Anesthesia Research

Cardiac anesthesia; regional anesthesia; anesthesia for airway surgery

Biography

Dr. Aronson's practice interests include pediatric cardiac and regional anesthesia. She is also interested in the role of antifibrinolytics for large blood loss cases.

Dr. Aronson is Cincinnati Children's anesthesia resident education coordinator and is actively involved in resident and fellow education.

MD: University of Illinois, Chicago, IL, 1994.

Residency: Anesthesiology, University of North Carolina Hospitals, Chapel Hill, NC, 2000.

Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, OH, 1997.

Fellowship: Pediatric Anesthesiology, University of North Carolina Hospitals, Chapel Hill, NC.

Certification: Pediatrics, 1997; Anesthesiology, 2001; Cardiac Anesthesia.

Lin EP, Aronson LA. Successful resuscitation of bupivacaine-induced cardiotoxicity in a neonate. Paediatr Anaesth. 2010 Oct;20(10):955-7.

Aronson, LA; Spaeth, J.P.: Frontiers in Pediatric Anesthesia: Cardiac Anesthesia. International Anesthesiology Clinics: Frontiers in Pediatric Anesthesiology. Winter 2006; 44(1):33-49.

Aronson, LA; Dent, C.L.: Postoperative Respiratory Function and Its Management. Pediatric Cardiac Anesthesia. 2005.

Book Chapters

Aronson LA. Pediatrics and Neonatology: Hypoxemia. Complications in Anesthesia. Ed: John L Atlee, 2nd ed, 2007.

Anne Boat, MD Staff Anesthesiologist, Department of Anesthesia

is a pediatric anesthesiologist and director of Fetal Anesthesia. Her academic interests include education and research in fetal anesthesia and quality improvement in pediatric anesthesia. Anne is also the patient/family experience officer for Cincinnati Children’s. She is responsible for the patient/family experience quality improvement work and patient experience survey results.

513-636-4408 anne.boat@cchmc.org

Veronica O. Busso, MD

is a staff pediatric anesthesiologist whose specialties include general anesthesia, radiology based anesthesia, and intra-operative neuromonitoring. She is currently working with the Craniofacial Collaboration and Deep Brain Stimulation outcomes focus groups with a desire to improve clinical outcomes in these patient populations. In addition, she is interested in the use of intra-operative neuoromonitoring to better understand epilepsy.

513-375-1451 veronica.busso@cchmc.org

Vidya Chidambaran, MD Anesthesiologist, Department of Anesthesia

is a pediatric anesthesiologist and acute pain physician with special interests in personalization of pediatric analgesia and opioid pharmacogenomics, optimization of drug (propofol) dosing in morbidly obese children by study of pharmacokinetics/pharmacodynamics, evaluation of factors leading to persistent postoperative pain and use of capnography for early detection of opioid induced respiratory depression.

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Vidya Chidambaran, MD

Anesthesiologist, Department of Anesthesia

Academic Affiliation

Associate Professor

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Clinical

Pediatric anesthesia

Research

Pharmacogenetics; spine infection

MBBS: Medicine,Bangalore Medical College, India, 1997.

MD: Anesthesiology, Kasturba Medical College, India, 1998-2001.

Internship: Anesthesiology, Jackson Memorial Hospital, Miami, Florida, 2003-2004.

Residency: Anesthesiology, Brookdale University Hospital, Brooklyn, New York, 2004-2007.

Fellowship: Pediatric Anesthesia, Johns Hopkins Hospital, Baltimore, Maryland, 2007-2008.

Sadhasivam S, Fukuda T, Chidambaran V, Mizuno T, Venkatasubramanian R, Ngamprasertwong P, Olbrecht V, Esslinger H, Vinks AA. OCT1 Genetic Variants influence the pharmacokinetics of morphine in children. Pharmacogenomics. 2013 Jul;14(10):1141-51.

Chidambaran V, Sadhasivam S, Diepstraten J, Esslinger H, Cox S, Schnell BM, Samuels P, Inge T, Vinks AA, Knibbe CA. Evaluation of propofol anesthesia in morbidly obese children and adolescents. BMC Anesthesiology 2013, 13:8.

Chidambaran V, Gentry C, Ajuba-Iwuji C, Sponsellar PD, Ain M, Lin E, Zhang X, Klaus SA, Njoku DB. A Retrospective identification of gastroesophageal reflux disease as a new risk factor for surgical site infection in cerebral palsy patients after spine surgery. Anesth Analg. 2013 117(1):162-8.

Chidambaran V, Mahmoud M, Sadhasivam S. Risk for Peroneal Nerve Injury After Femur Osteosarcoma Resection: Is regional analgesia safe? J Clin Anesth. 2013 Feb;25(1):76-8.

Sadhasivam S and Chidambaran V. Pharmacogenomics of Opioids and Perioperative Pain Management. Pharmacogenomics. 2012 Nov;13(15):1719-40.

V Chidambaran, S Sadhasivam. Pediatric Acute and Surgical Pain Management: Recent Advances and Future Perspectives. "Contemporary Topics in Pediatric Anesthesiology" in International Anesthesiology Clinics 2012 Fall; 50(4):66-82.

Sadhasivam S, Krekels E, Chidambaran V, Esslinger H, Zhang K, Fukuda T, Vinks AA. Morphine Clearance in Children: Does Race or Genetics Matter? J Opioid Manag. 2012 Jul-Aug;8(4):217-26.

Chidambaran V, Rosing J, Soler X, Sadhasivam S. Muscle Trauma from Tourniquet (Mis)Use. Anesthesiology. 2012 Jul;117(1):179.

Diepstraten J, Chidambaran V, Sadhasivam S, Esslinger H, Cox S, Inge T, Knibbe CAJ, Vinks AA. Propofol Clearance in Morbidly Obese Children and Adolescents. Clin Pharmacokinet. 2012 Aug 1:51(8):543-51.

Sadhasivam S, Chidambaran V, Ngamprasertwong P, Esslinger H, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and Unequal Burden of Perioperative Pain and Opioid Related Adverse Effects in African-American and Caucasian Children. Pediatrics. 2012 May;129(5):832-8.

Robert C. Coghill, PhD Director of Research, Division of Anesthesiology

is focused on delineating the neural mechanisms supporting individual differences in pain.

513-636-4408 robert.coghill@cchmc.org

Robert C. Coghill, PhD

Director of Research, Division of Anesthesiology

Senior Scientist, Division of Anesthesiology

Academic Affiliation

Professor

Phone 513-636-4408

Email robert.coghill@cchmc.org

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Research Interests

Chronic pain; acute pain; brain imaging; sensory testing

Biography

Robert C. Coghill is focused on delineating the neural mechanisms supporting individual differences in pain. His research interleaves data obtained with functional MRI of brain activity with subjective reports of pain and psychological state. His work encompasses studies of the effects of expectations on pain, brain mechanisms supporting attention to pain, and processes associated with the cognitive modulation of pain. He is also highly interested in understanding how the nervous system evaluates and constructs an experience of sensory components of pain, including perceived intensity and location. Dr. Coghill also seeks to develop of better tools for the measurement of multiple dimensions of the pain experience.

