A photo of Timothy Weaver.

Co-Director, Division of Pulmonary Biology

Professor, UC Department of Pediatrics

513-636-7223

513-636-7868

Biography & Affiliation

Biography

Dr. Weaver has a long-standing interest in lung development and disease. His early work with Dr. Whitsett uncovered the function of surfactant proteins SP-B and SP-C, a discovery that has profoundly influenced the treatment of respiratory distress syndrome and survival of pre-term infants worldwide. His current research is focused to the molecular pathways (ER stress and autophagy) that link mutations in the SFTPC gene (encoding surfactant protein C) to development of interstitial lung disease (ILD) in both children and adults. His work has been continuously funded by the National Institutes of Health since 1986, including a MERIT (R37) award from the National Heart, Lung and Blood Institute (2001-2011).

Dr. Weaver has trained 14 graduate students in the past 15 years and is the past director of the Molecular and Developmental Biology Graduate Program. During the same period of time he has trained 11 postdoctoral fellows, eight of whom are current faculty members at institutions in the US, Germany, France, Japan and UK. 

Research Interests

Lung development; chaperone biology and diseases of protein misfolding; pulmonary fibrosis; asthma; respiratory distress syndrome; acute and chronic lung disease

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Pulmonary Biology, Fibrosis

Education

BS: Biology, Bob Jones University, Greenville, SC, 1975.

MS: Embryology, Hahnemann Medical College, Philadelphia, PA, 1979.

PhD: Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 1983.

Postdoc: Molecular Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 1986.

Publications

Selected Publication

Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome. Sitaraman, S; Na, C; Yang, L; Filuta, A; Bridges, JP; Weaver, TE. Scientific Reports. 2019; 9.

The Phosphatidylcholine Transfer Protein Stard7 is Required for Mitochondrial and Epithelial Cell Homeostasis. Yang, L; Na, C; Luo, S; Wu, D; Hogan, S; Huang, T; Weaver, TE. Scientific Reports. 2017; 7.

Haploinsufficiency for Stard7 Is Associated with Enhanced Allergic Responses in Lung and Skin. Yang, L; Lewkowich, I; Apsley, K; Fritz, JM; Wills-Karp, M; Weaver, TE. Journal of immunology (Baltimore, Md. : 1950). 2015; 194:5635-5643.

Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects. Fritz, JM; Dong, M; Apsley, KS; Martin, EP; Na, C; Sitaraman, S; Weaver, TE. Molecular Biology of the Cell. 2014; 25:431-440.

Comparative Proteomic Analysis of Lung Lamellar Bodies and Lysosome-Related Organelles. Ridsdale, R; Na, C; Xu, Y; Greis, KD; Weaver, T. PLoS ONE. 2011; 6:e16482-e16482.

ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Dong, M; Bridges, JP; Apsley, K; Xu, Y; Weaver, TE. Molecular Biology of the Cell. 2008; 19:2620-2630.

Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. Bridges, JP; Xu, Y; Na, CL; Wong, HR; Weaver, TE. The Journal of Cell Biology. 2006; 172:395-407.

Processing of pulmonary surfactant protein B by napsin and cathepsin H. Ueno, T; Linder, S; Na, CL; Rice, WR; Johansson, J; Weaver, TE. The Journal of biological chemistry. 2004; 279:16178-16184.

Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice. Bridges, JP; Wert, SE; Nogee, LM; Weaver, TE. The Journal of biological chemistry. 2003; 278:52739-52746.

SP-B deficiency causes respiratory failure in adult mice. Melton, KR; Nesslein, LL; Ikegami, M; Tichelaar, JW; Clark, JC; Whitsett, JA; Weaver, TE. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2003; 285:L543-L549.