Statistical methodology research focuses on survival analysis, longitudinal data analysis, machine learning, meta-analysis and study designs. My applied research interests include the study of cancer, radiology, transmittable disease, heart diseases, environmental health and health behavior.
My colleagues and I want to answer specific research questions by performing advanced statistical methodology to find the unknown risk features of fatal diseases and chronic conditions.
We have uncovered several notable discoveries in our lab, such as refractory hypertension not being categorized by excess aldosteronism or larger fluid retention related to controlled resistance hypertension (RHTN). If confirmed, this would have important implications for patients' clinical management in that continued titration of diuretic therapy and/or mineralocorticoid receptor antagonists may not be appropriate. It may even be counterproductive because it may activate reflexive pressor responses and may raise the risk of adverse events.
In addition, our paper Quantitative MRI of fatty liver disease in a large pediatric cohort: correlation between liver fat fraction, stiffness, volume, and patient-specific factors reports that the liver volume, stiffness and fat fraction are linked and related to various patient-specific features. These connections require further study since magnetic resonance imaging (MRI) is gradually utilized as a non-invasive biomarker for fatty liver disease diagnosis and examination.
I’ve held various positions, including lead statistician for the Collaborative Antiviral Study Group (CASG) and deputy director of the Statistical and Data Management Center of Mycoses Study Group (MSG). I’ve also been a Steering Committee member for the Consortium of Hospitals to Advance Research on Tobacco (CHART) trials.
I enjoy applying what I’ve learned and developing new methods to improve people’s health. Additionally, I have received multiple awards and recognitions throughout my career, including:
I have more than 10 years’ experience in biostatistics and joined the team at Cincinnati Children’s in 2012. My research has been published in a multitude of journals, such as Biometrics, Radiology, Journal of Hip Preservation Surgery, Hypertension and Journal of the American College of Radiology.
BS: University of Science and Technology of China, Hefei, Anhui, China.
PhD: University of Missouri, Columbia, MO.
Biostatistics and Epidemiology
Effect of maternal vaccination on infant morbidity in Bangladesh. BMC Public Health. 2024; 24:1213.
Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes. Critical Care (UK). 2024; 28:246.
Feature screening for ultra-high-dimensional data via multiscale graph correlation. Communications in Statistics: Theory and Methods. 2024; 53:7942-7979.
Abstract Sa402: CPR Coaches Improve Cardiopulmonary Resuscitation Guideline Adherence in Pediatric In-Hospital Cardiac Arrest. Circulation. 2024; 150:asa402.
Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock. Pediatric Critical Care Medicine. 2024; 25:1005-1016.
Tolerability and Acceptability of Autonomous Immersive Virtual Reality Incorporating Digital Twin Technology for Mass Training in Healthcare. Simulation in Healthcare: Journal of the society for simulation in healthcare. 2024; 19:e99-e116.
MR enterography radiologic ulcers in newly diagnosed ileal Crohn disease in children: frequency, inter-radiologist agreement, and clinical correlation. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2024; 54:1842-1849.
Effects of night-float shifts on cognitive function among radiology residents. Emergency Radiology. 2024; 31:725-731.
The effect of recombinant zoster vaccine on patients with chronic obstructive pulmonary diseases: A multi-institutional propensity score-matched cohort study. Journal of Medical Virology. 2024; 96:e29911.
Pectus excavatum: the effect of tricuspid valve compression on cardiac function. Pediatric Radiology: roentgenology, nuclear medicine, ultrasonics, CT, MRI. 2024; 54:1462-1472.