Experimental Hematology and Cancer Biology

Publications

Abu-Shihab, Y; Nicolet, D; Mrózek, K; Routbort, M; Patel, KP; Walker, CJ; Buss, J; Stiff, A; Laganson, A; DiNardo, CD; et al. BRAF-Mutated Acute Myeloid Leukemia (AML) Represents a Distinct, Prognostically Poor Subgroup Enriched in Myelodysplasia-Related (MR-)AML. Blood. 2023; 142:1575.

Adair, JE; Androski, L; Bayigga, L; Bazira, D; Brandon, E; Dee, L; Deeks, S; Draz, M; Dubé, K; Dybul, M; et al. Towards access for all: 1st Working Group Report for the Global Gene Therapy Initiative (GGTI). Gene Therapy (Basingstoke). 2023; 30:216-221.

Babic, I; Bryan, N; Cunningham, C; Sampson, A; Starczynowski, D; Nurmemmedov, E. Abstract 2759: Real-time cellular target engagement and protein quantification for drug discovery. Cancer Research. 2023; 83:2759.

Bennett, J; Ishikawa, C; Agarwal, P; Yeung, J; Sampson, A; Uible, E; Vick, E; Bolanos, LC; Hueneman, K; Wunderlich, M; et al. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood. 2023; 142:989-1007.

Bouffi, C; Wikenheiser-Brokamp, KA; Chaturvedi, P; Sundaram, N; Goddard, GR; Wunderlich, M; Brown, NE; Staab, JF; Latanich, R; Zachos, NC; et al. In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice. Nature Biotechnology. 2023; 41:824-831.

Butler-Foster, T; Khandelwal, A; Montemayor, C; Miller, YM; Yan, MT S; Holmberg, JA; Ipe, TS; Accooe, P; Cancelas, JA. From MPOX to the next epidemic: Words matter when talking about equity-deserving groups. Transfusion. 2023; 63:646-651.

Ceolan, J; Seu, K; Ntoumaziou, A; Elgammal, Y; Emberesh, S; Bilston, L; Richards, D; Dickerson, KE; Chonat, S; Rydz, N; et al. Erythrocyte Disorders Mimicking Congenital Dyserythropoietic Anemia Based on Bone Marrow Pathology Exposed By Genetic Evaluation. Blood. 2023; 142:2459.

Chlon, TM; Patnaik, MM. Germline DDX41 mutant predisposition syndromes: Slow driver states to hematological malignancies. American Journal of Hematology. 2023; 98:1673-1676.

Chlon, TM; Stepanchick, E; Sulentic, A; Wilson, A; Starczynowski, DT. Abstract A46: Heterozygous mutations in DDX41 cause erythroid progenitor cell defects and cooperate with p53 mutations to cause hematologic malignancy. 2023; 4:a46.

Cullion, K; Ostertag-Hill, CA; Pan, M; Timko, B; Boscolo, E; Kohane, DS. Ablation of Venous Malformations by Photothermal Therapy with Intravenous Gold Nanoshells. Nano Letters: a journal dedicated to nanoscience and nanotechnology. 2023; 23:7092-7099.

Dandamudi, A; Akbar, H; Cancelas, J; Zheng, Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023; 24:2519.

Dandamudi, A; Seibel, W; Tourdot, B; Cancelas, JA; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023; 24:4167.

Dean, ST; Ishikawa, C; Zhu, X; Walulik, S; Nixon, T; Jordan, JK; Henderson, S; Wyder, M; Salomonis, N; Wunderlich, M; et al. Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. Blood Advances. 2023; 7:4822-4837.

Doherty, AC; Huddleston, DA; Horn, PS; Ratner, N; Simpson, BN; Schorry, EK; Aschbacher-Smith, L; Prada, CE; Gilbert, DL. Motor Function and Physiology in Youth With Neurofibromatosis Type 1. Pediatric Neurology. 2023; 143:34-43.

Dourson, AJ; Fadaka, AO; Warshak, AM; Paranjpe, A; Weinhaus, B; Queme, LF; Hofmann, MC; Evans, HM; Donmez, OA; Forney, C; et al. Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming. 2023; 4:2023.02.13.528015.

Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; et al. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia. 2023; 37:2073-2081.

Fichter, KM; Setayesh, T; Malik, P. Strategies for precise gene edits in mammalian cells. Molecular Therapy-Nucleic Acids. 2023; 32:536-552.

Filippi, MD. The multifaceted role of mitochondria in HSC fate decisions: energy and beyond. Experimental Hematology. 2023; 128:19-29.

Galletta, TJ; Lane, A; Lutzko, C; Leemhuis, T; Cancelas, JA; Khoury, R; Wang, YZ M; Hanley, PJ; Keller, MD; Bollard, CM; et al. Third-Party and Patient-Specific Donor-Derived Virus-Specific T Cells Demonstrate Similar Efficacy and Safety for Management of Viral Infections after Hematopoietic Stem Cell Transplantation in Children and Young Adults. Transplantation and cellular therapy. 2023; 29:305-310.

Garrett, MC; Albano, R; Carnwath, T; Elahi, L; Behrmann, CA; Pemberton, M; Woo, D; O’Brien, E; VanCauwenbergh, B; Perentesis, J; et al. HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma. Scientific Reports. 2023; 13:12433.

Gonzalez, LS; Fisher, AA; D'souza, SP; Cotella, EM; Lang, RA; Robinson, JE. Ventral striatum dopamine release encodes unique properties of visual stimuli in mice. eLife. 2023; 12:e85064.

Gonzalez-Muñoz, T; Giannatale, AD; García-Silva, S; Santos, V; Sanchez-Redondo, S; Savini, C; Graña-Castro, O; Blanco-Aparicio, C; Fischer, S; De Wever, O; et al. Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis. Clinical Cancer Research. 2023; 29:3744-3758.

Gorak, EJ; Otterstatter, M; Al Baghdadi, T; Gillis, N; Foran, JM; Liu, JJ; Bejar, R; Gore, SD; Kroft, SH; Harrington, A; et al. Discordant pathologic diagnoses of myelodysplastic neoplasms and their implications for registries and therapies. Blood Advances. 2023; 7:6120-6129.

Gurska, LM; Okabe, R; Schurer, A; Tong, MM; Soto, M; Choi, D; Ames, K; Glushakow-Smith, S; Montoya, A; Tein, E; et al. Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms. Clinical Cancer Research. 2023; 29:943-956.

Han, L; Dong, L; Leung, K; Zhao, Z; Li, Y; Gao, L; Chen, Z; Xue, J; Qing, Y; Li, W; et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023; 30:52-68.e13.

Hashimoto, M; Li, J; Andreassen, PR; Huang, G. CPT1a Controls the Function of Long-Term Hematopoietic Stem Cells By Regulating the Balance between Fatty Acid Oxidation and Oxphos in Mitochondria. Blood. 2023; 142:4089.

Hegde, S; Nestheide, S; Wellndorf, A; Zheng, Y; Cancelas, J. 3080 – RHOA SIGNALING IS REQUIRED FOR THE COLD-INDUCED PLATELET LESION AND REVERSIBLE TARGETING OF RHOA IN A NEW PLATELET ADDITIVE SOLUTION EXTENDS DONOR-DERIVED PLATELET SHELF-LIFE TO FOURTEEN DAYS. Experimental Hematology. 2023; 124:s90.

Hennigan, RF; Thomson, CS; Stachowski, K; Nassar, N; Ratner, N. Merlin tumor suppressor function is regulated by PIP2-mediated dimerization. Editor, van der Wel P. PloS one. 2023; 18:e0281876.

Hu, X; Wu, X; Berry, K; Zhao, C; Xin, D; Ogurek, S; Liu, X; Zhang, L; Luo, Z; Sakabe, M; et al. Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis. Nature Cell Biology. 2023; 25:323-336.

Ishikawa, C; Barreyro, L; Sampson, A; Hueneman, K; Choi, K; Bolanos, LC; Volk, A; Watowich, SS; Greis, K; Starczynowski, DT. UBE2N Regulates Oncoprotein Networks in Myeloid Malignancies. Blood. 2023; 142:2762.