Together, these pain assessments, psychological profiles, and neuroimaging endpoints can be used in combination to develop strategies to better predict, diagnose, and treat pain. More importantly, this research will be critically important for advancing personalized medicine, with the long-term goal of identifying the best treatment for each individual child.

PhD: Virginia Commonwealth University, Richmond, VA, 1991.

Post-doctoral Fellowship: University of Montreal, Montreal, Quebec.

Post-doctoral Fellowship: National Institutes of Health, Bethesda, MD.

Emerson NM, Zeidan F, Lobanov OV, Hadsel MS, Martucci KT, Quevedo AS, Starr CJ, Nahman-Averbuch H, Weissman-Fogel I, Granovsky Y, Yarnitsky D, Coghill RC. Pain sensitivity is inversely related to regional grey matter density in the brain. Pain. 2014;155(3):566-573.

Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain. 2011;134(Pt7):1987-2004.

Quevedo AS, Coghill RC. Attentional modulation of spatial integration of pain: Evidence for dynamic spatial tuning. J Neurosci. 2007;27(43):11635-40.

Koyama T, McHaffie J, Laurienti P, Coghill RC. The subjective experience of pain: Where expectations become reality. Proc Natl Acad Sci. 2005;102:12950-12955.

Coghill RC, McHaffie JG, Yen Y-F. Neural correlates of inter-individual differences in the subjective experience of pain. Proc Natl Acad Sci. 2003;100:8538-8542.

Grill JD, Coghill RC. Transient analgesia evoked by noxious stimulus offset. J Neurophysiol. 2002 Apr;87(4):2205-8.

Coghill RC, Sang CN, Maisog JM, Iadarola MJ. Pain intensity processing within the human brain: A bilateral, distributed mechanism. J Neurophysiol. 1999;82:1934-1943.

Coghill RC, Talbot JD, Meyer E, Gjedde A, Evans AC, Bushnell MC, Duncan GH. Distributed processing of pain and vibration in the human brain. J Neurosci. 1994;14:4095-4108.

Grants

Brain Mechanisms Supporting Individual Differences in Pain. Principal Investigator. National Institutes of Neurological Disorders and Stroke. Jul 2015-Apr 2020.

Steve C. Danzer, PhD

is a developmental neurobiologist with a research program examining the role of adult-generated hippocampal granule cells in the development of epilepsy. Research on the impact of granule cells in autism is a second lab focus. Techniques used include models of epilepsy and autism, confocal microscopy, electrophysiology, immunohistochemistry, organotypic slice culture, and genetic manipulations of target genes.
Visit the Danzer Lab.

513-636-4526 steve.danzer@cchmc.org

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Steve C. Danzer, PhD

Academic Affiliation

Associate Professor

Phone 513-636-4526

Email steve.danzer@cchmc.org

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Research Interests

Epilepsy; autism; neurodevelopmental disease

Visit the Danzer Lab.

PhD: University of Arizona, Tucson, Arizona

Postdoctoral Research: Duke University, Durham, NC.

Pun RYK, Rolle IJ, LaSarge CL, Hosford BE, Rosen JM, Uhl JD, Schmeltzer SN, Faulkner C, Bronson SL, Murphy BL, Richards DA, Holland KD, SC Danzer. Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy. Neuron. 2012;75(6):1022-34.

Castro OW, Santos VR, Pun RYK, McKlveen JM, Batie M, Holland KD, Gardner M, Garcia-Cairasco N, Herman JP, SC Danzer. Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy. PLoS One. 2012;7(9):e46044.

Murphy BL, Hofacer RD, Faulkner CN, Loepke AW and SC Danzer. Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced post-injury neurogenesis. Epilepsia. 2012;53 (5):908-921.

Danzer SC. Depression, stress, epilepsy and adult neurogenesis. Experimental Neurology. 2012;233(1):22-32.

Santos VR, Wagner de Castro O, Pun RYK, Hester MS, Murphy BL, Loepke AW, Garcia-Cairasco N and SC Danzer. Contributions of mature granule cells to structural plasticity in temporal lobe epilepsy. Neuroscience. 2011;197:348-57.

Murphy BL and SC Danzer. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. Journal of Neuroscience. 2011;31(8):2959-64.

Murphy BL, Pun RY, Yin H, Faulkner CR, Loepke AW and SC Danzer. Heterogeneous integration of adult-generated granule cells into the epileptic brain. Journal of Neuroscience. 2011;31(1):105-17.

McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topalá R, Richards DA and SC Danzer. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus. 2011 Jan;21(1):93-107.

Danzer SC. Postnatal and adult neurogenesis in the development of human disease. Neuroscientist. ct;14(5):446-58. Review. 2008.

Walter C, Murphy BL, Pun RYK, Spieles-Engemann AL and SC Danzer. Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells. Journal of Neuroscience. 2007 Jul;27(28):7541-52.

Hilary A. Flint, DO, MEd Pediatrician, Palliative Medicine Specialist, Department of Anesthesia

is a pediatrician that specializes in palliative medicine, pain and symptom management as well as the care for medically fragile children. Her primary research interest is developing palliative medicine educational interventions for pediatric residents and fellows which focus on training medical learners to communicate effectively with patients and families as well as how to care for patients with serious illness.

513-636-5479 hilary.flint@cchmc.org

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Hilary A. Flint, DO, MEd

Pediatrician, Palliative Medicine Specialist, Department of Anesthesia

Academic Affiliation

Assistant Professor

Phone 513-636-5479

Email hilary.flint@cchmc.org

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Palliative medicine; end of life care; care of children with complex medical needs; pain management; director of the Pediatric Hospice and Palliative Medicine Fellowship Program.

Biography

Hilary Flint, DO, MEd, is a board-certified pediatrician who specializes in palliative medicine, pain and symptom management as well as care for medically fragile children. Originally from Mississippi, Dr. Flint completed a pediatric residency at the University of Mississippi Medical Center-Blair Batson Children’s Hospital. After developing an interest in pediatric palliative medicine, Dr. Flint pursued a fellowship in hospice and palliative medicine at Children’s Hospital of Philadelphia.

Dr. Flint moved to Cincinnati after completing her fellowship and joined the Pediatric Palliative and Comfort Care Team (PACT) at Cincinnati Children’s where she focuses on enhancing the quality of life for children with life-threatening conditions. In keeping with her interest in caring for children with medically complex disease, Dr. Flint also joined the Center for Infants and Children with Special Needs, now the Complex Care Center, where she practices family-centered, comprehensive care.

Dr. Flint is passionate about caring for children who are suffering from complex or life-threatening conditions. She, along with an interdisciplinary team, accomplishes this by assessing and treating the unique physical, psychosocial, and spiritual needs of patients and families under her care.

DO: Kansas City University of Medicine and Biosciences, College of Osteopathic Medicine, 2006.

Residency: University of Mississippi Medical Center, 2009.

Fellowship: Children's Hospital of Philadelphia, 2010.

Certification: Pediatrics, 2009; Board-eligible-Hospice and Palliative Medicine, 2010.

