Experimental Hematology and Cancer Biology

Experimental Hematology and Cancer Biology

Publications

Cannon, P; Asokan, A; Czechowicz, A; Hammond, P; Kohn, DB; Lieber, A; Malik, P; Marks, P; Porteus, M; Verhoeyen, E; et al. Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development. Human Gene Therapy. 2021; 32:31-42.

Cho, JR; Chen, X; Kahan, A; Robinson, JE; Wagenaar, DA; Gradinaru, V. Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context. Journal of Neuroscience. 2021; 41:2645-2655.

Colling, ME; Tourdot, BE; Kanthi, Y. Inflammation, Infection and Venous Thromboembolism. Circulation Research. 2021; 128:2017-2036.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Filippi, MD. Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division. Experimental Hematology. 2021; 96:27-34.

Galvin, R; Watson, AL; Largaespada, DA; Ratner, N; Osum, S; Moertel, CL. Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib. Current Oncology Reports. 2021; 23.

Gbotosho, OT; Taylor, M; Malik, P. Cardiac pathophysiology in sickle cell disease. Journal of Thrombosis and Thrombolysis. 2021.

Geraldo, LH; Xu, Y; Jacob, L; Pibouin-Fragner, L; Rao, R; Maïssa, N; Verreault, M; Lemaire, N; Knosp, C; Lesaffre, C; et al. SLIT2/ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia. Journal of Clinical Investigation. 2021.

Goines, J; Boscolo, E. A Xenograft Model for Venous Malformation. . 2021.

Guidi, N; Marka, G; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem Cells. 2021.

Guo, F. RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?. Precision Clinical Medicine. 2021; 4:56-61.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Karkoska, K; Todd, K; Niss, O; Clapp, K; Fenchel, L; Kalfa, TA; Malik, P; Quinn, CT; Ware, RE; McGann, PT. Implementation of near-universal hydroxyurea uptake among children with sickle cell anemia: A single-center experience. Pediatric Blood and Cancer. 2021; 68.

Kuerbitz, J; Madhavan, M; Ehrman, LA; Kohli, V; Waclaw, RR; Campbell, K. Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse. Cerebral Cortex. 2021; 31:1744-1762.

Lin, Y; Lu, S; Zhang, J; Zheng, Y. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure with Folding & design. 2021; 29:553-563.e5.

Lin, Y; Watanabe-Chailland, M; Zheng, Y. Protocol for structural and biochemical analyses of RhoA GTPase. STAR Protocols. 2021; 2.

Luo, Z; Dong, X; Xia, Y; Berry, KP; Rao, R; Xu, L; Xue, P; Chen, T; Lin, Y; Yu, J; et al. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in Cell and Developmental Biology. 2021; 9.

Marinaccio, C; Suraneni, P; Celik, H; Volk, A; Wen, QJ; Ling, T; Bulic, M; Lasho, T; Koche, RP; Famulare, CA; et al. LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Cancer Discovery. 2021; 11:1398-1410.

Muraleedharan, R; Nardini, D; Waclaw, RR; Dasgupta, B. Analysis of reactive astrogliosis in mouse brain using in situ hybridization combined with immunohistochemistry. STAR Protocols. 2021; 2.

Na, Y; Hall, A; Choi, K; Hu, L; Rose, J; Coover, RA; Miller, A; Hennigan, RF; Dombi, E; Kim, MO; et al. MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK. Oncogene. 2021; 40:951-963.

Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience. 2021; 24.

Narciso, MG; Hoeting, B; James, JM; VandenHeuvel, K; Nasimuzzaman, M. A mutant fibrinogen that is unable to form fibrin can improve renal phenotype in mice with sickle cell anemia. 2021.

Niss, O; Lorsbach, RB; Berger, M; Chonat, S; McLemore, M; Buchbinder, D; McCavit, T; Shaffer, LG; Simpson, J; Schwartz, JH; et al. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood Cells, Molecules, and Diseases. 2021; 87.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; et al. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science advances. 2021; 7.

