A photo of Mei Xin.

Member, Division of Experimental Hematology & Cancer Biology

Assistant Professor, UC Department of Pediatrics

513-803-3464

513-636-3549

Biography & Affiliation

Biography

Mei Xin received her PhD from the University of Texas Southwestern Medical Center at Dallas. She completed her postdoctoral training in Eric Olson’s laboratory where she investigated microRNAs and Hippo signaling molecules regulating cardiovascular development and regeneration. In August 2013, Dr. Xin moved to Cincinnati Children’s Hospital Medical Center to study organogenesis including cardiovascular and peripheral nervous system development and diseases.

Research Interests

Regulation of organogenesis such as cardiovascular and heart growth and regeneration, and the nervous system development

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

MS: Robert Wood Johnson Medical School, Piscataway, NJ.

PhD: The University of Texas Southwestern Medical Center, Dallas, TX.

Postdoctoral Fellowship: The University of Texas Southwestern Medical Center, Dallas, TX.

Publications

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Blood. 2020; 136:1824-1836.

miR-143 Regulates Lysosomal Enzyme Transport across the Blood-Brain Barrier and Transforms CNS Treatment for Mucopolysaccharidosis Type I. Lin, Y; Wang, X; Rose, KP; Dai, M; Han, J; Xin, M; Pan, D. Molecular Therapy. 2020; 28:2161-2176.

EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Wang, J; Yang, L; Dong, C; Wang, J; Xu, L; Qiu, Y; Weng, Q; Zhao, C; Xin, M; Lu, QR. Science Advances. 2020; 6:eaaz6477-eaaz6477.

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Cancer Cell. 2019; 36:302-318.e7.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Zhao, C; Dong, C; Frah, M; Deng, Y; Marie, C; Zhang, F; Xu, L; Ma, Z; Dong, X; Lin, Y; et al. Developmental Cell. 2018; 45:753-768.e8.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. He, X; Zhang, L; Queme, LF; Liu, X; Lu, A; Waclaw, RR; Dong, X; Zhou, W; Kidd, G; Yoon, S; et al. Nature Medicine. 2018; 24:338-351.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Cancer Cell. 2018; 33:292-308.e7.

Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. He, L; Yu, K; Lu, F; Wang, J; Wu, LN; Zhao, C; Li, Q; Zhou, X; Liu, H; Mu, D; et al. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018; 38:1575-1587.

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Liu, M; Zhang, Z; Sampson, L; Zhou, X; Nalapareddy, K; Feng, Y; Akunuru, S; Melendez, J; Davis, AK; Bi, F; et al. Stem Cell Reports. 2017; 9:1961-1975.