A photo of Matthew W. Zackoff.

Matthew Zackoff, MD, MEd

  • Co-Director, Critical Care Fellowship Program
  • Assistant Professor, UC Department of Pediatrics



I am an intensivist with fellowship training in critical care medicine. I’m also a researcher who draws on my degrees in biomedical engineering and medical education — and formal training in improvement science methodologies — to investigate the use of novel technologies in physician training and patient care.

Providing the best possible care to patients requires timely and accurate recognition of clinical conditions. One of the best ways to accomplish this is to ensure that frontline healthcare providers are clinically competent and work in systems that support their efforts.

To that end, my research focuses on the use of novel technology to improve patient outcomes. I study how virtual reality, augmented reality and artificial intelligence technologies can enhance physician training, improve performance assessment and optimize healthcare delivery. I’m also interested in applying these technologies to boost the recognition and timely management of pediatric clinical decompensation.

In 2019, I was named Fellow Teacher of the Year by the Cincinnati Children's Pediatric Residency Program. This award is given annually to a clinical fellow who has shown dedication in their roles as a physician, teacher and role model.

Because I’m passionate about my clinical and research activities, I’m always interested in collaborations — within and outside of Cincinnati Children's — to explore new ideas or broaden interventions.

BS: Washington University in St. Louis School of Engineering and Applied Science, St. Louis, MO, 2008.

MD: Vanderbilt University School of Medicine, Nashville, TN, 2012.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

MEd: University of Cincinnati, Cincinnati, OH, 2018.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2019.


Pediatric critical care medicine

Services and Specialties

Pediatric Intensive Care Unit PICU


Education research; education scholarship; simulation

Research Areas

Critical Care


Implementation and Evaluation of an Artificial Intelligence Driven Simulation to Improve Resident Communication With Primary Care Providers. Merritt, C; Glisson, M; Dewan, M; Klein, M; Zackoff, M. Ambulatory Pediatrics. 2022; 22:503-505.

Assessment of a Situation Awareness Quality Improvement Intervention to Reduce Cardiac Arrests in the PICU. Dewan, M; Soberano, B; Sosa, T; Zackoff, M; Hagedorn, P; Brady, PW; Chima, RS; Stalets, EL; Moore, L; Britto, M; et al. Pediatric Critical Care Medicine. 2022; 23:4-12.

Remote Virtual Reality Teaching: Closing an Educational Gap During a Global Pandemic. Young, D; Real, FJ; Sahay, RD; Zackoff, M. Hospital pediatrics. 2021; 11:e258-e262.

Development and Implementation of Augmented Reality Enhanced High-Fidelity Simulation for Recognition of Patient Decompensation. Zackoff, MW; Cruse, B; Sahay, RD; Fei, L; Saupe, J; Schwartz, J; Klein, M; Geis, GL; Tegtmeyer, K. Simulation in Healthcare. 2021; 16:221-230.

Acute Ataxia and Paresthesia in a Healthy 5-year-old Girl. Taylor, RJ; Ritter, DM; Frazier, ME; Zackoff, MW. Pediatrics in Review. 2021; 42:329-331.

Establishing Objective Measures of Clinical Competence in Undergraduate Medical Education Through Immersive Virtual Reality. Zackoff, MW; Young, D; Sahay, RD; Fei, L; Real, FJ; Guiot, A; Lehmann, C; Klein, M. Ambulatory Pediatrics. 2021; 21:575-579.

Care Does Not Stop Following ROSC: A Quality Improvement Approach to Postcardiac Arrest Care. Pfeiffer, S; Zackoff, M; Bramble, K; Jacobs, L; Ruehlmann, K; Stalets, EL; Tegtmeyer, K; Dewan, M. Pediatric Quality and Safety. 2021; 6.

Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. Dean, PN; Hoehn, EF; Geis, GL; Frey, ME; Cabrera-Thurman, MK; Kerrey, BT; Zhang, Y; Stalets, EL; Zackoff, MW; Maxwell, AR; et al. Academic Emergency Medicine. 2020; 27:1241-1248.

Peri-Intubation Cardiac Arrest in the Pediatric Emergency Department: A Novel System of Care. Hoehn, EF; Dean, P; Lautz, AJ; Frey, M; Cabrera-Thurman, MK; Geis, GL; Stalets, E; Zackoff, M; Pham, T; Maxwell, A; et al. Pediatric Quality and Safety. 2020; 5.

The Effects of Care Team Roles on Situation Awareness in the Pediatric Intensive Care Unit: A Prospective Cross-Sectional Study. Soberano, BT; Brady, P; Yunger, T; Jones, R; Stoneman, E; Sosa, T; Stalets, EL; Zackoff, M; Chima, R; Tegtmeyer, K; et al. Journal of hospital medicine (Online). 2020; 15:594-597.

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