Kenneth R. Goldschneider, MD, FAAP Director, Pain Management Center

is interested in chronic pain in children and young adults. He is involved in several long-term studies of pain in children as well as in developing evidence-based pain care guidelines for epidermolysis bullosa. He is a founding member of the Pediatric Research Network for Pain (PRN-Pain), a collaborative organization of North American pediatric institutions dedicated to working in coordination with government and industry entities to improve pain research in children.

513-636-7768 kenneth.goldschneider@cchmc.org

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Kenneth R. Goldschneider, MD, FAAP

Director, Pain Management Center

Academic Affiliation

Professor

Phone 513-636-7768

Fax 513-636-2920

Email kenneth.goldschneider@cchmc.org

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Clinical

Complex chronic pain conditions in infants, children and young adults, including those related to vascular malformations, epidermolysis bullosa and cancer.

Research

Outcomes of pain treatment, with a focus on outpatient, chronic pain management.

MD: University of Connecticut Health Center School of Medicine, Farmington, CT, 1991.

Residency: Pediatrics, Duke University Medical Center, Durham, NC, 1991 - 1994; Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, 1994-1997.

Fellowship: Pediatric Anesthesia, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1997 - 1998; Pain Management, Longwood Combined Pain Fellowship, The Children's Hospital, Boston, MA, 1998-1999.

Certification: American Board of Pediatrics, 1994; American Board of Anesthesiology, 1998; ABA Pain Management, 2000.

Lynch-Jordan AM, Kashikar-Zuck S, Goldschneider KR. Parent perceptions of adolescent pain expression: the adolescent pain behavior questionnaire. Pain. 2010 Dec;151(3):834-42.

Goldschneider K, Lucky AW, Mellerio JE, Palisson F, del Carmen Viñuela Miranda M, Azizkhan RG. Perioperative care of patients with epidermolysis bullosa: proceedings of the 5th international symposium on epidermolysis bullosa, Santiago Chile, December 4-6, 2008. Paediatr Anaesth. 2010 Sep;20(9):797-804.

Goldschneider KR, Lucky AW. Pain management in epidermolysis bullosa. Dermatol Clin. 2010 Apr;28(2):273-82, ix. Review.

Meyer MJ, Goldschneider KR, Bielefeldt K, Zeltzer L, Lackner J, Keefer L. Functional abdominal pain in adolescence: a biopsychosocial phenomenon. J Pain. 2008 Nov;9(11):984-90.

Hosu L, Meyer MJ, Goldschneider KR. Cerebrospinal fluid cutaneous fistula after epidural analgesia in a child. Reg Anesth Pain Med. 2008 Jan-Feb;33(1):74-6.

Goldschneider KR, Racadio JM, Weidner NJ. Celiac plexus blockade in children using a three-dimensional fluoroscopic reconstruction technique: case reports. Reg Anesth Pain Med. 2007 Nov-Dec;32(6):510-5.

Lynch AM, Kashikar-Zuck S, Goldschneider KR, Jones BA. Sex and age differences in coping styles among children with chronic pain. J Pain Symptom Manage. 2007 Feb;33(2):208-16.

Lynch AM, Kashikar-Zuck S, Goldschneider KR, Jones BA. Psychosocial risks for disability in children with chronic back pain. J Pain. 2006 Apr;7(4):244-51.

Kashikar-Zuck S, Vaught MH, Goldschneider KR, Graham TB, Miller JC. Depression, coping, and functional disability in juvenile primary fibromyalgia syndrome. J Pain. 2002 Oct;3(5):412-9.

Kashikar-Zuck S, Goldschneider KR, Powers SW, Vaught MH, Hershey AD. Depression and functional disability in chronic pediatric pain. Clin J Pain. 2001 Dec;17(4):341-9.

Joel B. Gunter, MD Staff Anesthesiologist, Department of Anesthesia

513-636-4408 joel.gunter@cchmc.org

Joel B. Gunter, MD

Staff Anesthesiologist, Department of Anesthesia

Academic Affiliation

Professor

Phone 513-636-4408

Fax 513-636-7337

Email joel.gunter@cchmc.org

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Clinical

Anesthesia for congenital cardiac disease; anesthesia equipment and monitoring

Research

Anesthesia equipment and monitoring; regional anesthesia in children; outcomes after anesthesia in children

MD: University of Oklahoma, Oklahoma City, OK, 1982.

Residency: Barnes Hospital, St. Louis, MO, 1985.

Fellowship: Children's Hospital National Medical Center, Washington, DC, 1986.

Certification: Anesthesiology, 1986 (Recertified 2000).

Hoffmann CO, Samuels PJ, Beckman E, Hein EA, Shackleford TM, Overbey E, Berlin RE, Wang Y, Nick TG, Gunter JB. Insufflation vs intubation during esophagogastroduodenoscopy in children. Paediatr Anaesth. 2010 Sep;20(9):821-30.

Mahmoud M, Radhakrishman R, Gunter J, Sadhasivam S, Schapiro A, McAuliffe J, Kurth D, Wang Y, Nick TG, Donnelly LF. Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children. Paediatr Anaesth. 2010 Jun;20(6):506-15.

Sadhasivam S, Cohen LL, Hosu L, Gorman KL, Wang Y, Nick TG, Jou JF, Samol N, Szabova A, Hagerman N, Hein E, Boat A, Varughese A, Kurth CD, Willging JP, Gunter JB. Real-time assessment of perioperative behaviors in children and parents: development and validation of the perioperative adult child behavioral interaction scale. Anesth Analg. 2010 Apr 1;110(4):1109-15.

Mahmoud M, Gunter J, Donnelly LF, Wang Y, Nick TG, Sadhasivam S. A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesth Analg. 2009 Sep;109(3):745-53.

Mahmoud M, Gunter J, Sadhasivam S. Ciné MRI airway studies in children with sleep apnea: optimal images and anesthetic challenges. Pediatr Radiol. 2009 Oct;39(10):1034-7.

Sadhasivam S, Cohen LL, Szabova A, Varughese A, Kurth CD, Willging P, Wang Y, Nick TG, Gunter J. Real-time assessment of perioperative behaviors and prediction of perioperative outcomes. Anesth Analg. 2009 Mar;108(3):822-6.

Gunter JB, Ball J, Than-Win S. Preparation of the Dräger Fabius anesthesia machine for the malignant-hyperthermia susceptible patient. Anesth Analg. 2008 Dec;107(6):1936-45.

Varughese AM, Nick TG, Gunter J, Wang Y, Kurth CD. Factors predictive of poor behavioral compliance during inhaled induction in children. Anesth Analg. 2008 Aug;107(2):413-21.

Mahmoud M, Bryan Y, Gunter J, Kreeger RN, Sadhasivam S. Anesthetic implications of undiagnosed late onset central hypoventilation syndrome in a child: from elective tonsillectomy to tracheostomy. Paediatr Anaesth. 2007 Oct;17(10):1001-5.

Cohen MB, Gunter JB. How safe is intravenous sedation with midazolam and fentanyl for pediatric gastrointestinal endoscopy? Nat Clin Pract Gastroenterol Hepatol. 2007 Oct;4(10):538-9.

