Experimental Hematology and Cancer Biology

Publications

Aggarwal, RK; Sidoli, S; Sahu, S; Aluri, S; Vegivinti, C; Verma, D; Gordon-Mitchell, S; Agarwal, B; Verma, T; Starczynowski, DT; LaFave, LM; Cheng, H; Verma, A; Zou, Y. Abstract 1464: Smoking carcinogen-induced inflammation promotes lung carcinogenesis via IRAK4 activation. Cancer Research. 2024; 84:1464.

Akhtar, S; Sagar, K; Roy, A; Hote, MP; Arava, S; Sharma, A. CCR5-mediated homing of regulatory T cells and monocytic-myeloid derived suppressor cells to dysfunctional endothelium contributes to early atherosclerosis. Immunology. 2024; 173:712-729.

Akhtar, S; Sagar, K; Singh, A; Hote, MP; Roy, A; Sharma, A. Inflammation-induced sialin mediates nitrate efflux in dysfunctional endothelium affecting NO bioavailability. Nitric Oxide: Biology and Chemistry. 2024; 146:37-47.

Alavattam, KG; Esparza, JM; Hu, M; Shimada, R; Kohrs, AR; Abe, H; Munakata, Y; Otsuka, K; Yoshimura, S; Kitamura, Y; Kim, J; Andreassen, PR; Ishiguro, KI; Namekawa, SH. ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline. Genes and Development. 2024; 38:115-130.

Anandappa, AJ; Trivedi, V; Merlinsky, T; Delgaudio, N; Guzzardi, E; Wooten, A; Starczynowski, D; Bowman, RL; Levine, R; Miles, LA. Codon-Specific Differences in RAS Mutations in AML and Differential Response to Therapeutic Agents. Blood. 2024; 144:2713.

Arumugam, P; Carey, BC; Wikenheiser-Brokamp, KA; Krischer, J; Wessendarp, M; Shima, K; Chalk, C; Stock, J; Ma, Y; Black, D; Lowe-Daniels, D; Reeves, L; Kaiser, A; Trapnell, BC. A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice. Molecular Therapy-Methods & Clinical Development. 2024; 32:101213.

Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. Abstract 3092: MICRO-TAG: A novel fluorescence-based real-time cellular target engagement platform for drug discovery. Cancer Research. 2024; 84:3092.

Bao, C; Zhang, Q; He, C; Zou, H; Xia, Y; Yan, R; Hua, L; Wang, X; Lu, Q; Yao, Z. Neural responses to decision-making in suicide attempters with youth major depressive disorder. NeuroImage-Clinical. 2024; 43:103667.

Barreyro, L; Sampson, AM; Hueneman, K; Choi, K; Christie, S; Ramesh, V; Wyder, M; Wang, D; Pujato, M; Greis, KD; Huang, G; Starczynowski, DT. Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML. iScience. 2024; 27:109809.

Bedolla, A; Wegman, E; Weed, M; Stevens, MK; Ware, K; Paranjpe, A; Alkhimovitch, A; Ifergan, I; Taranov, A; Peter, JD; McClain, L; Roskin, KM; Greig, NH; Luo, Y. Adult microglial TGFβ1 is required for microglia homeostasis via an autocrine mechanism to maintain cognitive function in mice. Nature Communications. 2024; 15:5306.

Benjamin, ES B; Vinod, E; Illangeswaran, RS S; Rajamani, BM; Vidhyadharan, RT; Bagchi, A; Maity, A; Mohan, A; Parasuraman, G; Amirtham, SM; Abraham, A; Velayudhan, SR; Balasubramanian, P. Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs. Cellular Signalling. 2024; 116:111067.

Benson, TW; Pike, MM; Spuzzillo, A; Hicks, SM; Ali, S; Pham, M; Mix, DS; Brunner, SI; Wadding-Lee, C; Conrad, KA; Gardiner, EE; Mackman, N; Cameron, SJ; Owens, AP. Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target. Blood. 2024; 144:1663-1678.

