Experimental Hematology and Cancer Biology

Publications

Abe, H; Meduri, R; Li, Z; Andreassen, PR; Namekawa, SH. RNF8 is not required for histone-to-protamine exchange in spermiogenesis†. Biology of Reproduction. 2021; 105:1154-1159.

Adair, JE; Androski, L; Bayigga, L; Bazira, D; Brandon, E; Dee, L; Deeks, S; Draz, M; Dubé, K; Dybul, M; et al. Towards access for all: 1st Working Group Report for the Global Gene Therapy Initiative (GGTI). Gene Therapy. 2021.

Adori, C; Daraio, T; Kuiper, R; Barde, S; Horvathova, L; Yoshitake, T; Ihnatko, R; Valladolid-Acebes, I; Vercruysse, P; Wellendorf, AM; et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Science advances. 2021; 7.

Agarwal, P; Li, H; Choi, K; Hueneman, K; He, J; Welner, RS; Starczynowski, DT; Bhatia, R. TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling. Cell Reports. 2021; 36.

Andreassen, PR; Seo, J; Wiek, C; Hanenberg, H. Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses. Genes. 2021; 12.

Azhar, M; Kincaid, Z; Kesarwani, M; Ahmed, A; Wunderlich, M; Latif, T; Starczynowski, D; Azam, M. Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Blood Advances. 2021.

Azhar, M; Kincaid, Z; Kesarwani, M; Wunderlich, M; Latif, T; Starczynowski, D; Azam, M. Momelotinib Is a Highly Potent Inhibitor of FLT3-Mutant AML. Blood. 2021; 138:206-206.

Blizzard, LE; Menke, C; Patel, SD; Waclaw, RR; Lachke, SA; Stottmann, RW. A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. Journal of Developmental Biology. 2021; 9.

Boateng-Antwi, MK A; Lin, Y; Ren, S; Wang, X; Pan, D. New function of a well-known promoter: Enhancer activity of minimal CMV promoter enables efficient dual-cassette transgene expression. Journal of Gene Medicine. 2021; 23.

Cancelas, JA; Nestheide, S; Rugg, N; Eckerman, A; Macdonald, VW; L. Charles, M; Markstrom, L; Atkinson, AJ; King, MR; Snyder, M; et al. Characterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma. Transfusion. 2021.

Cannon, P; Asokan, A; Czechowicz, A; Hammond, P; Kohn, DB; Lieber, A; Malik, P; Marks, P; Porteus, M; Verhoeyen, E; et al. Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development. Human Gene Therapy. 2021; 32:31-42.

Chaney, KE; Perrino, MR; Kershner, LJ; Patel, AV; Wu, J; Choi, K; Rizvi, TA; Dombi, E; Szabo, S; Largaespada, DA; et al. Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST. Cancer Research. 2021; 80:4720-4730.

Charlton-Perkins, MA; Friedrich, M; Cook, TA. Semper's cells in the insect compound eye: Insights into ocular form and function. Developmental Biology. 2021; 479:126-138.

Chlon, TM; Stepanchick, E; Hershberger, CE; Daniels, NJ; Hueneman, KM; Kuenzi Davis, A; Choi, K; Zheng, Y; Gurnari, C; Haferlach, T; et al. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021; 28:1966-1981.e6.

Chlon, TM; Stepanchick, E; Sulentic, A; Hueneman, K; Starczynowski, D. Heterozygous Mutations in DDX41 Cause Erythroid Progenitor Cell Defects. Blood. 2021; 138:148-148.

Cho, JR; Chen, X; Kahan, A; Robinson, JE; Wagenaar, DA; Gradinaru, V. Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context. Journal of Neuroscience. 2021; 41:2645-2655.

Colling, ME; Tourdot, BE; Kanthi, Y. Inflammation, Infection and Venous Thromboembolism. Circulation Research. 2021; 128:2017-2036.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Duan, X; Perveen, R; Dandamudi, A; Adili, R; Johnson, J; Funk, K; Berryman, M; Davis, AK; Holinstat, M; Zheng, Y; et al. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific Reports. 2021; 11.

Earnest, KG; McConnell, EM; Hassan, EM; Wunderlich, M; Hosseinpour, B; Bono, BS; Chee, MJ; Mulloy, JC; Willmore, WG; DeRosa, MC; et al. Development and characterization of a DNA aptamer for MLL-AF9 expressing acute myeloid leukemia cells using whole cell-SELEX. Scientific Reports. 2021; 11.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13.

