A photo of Matthew W. Zackoff.

Attending Physician, Division of Critical Care Medicine

Instructor, UC Department of Pediatrics


Board Certified

My Biography & Research


I am an intensivist with fellowship training in critical care medicine. I’m also a researcher who draws on my degrees in biomedical engineering and medical education — and formal training in improvement science methodologies — to investigate the use of novel technologies in physician training and patient care.

Providing the best possible care to patients requires timely and accurate recognition of clinical conditions. One of the best ways to accomplish this is to ensure that frontline healthcare providers are clinically competent and work in systems that support their efforts.

To that end, my research focuses on the use of novel technology to improve patient outcomes. I study how virtual reality, augmented reality and artificial intelligence technologies can enhance physician training, improve performance assessment and optimize healthcare delivery. I’m also interested in applying these technologies to boost the recognition and timely management of pediatric clinical decompensation.

In 2019, I was named Fellow Teacher of the Year by the Cincinnati Children's Pediatric Residency Program. This award is given annually to a clinical fellow who has shown dedication in their roles as a physician, teacher and role model.

Because I’m passionate about my clinical and research activities, I’m always interested in collaborations — within and outside of Cincinnati Children's — to explore new ideas or broaden interventions.

Clinical Interests

Pediatric critical care medicine

Research Interests

Education research; education scholarship; simulation

Academic Affiliation

Instructor, UC Department of Pediatrics

Clinical Divisions

Pediatric Intensive Care Unit PICU

Research Divisions

Critical Care

My Education

BS: Washington University in St. Louis School of Engineering and Applied Science, St. Louis, MO, 2008.

MD: Vanderbilt University School of Medicine, Nashville, TN, 2012.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

MEd: University of Cincinnati, Cincinnati, OH, 2018.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2019.

My Publications

Assessment of a Situation Awareness Quality Improvement Intervention to Reduce Cardiac Arrests in the PICU. Dewan, M; Soberano, B; Sosa, T; Zackoff, M; Hagedorn, P; Brady, PW; Chima, RS; Stalets, EL; Moore, L; Britto, M; et al. Pediatric Critical Care Medicine. 2021.

Development and Implementation of Augmented Reality Enhanced High-Fidelity Simulation for Recognition of Patient Decompensation. Zackoff, MW; Cruse, B; Sahay, RD; Fei, L; Saupe, J; Schwartz, J; Klein, M; Geis, GL; Tegtmeyer, K. Simulation in Healthcare. 2021; 16:221-230.

Acute Ataxia and Paresthesia in a Healthy 5-year-old Girl. Taylor, RJ; Ritter, DM; Frazier, ME; Zackoff, MW. Pediatrics in Review. 2021; 42:329-331.

Establishing Objective Measures of Clinical Competence in Undergraduate Medical Education Through Immersive Virtual Reality. Zackoff, MW; Young, D; Sahay, RD; Fei, L; Real, FJ; Guiot, A; Lehmann, C; Klein, M. Ambulatory Pediatrics. 2021; 21:575-579.

Care Does Not Stop Following ROSC: A Quality Improvement Approach to Postcardiac Arrest Care. Pfeiffer, S; Zackoff, M; Bramble, K; Jacobs, L; Ruehlmann, K; Stalets, EL; Tegtmeyer, K; Dewan, M. Pediatric Quality and Safety. 2021; 6.

Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. Dean, PN; Hoehn, EF; Geis, GL; Frey, ME; Cabrera-Thurman, MK; Kerrey, BT; Zhang, Y; Stalets, EL; Zackoff, MW; Maxwell, AR; et al. Academic Emergency Medicine. 2020; 27:1241-1248.

Peri-Intubation Cardiac Arrest in the Pediatric Emergency Department: A Novel System of Care. Hoehn, EF; Dean, P; Lautz, AJ; Frey, M; Cabrera-Thurman, MK; Geis, GL; Stalets, E; Zackoff, M; Pham, T; Maxwell, A; et al. Pediatric Quality and Safety. 2020; 5.

The Effects of Care Team Roles on Situation Awareness in the Pediatric Intensive Care Unit: A Prospective Cross-Sectional Study. Soberano, BT; Brady, P; Yunger, T; Jones, R; Stoneman, E; Sosa, T; Stalets, EL; Zackoff, M; Chima, R; Tegtmeyer, K; et al. Journal of hospital medicine (Online). 2020; 15:594-597.

The Future of Onboarding: Implementation of Immersive Virtual Reality for Nursing Clinical Assessment Training. Zackoff, MW; Lin, L; Israel, K; Ely, K; Raab, D; Saupe, J; Klein, M; Sitterding, M. Journal for nurses in professional development. 2020; 36:235-240.

Impact of an Immersive Virtual Reality Curriculum on Medical Students' Clinical Assessment of Infants With Respiratory Distress. Zackoff, MW; Real, FJ; Sahay, RD; Fei, L; Guiot, A; Lehmann, C; Tegtmeyer, K; Klein, M. Pediatric Critical Care Medicine. 2020; 21:477-485.