1. Dr. Huang’s Lab is modeling and targeting cell-cell interaction (stromal-tumor-immune crosstalk) in disease microenvironment. He has collaborated with immunologists and cancer biologists on identifying and validating altered pathways in the tumor-stromal-immune environment, which drives cancer carcinogenesis and mediate chemo-resistance. The Huang Lab has developed computational cell-cell communication tools based on single-cell RNA/ATAC-seq data of tumor patients.
2. Integrating Multiple genomic and epigenomic data for driver signaling network analysis, drug repositioning and drug combination prediction: the Huang Lab has been integrating multiple genomic data, such as DNA-seq, RNA-seq, Copy number, ChIP-Seq, Methylation, and Proteomics, of same patients in order to derive driver signaling pathways. In order to overcome drug resistance and increase therapeutic choices, the Huang Lab has also actively investigated drug repurposing and synergistic drug combinations.