Filippi, MD. Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division. Experimental Hematology. 2021; 96:27-34.

Galvin, R; Watson, AL; Largaespada, DA; Ratner, N; Osum, S; Moertel, CL. Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib. Current Oncology Reports. 2021; 23.

Gbotosho, OT; Taylor, M; Malik, P. Cardiac pathophysiology in sickle cell disease. Journal of Thrombosis and Thrombolysis. 2021; 52:248-259.

Geraldo, LH; Xu, Y; Jacob, L; Pibouin-Fragner, L; Rao, R; Maissa, N; Verreault, M; Lemaire, N; Knosp, C; Lesaffre, C; et al. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. Journal of Clinical Investigation. 2021; 131.

Goines, J; Boscolo, E. A Xenograft Model for Venous Malformation. . 2021.

Grimley, M; Asnani, M; Shrestha, A; Felker, S; Lutzko, C; Arumugam, PI; Witting, S; Knight-Madden, J; Niss, O; Quinn, CT; et al. Safety and Efficacy of Aru-1801 in Patients with Sickle Cell Disease: Early Results from the Phase 1/2 Momentum Study of a Modified Gamma Globin Gene Therapy and Reduced Intensity Conditioning. Blood. 2021; 138:3970-3970.

Guidi, N; Marka, G; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem Cells. 2021; 39:1101-1106.

Guo, D; Wang, Y; Cheng, Y; Liao, S; Hu, J; Du, F; Xu, G; Liu, Y; Cai, KQ; Cheung, M; et al. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Journal of Experimental Medicine. 2021; 218.

Guo, F. RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?. Precision Clinical Medicine. 2021; 4:56-61.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2021.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Heinrich, A; Bhandary, B; Potter, SJ; Ratner, N; DeFalco, T. Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis. Cell Reports. 2021; 37.

Huang, Q; Zheng, X; Jiao, Y; Lei, Y; Li, X; Bi, F; Guo, F; Wang, G; Liu, M. A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old. Frontiers in Oncology. 2021; 11.

Huang, Y; Qi, L; Kogiso, M; Du, Y; Braun, FK; Zhang, H; Huang, LF; Xiao, S; Teo, WY; Lindsay, H; et al. Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion. Advanced Science. 2021; 8.

Javier, J; Hinge, A; Bartram, J; Xu, J; Filippi, M. TGFβ signaling modifies hematopoietic acute inflammatory response to drive bone marrow failure. Haematologica. 2021.

Kahan, A; Greenbaum, A; Jang, MJ; Robinson, JE; Cho, JR; Chen, X; Kassraian, P; Wagenaar, DA; Gradinaru, V. Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses. Cell Reports. 2021; 36.

Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in Immunology. 2021; 12.

Kandi, R; Senger, K; Grigoryan, A; Soller, K; Sakk, V; Schuster, T; Eiwen, K; Menon, MB; Gaestel, M; Zheng, Y; et al. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO Reports. 2021; 22.

Karkoska, K; Todd, K; Niss, O; Clapp, K; Fenchel, L; Kalfa, TA; Malik, P; Quinn, CT; Ware, RE; McGann, PT. Implementation of near-universal hydroxyurea uptake among children with sickle cell anemia: A single-center experience. Pediatric Blood and Cancer. 2021; 68.

Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021; 17:1-382.

Kuerbitz, J; Madhavan, M; Ehrman, LA; Kohli, V; Waclaw, RR; Campbell, K. Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse. Cerebral Cortex. 2021; 31:1744-1762.

Li, X; Yang, Y; Huang, Q; Deng, Y; Guo, F; Wang, G; Liu, M. Crosstalk Between the Tumor Microenvironment and Cancer Cells: A Promising Predictive Biomarker for Immune Checkpoint Inhibitors. Frontiers in Cell and Developmental Biology. 2021; 9.

Liao, Y; Luo, Z; Deng, Y; Zhang, F; Rao, R; Wang, J; Xu, L; Kumar, SS; Sengupta, S; Dewire-Schottmiller, M; et al. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes. Neuro-Oncology. 2021; 23:1183-1196.

Lin, Y; Lu, S; Zhang, J; Zheng, Y. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure with Folding & design. 2021; 29:553-563.e5.

Lin, Y; Watanabe-Chailland, M; Zheng, Y. Protocol for structural and biochemical analyses of RhoA GTPase. STAR Protocols. 2021; 2.

Luo, Z; Dong, X; Xia, Y; Berry, KP; Rao, R; Xu, L; Xue, P; Chen, T; Lin, Y; Yu, J; et al. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in Cell and Developmental Biology. 2021; 9.