Jackson, M; Ahmari, N; Wu, J; Rizvi, TA; Fugate, E; Kim, MO; Dombi, E; Arnhof, H; Boehmelt, G; Düchs, MJ; et al. Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage. The Journal of pharmacology and experimental therapeutics. 2023; 385:106-116.

Katayama, KI; Zheng, Y; Inoue, N. Rac is required for the survival of cortical neurons. Experimental Neurology. 2023; 361:114316.

Koo, DJ; Reynaud, D; Ziady, A; Kahn, S; Abdullah, S; Luebbering, N; Strecker, L; Lake, KE; Giordullo, L; Ibrahimova, A; et al. 166 Reduced Sphingosine-1-Phosphate Leads to Hypoxemia and Lung Injury after Hematopoietic Stem Cell Transplant. Transplantation and cellular therapy. 2023; 29:s134.

Koo, J; Ziady, AG; Reynaud, D; Abdullah, S; Luebbering, N; Kahn, S; Langenberg, L; Strecker, L; Lake, K; Dandoy, CE; et al. Increased Body Mass Index Augments Endothelial Injury and Clinical Outcomes after Hematopoietic Stem Cell Transplantation. Transplantation and cellular therapy. 2023; 29:704.e1-704.e8.

Li, J; Malouf, C; Miles, LA; Willis, MB; Pietras, EM; King, KY. Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells. Experimental Hematology. 2023; 127:8-13.

Li, J; Wu, Y; Xue, T; He, J; Zhang, L; Liu, Y; Zhao, J; Chen, Z; Xie, M; Xiao, B; et al. Cdc42 signaling regulated by dopamine D2 receptor correlatively links specific brain regions of hippocampus to cocaine addiction. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2023; 1869:166569.

Li, Y; Martin, TE; Hancock, JM; Li, R; Viswanathan, S; Lydon, JP; Zheng, Y; Ye, X. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of Reproduction. 2023; 108:204-217.

Li, Y; Xue, M; Deng, X; Dong, L; Nguyen, LX T; Ren, L; Han, L; Li, C; Xue, J; Zhao, Z; et al. TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal. Cell Stem Cell. 2023; 30:1072-1090.e10.

Lin, Y; Zhao, X; Liou, B; Fannin, V; Zhang, W; Liu, Y; Wang, X; Pan, D; Grabowski, G; Liu, C; et al. Earlier-onset, more severe neurodegeneration in PGRN KO mice with a decreased dose of D409V Gba1. Molecular Genetics and Metabolism. 2023; 138:107207.

Lin, Y; Zheng, Y. Rho Family GTPases and their Modulators. NADPH Oxidases Revisited: From Function to Structure. : Springer Nature; Springer Nature; 2023.

Liu, X; Sato, N; Yabushita, T; Li, J; Jia, Y; Tamura, M; Asada, S; Fujino, T; Fukushima, T; Yonezawa, T; et al. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Molecular Medicine. 2023; 15:e15631.

Lu, R; Luo, Z. MDB-02. NUCLEAR ENVELOPE PHOSPHATASE CTDNEP1 MUTATIONS POTENTIATE AGGRESSIVE MEDULLOBLASTOMA BY TRIGGERING MYC ACTIVATION AND GENOMIC INSTABILITY. Neuro-Oncology. 2023; 25:i61-i62.

Luo, Z; Lu, R. MDB-05. HUMAN FETAL CEREBELLAR CELL ATLAS INFORMS MEDULLOBLASTOMA ORIGIN AND ONCOGENESIS. Neuro-Oncology. 2023; 25:i62.

Luo, Z; Xin, D; Liao, Y; Berry, K; Ogurek, S; Zhang, F; Zhang, L; Zhao, C; Rao, R; Dong, X; et al. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature Communications. 2023; 14:762.

Magallón-Lorenz, M; Terribas, E; Ortega-Bertran, S; Creus-Bachiller, E; Fernández, M; Requena, G; Rosas, I; Mazuelas, H; Uriarte-Arrazola, I; Negro, A; et al. Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis. iScience. 2023; 26:106096.

