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A photo of Ting Wen.

Researcher, Cincinnati Center for Eosinophilic Disorders

Assistant Professor, UC Department of Pediatrics

513-636-9462

Biography & Affiliation

Biography

Ting Wen, MD, PhD, has characterized the unique, tissue-specific transcriptome of purified murine eosinophils under homeostasis and allergic conditions and demonstrated the expression and function of a couple of unexpected molecules, CD22 and CAR4, on gastrointestinal and lung eosinophils, respectively (Wen et al., 2012 and 2014, Journal of Immunology).

Dr. Wen also developed a murine eosinophil transfer model system that has proven to be useful in assessing the function of a gene of interest that is expressed on eosinophils or target tissue (Wen et al., 2013, PNAS).

Dr. Wen is a co-inventor of the EoE Diagnostic Panel (EDP), created in part due to his expertise in molecular biopsy and bioinformatics. The Cincinnati Children's-owned patent is now licensed to the diagnostic company Diagnovus, LLC, as Engauge GI-EoE test and is in use in clinical practice (Wen et al., 2013, Gastroenterology).

In the past three years, Dr. Wen won the following awards for his eosinophil-related studies:

  • 2011, Fellow-In-Training Travel Award, American Academy of Allergy, Asthma, and Immunology (AAAAI)
  • 2013 Outstanding Poster Presentation, 2nd Place, Imaging and Cytometry Research Symposium, Ohio River Valley Cytometry Association (ORVCA)
  • 2014 Outstanding Poster Presentation, 1st Place, Imaging and Cytometry Research Symposium, Ohio River Valley Cytometry Association (ORVCA

Dr. Wen has also been an invited speaker on several national and international meetings related to eosinophilic disorders and co-authored to two book chapters.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Divisions

Allergy and Immunology, Eosinophilic Disorders

Science Blog

Education

PhD: Cell Biology and Neuroscience, University of Medicine and Dentistry of New Jersey / Rutgers University, Piscataway, NJ.

Postdoctoral Fellowship: Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis. Vanoni, S; Zeng, C; Marella, S; Uddin, J; Wu, D; Arora, K; Ptaschinski, C; Que, J; Noah, T; Waggoner, L; et al. Journal of Allergy and Clinical Immunology. 2020; 145:239-254.e2.

Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study. Shoda, T; Wen, T; Caldwell, JM; Collins, MH; Besse, JA; Osswald, GA; Abonia, JP; Arva, NC; MDd, DA; Capocelli, KE; et al. Journal of Allergy and Clinical Immunology. 2020; 145:255-269.

Cell-by-cell deciphering of T cells in allergic inflammation. Wen, T; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2019; 144:1143-1149.

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Journal of Clinical Investigation. 2019; 129:2014-2028.

Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia. Krishnan, U; Lijuan, C; Andrew, GJ; Rothenberg, ME; Wen, T. Journal of Allergy and Clinical Immunology. 2019; 143:1455-1464.e2.

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Clinical and Experimental Allergy. 2019; 49:92-107.

Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis. Zeng, C; Vanoni, S; Wu, D; Caldwell, JM; Wheeler, JC; Arora, K; Noah, TK; Waggoner, L; Besse, JA; Yamani, AN; et al. Journal of Allergy and Clinical Immunology. 2018; 142:1843-1855.

Eosinophils support adipocyte maturation and promote glucose tolerance in obesity. Lee, E; Itan, M; Jang, J; Gu, H; Rozenberg, P; Mingler, MK; Wen, T; Yoon, J; Park, S; Roh, JY; et al. Scientific Reports. 2018; 8.

Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Dellon, ES; Liacouras, CA; Molina-Infante, J; Furuta, GT; Spergel, JM; Zevit, N; Spechler, SJ; Attwood, SE; Straumann, A; Aceves, SS; et al. Gastroenterology. 2018; 155:1022-1033.e10.

Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis. Rosenberg, CE; Mingler, MK; Caldwell, JM; Collins, MH; Fulkerson, PC; Morris, DW; Mukkada, VA; Putnam, PE; Shoda, T; Wen, T; et al. Allergy: European Journal of Allergy and Clinical Immunology. 2018; 73:1892-1901.