Marinaccio, C; Suraneni, P; Celik, H; Volk, A; Wen, QJ; Ling, T; Bulic, M; Lasho, T; Koche, RP; Famulare, CA; et al. LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Cancer Discovery. 2021; 11:1398-1410.

Mori, Y; Takashima, S; Kanatsu-Shinohara, M; Yi, Z; Shinohara, T. Cdc42 is required for male germline niche development in mice. Cell Reports. 2021; 36.

Muraleedharan, R; Nardini, D; Waclaw, RR; Dasgupta, B. Analysis of reactive astrogliosis in mouse brain using in situ hybridization combined with immunohistochemistry. STAR Protocols. 2021; 2.

Na, Y; Hall, A; Choi, K; Hu, L; Rose, J; Coover, RA; Miller, A; Hennigan, RF; Dombi, E; Kim, MO; et al. MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK. Oncogene. 2021; 40:951-963.

Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. Journal of Neuroscience. 2021; 41:10247-10260.

Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience. 2021; 24.

Narciso, MG; Hoeting, B; James, JM; VandenHeuvel, K; Nasimuzzaman, M. A mutant fibrinogen that is unable to form fibrin can improve renal phenotype in mice with sickle cell anemia. 2021; 2:462-465.

Nayak, RC; Trump, L; Emberesh, S; Lee, Y; Singh, AK; Wellendorf, AM; Horwitz, MS; Kalfa, TA; Lutzko, C; Cancelas, JA. SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors. Blood. 2021; 138:433-433.

Niederkorn, M; Ishikawa, C; M. Hueneman, K; Bartram, J; Stepanchick, E; R. Bennett, J; E. Culver-Cochran, A; Bolanos, LC; Uible, E; Choi, K; et al. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. Leukemia. 2021.

Niss, O; Lorsbach, RB; Berger, M; Chonat, S; McLemore, M; Buchbinder, D; McCavit, T; Shaffer, LG; Simpson, J; Schwartz, JH; et al. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood Cells, Molecules, and Diseases. 2021; 87.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; et al. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science advances. 2021; 7.

Ohanian, M; Cancelas, JA; Davenport, R; Pullarkat, V; Hervig, T; Broome, C; Marek, K; Kelly, M; Gul, Z; Rugg, N; et al. Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies. American Journal of Hematology. 2021.

Patritti-Cram, J; Coover, RA; Jankowski, MP; Ratner, N. Purinergic signaling in peripheral nervous system glial cells. GLIA. 2021; 69:1837-1851.

Prus, K; Alquist, CR; Cancelas, JA; Oh, D. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion. 2021; 61:651-654.

Quinn, CT; Niss, O; Dong, M; Pfeiffer, A; Korpik, J; Reynaud, M; Bonar, H; Kalfa, TA; Smart, LR; Malik, P; et al. Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. British Journal of Haematology. 2021; 194:617-625.

Rao, R; Han, R; Ogurek, S; Wu, LM; Zhang, L; Hu, J; Garrett, M; Phoenix, T; Waggoner, SN; Lu, QR. TAMI-31. GLIOBLASTOMA GENETIC DRIVERS DICTATE THE FUNCTION OF TUMOR-ASSOCIATED MACROPHAGES/MICROGLIA AND RESPONSES TO CSF1R INHIBITION. Neuro-Oncology. 2021; 23:vi204-vi204.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; et al. Glioblastoma Genetic Drivers Dictate the Function of Tumor-Associated Macrophages/Microglia and Responses to CSF1R Inhibition. Neuro-Oncology. 2021.

Rubinstein, JD; Jodele, S; Heyenbruch, D; Wilhelm, J; Thomas, S; Lutzko, C; Zhu, X; Leemhuis, T; Cancelas, JA; Keller, M; et al. Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients. Transplantation and cellular therapy. 2021.

Rubinstein, JD; Zhu, X; Leemhuis, T; Pham, G; Ray, L; Emberesh, S; Jodele, S; Thomas, S; Cancelas, JA; Bollard, CM; et al. Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Advances. 2021; 5:3309-3321.

Sadaf, A; Quinn, CT; Korpik, JB; Pfeiffer, A; Reynaud, M; Niss, O; Malik, P; Ware, RE; Kalfa, TA; McGann, PT. Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response. Blood Cells, Molecules, and Diseases. 2021; 90.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; et al. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood. 2021.