Nancy S. Hagerman, MD

is a pediatric anesthesiologist and medical director of Same Day Surgery and Pre-Anesthesia Consultation Clinic. Her academic interests include outcomes related to preoperative evaluation and preparation for pediatric anesthesia, preoperative pediatric anxiety and related outcomes, and quality improvement science and its role in pediatric anesthesia.

513-636-4408 nancy.hagerman@cchmc.org

Elizabeth A. Hein, MD Staff Anesthesiologist, Department of Anesthesia

513-636-4408 elizabeth.hein@cchmc.org

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Elizabeth A. Hein, MD

Staff Anesthesiologist, Department of Anesthesia

Academic Affiliations

Associate Professor, UC Department of Pediatrics

UC Department of Anesthesiology

Phone 513-636-4408

Fax 513-636-7337

Email elizabeth.hein@cchmc.org

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Anesthesia for airway surgery; ENT anesthesia

MD: Medical College of Ohio, Toledo, OH, 1993.

Internship: The Cleveland Clinic Foundation, Cleveland, OH, 1994.

Residency: Cleveland Clinic Foundation, Cleveland, OH, 1997.

Fellowship: Children's Hospital, Columbus, OH, 1999; Children's Hospital of Pittsburgh, Pittsburgh, PA, 1998.

Certification: Anesthesiology, 1999; PALS, 2007; ACLS, 2008.

Hoffmann CO, Samuels PJ, Beckman E, Hein EA, Shackleford TM, Overbey E, Berlin RE, Wang Y, Nick TG, Gunter JB. Insufflation vs intubation during esophagogastroduodenoscopy in children. Paediatr Anaesth. 2010 Sep;20(9):821-30.

Sadhasivam S, Cohen LL, Hosu L, Gorman KL, Wang Y, Nick TG, Jou JF, Samol N, Szabova A, Hagerman N, Hein E, Boat A, Varughese A, Kurth CD, Willging JP, Gunter JB. Real-time assessment of perioperative behaviors in children and parents: development and validation of the perioperative adult child behavioral interaction scale. Anesth Analg. 2010 Apr 1;110(4):1109-15.

Hein EA, Rutter MJ. New perspectives in pediatric airway reconstruction. Int Anesthesiol Clin. 2006 Winter;44(1):51-64. Review.

Clifford O. Hoffmann, MD Staff Anesthesiologist, Department of Anesthesia

513-636-4408 cliff.hoffmann@cchmc.org

Michael P. Jankowski, PhD

is a neuroscientist with expertise in molecular biology, electrophysiology and neuroanatomy. His basic and translational research program analyzes the molecular mechanisms of musculoskeletal pain and the developmental plasticity of sensory neurons before and after peripheral injury. Specifically, the laboratory focuses on effects of inflammation and ischemia on muscle afferent sensitization, and how neonatal injuries can alter the function of sensory neurons both during development and into adulthood.

Visit the Jankowski Lab.

513-803-7966 michael.jankowski@cchmc.org

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Michael P. Jankowski, PhD

Academic Affiliation

Assistant Professor

Phone 513-803-7966

Email michael.jankowski@cchmc.org

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Chronic pain; neurodevelopmental diseases

Visit the Jankowski Lab.

Biography

Dr. Jankowski joined the faculty in the Department of Anesthesia/Division of Pain Management at Cincinnati Children’s Hospital Medical Center within the University of Cincinnati College of Medicine in November of 2011. Previously, he had been awarded both pre-doctoral (2006) and postdoctoral National Research Service Awards (2008) prior to becoming faculty at the University of Pittsburgh. While a member of the Department of Neurobiology at the University of Pittsburgh, he presented several public presentations including one seminar titled, “Interfering with the Molecular Mechanisms of Pain” at the Center for Neuroscience at the University of Pittsburgh’s Annual Retreat in 2009, and another titled, ”Preparation and Delivery of siRNAs to Sensory Neurons” at the International Association for the Study of Pain’s Satellite Symposium: “Nociceptors: New Biology” in Edinburgh, Scotland in 2008.

Dr. Jankowski has also been the recent recipient of two NIH grants in 2013: one from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD077483) and another from the National Institute of Arthritis, and Musculoskeletal and Skin Diseases (R01AR064551). He also is a Rita Allen Scholar and was recently named a Cincinnati Children's Trustee Scholar. In addition, Dr. Jankowski is on the training faculty in the graduate program in neuroscience, and in the Molecular and Developmental Biology Graduate Program. He is currently a member of the Society for Neuroscience, the International Association for the Study of Pain, the Society for Pediatric Anesthesia, and the American Pain Society.

MS: Neuroscience, University of Pittsburgh, Pittsburgh, PA, 2003.

PhD: Neurobiology, University of Pittsburgh, Pittsburgh, PA, 2006.

Postdoctoral Training: University of Pittsburgh, Pittsburgh, PA, 2006-2010.

Ross JL, Queme LQ, Cohen EC, Green KG, Lu P, An S, Shank AT, Hudgins RC, Jankowski MP. Muscle IL1β drives ischemic myalgia via ASIC3-mediated sensory neuron sensitization. J Neurosci. 2016;36:6857-6871.

Queme LQ, Ross JL, Shank AT, Hudgins RC, Jankowski MP. Dual modulation of nociception and cardiovascular reflexes during peripheral ischemia through P2Y1 receptor dependent sensitization of muscle afferents. J Neurosci. 2016;36:19-30.

Wu LM, Wang J, Conidi A, Zhao C, Haibo W, Ford ZK, Zhang L, Zweir C, Ayee BG, Maurel P, Zwijsen A, Chan J, Jankowski, MP, Huylebroeck D, Lu QR. Zeb2 Recruits HDAC-NuRD to Inhibit Notch and Controls Schwann Cell Differentiation and Remyelination. Nature Neurosci. 2016 Aug;19(8):1060-1072.

Molliver DC, Rau KK, Jankowski MP, Soneji DJ, Baumbauer KM, Koerber HR. Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in a population of TRPV1-containing cutaneous afferents. Neuroscience. 2016 Jul 5;332:223-230.

Shabnam P, Xiaona L, Sameer K, Anderson J, Fumiyasu I, Wujuan S, Ciraolo G, Ratner N, Setchell K, Yoshida Y, Jankowski MP, Dasgupta B. The tumor suppressor LKB1 regulates myelination through mitochondrial metabolism. Nature Comm. 2014;5:4993.

Ross JL, Queme LQ, Shank AT, Hudgins RC, Jankowski MP. Sensitization of group III and IV muscle afferents after ischemia and reperfusion injury. J Pain. 2014;15:1257-1270.

Jankowski MP, Ross JL, Weber JD, Lee FL, Shank AT, Hudgins RC. Age-dependent sensitization of cutaneous nociceptors during developmental inflammation. Mol Pain. 2014;10:34.

Jankowski MP, Rau KK, Ekmann KM, Anderson CE, Koerber HR. Comprehensive phenotyping of group III and IV muscle afferents in mouse. J Neurophys. 2013;109:2374-2381.