Bowman, RL; Dunbar, AJ; Mishra, T; Xiao, W; Waarts, MR; Maestre, IF; Eisman, SE; Cai, L; Mowla, S; Shah, N; Miles, LA; Ferrell, PB; Trowbridge, JJ; Levine, RL. In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy. Cancer Cell. 2024; 42:1955-1969.e7.

Chang, YH; Yamamoto, K; Fujino, T; Wang, TW; Sugimoto, E; Zhang, W; Yabushita, T; Suzaki, K; Pietsch, EC; Weir, BA; Enomoto, Y; Imai, Y; Kitamura, T; Goyama, S. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation. Cell Reports. 2024; 43:114536.

Chen, N; Sakabe, M; Xin, M. Abstract We146: CHD8 is Essential for Postnatal Heart Function through Preserving Mitochondrial Integrity. Circulation Research. 2024; 135:awe146.

Chi, M; Vandenheuvel, K; Malik, P. Splenic Ossification in Sickle Cell Anemia Mice. Blood. 2024; 144:5283.

Clark, J; Wunderlich, M; Chen, J; Starczynowski, D; Lee, L. Abstract A017: IGF2BP1 is essential for ETO2/GLIS2 leukemogenesis via stabilization of primitive myeloid transcriptional programs. Molecular Cancer Therapeutics. 2024; 23:a017.

Cui, S; Chen, T; Xin, D; Chen, F; Zhong, X; Dong, C; Chen, X; Chen, H; Zhou, W; Lin, Y; Lu, QR. Zinc-Finger Protein ZFP488 Regulates the Timing of Oligodendrocyte Myelination and Remyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024; 44:e0141242024.

Culver-Cochran, AE; Hassan, A; Hueneman, K; Choi, K; Ma, A; VanCauwenbergh, B; O’Brien, E; Wunderlich, M; Perentesis, JP; Starczynowski, DT. Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis. Nature Communications. 2024; 15:9189.

Dourson, AJ; Fadaka, AO; Warshak, AM; Paranjpe, A; Weinhaus, B; Queme, LF; Hofmann, MC; Evans, HM; Donmez, OA; Forney, C; Weirauch, MT; Kottyan, LC; Lucas, D; Deepe, GS; Jankowski, MP. Macrophage memories of early-life injury drive neonatal nociceptive priming. Cell Reports. 2024; 43:114129.

Drucker, M; Dhingra, D; Wunderlich, M; Perentesis, J; Starczynowski, D; Bowman, RL; Miles, LA. Single-Cell Multi-Omic Analysis of KMT2A-Rearranged Pediatric Acute Leukemia Clonal Evolution. Blood. 2024; 144:66.

Du, Y; Liu, J; Lin, R; Chattun, MR; Gong, W; Hua, L; Tang, H; Han, Y; Lu, Q; Yao, Z. The mediating role of family functioning between childhood trauma and depression severity in major depressive disorder and bipolar disorder. Journal of Affective Disorders. 2024; 365:443-450.

Elgamal, OA; Fobare, S; Vibhute, S; Mehmood, A; Vroom, DC; Johnson, ML; Stearns, B; Lerma, JR; Truxall, J; Stahl, E; Hilinski, G; Bennett, CE; Hertlein, E; Byrd, JC. Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia. JCI insight. 2024; 9:e173646.

Fobare, S; Elgamal, OA; Wunderlich, M; Stahl, E; Mehmood, A; Furby, C; Lerma, JR; Sesterhenn, TM; Pan, J; Rai, J; Johnson, ML; Rai, SN; Byrd, JC; Hertlein, E. Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia. Cancers. 2024; 16:569.

Garcia-Manero, G; Platzbecker, U; Lim, K; Nowakowski, G; Abdel-Wahab, O; Kantarjian, H; Verma, A; Starczynowski, DT. Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer. 2024; 3:1339870.