McDonald, CL; Qasba, P; Anderson, DG; Bao, G; Colvin, RA; Kohn, DB; Malik, P; Mitchell, MJ; Pu, WT; Rawlings, DJ; et al. Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. Human Gene Therapy. 2023; 34:83-89.

Menéndez-Gutiérrez, MP; Porcuna, J; Nayak, R; Paredes, A; Niu, H; Núñez, V; Paranjpe, A; Gómez, MJ; Bhattacharjee, A; Schnell, DJ; et al. Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis. Blood. 2023; 141:592-608.

Modur, V; Muhammad, B; Yang, JQ; Zheng, Y; Komurov, K; Guo, F. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell Reports. 2023; 42:112364.

Muto, T; Walker, CS; Agarwal, P; Vick, E; Sampson, A; Choi, K; Niederkorn, M; Ishikawa, C; Hueneman, K; Varney, M; et al. Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation. Haematologica: the hematology journal. 2023; 108:2715-2729.

Na, Y; Hall, A; Yu, Y; Hu, L; Choi, K; Burgard, JA; Szabo, S; Huang, G; Ratner, N; Wu, J. Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis. Oncogene: Including Oncogene Reviews. 2023; 42:1038-1047.

Neidemire-Colley, LM; Khanal, S; Braunreiter, KM; Snyder, KJ; Gao, Y; Kalyan, S; Kararoud, MN; Duszynsk, M; Chi, M; Malik, P; et al. CRISPR/Cas9 Gene Editing of MIR155HG in Primary Human T Cells to Prevent Acute Graft-Versus-Host Disease. Journal of immunology (Baltimore, Md. : 1950). 2023; 210:173.21.

Ottesen, EW; Singh, NN; Luo, D; Kaas, B; Gillette, BJ; Seo, J; Jorgensen, HJ; Singh, RN. Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy. Nucleic Acids Research. 2023; 51:5948-5980.

Pillay-Smiley, N; Fletcher, JS; de Blank, P; Ratner, N. Shedding New Light: Novel Therapies for Common Disorders in Children with Neurofibromatosis Type I. Pediatric Clinics of North America. 2023; 70:937-950.

Radulovic, I; Schündeln, MM; Müller, L; Ptok, J; Honisch, E; Niederacher, D; Wiek, C; Scheckenbach, K; Leblanc, T; Larcher, L; et al. A novel cancer risk prediction score for the natural course of FA patients with biallelic BRCA2/FANCD1 mutations. Human Molecular Genetics. 2023; 32:1836-1849.

Ratner, N; Hu, L; Pundavela, J; Epstein, JA. Abstract IA17: Use of RAS isoforms in nerve tumors. Molecular cancer research : MCR. 2023; 21:ia17.

Robinson, TM; Bowman, RL; Persaud, S; Liu, Y; Neigenfind, R; Gao, Q; Zhang, J; Sun, X; Miles, LA; Cai, SF; et al. Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia. Science Advances. 2023; 9:eadg0488.

Schrenk, S; Bischoff, LJ; Goines, J; Cai, Y; Vemaraju, S; Odaka, Y; Good, SR; Palumbo, JS; Szabo, S; Reynaud, D; et al. MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ. Nature Communications. 2023; 14:1929.

Schwede, M; Jahn, K; Kuipers, J; Miles, LA; Bowman, RL; Robinson, T; Furudate, K; Uryu, H; Tanaka, T; Sasaki, Y; et al. Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity. 2023; 4:rs.3.rs-3516536.

Schwede, M; Jahn, K; Miles, LA; Bowman, RL; Kuipers, J; Robinson, TM; Ediriwickrema, A; Gentles, AJ; Levine, R; Beerenwinkel, N; et al. Abstract A49: Characterizing the order of mutation acquisition in acute myeloid leukemia using large-scale single-cell sequencing. 2023; 4:a49.

Singh, AK; Prasad, P; Cancelas, JA. Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis. Frontiers in Cell and Developmental Biology. 2023; 11:1325291.

