Mei Xin, PhD

Member, Division of Experimental Hematology & Cancer Biology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-3464

Fax 513-636-3549

Email mei.xin@cchmc.org

Regulation of organogenesis such as cardiovascular and heart growth and regeneration, and the nervous system development
Mei Xin received her PhD from the University of Texas Southwestern Medical Center at Dallas. She completed her postdoctoral training in Eric Olson’s laboratory where she investigated microRNAs and Hippo signaling molecules regulating cardiovascular development and regeneration. In August 2013, Dr. Xin moved to Cincinnati Children’s Hospital Medical Center to study organogenesis including cardiovascular and peripheral nervous system development and diseases.

MS: Robert Wood Johnson Medical School, Piscataway, NJ.

PhD: The University of Texas Southwestern Medical Center, Dallas, TX.

Postdoctoral Fellowship: The University of Texas Southwestern Medical Center, Dallas, TX.

View PubMed Publications

Sakabe M, Fan J, Odaka Y, Liu N, Hasan A, Duan X, Byerly L, Donalson M, Stump P, Hao J, Fruttiger M, Lu QR, Zheng Y, Lang R, Xin M. YAP/TAZ-Cdc42 signaling regulates vascular tip cell migration. Proc Natl Acad Sci U S A. 2017 Sep.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc Natl Acad Sci U S A. 2017 Sep 15.

Yaqi D, Wu L, Bai S, Zhao C, Wang H, Wang J, Xu L, Sakabe M, Zhou W, Mei Xin M, Lu QR. A Reciprocal Regulatory Loop Between TAZ/YAP and G-protein Gαs Regulates Schwann Cell Proliferation and Myelination. Nature Comms. 2017;26;8:15161.

Das M, Tanigawa S, Karner CM, Xin M, McNeil H, Lum L, Chen C, Olson EN, Alan O. Perantoni AO, Carroll TJ. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nature Cell Biology. 2013 Oct 1;15(10):1260.

Xin M, Sutherland LB, Qi X, McAnally J, Richardson JA, Sadek H, Bassel-Duby R, Olson EN. Yap Controls heart regeneration and repair. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44.

Xin M, Bassel-Duby R, Olson EN. Cardiac Development as a Foundation for Adult Heart Regeneration and Repair. Nature Reviews Molecular Cell Biology. 2013 Aug;14(8):529-41.

Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, Richardson JA, Bassel-Duby R, Olson EN. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Science Signal. 2011 Oct 25;4(196):ra70.

Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 2009 Sep 15;23(18):2166-78.

Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7975-80.

Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11189-94.

Hippo signaling in heart development and repair. Principal Investigator. National Institutes of Health (NHLBI). Apr 2016-Mar 2021. 1R01HL132211-01.