Gatterdam, C; Emberesh, S; Elgammal, Y; Lutzko, C; Blanc, L; Cancelas, J; Kalfa, TA; Seu, K. The Dominant Negative Acting VPS4AE228Q Mutation Causes Dyserythropoiesis in Human iPSC-Derived Erythroblast Cultures That Phenocopies Cimdag Syndrome-Associated Anemia. Blood. 2024; 144:2458.

Govindarajah, V; Sakabe, M; Good, S; Solomon, M; Arasu, A; Chen, N; Zhang, X; Grimes, HL; Kendler, A; Xin, M; Reynaud, D. Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring. The Journal of Clinical Investigation. 2024; 134:e169730.

Hammill, AM; Boscolo, E. Capillary malformations. The Journal of Clinical Investigation. 2024; 134:e172842.

Hegde, S; Akbar, H; Wellendorf, AM; Nestheide, S; Johnson, JF; Zhao, X; Setchell, KD; Zheng, Y; Cancelas, JA. Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets. Blood. 2024; 144:1732-1746.

Hofstetter, KS; Haas, PM; Kuntz, JP; Zheng, Y; Fuhrmann, S. Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse. Frontiers in Cellular Neuroscience. 2024; 18:1474010.

Huang, G; Li, Z; Liu, X; Guan, M; Zhou, S; Zhong, X; Zheng, T; Xin, D; Gu, X; Mu, D; Guo, Y; Zhang, L; Zhang, L; Lu, QR; He, X. DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice. Nature Neuroscience. 2024; 27:2073-2085.

Huynh, NP T; Osipovitch, M; Foti, R; Bates, J; Mansky, B; Cano, JC; Benraiss, A; Zhao, C; Lu, QR; Goldman, SA. Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia. Brain: a journal of neurology. 2024; 147:3099-3112.

Ikegami, S; Amanda, D; Heyenbruch, D; Leemhuis, T; Lutzko, C; Alquist, CR; Cancelas, J. CMV SEROSTATUS IS MOST IMPORTANT TO SELECT DONORS OF MONONUCLEAR CELL PRODUCTS AIMED TO THE GENERATION OF ANTI-CMV VIRUS-SPECIFIC T CELL (VSTS) PRODUCTS. Cytotherapy (Informa). 2024; 26:e20-e21.

Jebanesan, DZ P; Illangeswaran, RS S; Rajamani, BM; Vidhyadharan, RT; Das, S; Bijukumar, NK; Balakrishnan, B; Mathews, V; Velayudhan, SR; Balasubramanian, P. Inhibition of NRF2 signaling overcomes acquired resistance to arsenic trioxide in FLT3-mutated Acute Myeloid Leukemia. Annals of Hematology. 2024; 103:1919-1929.

Khoury, R; Grimley, MS; Nelson, AS; Leemhuis, T; Cancelas, JA; Cook, E; Wang, YZ; Heyenbruch, D; Bollard, CM; Keller, MD; Hanley, PJ; Lutzko, C; Pham, G; Davies, SM; Rubinstein, JD. Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant. American Journal of Transplantation. 2024; 24:1634-1643.

Kiang, KM; Ahad, L; Zhong, X; Lu, QR. Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer. Trends in Cell Biology. 2024; 34:566-577.

Klaver, YL B; Hoogeman, MS; Lu, QR; Amos, RA; Hawkins, MA; Simone, CB. Requirements and Study Design for the Next Proton Flash Clinical Trials: An International Multidisciplinary Delphi Consensus. International Journal of Radiation: Oncology - Biology - Physics. 2024; 120:s108-s109.

Kocoshis, TS; Kalfa, TA; Miethke, AG; Balistreri, WF; Seu, KG; Slaughter, CG; Singh, R; Mullen, M; Kocoshis, SA. Red cell abnormalities characterized by ektacytometry in children with cholestasis. Pediatric Research. 2024; 95:1035-1040.