Jankowski MP, Anderson W, Anderson CE, Koerber HR. Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration. J Neurosci. 2012;32:17869-73.

Li L, Rutlin M, Abraira V, Cassidy C, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011;147:1615-27.

Grants

Mechanisms of muscle afferent sensitization after ischemia. Principal Investigator. National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Sep 2013 – Sep 2018.

Growth hormone, pediatric pain and sensory development. Principal Investigator. Cincinnati Children's Hospital Medical Center. Sep 2015 - Sep 2016.

Linking sex differences in cardiovascular reflexes and pain perception. Sponsor. National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases. Jul 2016 - Jul 2018. F31AR068896-01A1.

Role of GDNF in the dual modulation of nociception and cardiovascular reflexes during peripheral ischemia. Sponsor. American Heart Association. Jul 2016 - Jul 2018. 16POST29750004.

Thomas J. Kabalin, MD Staff Anesthesiologist, Department of Anesthesia

513-636-4408 thomas.kabalin@cchmc.org

Ali I. Kandil, DO, MPH Anesthesiologist, Division of Anesthesiology

investigates the interpretability of auditory brainstem response comparing different anesthetic techniques. The goal of this research is the provide insight into the effects of different anesthetics on the interpretability of hearing tests in children undergoing general anesthesia.

513-636-4408 ali.kandil@cchmc.org

Ali I. Kandil, DO, MPH

Anesthesiologist, Division of Anesthesiology

Intra-operative Neuromonitoring Physician, Intraoperative Neurophysiology

Academic Affiliations

Assistant Professor, UC Department of Anesthesia

Phone 513-636-4408

Email ali.kandil@cchmc.org

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Intraoperative neurophysiology; auditory brainstem response; pediatric airway

DO: Lake Erie College of Osteopathic Medicine, Erie, PA.

MPH: Epidemiology/Biostatistics, University of South Florida College of Public Health, Tampa, FL.

Residency: Anesthesiology, Saint Barnabas Medical Center, Livingston, NJ.

Fellowship: Pediatric Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Advanced Fellowship: Intraoperative Neurophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Anesthesiology, 2015; Pediatric Anesthesiology, 2015.

Kandil A, Subramanyam R, Hossain MM, Ishman S, Shott S, Tewari A, Mahmoud M. Comparison of the Combination of Dexmedetomidine and Ketamine with Propofol and Propofol/Sevoflurane for Drug-Induced Sleep Endoscopy in Children. Paediatr Anaesth. 2016 Jul;26(7):742-51.

Murr MM, Martin T, Haines K, Dragotti R, Kandil A, Gallagher SF, Harmsen S. A state-wide review of contemporary outcomes of gastric bypass in Florida: does provider volume impact outcomes? Ann Surg. 2007 May;245(5):699-706.

Haines K, Nelson LG, Gonzalez R, Torrella TA, Kandil A, Dragotti R, Martin T, Anderson M, Gallagher S, Murr M. Objective Evidence that Bariatric Surgery Improves Obesity Related Obstructive Sleep Apnea. Surgery. 2007 Mar;141(3):354-8.

Michael J. Kibelbek, MD Anesthesiologist, Department of Anesthesia

513-636-4408 michael.kibelbek@cchmc.org

Christopher D. King, PhD

investigates the mechanisms related to the development and persistence of chronic pain and altered sensory processing in adults and children using several multidisciplinary techniques to evaluate physiological reactivity of stress-related biomarkers, psychological factors that may co-vary with altered sensory processing, and the use of quantitative sensory testing to examine differences in the processing of experimental pain stimuli.

513-636-4408 christopher.king@cchmc.org

Christopher D. King, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4408

Email christopher.king@cchmc.org

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Research Interests

Pain; stress; inflammation

Biography

Dr. King has contributed to science by looking at psychological and group-level (i.e., subgrouping of patients) factors underlying analgesic responses to opioid analgesics in healthy adults, opioid regulation of conditioned pain modulation (CPM), and ethnic differences in experimental pain sensitivity, clinical pain, and pain-related disability in patients with knee osteoarthritis (OA). CPM is used to look at the modulatory capacity in humans. It is reduce in chronic pain and older age. Reduction of CPM may contribute to pain and alter somatosensory processing and autonomic regulation. As part of the OA study, Dr. King also examined predictors of knee pain prospectively. Lastly, Dr. King has been involved in several independent studies exploring possible stress-related markers associated with cold pain, which is used as the conditioning stimulus in CPM. He has shown that pain induces the release of endocrine and immune markers, and that they can influence pain responsiveness in pain-free subjects.

Dr. King recently finished a study with naltrexone, an opioid antagonist, on pain modulation, which revealed an interesting interaction between the ability to inhibit pain through endogenous opioids and psychological functioning in pain-free subjects. The recent studies are a first step in a process to evaluate physiological responses induced by pain.

PhD: University of Florida, Gainesville, FL, 2006.

Cruz-Almeida Y, Sibille KT, Goodin BR, Petrov ME, Bartley EJ, Riley JL 3rd, King CD, Glover TL, Sotolongo A, Herbert MS, Schmidt JK, Fessler BJ, Staud R, Redden D, Bradley LA, Fillingim RB. Racial and ethnic differences in older adults with knee osteoarthritis. Arthritis Rheumatol. 2014 Jul;66(7):1800-10.

King CD. A possible mechanism underlying conditioned pain modulation. Pain. 2014 Jun;155(6):1047-8.

Vierck CJ, Wong F, King CD, Mauderli AP, Schmidt S, Riley JL 3rd. Characteristics of sensitization associated with chronic pain conditions. Clin J Pain. 2014 Feb;30(2):119-28

Goodin BR, Pham QT, Glover TL, Sotolongo A, King CD, Sibille KT, Herbert MS, Cruz-Almeida Y, Sanden SH, Staud R, Redden DT, Bradley LA, Fillingim RB. Perceived racial discrimination, but not mistrust of medical researchers, predicts the heat pain tolerance of African Americans with symptomatic knee osteoarthritis. Health Psychol. 2013 Nov;32(11):1117-26.

Cruz-Almeida Y, King CD, Goodin BR, Sibille KT, Glover TL, Riley JL, Sotolongo A, Herbert MS, Schmidt J, Fessler BJ, Redden DT, Staud R, Bradley LA, Fillingim RB. Psychological profiles and pain characteristics of older adults with knee osteoarthritis. Arthritis Care Res (Hoboken). 2013 Nov;65(11):1786-94.

King CD, Sibille KT, Goodin BR, Cruz-Almeida Y, Glover TL, Bartley E, Riley JL, Herbert MS, Sotolongo A, Schmidt J, Fessler BJ, Redden DT, Staud R, Bradley LA, Fillingim RB. Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2013 Sep;21(9):1243-52.

King CD, Goodin B, Kindler LL, Caudle RM, Edwards RR, Gravenstein N, Riley JL 3rd, Fillingim RB. Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing. J Behav Med. 2013 Jun;36(3):315-27.

Goodin BR, Kronfli T, King CD, Glover TL, Sibille K, Fillingim RB. Testing the relation between dispositional optimism and conditioned pain modulation: does ethnicity matter? J Behav Med. 2013 Apr;36(2):165-74.

