My research focuses on T-cells, type 2 inflammation and allergies. I work to identify molecular mechanisms for Th2 cytokine production, and Th2 differentiation and activation. With my research, I aim to find a cure for human atopic disorders, including eosinophilic esophagitis (EoE).
I have helped to characterize the unique, tissue-specific transcriptome of purified murine eosinophils under homeostasis and allergic conditions. I have also demonstrated the expression and function of certain unexpected molecules, CD22 and CAR4, on gastrointestinal and lung eosinophils, respectively.
I developed a murine eosinophil transfer model system that is useful in assessing the function of genes of interest that are expressed on eosinophils or other target tissues. I am also the co-inventor of the EoE Diagnostic Panel (EDP), licensed to the diagnostic company Diagnovus, LLC. The EDP is an Engauge GI-EoE test currently used in clinical practice.
I have received several awards, including:
- 2011 American Academy of Allergy, Asthma, and Immunology Fellow-in-Training Travel Award
- 2013 Ohio River Valley Cytometry Association Imaging and Cytometry Research Symposium Outstanding Poster Presentation, 2nd Place
- 2014 Ohio River Valley Cytometry Association Imaging and Cytometry Research Symposium Outstanding Poster Presentation, 1st Place
I have also co-authored two book chapters and have been an invited speaker for several national and international meetings related to eosinophilic disorders.
Assistant Professor, UC Department of Pediatrics
Allergy and Immunology, Eosinophilic Disorders