Koschmann, C; Al-Holou, WN; Alonso, MM; Anastas, J; Bandopadhayay, P; Barron, T; Becher, O; Cartaxo, R; Castro, MG; Chung, C; Yadav, VN; Zhang, X; Zhang, Q; Venneti, S. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024; 42:1-5.

Kusne, Y; Badar, T; Lasho, T; Ferrer, A; Mangaonkar, AA; Finke, C; Marando, L; Foran, JM; Al-Kali, A; Alkhateeb, HB; Chlon, T; Patnaik, MM. Absence of PNH-clones in DDX41mutant-GPS aids in their distinction from acquired BM failure syndromes. Leukemia Research: clinical and laboratory studies. 2024; 145:107561.

Laranjeira, AB A; Kong, T; Snyder, SC; Fulbright, MC; Fisher, DA C; Starczynowski, DT; Oh, ST. In vivo ablation of NF-κB cascade effectors alleviates disease burden in myeloproliferative neoplasms. Blood. 2024; 143:2414-2424.

Lee, D; Abu-Shihab, Y; Nicolet, D; Mrózek, K; Routbort, M; Patel, KP; Walker, CJ; Buss, J; Stiff, A; Laganson, A; Blachly, JS; Loghavi, S; Eisfeld, A; Miles, LA. BRAF-Mutated Acute Myeloid Leukemia (AML) Represents a Prognostically Poor Subgroup Enriched for Myelodysplasia-Related Subtypes and Distinct from Other RAS Pathway Mutant AML. Blood. 2024; 144:2921.

Lee, SC-E S; Pyo, AH A; Mohammadi, H; Zhang, J; Dvorkin-Gheva, A; Malbeteau, L; Chung, S; Khan, S; Ciudad, MT; Rondeau, V; Culp-Hill, R; D'Alessandro, A; Jones, CL; Koritzinsky, M. Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism. Science Advances. 2024; 10:eadq0355.

Li, J; Hashimoto, M; Pan, M; Zeng, H; Andreassen, PR; Huang, G. Loss of Cpt1a Results in Elevated Mitochondrial Reactive Oxygen Species from Glucose-Fueled Mitochondrial Oxidative Phosphorylation and Defective Hematopoietic Stem Cells. Blood. 2024; 144:4035.

Lin, Y; Ramelot, TA; Senyuz, S; Gursoy, A; Jang, H; Nussinov, R; Keskin, O; Zheng, Y. Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature Communications. 2024; 15:7176.

Lin, Y; Zhao, X; Liou, B; Fannin, V; Zhang, W; Setchell, KD R; Wang, X; Pan, D; Grabowski, GA; Liu, CJ; Sun, Y. Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease. Human Molecular Genetics. 2024; 33:1771-1788.

Little, K; Zhu, Z; Gbotosho, O; Malik, P. Blockade of Angiotensin II Signaling Ameliorates Cardiac Fibrosis and Improves Diastolic Dysfunction in Mice with Sickle Cell Anemia. Blood. 2024; 144:2480.

Liu, X; Xin, DE; Zhong, X; Zhao, C; Li, Z; Zhang, L; Dourson, AJ; Lee, L; Mishra, S; Bayat, AE; Jankowski, MP; Barton, SK; He, X; Lu, QR. Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell. 2024; 187:2465-2484.e22.

Lv, X; Lu, Q; Yang, J. Methodological issues in the evaluation of cold snare endoscopic mucosal resection for colon polyps. Endoscopy. 2024; 56:79.

Matsui, S; Ri, C; Bolanos, LC; Choi, K; Shibamiya, A; Ishii, A; Takaishi, K; Oshima-Hasegawa, N; Tsukamoto, S; Takeda, Y; Yokote, K; Starczynowski, DT; Sakaida, E; Muto, T. Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression. Leukemia. 2024; 38:1032-1045.