King CD, Goodin B, Glover TL, Riley JL, Hou W, Staud R, Fillingim RB. Is the pain-reducing effect of opioid medication reliable? A psychophysical study of morphine and pentazocine analgesia. Pain. 2013 Mar;154(3):476-83.

Goodin BR, Glover TL, Sotolongo A, King CD, Sibille KT, Herbert MS, Cruz-Almeida Y, Sanden SH, Staud R, Redden DT, Bradley LA, Fillingim RB. The association of greater dispositional optimism with less endogenous pain facilitation is indirectly transmitted through lower levels of pain catastrophizing. J Pain. 2013 Feb;14(2):126-35.

Renee Kreeger, MD

is a pediatric anesthesiologist who specializes in anesthesia for congenital heart disease. Her other interests include anesthesia safety and quality improvement, as well as neurologic outcome after cardiac surgery. She serves as the associate safety officer for the Department of Anesthesia and is currently a co-investigator in clinical research examining neurologic monitoring during congenital cardiac surgery and its effect on outcome.

513-636-4408 renee.kreeger@cchmc.org

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Renee Kreeger, MD

Academic Affiliation

Assistant Professor

Phone 513-636-4408

Fax 513-636-7337

Email renee.kreeger@cchmc.org

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Anesthesia for congenital cardiac disease

Biography

Renee Kreeger, MD, joined the faculty at Cincinnati Children’s within the University of Cincinnati College of Medicine after practicing as a pediatric anesthesiologist at Seattle Children’s Hospital. She has a special interest in anesthesia for congenital cardiac disease.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 2003.

Internship: Jewish Hospital, Cincinnati, OH, 2004.

Residency: University Hospital, Cincinnati, OH, 2007.

Fellowship: Pediatric Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008; Pediatric Cardiovascular Anesthesiology, Texas Children’s Hospital, Houston, TX (to be completed November 2009).

Certification: Anesthesiology, 2008.

Kreeger, R.N. Conscious Sedation. Mont Reid Surgical Handbook. 6th ed., 2008.

Mahmoud M, Bryan Y, Gunter J, Kreeger RN, Sadhasivam S. Anesthetic implications of undiagnosed late onset central hypoventilation syndrome in a child: from elective tonsillectomy to tracheostomy. Paediatr Anaesth. 2007 Oct;17(10):1001-5.

Kreeger RN, Hilvano A. Anesthetic options for the parturient with a neural tube defect. Int Anesthesiol Clin. 2005 Fall;43(4):65-80. Review.

Jennifer E. Lam, DO Physician, Department of Anesthesia

is a pediatric cardiac anesthesiologist and serves as the director of the pediatric cardiac anesthesia fellowship. She is also responsible for staff medical education and anesthesia grand rounds. She is very involved in fellow and resident education, providing formal lectures and mentorship throughout the year. In addition, Jennifer sits on the hospital’s Blood Utilization Review Committee as a representative for the department.

513-636-4408 jennifer.lam@cchmc.org

Christopher S. Lee, MD Staff Anesthesiologist, Department of Anesthesia

is a pediatric anesthesiologist whose primary basic science and translational research interest is exploring the protective effects of ischemic conditioning on tissue injury, sensory transduction and pain. Secondary interests include blood product management and pediatric regional anesthesia.

513-636-4408 christopher.lee@cchmc.org

Erica P. Lin, MD Attending Anesthesiologist, Department of Anesthesia

is a pediatric cardiac anesthesiologist. As the departmental expert in ventricular assist devices, she coordinates care for our heart failure patients with implanted devices. She also facilitates VAD-training among the pediatric cardiac anesthesia division. Erica is also actively involved in fellow and resident education. Her basic research interests focus on hypoxia-ischemia and its effect on neurodevelopmental outcome.

513-636-4408 erica.lin@cchmc.org

Andreas W. Loepke, MD, PhD Staff Anesthesiologist, Division of Cardiac Anesthesia

is a pediatric cardiac anesthesiologist and clinician-scientist who directs a research laboratory investigating the effects of anesthetics on the developing brain. He chairs the department’s Data Safety Monitoring Board and serves on the Editorial Advisory Board for the journal Pediatric Anesthesia as well as the SmartTots Affiliate Advisory Council for the International Anesthesia Research Society.
Visit the Loepke Lab.

513-636-4408

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Andreas W. Loepke, MD, PhD

Staff Anesthesiologist, Division of Cardiac Anesthesia

Academic Affiliation

Professor

UC Department of Pediatrics

Phone 513-636-4408

Fax 513-636-7337

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Anesthesia for neonates; congenital heart surgery; single-ventricle physiology

Visit the Loepke Lab.

Biography

Andreas W. Loepke, MD, PhD, has been practicing pediatric cardiac anesthesiology since 2000, first at the Children's Hospital of Philadelphia, and since 2003 at Cincinnati Children's Hospital Medical Center.

Dr. Loepke’s research laboratory investigates the potential use of anesthetics for neurological protection during brain ischemia as well as their possible adverse effects on brain development. His research group discovered in animals that anesthetics differentially affect brain regions, dependent on the age during exposure. Related to these findings, his lab made the discovery that neurons are susceptible to the anesthetics’ toxic effects during a specifically vulnerable stage of their development.

MD: University of Dusseldorf, Germany, 1993.

PhD: University of Dusseldorf, Germany, 1995.

Internship: General Surgery, Pennsylvania Hospital, Philadelphia, PA, 1996.

Residency: Anesthesiology, Thomas Jefferson Medical College, Philadelphia, PA, 1999.

Fellowship: Pediatric Anesthesia and Pediatric Cardiac Anesthesia, Children's Hospital of Philadelphia, Philadelphia, PA, 2000.

Certification: Anesthesiology, 2000.

Maintenance of Certification: Anesthesiology, 2010.

Hofacer RD, Deng M, Ward CG, Joseph B, Hughes EA, Jiang C, Danzer SC, Loepke AW. Cell-age specific vulnerability of neurons to anesthetic toxicity. Ann Neurol. 2013.

Istaphanous GK, Ward CG, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer, SC, Loepke AW. Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death In Mouse Cerebral Cortex. Anes Analg. 2013; 116(4): 845-54.

Mintz CD, Wagner M, Loepke AW. Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls. J Neurosurg Anesthesiol. 2012; 24(4): 362-7.

Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice. Anesthesiology. 2011; 114(3): 578-87.

Loepke AW. Developmental Neurotoxicity of Sedatives and Anesthetics – A Concern For Neonatal and Pediatric Critical Care Medicine? Pediatr Crit Care Med. 2010; 11(2): 217-226.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, Isoflurane and Sevoflurane Provide Limited Neuroprotection Against Neonatal Hypoxia-Ischemia in a Delayed-Preconditioning Paradigm. Anesthesiology. 2009; 111(3): 533-46.

Loepke AW, Istaphanous GK, McAuliffe JJ, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory. Anesth Analg. 2009; 108(1): 90-104.

