What Is Primary Ovarian Insufficiency?

Primary ovarian insufficiency (POI), also known as primary ovarian failure or premature menopause, is a rare condition that affects teenagers and young women under the age of 40 years.

Patients with this condition will have menstrual periods less often, or will not have menstrual periods at all for four months or more. POI affects many parts of a girl’s life, including her physical health, emotional health and well-being.

Patients with POI have low levels of the hormone estrogen. Low estrogen may cause osteoporosis (weak bones and a higher chance of fractures) and heart disease at a younger age.