A photo of Matthew W. Zackoff.

Matthew W. Zackoff, MD, MEd

  • Director, Critical Care Fellowship Program
  • Co-Lead Digital Simulation, Center for Simulation and Research
  • Attending Physician, Pediatric Intensive Care Unit
  • Assistant Professor, UC Department of Pediatrics



I am an intensivist with fellowship training in critical care medicine. I’m also a researcher who draws on my degrees in biomedical engineering and medical education — and formal training in improvement science methodologies — to investigate the use of novel technologies in physician training and patient care.

Providing the best possible care to patients requires timely and accurate recognition of clinical conditions. One of the best ways to accomplish this is to ensure that frontline healthcare providers are clinically competent and work in systems that support their efforts.

To that end, my research focuses on the use of novel technology to improve patient outcomes. I study how virtual reality, augmented reality and artificial intelligence technologies can enhance physician training, improve performance assessment and optimize healthcare delivery. I’m also interested in applying these technologies to boost the recognition and timely management of pediatric clinical decompensation.

In 2019, I was named Fellow Teacher of the Year by the Cincinnati Children's Pediatric Residency Program. This award is given annually to a clinical fellow who has shown dedication in their roles as a physician, teacher and role model.

Because I’m passionate about my clinical and research activities, I’m always interested in collaborations — within and outside of Cincinnati Children's — to explore new ideas or broaden interventions.

BS: Washington University in St. Louis School of Engineering and Applied Science, St. Louis, MO, 2008.

MD: Vanderbilt University School of Medicine, Nashville, TN, 2012.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Chief Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

MEd: University of Cincinnati, Cincinnati, OH, 2018.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2019.


Pediatric critical care medicine

Services and Specialties

Pediatric Intensive Care Unit PICU


Education research; education scholarship; simulation

Research Areas

Critical Care


1229: THE USE OF ENHANCED SITUATION AWARENESS TO REDUCE FAILURE TO RESCUE EVENTS. Fitzsimmons, J; Zackoff, M; Loeb, D; James, K; Collins, K; Dewan, M. Critical Care Medicine. 2024; 52:s586.

1577: TRIALS OF EXTUBATION IN PEDIATRIC TRAUMA PATIENTS UNDERGOING PROLONGED MECHANICAL VENTILATION. Grassia, K; Kotagal, M; Zackoff, M; Dewan, M; Varisco, B. Critical Care Medicine. 2024; 52:s759.

New Nurse Self-assessed Clinical Competence, Immersion, and Attitudes Following Virtual Reality Training on the Assessment of Pediatric Respiratory Distress. Raab, DL; Ely, K; Donnellan, A; Israel, K; Lin, L; Saupe, J; Klein, M; Zackoff, MW. Clinical Simulation in Nursing. 2023; 84:101461.

Use of design thinking and human factors approach to improve situation awareness in the pediatric intensive care unit. Gifford, A; Butcher, B; Chima, RS; Moore, L; Brady, PW; Zackoff, MW; Dewan, M. Journal of hospital medicine (Online). 2023; 18:978-985.

Just-in-Time, Just-in-Place Virtual Training in the Pediatric Emergency Department: A Novel Approach to Impact the Perfusion Exam. Shah, AS; Sobolewski, B; Chon, S; Cruse, B; Glisson, MD; Zackoff, MW; Davis, D; Zhang, Y; Schumacher, DJ; Geis, GL. Advances in Medical Education and Practice. 2023; 14:901-911.

How Augmenting Reality Changes the Reality of Simulation: Ethnographic Analysis. Loeb, D; Shoemaker, J; Parsons, A; Schumacher, D; Zackoff, M. JMIR Medical Education. 2023; 9:e45538.

Virtual Reality to Assess Resident Recognition of Impending Respiratory Failure During COVID-19. Odum, JD; Real, FJ; Rice, J; Meisman, A; Sahay, R; Zhang, B; Zackoff, MW. Hospital Pediatrics. 2023; 13:e135-e139.

Impact of a Remote Virtual Reality Curriculum Pilot on Clinician Conflict Communication Skills. Herrmann, LE; Elliott, LE; Sucharew, H; Jerardi, K; Zackoff, MW; Klein, M; Real, FJ. Hospital Pediatrics. 2023; 13:527-540.

Using Technology to Overcome Vaccine Hesitancy. Real, FJ; Zackoff, MW; Rosen, BL. Pediatric Clinics of North America. 2023; 70:297-308.

Interprofessional Immersive Virtual Reality Training on Sepsis Recognition. Zackoff, MW; Cruse, B; Sahay, RD; Zhang, B; Sosa, T; Schwartz, J; Depinet, H. Pediatric Quality and Safety. 2023; 8:e627.

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