Myers, B; Brayer, K; Paez-Beltran, L; Keith, M; Suzuki, H; New, J; Anderson, R; Lo, Y; Mertz, C; Kollipara, R; Borromeo, M; Lu, R; Bachoo, R; Johnson, J; Vue, TY. CNSC-46. GLIOBLASTOMA INITIATION, MIGRATION, AND CELL TYPES ARE REGULATED BY CORE BHLH TRANSCRIPTION FACTORS ASCL1 AND OLIG2. Neuro-Oncology. 2024; 26:viii51.

Myers, BL; Brayer, KJ; Paez-Beltran, LE; Villicana, E; Keith, MS; Suzuki, H; Newville, J; Anderson, RH; Lo, Y; Mertz, CM; Lu, QR; Bachoo, RM; Johnson, JE; Vue, TY. Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration. Nature Communications. 2024; 15:10363.

Neidemire-Colley, L; Khanal, S; Braunreiter, KM; Gao, Y; Kumar, R; Snyder, KJ; Weber, MA; Surana, S; Toirov, O; Karunasiri, M; Kararoudi, MN; Choe, HK; Garzon, R; Ranganathan, P. CRISPR/Cas9 deletion of MIR155HG in human T cells reduces incidence and severity of acute GVHD in a xenogeneic model. Blood Advances. 2024; 8:947-958.

Niss, O; Fenchel, M; Kingsley, E; Latham, TS; Malik, P; Quinn, CT. Underutilization of Disease-Modifying Therapies in Sickle Cell Disease: A Real-World Analysis from the ASH Research Collaborative Data Hub. Blood. 2024; 144:2312.

Niss, O; Morin, C; Lang, SM; Alsaied, T; Tasset, M; Malik, P; Quinn, CT. Longitudinal Assessment of Myocardial Fibrosis in Sickle Cell Disease. Blood. 2024; 144:799.

Ntoumaziou, A; Nguyen, D; Elgammal, Y; Husami, A; Zhang, W; Weaver, KD; Kasten, JL; Grier, DD; Zheng, Y; Lutzko, C; Risinger, M; Frayne, J; Seu, K; Kalfa, TA. Loss of ATG5 in Humans Causes Syndromic Congenital Dyserythropoietic Anemia with Impaired Mitophagy in Late Stages of Terminal Erythropoiesis. Blood. 2024; 144:1084.

Oatman, N; Gawali, MV; Congrove, S; Cáceres, R; Sukumaran, A; Gupta, N; Murugesan, N; Arora, P; Subramanian, S; Choi, K; Desai, P; D'Alessandro, A; Komurov, K; Dasgupta, B. A Multimodal Drug-Diet-Immunotherapy Combination Restrains Melanoma Progression and Metastasis. Cancer Research. 2024; 84:2333-2351.

Ottesen, EW; Seo, J; Luo, D; Singh, NN; Singh, RN. A super minigene with a short promoter and truncated introns recapitulates essential features of transcription and splicing regulation of the SMN1 and SMN2 genes. Nucleic Acids Research (NAR). 2024; 52:3547-3571.

Ottesen, EW; Singh, NN; Seo, J; Singh, RN. U1 snRNA interactions with deep intronic sequences regulate splicing of multiple exons of spinal muscular atrophy genes. Frontiers in Neuroscience. 2024; 18:1412893.

Pai, AA; Mohanan, E; Panetta, JC; Kulkarni, UP; Illangeswaran, RS S; Balakrishnan, B; Jayaraman, A; Edison, ES; Lakshmi, KM; Devasia, AJ; Srivastava, A; Mathews, V; Standing, JF; Balasubramanian, P. Treosulfan Exposure Predicts Thalassemia-Free Survival in Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Cell Transplantation. Clinical Pharmacology and Therapeutics. 2024; 115:116-125.

Pastura, P; McDaniel, CG; Alharbi, S; Fox, D; Coleman, B; Malik, P; Adams, DM; Le Cras, TD. NRASQ61R mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model. Pediatric Blood and Cancer. 2024; 71:e31032.