Prus, K; Alquist, CR; Cancelas, JA; Oh, D. Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time. Transfusion. 2021; 61:651-654.

Serrano-Lopez, J; Hegde, S; Kumar, S; Serrano, J; Fang, J; Wellendorf, AM; Roche, PA; Rangel, Y; Carrington, LJ; Geiger, H; et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; et al. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood. 2021.

Shrestha, A; Chi, M; Wagner, K; Malik, A; Korpik, J; Drake, A; Fulzele, K; Guichard, S; Malik, P. FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. Blood Advances. 2021; 5:2385-2390.

Singh, AK; Cancelas, JA. Mitochondria Transfer in Bone Marrow Hematopoietic Activity. Current stem cell reports. 2021; 7:1-12.

Tackenberg, H; Möller, S; Filippi, MD; Laskay, T. The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria. Frontiers in Immunology. 2021; 12.

Talley, MJ; Nardini, D; Shabbir, N; Ehrman, LA; Prada, CE; Waclaw, RR. Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Frontiers in Cell and Developmental Biology. 2021; 9.

Tang, Y; Xu, Q; Hu, L; Yan, X; Feng, X; Yokota, A; Wang, W; Zhan, D; Krishnamurthy, D; Ochayon, DE; et al. Tumor Microenvironment-Derived R-spondins Enhance Anti-Tumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy. Cancer Discovery. 2021.

Thomson, CS; Pundavela, J; Perrino, MR; Coover, RA; Choi, K; Chaney, KE; Rizvi, TA; Largaespada, DA; Ratner, N. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene. 2021; 40:4229-4241.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, R; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021.

Vélez-Reyes, GL; Koes, N; Ryu, JH; Kaufmann, G; Berner, M; Weg, MT; Wolf, NK; Rathe, SK; Ratner, N; Moriarity, BS; et al. Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development. Cancers. 2021; 13.

Wang, T; Pine, AR; Kotini, AG; Yuan, H; Zamparo, L; Starczynowski, DT; Leslie, C; Papapetrou, EP. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. Cell Stem Cell. 2021; 28:1074-1089.e7.

Weiss, BD; Wolters, PL; Plotkin, SR; Widemann, BC; Tonsgard, JH; Blakeley, J; Allen, JC; Schorry, E; Korf, B; Robison, NJ; et al. NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas. Journal of Clinical Oncology. 2021; 39:797-806.

Wunderlich, M; Manning, N; Sexton, C; O’Brien, E; Byerly, L; Stillwell, C; Perentesis, JP; Mulloy, JC; Mizukawa, B. PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of Relapsed Pediatric B-Cell Acute Lymphoblastic Leukemia. Frontiers in Oncology. 2021; 11.

Young, K; Eudy, E; Bell, R; Loberg, MA; Stearns, T; Sharma, D; Velten, L; Haas, S; Filippi, MD; Trowbridge, JJ. Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging. Cell Stem Cell. 2021.

Zaslavsky, A; Adams, M; Cao, X; Yamaguchi, A; Henderson, J; Busch-Østergren, P; Udager, A; Pitchiaya, S; Tourdot, B; Kasputis, T; et al. Antisense oligonucleotides and nucleic acids generate hypersensitive platelets. Thrombosis Research. 2021; 200:64-71.

Zhang, J; Wu, Q; Johnson, CB; Pham, G; Kinder, JM; Olsson, A; Slaughter, A; May, M; Weinhaus, B; D’Alessandro, A; et al. In situ mapping identifies distinct vascular niches for myelopoiesis. Nature: New biology. 2021; 590:457-462.

Zhang, Y; Park, JY; Zhang, F; Olson, SH; Orlow, I; Li, Y; Kurtz, RC; Ladanyi, M; Chen, J; Toland, AE; et al. The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. Human Mutation. 2021; 42:150-163.