greineder, CF; Tourdot, BE. Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies. Blood Advances. 2022; 6:4645-4656.

Mock, DM; Stowell, SR; Franco, RS; Kyosseva, SV; Nalbant, D; Schmidt, RL; Cress, GA; Strauss, RG; Cancelas, JA; von Goetz, M; et al. Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival. Transfusion. 2022; 62:770-782.

Muhammad, B; Parks, LG; Komurov, K; Privette Vinnedge, LM. Defective transcription elongation in human cancers imposes targetable proteotoxic vulnerability. Translational Oncology. 2022; 16.

Muto, T; Guillamot, M; Yeung, J; Fang, J; Bennett, J; Nadorp, B; Lasry, A; Redondo, LZ; Choi, K; Gong, Y; et al. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. 2022; 29:298-314.e9.

Nalapareddy, K; Zheng, Y; Geiger, H. Aging of intestinal stem cells. Stem Cell Reports. 2022; 17:734-740.

Niederkorn, M; Ishikawa, C; M. Hueneman, K; Bartram, J; Stepanchick, E; R. Bennett, J; E. Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; et al. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2022; 36:438-451.

Ohanian, M; Cancelas, JA; Davenport, R; Pullarkat, V; Hervig, T; Broome, C; Marek, K; Kelly, M; Gul, Z; Rugg, N; et al. Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies. American Journal of Hematology. 2022; 97:256-266.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; Lu, QR. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-Oncology. 2022; 24:584-597.

Romano, LM; Seu, KG; Papoin, J; Muench, DE; Konstantinidis, D; Olsson, A; Schlum, K; Chetal, K; Chasis, JA; Mohandas, N; et al. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood. 2022.

Rubinstein, JD; Jodele, S; Heyenbruch, D; Wilhelm, J; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; Keller, M; et al. Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy. 2022; 28:116.e1-116.e7.

Rubinstein, JD; Lutzko, C; Leemhuis, T; Zhu, X; Pham, G; Ray, L; Thomas, S; Dourson, C; Wilhelm, J; Lane, A; et al. Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant. Blood Advances. 2022; 6:2897-2907.

Schrenk, S; Boscolo, E. A transcription factor is the target of propranolol treatment in infantile hemangioma. Journal of Clinical Investigation. 2022; 132.

Tirtakusuma, R; Szoltysek, K; Milne, P; Grinev, V; Ptasinska, A; Chin, PS; Meyer, C; Nakjang, S; Hehir-Kwa, JY; Williamson, D; et al. Epigenetic regulator genes direct lineage switching in MLL/AF4 leukaemia. Blood. 2022.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell Reports. 2022; 40.

Tu, Z; Zheng, Y. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current Opinion in Hematology. 2022; 29:174-180.

Vogel, M; Möhrle, B; Sakk, V; Brown, A; Palmer, A; Braumüller, S; Huber-Lang, M; Allgöwer, A; Cancelas, JA; Geiger, H. A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome. Shock. 2022; 57:260-267.

Xu, X; Zhang, C; Jiang, J; Xin, M; Hao, J. Effect of TDP43-CTFs35 on Brain Endothelial Cell Functions in Cerebral Ischemic Injury. Molecular Neurobiology. 2022; 59:4593-4611.

Yeaton, A; Cayanan, G; Loghavi, S; Dolgalev, I; Leddin, EM; Loo, CE; Torabifard, H; Nicolet, D; Wang, J; Corrigan, K; et al. The impact of inflammation-induced tumor plasticity during myeloid transformation. Cancer Discovery. 2022.

Yi, J; Kim, B; Shi, X; Zhan, X; Lu, QR; Xuan, Z; Wu, J. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer Research. 2022; 82:2874-2886.

Ying, L; Zhao, J; Ye, Y; Liu, Y; Xiao, B; Xue, T; Zhu, H; Wu, Y; He, J; Qin, S; et al. Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease. Aging Cell. 2022; 21.

Zhang, J; Guan, M; Zhou, X; Berry, K; He, X; Lu, QR. Long Noncoding RNAs in CNS Myelination and Disease. Neuroscientist. 2022.

Zhang, Z; Zhang, F; Davis, AK; Xin, M; Walz, G; Tian, W; Zheng, Y. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell Reports. 2022; 38.

Zhao, H; Lu, J; Yan, T; Han, F; Sun, J; Yin, X; Shen, C; Wunderlich, M; Yun, W; Yang, L; et al. Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2. Cell Reports. 2022; 38.