Shrestha, A; Chi, M; Wagner, K; Malik, A; Korpik, J; Drake, A; Fulzele, K; Guichard, S; Malik, P. FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. Blood Advances. 2021; 5:2385-2390.

Singh, AK; Cancelas, JA. Mitochondria Transfer in Bone Marrow Hematopoietic Activity. Current stem cell reports. 2021; 7:1-12.

Tackenberg, H; Möller, S; Filippi, MD; Laskay, T. The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria. Frontiers in Immunology. 2021; 12.

Talley, MJ; Nardini, D; Qin, S; Prada, CE; Ehrman, LA; Waclaw, RR. A role for sustained MAPK activity in the mouse ventral telencephalon. Developmental Biology. 2021; 476:137-147.

Talley, MJ; Nardini, D; Shabbir, N; Ehrman, LA; Prada, CE; Waclaw, RR. Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Frontiers in Cell and Developmental Biology. 2021; 9.

Tang, Y; Xu, Q; Hu, L; Yan, X; Feng, X; Yokota, A; Wang, W; Zhan, D; Krishnamurthy, D; Ochayon, DE; et al. Tumor Microenvironment-Derived R-spondins Enhance Anti-Tumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy. Cancer Discovery. 2021.

Thomson, CS; Pundavela, J; Perrino, MR; Coover, RA; Choi, K; Chaney, KE; Rizvi, TA; Largaespada, DA; Ratner, N. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene. 2021; 40:4229-4241.

Trowbridge, JJ; Starczynowski, DT. Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS. Journal of Experimental Medicine. 2021; 218.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021; 138:221-233.

Vélez-Reyes, GL; Koes, N; Ryu, JH; Kaufmann, G; Berner, M; Weg, MT; Wolf, NK; Rathe, SK; Ratner, N; Moriarity, BS; et al. Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development. Cancers. 2021; 13.

Volk, A. NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia. Communications Biology. 2021; 4.

Wang, T; Pine, AR; Kotini, AG; Yuan, H; Zamparo, L; Starczynowski, DT; Leslie, C; Papapetrou, EP. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell Stem Cell. 2021; 28:1074-1089.e7.

Wargent, ET; Ahmad, SJ S; Lu, QR; Kostenis, E; Arch, JR S; Stocker, CJ. Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin. Frontiers in Endocrinology. 2021; 12.

Weiss, BD; Wolters, PL; Plotkin, SR; Widemann, BC; Tonsgard, JH; Blakeley, J; Allen, JC; Schorry, E; Korf, B; Robison, NJ; et al. NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas. Journal of Clinical Oncology. 2021; 39:797-806.

Wunderlich, M; Manning, N; Sexton, C; O’Brien, E; Byerly, L; Stillwell, C; Perentesis, JP; Mulloy, JC; Mizukawa, B. PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia. Frontiers in Oncology. 2021; 11.

Young, K; Eudy, E; Bell, R; Loberg, MA; Stearns, T; Sharma, D; Velten, L; Haas, S; Filippi, MD; Trowbridge, JJ. Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. 2021; 28:1473-1482.e7.

Zaslavsky, A; Adams, M; Cao, X; Yamaguchi, A; Henderson, J; Busch-Østergren, P; Udager, A; Pitchiaya, S; Tourdot, B; Kasputis, T; et al. Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thrombosis Research. 2021; 200:64-71.

Zhang, B; Nguyen, LX T; Zhao, D; Frankhouser, DE; Wang, H; Hoang, DH; Qiao, J; Abundis, C; Brehove, M; Su, YL; et al. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of Hematology and Oncology. 2021; 14.

Zhang, J; Wu, Q; Johnson, CB; Pham, G; Kinder, JM; Olsson, A; Slaughter, A; May, M; Weinhaus, B; D’Alessandro, A; et al. In situ mapping identifies distinct vascular niches for myelopoiesis. Nature: New biology. 2021; 590:457-462.

Zhang, M; Wang, J; Zhang, K; Lu, G; Liu, Y; Ren, K; Wang, W; Xin, D; Xu, L; Mao, H; et al. Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature Communications. 2021; 12.

Zhang, Y; Park, JY; Zhang, F; Olson, SH; Orlow, I; Li, Y; Kurtz, RC; Ladanyi, M; Chen, J; Toland, AE; et al. The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. Human Mutation. 2021; 42:150-163.

Zhang, Z; Liu, M; Zheng, Y. Role of Rho GTPases in stem cell regulation. Biochemical Society Transactions. 2021; 49:2941-2955.