A photo of Ting Wen.

Researcher, Cincinnati Center for Eosinophilic Disorders

Assistant Professor, UC Department of Pediatrics

513-636-9462

My Biography & Research

Biography

Ting Wen, MD, PhD, has characterized the unique, tissue-specific transcriptome of purified murine eosinophils under homeostasis and allergic conditions and demonstrated the expression and function of a couple of unexpected molecules, CD22 and CAR4, on gastrointestinal and lung eosinophils, respectively (Wen et al., 2012 and 2014, Journal of Immunology).

Dr. Wen also developed a murine eosinophil transfer model system that has proven to be useful in assessing the function of a gene of interest that is expressed on eosinophils or target tissue (Wen et al., 2013, PNAS).

Dr. Wen is a co-inventor of the EoE Diagnostic Panel (EDP), created in part due to his expertise in molecular biopsy and bioinformatics. The Cincinnati Children's-owned patent is now licensed to the diagnostic company Diagnovus, LLC, as Engauge GI-EoE test and is in use in clinical practice (Wen et al., 2013, Gastroenterology).

In the past three years, Dr. Wen won the following awards for his eosinophil-related studies:

  • 2011, Fellow-In-Training Travel Award, American Academy of Allergy, Asthma, and Immunology (AAAAI)
  • 2013 Outstanding Poster Presentation, 2nd Place, Imaging and Cytometry Research Symposium, Ohio River Valley Cytometry Association (ORVCA)
  • 2014 Outstanding Poster Presentation, 1st Place, Imaging and Cytometry Research Symposium, Ohio River Valley Cytometry Association (ORVCA

Dr. Wen has also been an invited speaker on several national and international meetings related to eosinophilic disorders and co-authored to two book chapters.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Departments

Allergy and Immunology, Allergy and Immunology, Eosinophilic Disorders, Eosinophilic Disorders

My Education

PhD: Cell Biology and Neuroscience, University of Medicine and Dentistry of New Jersey / Rutgers University, Piscataway, NJ.

Postdoctoral Fellowship: Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

My Publications

Wen T, Dellon ES, Moawad FJ, Furuta GT, Aceves SS, Rothenberg ME. Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation. J Allergy Clin Immunol. 2014;S0091-6749(14)01271-8.

Wen T, Mingler MK, Wahl B, Pabst O, Khorki EM, Zimmermann N, Rothenberg ME. Carbonic anhydrase IV (CAR4) is an activation marker of murine lung eosinophils. Journal of Immunology.  2014;192(12):5481-9.

Butz BK*, Wen T*, Gleich GJ, Furuta GT, Spergel J, King E, Kramer RE, Collins MH, Stucke E,  Mangeot C, Jackson WD, O'Gorman M, Abonia JP, Pentiuk S, Putnam PE, Rothenberg ME. Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology. 2014;147(2):324-33.e5. * Co-1st-author

Rothenberg ME, Wen T, Greenberg A, Hirano I, Nadeau K, Alpan O, Wright A, Espié P, Arm J, Strieiter R, Sabo R, Gunawardena KA. A double-blinded, randomized, placebo-controlled trial of intravenous anti-IL-13 AQX576 in the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 13;pii:S0091-6749(14)01053-7.

Wen T, Besse JA, Mingler MK, Fulkerson PC, Rothenberg ME. Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. Proceedings of the National Academy of Sciences of the United States of America.  2013;110(15):6067-6072. 

Abonia JP, Wen T, Stucke EM, Grotjan T, Griffith MS, Kemme KA, Collins MH, Putnam PE, Franciosi JP, von Tiehl KF, Tinkle BT, Marsolo KA, Martin LJ, Ware SM, Rothenberg ME. High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders. Journal of Allergy and Clinical Immunology. 2013;132(2):378-386. 

Wen T, Stucke EM, Grotjan TM, Kemme KA, Abonia JP, Putnam PE, Franciosi JP, Garza JM, Kaul A, King EC, Collins MH, Kushner JP, Rothenberg ME. Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology. 2013;145(6):1289-1299.

Wen T, Mingler MK, Blanchard C, Wahl B, Pabst O, Rothenberg ME. The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. Journal of Immunology. 2012;188(3):1075-1082.

Wen T, Peng B, Pintar JE. The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion. Molecular Endocrinology. 2009;23(5):671-678. 

Wen T, Ansonoff MA, Pintar JE. The tail pigmentation pattern of C57BL/6J mice affects nociception/pain quantification in the tail flick test. European Journal of Pain. 2009;13(6):564-567.