Experimental Hematology and Cancer Biology

Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology. 2020; 30:408-420.e5.

Agrawal, M; Schwarz, P; Giaimo, BD; Bedzhov, I; Corbacioglu, A; Weber, D; Gaidzik, VI; Jahn, N; Ruecker, FG; Schroeder, T; et al. Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML). Leukemia. 2020; 34:630-634.

Berry, K; Wang, J; Richard Lu, Q. Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases. F1000Research. 2020; 9:105-105.

Berry, KP; Lu, QR. Chromatin modification and epigenetic control in functional nerve regeneration. Seminars in Cell and Developmental Biology. 2020; 97:74-83.

Brown, A; Geiger, H. Role of cell cycle control, checkpoints, and DNA repair mechanisms in stem cells and changes with aging and cancerogenesis. Geriatric Oncology. : Springer International Publishing; Springer International Publishing; 2020.

Brown, A; Schuetz, D; Han, Y; Daria, D; Nattamai, KJ; Eiwen, K; Sakk, V; Pospiech, J; Saller, T; van Zant, G; et al. The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function. Haematologica: the hematology journal. 2020; 105:317-324.

D'Alessandro, A; Yoshida, T; Nestheide, S; Nemkov, T; Stocker, S; Stefanoni, D; Mohmoud, F; Rugg, N; Dunham, A; Cancelas, JA. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020; 60:786-798.

Freedman, J; Tran, A; Tourdot, BE; Kalyanaraman, C; Perry, S; Holinstat, M; Jacobson, MP; Holman, TR. Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Biochemistry. 2020; 59:1832-1844.

Gasilina, A; Premnauth, G; Gurjar, P; Biesiada, J; Hegde, S; Milewski, D; Ma, G; Kalin, TV; Merino, E; Meller, J; et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PLoS ONE. 2020; 15:e0229801-e0229801.

Gripp, KW; Schill, L; Schoyer, L; Stronach, B; Bennett, AM; Blaser, S; Brown, A; Burdine, R; Burkitt-Wright, E; Castel, P; et al. The sixth international RASopathies symposium: Precision medicine—From promise to practice. American Journal of Medical Genetics, Part A. 2020; 182:597-606.

Guo, J; Chaney, KE; Choi, K; Witek, G; Patel, AV; Xie, H; Lin, D; Whig, K; Xiong, Y; Schultz, DC; et al. Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas. American Journal of Cancer Research. 2020; 10:856-869.

Heinrich, A; Potter, SJ; Guo, L; Ratner, N; DeFalco, T. Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Reports. 2020; 31:107513-107513.

Hetzel, M; Lopez-Rodriguez, E; Mucci, A; Ha Nguyen, AH; Suzuki, T; Shima, K; Buchegger, T; Dettmer, S; Rodt, T; Bankstahl, JP; et al. Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis. Haematologica: the hematology journal. 2020; 105:1147-1157.

Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26:420-430.e6.

Jones, LM; Melgar, K; Bolanos, L; Hueneman, K; Walker, MM; Jiang, J; Wilson, KM; Zhang, X; Shen, J; Jiang, F; et al. Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. Journal of Clinical Investigation. 2020; 130:2017-2023.

Khandelwal, P; Chaturvedi, V; Owsley, E; Lane, A; Heyenbruch, D; Lutzko, CM; Leemhuis, T; Grimley, MS; Nelson, AS; Davies, SM; et al. CD38^brightCD8⁺ T Cells Associated with the Development of Acute GVHD Are Activated, Proliferating, and Cytotoxic Trafficking Cells. Biology of Blood and Marrow Transplantation. 2020; 26:1-6.

Khodoun, MV; Morris, SC; Angerman, E; Potter, C; Schuman, R; Wunderlich, M; Maciag, JJ; Locker, KC S; Mulloy, JC; Herr, AB; et al. Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies. Journal of Allergy and Clinical Immunology. 2020; 145:907-921.e3.

Lucas, D; Salomonis, N; Grimes, HL. Unraveling bone marrow architecture. Nature Cell Biology. 2020; 22:5-6.