Patritti-Cram, J; Rahrmann, EP; Rizvi, TA; Scheffer, KC; Phoenix, TN; Largaespada, DA; Ratner, N. NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14. iScience. 2024; 27:110294.

Paudel, SN; Hutzen, BJ; Miller, KE; Garfinkle, EA R; Chen, CY; Wang, PY; Glaspell, AM; Currier, MA; Ringwalt, EM; Boon, L; Ratner, N; Dodd, RD; Cassady, KA; Cripe, TP. Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors. Frontiers in Immunology. 2024; 15:1384623.

Perrino, MR; Ahmari, N; Hall, A; Jackson, M; Na, Y; Pundavela, J; Szabo, S; Woodruff, TM; Dombi, E; Kim, MO; Köhl, J; Wu, J; Ratner, N. C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance. 2024; 7:e202302229.

Pundavela, J; Dinglasan, SA; Touvron, M; Hummel, SA; Hu, L; Rizvi, TA; Choi, K; Hildeman, DA; Ratner, N. Stimulator of interferon gene facilitates recruitment of effector CD8 T cells that drive neurofibromatosis type 1 nerve tumor initiation and maintenance. Science Advances. 2024; 10:eado6342.

Qiao, J; Tao, S; Sun, Y; Shi, J; Chen, Y; Tian, S; Yao, Z; Lu, Q. The Effects of Variation in the GABAA Receptor Gene on Anxious Depression are Mediated by the Functional Connectivity Between the Amygdala and Middle Frontal Gyrus. Neuropsychiatric Disease and Treatment. 2024; 20:1781-1796.

Raut, NG R; Maile, LA; Oswalt, LM; Mitxelena, I; Adlakha, A; Sprague, KL; Rupert, AR; Bokros, L; Hofmann, MC; Patritti-Cram, J; Rizvi, TA; Queme, LF; Choi, K; Ratner, N; Jankowski, MP. Schwann cells modulate nociception in neurofibromatosis 1. JCI insight. 2024; 9:e171275.

Reynaud, D. GM-CSF brings (good) memories. Blood. 2024; 143:2683-2684.

Riabov, V; Xu, Q; Schmitt, N; Streuer, A; Ge, G; Bolanos, L; Wunderlich, M; Jann, JC; Wein, A; Altrock, E; Steiner, L; Jawhar, M; Hofmann, WK; Nowak, D. ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms. Haematologica: the hematology journal. 2024; 109:1426-1438.

Rondeau, V; Berman, JM; Ling, T; O’Brien, C; Culp-Hill, R; Reisz, JA; Wunderlich, M; Chueh, Y; Jiménez-Camacho, KE; Sexton, C; Minden, MD; Raught, B; D’Alessandro, A; Jones, CL. Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models. Science Translational Medicine. 2024; 16:eadn1285.

Rudman-Melnick, V; Adam, M; Stowers, K; Potter, A; Ma, Q; Chokshi, SM; Vanhoutte, D; Valiente-Alandi, I; Lindquist, DM; Nieman, ML; Kofron, JM; Chung, E; Park, JS; Potter, SS; Devarajan, P. Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis. Scientific Reports. 2024; 14:439.

Rudman-Melnick, V; Vanhoutte, D; Stowers, K; Sargent, M; Adam, M; Ma, Q; Perl, AK T; Miethke, AG; Burg, A; Shi, T; Hildeman, DA; Woodle, ES S; Kofron, JM; Devarajan, P. Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts. Scientific Reports. 2024; 14:29307.

Schmidt, AL; Kremp, M; Aratake, T; Cui, S; Lin, Y; Zhong, X; Lu, QR; Zhang, C; Qiu, M; Aberle, T; Wegner, M. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. Glia. 2024; 72:1304-1318.

Schrenk, S; Bischoff, LJ; Boscolo, E. Protocol for three-dimensional whole-mount imaging of the vascular network in the intestinal muscle. Star Protocols. 2024; 5:103170.

