A photo of Bin Zhang.

Bin Zhang, PhD


  • Professor, UC Department of Pediatrics

About

Biography

Statistical methodology research focuses on survival analysis, longitudinal data analysis, machine learning, meta-analysis and study designs. My applied research interests include the study of cancer, radiology, transmittable disease, heart diseases, environmental health and health behavior.

My colleagues and I want to answer specific research questions by performing advanced statistical methodology to find the unknown risk features of fatal diseases and chronic conditions.

We have uncovered several notable discoveries in our lab, such as refractory hypertension not being categorized by excess aldosteronism or larger fluid retention related to controlled resistance hypertension (RHTN). If confirmed, this would have important implications for patients' clinical management in that continued titration of diuretic therapy and/or mineralocorticoid receptor antagonists may not be appropriate. It may even be counterproductive because it may activate reflexive pressor responses and may raise the risk of adverse events.

In addition, our paper Quantitative MRI of fatty liver disease in a large pediatric cohort: correlation between liver fat fraction, stiffness, volume, and patient-specific factors reports that the liver volume, stiffness and fat fraction are linked and related to various patient-specific features. These connections require further study since magnetic resonance imaging (MRI) is gradually utilized as a non-invasive biomarker for fatty liver disease diagnosis and examination.

I’ve held various positions, including lead statistician for the Collaborative Antiviral Study Group (CASG) and deputy director of the Statistical and Data Management Center of Mycoses Study Group (MSG). I’ve also been a Steering Committee member for the Consortium of Hospitals to Advance Research on Tobacco (CHART) trials.

I enjoy applying what I’ve learned and developing new methods to improve people’s health. Additionally, I have received multiple awards and recognitions throughout my career, including:

  • I became an Elected Member of the International Statistical Institute (ISI) (2016).
  • Our findings in “Can a school-based hand hygiene program reduce asthma exacerbations among elementary school children?” were reported on by Reuters and various social media sites.
  • Our paper “Quantitative MRI of fatty liver disease in a large pediatric cohort: correlation between liver fat fraction, stiffness, volume, and patient-specific factors” was selected as the article of the year for Abdominal Radiology.
  • Our published research on “Women's Rehabilitation Experiences Following Breast Cancer Surgery” won the Rehabilitation Nursing Writers’ Award: Editor’s Choice Award (2018).
  • Our paper on “Masked Uncontrolled Hypertension Is Not Attributable to Medication Nonadherence” was awarded the “High Impact Paper in Hypertension” (Fall 2019).

I have more than 10 years’ experience in biostatistics and joined the team at Cincinnati Children’s in 2012. My research has been published in a multitude of journals, such as Biometrics, Radiology, Journal of Hip Preservation Surgery, Hypertension and Journal of the American College of Radiology.

Publications

Structural lung disease in preschool children with cystic fibrosis: An 18 month natural history study. Brody, AS; Huang, R; Zhang, B; Long, FR; Powers, SW. Journal of Cystic Fibrosis. 2021.

Analysis of 612 Benign Papillomas Diagnosed at Core Biopsy: Rate of Upgrade to Malignancy, Factors Associated With Upgrade, and a Proposal for Selective Surgical Excision. Lee, SJ; Wahab, RA; Sobel, LD; Zhang, B; Brown, AL; Lewis, K; Vijapura, C; Mahoney, MC. American Journal of Roentgenology. 2021; 217:1299-1311.

Comparison of 0.3-mSv CT to Standard-Dose CT for Detection of Lung Nodules in Children and Young Adults With Cancer. Thapaliya, S; Gilligan, LA; Brady, SL; Anton, CG; Crotty, EJ; Nasser, MP; Geller, JI; Pressey, JG; Zhang, B; Dillman, JR; et al. American Journal of Roentgenology. 2021; 217:1444-1451.

Evaluation of the effect of multiple administrations of gadopentetate dimeglumine or gadoterate meglumine on brain T1-weighted hyperintensity in pediatric patients. Towbin, AJ; Zhang, B; Dillman, JR. Pediatric Radiology. 2021; 51:2568-2580.

Prenatal Evaluation of Intracranial Hemorrhage on Fetal MRI: A Retrospective Review. Epstein, KN; Kline-Fath, BM; Zhang, B; Venkatesan, C; Habli, M; Dowd, D; Nagaraj, UD. American Journal of Neuroradiology. 2021; 42:2222-2228.

Latent Tuberculosis Infection and Subclinical Coronary Atherosclerosis in Peru and Uganda. Huaman, MA; De Cecco, CN; Bittencourt, MS; Ticona, E; Kityo, C; Ballena, I; Nalukwago, S; Nazzinda, R; Ticona, C; Azañero, R; et al. Clinical Infectious Diseases. 2021; 73:e3384-e3390.

Variation in imaging outcomes associated with individual sonographers and radiologists in pediatric acute appendicitis: a retrospective cohort of 9271 examinations. Gilligan, LA; Trout, AT; Davenport, MS; Zhang, B; O’Hara, SM; Dillman, JR. European Radiology. 2021; 31:8565-8577.

Characterization of common breast MRI abnormalities: comparison between abbreviated and full MRI protocols. Wahab, RA; Albasha, H; Martin, J; Lee, SJ; Zhang, B; Brown, AL; Vijapura, C; Lewis, K; Sobel, LD; Mahoney, MC. Clinical Imaging. 2021; 79:125-132.

Cytomegalovirus infection is associated with increased prevalence of latent tuberculosis infection. van der Heijden, YF; Zhang, B; Chougnet, CA; Huaman, MA. Open Forum Infectious Diseases. 2021.

Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change. Aryal, SR; Siddiqui, M; Sharifov, OF; Coffin, MD; Zhang, B; Gaddam, KK; Gupta, H; Denney, TS; Dell’italia, LJ; Oparil, S; et al. Journal of the American Heart Association. 2021; 10.