Stahl, M; Derkach, A; Farnoud, N; Bewersdorf, JP; Robinson, T; Famulare, C; Cho, C; Devlin, S; Menghrajani, K; Patel, MA; et al. Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. American Journal of Hematology. 2023; 98:79-89.

Talley, MJ; Nardini, D; Ehrman, LA; Lu, QR; Waclaw, RR. Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Development. 2023; 18:5.

Tamang, HK; Stringham, EN; Tourdot, BE. Platelet Functional Testing Via High-Throughput Microtiter Plate-Based Assays. 2023; 3:e668.

Thant, M; Cancelas, J; Kaplan, A. The enhanced direct antiglobulin test in current practice has a limited impact on management of adult patients. Transfusion and Apheresis Science. 2023; 62:103768.

Thompson, M; Sakabe, M; Verba, M; Hao, J; Meadows, SM; Lu, QR; Xin, M. PRDM16 regulates arterial development and vascular integrity. Frontiers in Physiology. 2023; 14:1165379.

Thompson, M; Sakabe, M; Xin, M. Abstract 664: Essential Roles Of Prdm16 In Repression Of Venous Marker In The Artery. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023; 43.

Treichel, S; Filippi, MD. Linking cell cycle to hematopoietic stem cell fate decisions. Frontiers in Cell and Developmental Biology. 2023; 11:1231735.

Verma, R; Chen, X; Xin, D; Luo, Z; Ogurek, S; Xin, M; Rao, R; Berry, K; Lu, QR. Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer Research. 2023; 83:890-905.

Walulik, S; Dean, S; Vick, EJ; Zhu, X; Wunderlich, M; Chou, C; Choi, K; Grimes, HL; Starczynowski, DT; Miles, LA; et al. The Mechanism of Therapy Resistance By Lineage Plasticity in AML and How to Overcome It. Blood. 2023; 142:1410.

Wang, C; Tu, Z; Cai, X; Wang, W; Davis, AK; Nattamai, K; Paranjpe, A; Dexheimer, P; Wu, J; Huang, FL; et al. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood Advances. 2023; 7:2590-2605.

Wang, C; Zheng, Y; Fan, C; Tu, Z; Cai, X; Wu, J; Huang, G. Conserved and Unique Regulatory Mechanisms of RUNX1 in Hematopoietic Stem/Progenitor Cell Subpopulations in Both Normal Hematopoiesis and FPD/AML Development. Blood. 2023; 142:1314.

Wang, F; Wang, W; Gu, S; Qi, D; Smith, NA; Peng, W; Dong, W; Yuan, J; Zhao, B; Mao, Y; et al. Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice. Nature Communications. 2023; 14:2186.

Yamaguchi, A; van Hoorebeke, C; Tourdot, BE; Perry, S; Lee, G; Rhoads, N; Rickenberg, A; Green, A; Sorrentino, J; Yeung, J; et al. Fatty acids negatively regulate platelet function through formation of noncanonical 15-lipoxygenase-derived eicosanoids. Pharmacology Research and Perspectives. 2023; 11:e01056.

Yoshimatsu, S; Okahara, J; Yoshie, J; Igarashi, Y; Nakajima, R; Sanosaka, T; Qian, E; Sato, T; Kobayashi, H; Morimoto, S; et al. Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing. Cell Reports: Methods. 2023; 3:100590.

Zhang, J; Guan, M; Zhou, X; Berry, K; He, X; Lu, QR. Long Noncoding RNAs in CNS Myelination and Disease. The Neuroscientist: reviews at the interface of basic and clinical neurosciences. 2023; 29:287-301.

Zhang, Z; Wang, X; Lin, Y; Pan, D. A multifaceted evaluation of microgliosis and differential cellular dysregulations of mTOR signaling with fluctuating lysosome function in neuronopathic Gaucher disease. Molecular Genetics and Metabolism. 2023; 138:107366.

Zhu, M; Xiao, B; Xue, T; Qin, S; Ding, J; Wu, Y; Tang, Q; Huang, M; Zhao, N; Ye, Y; et al. Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype. Brain: a journal of neurology. 2023; 146:4350-4365.