Schwede, M; Jahn, K; Kuipers, J; Miles, LA; Bowman, RL; Robinson, T; Furudate, K; Uryu, H; Tanaka, T; Sasaki, Y; Levine, R; Beerenwinkel, N; Takahashi, K; Majeti, R. Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity. Leukemia. 2024; 38:1501-1510.

Setayesh, T; Chi, M; Oestreicher, Z; Sakabe, M; Mei, X; Vandenheuvel, K; Townes, TM; Hu, Y; Malik, P. A Novel Mouse Model of Hemoglobin-SC Disease: Bridging the Knowledge Gap in Sickle Cell Disease. Blood. 2024; 144:620.

Shadid, M; Shrestha, A; Malik, P. Preclinical safety assessment of modified gamma globin lentiviral vector-mediated autologous hematopoietic stem cell gene therapy for hemoglobinopathies. Editor, Ling C. PloS one. 2024; 19:e0306719.

Sheth, AI; Althoff, MJ; Tolison, H; Engel, K; Amaya, ML; Krug, AE; Young, TN; Minhajuddin, M; Pei, S; Patel, SB; Smith, CA; Pollyea, DA; Stevens, BM; Jordan, CT. Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium. Cancer Discovery. 2024; 14:1922-1939.

Simkin, J; Aloysius, A; Adam, M; Safaee, F; Donahue, RR; Biswas, S; Lakhani, Z; Gensel, JC; Thybert, D; Potter, S; Seifert, AW. Tissue-resident macrophages specifically express Lactotransferrin and Vegfc during ear pinna regeneration in spiny mice. Developmental Cell. 2024; 59:496-516.e6.

Solomon, M; Song, B; Govindarajah, V; Good, S; Arasu, A; Hinton, EB; Thakkar, K; Bartram, J; Filippi, MD; Cancelas, JA; Salomonis, N; Grimes, HL; Reynaud, D. Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. The Journal of Experimental Medicine. 2024; 221:e20231035.

Stepanchick, E; Wilson, A; Sulentic, AM; Choi, K; Hueneman, K; Starczynowski, DT; Chlon, TM. DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy. Leukemia. 2024; 38:1787-1798.

Stiff, A; Fornerod, M; Kain, BN; Nicolet, D; Kelly, BJ; Miller, KE; Mrózek, K; Boateng, I; Bollas, A; Garfinkle, EA R; Salomonis, N; Grimes, HL; Mardis, ER; Eisfeld, AK. Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia. Nature Genetics. 2024; 56:2434-2446.

Tang, H; Shi, J; Zhang, S; Chen, Y; Xiong, T; Wang, X; Chen, Z; Dai, Z; Yao, Z; Lu, Q. Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients. Brain Connectivity. 2024; 14:542-549.

Tang, H; Xia, Y; Hua, L; Dai, Z; Wang, X; Yao, Z; Lu, Q. Electrophysiological predictors of early response to antidepressants in major depressive disorder. Journal of Affective Disorders. 2024; 365:509-517.

Thorman, AW; Reigle, J; Chutipongtanate, S; Yang, J; Shamsaei, B; Pilarczyk, M; Fazel-Najafabadi, M; Adamczak, R; Kouril, M; Bhatnagar, S; Hildeman, DA; Medvedovic, M; Herr, AB; Meller, J. Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking. Science Advances. 2024; 10:eadj3010.

Vandenbroeke, T; Gloor, C; Wingfield, T; Leite, C; Carr, K; Turner, C; Ngamsuntikul, S; Sutor, L; Compton, F; Nestheide, S; Rugg, N; Cancelas, JA; Dumont, LJ. In vitro quality parameters of whole blood-derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar. Transfusion. 2024; 64:132-140.

Waarts, MR; Mowla, S; Boileau, M; Martinez Benitez, AR; Sango, J; Bagish, M; Fernández-Maestre, I; Shan, Y; Eisman, SE; Park, YC; Butler, JM; Cai, SF; Bowman, RL; Levine, RL. CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells. Cancer Discovery. 2024; 14:1860-1878.

