Most of the time, the cause of POI is unknown. Sometimes, POI happens as part of another condition, such as Turner syndrome, fragile X syndrome, Fanconi anemia or galactosemia.
Some girls with POI have autoimmune conditions such as thyroid disease or celiac disease.
Patients with a family history of POI have a higher chance of developing POI.
Patients who receive chemotherapy or radiation may be at risk for POI.
Certain environmental exposures (cigarette smoke, pesticides and viruses) have been linked to POI, but we do not yet know if these things actually cause POI.
Research is being done to understand the causes POI in girls and young women.