A photo of Ting Wen.

Researcher, Cincinnati Center for Eosinophilic Disorders

Assistant Professor, UC Department of Pediatrics

513-636-9462

Biography & Affiliation

Biography

My research focuses on T-cells, type 2 inflammation and allergies. I work to identify molecular mechanisms for Th2 cytokine production, and Th2 differentiation and activation. With my research, I aim to find a cure for human atopic disorders, including eosinophilic esophagitis (EoE).

I have helped to characterize the unique, tissue-specific transcriptome of purified murine eosinophils under homeostasis and allergic conditions. I have also demonstrated the expression and function of certain unexpected molecules, CD22 and CAR4, on gastrointestinal and lung eosinophils, respectively.

I developed a murine eosinophil transfer model system that is useful in assessing the function of genes of interest that are expressed on eosinophils or other target tissues. I am also the co-inventor of the EoE Diagnostic Panel (EDP), licensed to the diagnostic company Diagnovus, LLC. The EDP is an Engauge GI-EoE test currently used in clinical practice.

I have received several awards, including:

  • 2011 American Academy of Allergy, Asthma, and Immunology Fellow-in-Training Travel Award
  • 2013 Ohio River Valley Cytometry Association Imaging and Cytometry Research Symposium Outstanding Poster Presentation, 2nd Place
  • 2014 Ohio River Valley Cytometry Association Imaging and Cytometry Research Symposium Outstanding Poster Presentation, 1st Place

I have also co-authored two book chapters and have been an invited speaker for several national and international meetings related to eosinophilic disorders.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Divisions

Allergy and Immunology, Eosinophilic Disorders



Blog Posts

Education

PhD: Cell Biology and Neuroscience, University of Medicine and Dentistry of New Jersey / Rutgers University, Piscataway, NJ.

Postdoctoral Fellowship: Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort. Dunn, JL M; Shoda, T; Caldwell, JM; Wen, T; Aceves, SS; Collins, MH; Dellon, ES; Falk, GW; Leung, J; Martin, LJ; et al. Journal of Allergy and Clinical Immunology. 2020; 145:1629-1640.e4.

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Ben Baruch-Morgenstern, N; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; et al. Science Translational Medicine. 2020; 12:eaaz7773-eaaz7773.

Eosinophilic Esophagitis Histology Remission Score: Significant Relations to Measures of Disease Activity and Symptoms. Collins, MH; Martin, LJ; Wen, T; Abonia, JP; Putnam, PE; Mukkada, VA; Rothenberg, ME. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:598-603.

Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. Vanoni, S; Zeng, C; Marella, S; Uddin, J; Wu, D; Arora, K; Ptaschinski, C; Que, J; Noah, T; Waggoner, L; et al. Journal of Allergy and Clinical Immunology. 2020; 145:239-254.e2.

Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study. Shoda, T; Wen, T; Caldwell, JM; Collins, MH; Besse, JA; Osswald, GA; Abonia, JP; Arva, NC; MDd, DA; Capocelli, KE; et al. Journal of Allergy and Clinical Immunology. 2020; 145:255-269.

Cell-by-cell deciphering of T cells in allergic inflammation. Wen, T; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2019; 144:1143-1149.

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Journal of Clinical Investigation. 2019; 129:2014-2028.

Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia. Krishnan, U; Lijuan, C; Andrew, GJ; Rothenberg, ME; Wen, T. Journal of Allergy and Clinical Immunology. 2019; 143:1455-1464.e2.

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Clinical and Experimental Allergy. 2019; 49:92-107.

Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis. Zeng, C; Vanoni, S; Wu, D; Caldwell, JM; Wheeler, JC; Arora, K; Noah, TK; Waggoner, L; Besse, JA; Yamani, AN; et al. Journal of Allergy and Clinical Immunology. 2018; 142:1843-1855.