Wang, J; Yang, L; Du, Y; Wang, J; Weng, Q; Liu, X; Nicholson, E; Xin, M; Lu, QR. BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination. The Journal of Cell Biology. 2024; 223:e202310143.

Wang, X; Zhang, H; Dong, L; Zhang, X; Xue, M; Ren, L; Bi, H; Ghoda, LY; Wunderlich, M; Mulloy, JC; Heisterkamp, N; Kortylewski, M; Chen, J; Su, R. Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML. Blood. 2024; 144:625.

Watanabe, H; Rana, M; Son, M; Chiu, PY; Fei-Bloom, Y; Choi, K; Diamond, B; Sherry, B. Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice. Molecular medicine (Cambridge, Mass.). 2024; 30:202.

Wei, J; Li, W; Zhang, P; Guo, F; Liu, M. Current trends in sensitizing immune checkpoint inhibitors for cancer treatment. Molecular Cancer. 2024; 23:279.

Wu, J; Ratner, N. Neurofibromatosis Type I: Preclinical Modeling. The RASopathies. : Springer Nature; Springer Nature; 2024.

Wu, Q; Zhang, J; Kumar, S; Shen, S; Kincaid, M; Johnson, CB; Zhang, YS; Turcotte, R; Alt, C; Ito, K; Ito, K; Way, SS; Kofron, JM; Lucas, D. Resilient anatomy and local plasticity of naive and stress haematopoiesis. Nature. 2024; 627:839-846.

Xin, DE; Liao, Y; Rao, R; Ogurek, S; Sengupta, S; Xin, M; Bayat, AE; Seibel, WL; Graham, RT; Koschmann, C; Lu, QR. Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201. Neuro-Oncology. 2024; 26:735-748.

Xin, E; Zhong, X; Huang, C; Lu, R. CSIG-26. TARGETING EPIGENETIC DYSREGULATION AND ADAPTIVE RESISTANCE MECHANISMS IN DIPG/DMG. Neuro-Oncology. 2024; 26:viii69.

Yang, J; Zheng, Y; Guo, F. Autism-related CHD8 is required for maintaining Treg cell fitness. Journal of immunology (Baltimore, Md. : 1950). 2024; 212:1217_5681.

Yang, Y; Huang, Q; Cheng, M; Deng, L; Liu, X; Zheng, X; Wei, J; Lei, Y; Li, X; Guo, F; Deng, Y; Zheng, Y; Bi, F; Wang, G; Liu, M. Efficacy and advantage of immunotherapy for melanoma via intramuscular co-expression of plasmid-encoded PD-1 and CTLA-4 scFvs. AMERICAN JOURNAL OF CANCER RESEARCH. 2024; 14:2626-2642.

Zhang, D; Tang, W; Niu, H; Tse, W; Ruan, HB; Dolznig, H; Knösel, T; Karl-Heinz, F; Themanns, M; Wang, J; Kenner, L; Moriggl, R; Zheng, Y; Han, X. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes and Diseases. 2024; 11:413-429.

Zhang, Q; Du, Y; Bao, C; Hua, L; Yan, R; Dai, Z; Xia, Y; Zou, H; He, C; Sun, H; Lu, Q; Yao, Z. Aberrant high-beta band functional connectivity during reward processing in melancholic major depressive disorder: An MEG study. NeuroImage-Clinical. 2024; 43:103666.

Zhang, Y; Wang, X; Zhu, R; Sakabe, M; Chowdhury, D; Li, Z; Chen, J; Huang, W; Xin, M; Fan, G. Abstract 4118360: Lipocalin10 is Critical for Macrophage Efferocytosis to Repair Myocardial Ischemia/Reperfusion Injury. Circulation. 2024; 150:a4118360.

Zheng, Y. Conditioning for alloengraftment in FA. Blood. 2024; 143:2120-2122.