Loepke AW, Soriano SG. An Assessment of the Effects Of General Anesthetics on Developing Brain Structure and Neurocognitive Function. Anesth Analg. 2008; 106: 1681-1707.

Loepke AW, McCann JC, Kurth CD, McAuliffe JJ. Physiologic Effects of Isoflurane Anesthesia in Neonatal Mice. Anesth Analg. 2006; 102: 75-80.

Loepke AW, Priestley MA, Schultz SE, McCann JC, Kurth CD. Desflurane Improves Outcome After Low-Flow Cardiopulmonary Bypass in Newborn Pigs. Anesthesiology. 2002; 97: 1521-7.

Mohamed A. Mahmoud, MD Staff Anesthesiologist

is a pediatric anesthesiologist who has clinical research programs in pediatric airway morphology and neuromonitoring. His primary research interest is examining the effect of currently available anesthetic agents on the upper airway morphology in children with history of obstructive sleep apnea. Effect of anesthesia on neuromonitoring modalities is a second clinical research focus.

513-636-4408 mohamed.mahmoud@cchmc.org

John J. McAuliffe III, MD, MBA Research Director

513-636-4408 john.mcauliffe@cchmc.org

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John J. McAuliffe III, MD, MBA

Research Director

Staff Anesthesiologist

Director, Institute Pediatric Anesthesia

Academic Affiliation

Professor

Phone 513-636-4408

Fax 513-636-7337

Email john.mcauliffe@cchmc.org

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Clinical

Cardiac anesthesia; neonatal anesthesia

Research

Anesthesia on the developing brain

MD: McGill University, Montreal, Canada, 1977.

Residency: Anesthesiology, Brigham and Women's Hospital, Boston, MA, 1982-84; Pediatrics, University of Minnesota, Minneapolis, MN, 1981-82; Pediatrics, University of Minnesota, Minneapolis, MN, 1978-79.

Fellowship: Pediatric Anesthesiology, Children's Hospital Medical Center, Boston, MA, 1984-85.

Certification: Pediatrics, 1984; Anesthesiology, 1985.

Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice. Anesthesiology. 2011 Feb 2.

McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topalá R, Richards DA, Danzer SC. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus. 2011 Jan;21(1):93-107.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology. 2009 Sep;111(3):533-46.

Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg. 2009 Jan;108(1):90-104.

McAuliffe JJ, Joseph B, Hughes E, Miles L, Vorhees CV. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments. Brain Res. 2008 Jan 23;1190:175-85.

McAuliffe JJ, Joseph B, Vorhees CV. Isoflurane-delayed preconditioning reduces immediate mortality and improves striatal function in adult mice after neonatal hypoxia-ischemia. Anesth Analg. 2007 May;104(5):1066-77, tables of contents.

Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006 Nov;16(11):1153-65.

McAuliffe JJ, Miles L, Vorhees CV. Adult neurological function following neonatal hypoxia-ischemia in a mouse model of the term neonate: water maze performance is dependent on separable cognitive and motor components. Brain Res. 2006 Nov 6;1118(1):208-21.

Loepke AW, McCann JC, Kurth CD, McAuliffe JJ. The physiologic effects of isoflurane anesthesia in neonatal mice. Anesth Analg. 2006 Jan;102(1):75-80.

Gunter JB, McAuliffe JJ, Gregg T, Weidner NJ, Varughese AM, Sweeney, DM. Continuous epidural butorphanol relieves pruritus associated with epidural morphine infusions in children. Paediatric Anaesthesia. 2000 10(2):167-172.

Mark Meyer, MD Medical Director, Pediatric Palliative and Comfort Care Team

is a pediatric anesthesiologist and palliative care physician with quality improvement research interests in opioid safety and communication. He possesses special clinical expertise in pediatric cancer pain and symptom management in life-threatening illness.

513-636-4408 mark.meyer@cchmc.org

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Mark Meyer, MD

Medical Director, Pediatric Palliative and Comfort Care Team

Anesthesiologist, Department of Anesthesia

Academic Affiliation

Associate Professor

Phone 513-636-4408

Fax 513-636-2920

Email mark.meyer@cchmc.org

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Clinical

Palliative medicine; end of life care; anesthesiology; pain management

Research

Anesthesia; pain management

Biography

Mark Meyer, MD, is a board-certified anesthesiologist who completed his residency at the Cleveland Clinic in Cleveland, Ohio.

Dr. Meyer joined the Department of Anesthesia in 2003 following his Pediatric Anesthesia Fellowship at Cincinnati Children's Hospital Medical Center.

Dr. Meyer is a staff anesthesiologist, as well as an attending physician in the Division of Pain Management, caring for patients with acute pain. In addition, Dr. Meyer is an attending physician for StarShine Hospice, the pediatric hospice at Cincinnati Children's.

In 2006, Dr. Meyer received his board certification from the American Board of Hospice and Palliative Medicine. He has been an integral part of the development and implementation of the Pediatric Palliative and Comfort Care Team / PACT at Cincinnati Children's.

Dr. Meyer is the PACT consulting physician, partnering with families in order to offer a range of comprehensive, family-centered care for children with chronic, complex or life-threatening conditions.

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1998.

Residency: Cleveland Clinic Foundation, Cleveland, OH, 2002.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2003.

Certification: Anesthesiology, 2004; Hospice and Palliative Medicine, 2006.

David L. Moore, MD

is a pediatric anesthesiologist and pain management physician, with interests in education of regional anesthesia and pain medicine. His research investigates use of simulation in education, relation of education to pain management outcomes, and role of anxiety and regional anesthesia on pain management outcomes.

513-636-8530 david.moore@cchmc.org

Jacquelyn Morillo-Delerme, MD Director of Anesthesia, Liberty Campus

513-636-4408 jacquelyn.morillo-delerme@cchmc.org

Pornswan Ngamprasertwong, MD, MSc Anesthesiologist, Department of Anesthesia

is an anesthesiologist and physician scientist. Her research focus is in the area of fetal-neonatal anesthesia and pharmacology. Her expertise is in fetal-neonatal anesthesia and research related to pharmacokinetics-pharmacodynamics of anesthetic drugs and developmental physiology. She has participated as principle investigator and co-investigator in many pharmacokinetics and personalized medicine research at Cincinnati Children’s, using various anesthetic agents in both human and animal model.

513-636-4408 pornswan.ngamprasertwong@cchmc.org

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Pornswan Ngamprasertwong, MD, MSc

Anesthesiologist, Department of Anesthesia

Academic Affiliation

Assistant Professor

Phone 513-636-4408

Email pornswan.ngamprasertwong@cchmc.org

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Fetal and neonatal anesthesia; fetal and neonatal pharmacology of anesthetic agents

Biography

Under mentorship of Dr. Vinks and Dr. Sadhasivam she has received extensive training, not only in applied pharmacology using PK-PD modeling and simulation, but also in research study design, critical thinking, grant and scientific writing skill. She received a scholarship from Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to attend the summer institute in maternal-fetal pharmacology in 2010. She received the Foundation for Anesthesia Education and Research (FAER) Fellow research grant 2010 for her project: The effects of maternal anesthesia on fetal outcomes in sheep model. She also received the Young Investigator Research Awards in 2011 and 2012 from the Society of Pediatric Anesthesia.