Muench, DE; Olsson, A; Ferchen, K; Pham, G; Serafin, RA; Chutipongtanate, S; Dwivedi, P; Song, B; Hay, S; Chetal, K; et al. Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature. 2020; 582:109-114.

Munir, S; Basu, A; Maity, P; Krug, L; Haas, P; Jiang, D; Strauss, G; Wlaschek, M; Geiger, H; Singh, K; et al. TLR4-dependent shaping of the wound site by MSCs accelerates wound healing. EMBO Reports. 2020; 21.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Na, Y; Huang, G; Wu, J. The Role of RUNX1 in NF1-Related Tumors and Blood Disorders. Molecules and Cells. 2020; 43:153-159.

Nie, Y; Wilson, AF; DeFalco, T; Meetei, AR; Namekawa, SH; Pang, Q. FANCD2 is required for the repression of germline transposable elements. Reproduction. 2020; 159:659-668.

Niederkorn, M; Hueneman, K; Choi, K; Varney, ME; Romano, L; Pujato, MA; Greis, KD; Inoue, J; Meetei, R; Starczynowski, DT. TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Cell Reports. 2020; 30:2776-2790.e6.

Niss, O; Lane, A; Asnani, MR; Yee, ME; Raj, A; Creary, S; Fitzhugh, C; Bodas, P; Saraf, SL; Sarnaik, S; et al. Progression of albuminuria in patients with sickle cell anemia: A multicenter, longitudinal study. Blood Advances. 2020; 4:1501-1511.

Rodriguez, S; Abundis, C; Boccalatte, F; Mehrotra, P; Chiang, MY; Yui, MA; Wang, L; Zhang, H; Zollman, A; Bonfim-Silva, R; et al. Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL. Leukemia. 2020; 34:1241-1252.

Rubinstein, JD; Burns, K; Absalon, M; Lutzko, C; Leemhuis, T; Chandra, S; Hanley, PJ; Keller, MD; Davies, SM; Nelson, A; et al. EBV-directed viral-specific T-lymphocyte therapy for the treatment of EBV-driven lymphoma in two patients with primary immunodeficiency and DNA repair defects. Pediatric Blood and Cancer. 2020; 67.

Schrenk, S; Goines, J; Boscolo, E. A Patient-Derived Xenograft Model for Venous Malformation. Jove-Journal of Visualized Experiments. 2020.

Singh, AK; Cancelas, JA. Gap junctions in the bone marrow lympho-hematopoietic stem cell niche, leukemia progression, and chemoresistance. International Journal of Molecular Sciences. 2020; 21:796-796.

Tackenberg, H; Moeller, S; Filippi, M; Laskay, T. The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions. Frontiers in Immunology. 2020; 11.

Weng, Q; Zhao, M; Zheng, J; Yang, L; Xu, Z; Zhang, Z; Wang, J; Wang, J; Yang, B; Lu, QR; et al. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell Death and Differentiation. 2020; 27:130-145.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica: the hematology journal. 2020; 105:925-936.

Yazer, MH; Spinella, PC; Doyle, L; Kaufman, RM; Dunn, R; Hess, JR; Filho, LA; Fontaine, M; Gathof, B; Jackson, B; et al. Transfusion of uncrossmatched group o erythrocyte-containing products does not interfere with most ABO typings. Anesthesiology. 2020; 132:525-534.

Yokota, A; Huo, L; Lan, F; Wu, J; Huang, G. The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies. Molecules and Cells. 2020; 43:145-152.

Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; et al. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathologica. 2020; 139:157-174.

Zeng, X; Zhu, S; Hou, Y; Zhang, P; Li, L; Li, J; Huang, LF; Lewis, SJ; Nussinov, R; Cheng, F. Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest. Bioinformatics. 2020; 36:2805-2812.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica: the hematology journal. 2020; 105:573-584.

Zhang, H; Qi, L; Du, Y; Huang, LF; Braun, FK; Kogiso, M; Zhao, Y; Li, C; Lindsay, H; Zhao, S; et al. Patient-derived orthotopic xenograft (PDOX) mouse models of primary and recurrent meningioma. Cancers. 2020; 12:1478-17.