Myelination in the CNS by oligodendrocytes is critical for normal neuronal function. Failure of myelin regeneration causes demyelinating diseases such as multiple sclerosis, which affect 2 millions people worldwide. We are exploring the roles of histone deacetylases (HDACs), chromatin remodeling factors such as Brg1 complexes, and non-coding RNAs such as microRNAs in the control of myelination and remyelination in the CNS and PNS. We are also investigating the small molecules that regulate the activity of chromatin remodeling enzymes in controlling myelination and myelin repair.
Chromatin remodeling control of CNS myelination.