Mei Xin, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-3464

Email mei.xin@cchmc.org

Regulation of organogenesis such as cardiovascular and heart growth and regeneration, and the nervous system development
Mei Xin received her PhD from the University of Texas Southwestern Medical Center at Dallas. She completed her postdoctoral training in Eric Olson’s laboratory where she investigated microRNAs and Hippo signaling molecules regulating cardiovascular development and regeneration. In August 2013, Dr. Xin moved to Cincinnati Children’s Hospital Medical Center to study organogenesis including cardiovascular and peripheral nervous system development and diseases.

MS: Robert Wood Johnson Medical School, Piscataway, NJ.

PhD: The University of Texas Southwestern Medical Center, Dallas, TX.

Postdoctoral Fellowship: The University of Texas Southwestern Medical Center, Dallas, TX.

View PubMed Publications

Lu F, Chen Y, Zhao C, Wang H, He D, Xu L, Wang J, He X, Deng Y, Lu EE, Liu X, Verma R, Bu H, Drissi R, Fouladi M, Stemmer-Rachamimov AO, Burns D, Xin M, Rubin JB, Bahassi el M, Canoll P, Holland EC, Lu QR. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell. 2016 May 9;29(5):669-83.

Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, Parry L, Goldman SA, Clevers H, Lu QR. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nat Commun. 2016 Mar 9;7:10883.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell. 2016 Feb 8;36(3):316-30.

Das M, Tanigawa S, Karner CM, Xin M, McNeil H, Lum L, Chen C, Olson EN, Alan O. Perantoni AO, Carroll TJ. Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nature Cell Biology. 2013 Oct 1;15(10):1260.

Xin M, Sutherland LB, Qi X, McAnally J, Richardson JA, Sadek H., Bassel-Duby R, Olson EN. Yap Controls heart regeneration and repair. Proc Natl Acad Sci USA. 2013 Aug 20;110(34):13839-44.

Xin M, Bassel-Duby R and Olson EN. Cardiac Development as a Foundation for Adult Heart Regeneration and Repair. (Invited review) Nature Reviews Molecular Cell Biology. 2013 Aug;14(8):529-41.

Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, Richardson JA, Bassel-Duby R, Olson EN. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Science Signal. 2011 Oct 25;4(196):ra70.

Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN. MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 2009 Sep15;23(18):2166-78.

Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci USA. 2007 May 8;104(19):7975-80.

Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci USA. 2006 Jul25;103(30):11189-94.

Hippo signaling in heart development and repair. Principal Investigator. National Institutes of Health (NHLBI). Apr 2016-Mar 2021. 1R01HL132211-01.