MD: Chulalongkorn University, Bangkok, Thailand, 1998.

Anesthesiology Residency: King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 2002.

Fellowship: Pediatric Anesthesia, Children’s National Medical Center, Washington, DC, 2005.

Fellowship: Cardiac Anesthesia, Children’s National Medical Center, Washington, DC, 2006.

Fellowship: Pediatric Anesthesia (under the 4 year ABA alternative pathway program), Cincinnati Children’s Hospital Medical Center, OH, 2011.

MS: Translational Research, University of Cincinnati, Cincinnati, OH, 2012.

View PubMed Publications.

Sherwin CM, Ngamprasertwong P, Sadhasivam S, Vinks AA. Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study. Curr Clin Pharmacol. 2014 Feb;9(1):64-9.

Ngamprasertwong P, Habli M, Boat A, Lim FY, Esslinger H, Ding L, Sadhasivam S. Maternal hypotension during fetoscopic surgery: incidence and its impact on fetal survival outcome. Scientific World Journal. 2013 Oct 21;2013:709059.

Fukuda T, Chidambaran V, Mizuno T, Venkatasubramanian R, Ngamprasertwong P, Olbrecht V, Esslinger HR, Vinks AA, Sadhasivam S. Oct1 genetic variants influence the pharmacokinetics of morphine in children. Pharmacogenomics. 2013 Jul;14(10):1141-51.

Ngamprasertwong P, Michelfelder EC, Arbabi S, Choe YS, Statile C, Ding L, Boat A, Eghtesady P, Holland K, Sadhasivam S. Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcome in sheep model. Anesthesiology. 2013 Apr; 118(4):796-808.

Ngamprasertwong P, Vinks AA, Boat A. Update in fetal anesthesia for the ex-utero intrapartum (EXIT) procedure. Int Anesthesiol Clin. 2012 Fall;50(4):26-40.

Sadhasivam S, Krekels EH, Chidambaran V, Esslinger HR, Ngamprasertwong P, Zhang K, Fukuda T, Vinks AA. Morphine clearance in children: does race or genetics matter? J Opioid Manag. 2012 Jul-Aug;8(4):217-26.

Sadhasivam S, Chidambaran V, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and unequal burden of perioperative pain and opioid related adverse effects in children. Pediatrics. 2012 May;129(5):832-8.

Chidambaran V, Ngamprasertwong P, Vinks AA, Sadhasivam S. Pharmacogenetics and anesthetic drugs. Curr Clin Pharmacol. 2012 May;7(2):78-101.

Sadhasivam S, Chidambaran V, Ngamprasertwong P, Esslinger HR, Prows C, Zhang X, Martin LJ, McAuliffe J. Race and Unequal burden of perioperative pain and opioid related adverse effects in children. Pediatrics. 2012 May;129(5):832-8.

Vanessa A. Olbrecht, MD, MBA Anesthesiologist, Department of Anesthesia

is a pediatric anesthesiologist and acute pain physician with interests in understanding opioid-induced effects on tumor biology, recurrence and metastasis and determining whether perioperative administration of narcotics influences long-term clinical outcomes in children having tumor resections. She is currently working with Dr. John Perentesis’ group in the Cancer and Blood Diseases Institute.

513-636-4408 vanessa.olbrecht@cchmc.org

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Vanessa A. Olbrecht, MD, MBA

Anesthesiologist, Department of Anesthesia

Academic Affiliation

Assistant Professor

Phone 513-636-4408

Email vanessa.olbrecht@cchmc.org

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Pediatric general anesthesia; pediatric regional anesthesia; acute pain management; clinical outcomes research

Biography

Vanessa Olbrecht, MD, MBA, graduated as class valedictorian and Alpha Omega Alpha from the Johns Hopkins University School of Medicine in 2007 and received the William Stewart Halsted award in surgery. She completed her internship in surgery at the Massachusetts General Hospital in 2008 before transitioning to her Anesthesia residency at the same institution. She joined the faculty of Cincinnati Children’s Hospital Medical Center as an assistant professor within the UC Department of Anesthesiology after finishing her pediatric anesthesia fellowship at the Children’s Hospital of Philadelphia. She received her MBA in 2015 from the University of North Carolina at Chapel Hill.

Dr. Olbrecht’s achievements include multiple research publications in major journals focused on clinical outcomes in both surgery and anesthesia. She has presented her work at local and national meetings and has won several awards for these presentations, including a Gertie Marx award and the Society of Pediatric Anesthesia Young Investigator Award.

BA: Cornell University, Ithaca, NY, 2003.

MD: The Johns Hopkins University School of Medicine, Baltimore, MD, 2007.

MBA: The University of North Carolina Chapel Hill, Chapel Hill, NC, 2015.

Internship: General Surgery, The Massachusetts General Hospital, Harvard University, Boston, MA, 2007-2008.

Residency: Anesthesia, The Massachusetts General Hospital, Harvard University, Boston, MA, 2008-2011.

Fellowship: Pediatric Anesthesia, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, 2011-2012.

Certification: Anesthesiology, 2012; Pediatric Anesthesia, 2013.

View PubMed Publications.

Bateman BT, Olbrecht VA, Minehart RD, Schwamm LH, Leffert LR. Subarachnoid hemorrhage in pregnancy: nationwide data and institutional experience. Anesthesiology. 2012 Feb;116(2):324-333.

Olbrecht VA, Nabaweesi R, Arnold MA, Chandler N, Chang DC, McIltrot KH, Abdullah F, Paidas CN, Colombani PM. Pectus bar repair of pectus excavatum in patients with connective tissue disease. Journal of Pediatric Surgery. 2009 Sep;44(9):1812-1816.

Olbrecht VA, Arnold MA, Nabaweesi R, Chang DC, McIltrot KH, Abdullah F, Paidas CN, Colombani PM. Lorenz bar repair of pectus excavatum in the adult population: should it be done? Annals of Thoracic Surgery. 2008 Aug;86(2):402-408; discussion 408-409.

Olbrecht VA, Abdullah F, Arnold MA, Nabaweesi R, Chang DC, McIltrot KH, Paidas CN, Colombani PM. Upper sternal depression following Lorenz bar repair of pectus excavatum. Pediatric Surgery International. 2008 Jul;24(7):843-846.

Pawlik TM, Olbrecht VA, Pitt HA, Gleisner AL, Choti MA, Schulick RD, Cameron JL. Primary sclerosing cholangitis: role of extrahepatic biliary resection. Journal of the American College of Surgeons.2008 May;206(5):822-830; discussion 830-832.

Olbrecht VA, Barreiro CJ, Bonde PN, Williams JA, Baumgartner WA, Gott VL, Conte JV. Clinical outcomes of noninfectious sternal dehiscence after median sternotomy. Annals of Thoracic Surgery. 2006 Sep;82(3):902-907.

Grants

Functional Near Infrared Spectroscopy (fNIRS) to Detect and Predict Pain in Children in the Inpatient and Outpatient Setting. Principal Investigator. Cincinnati Children's Hospital Medical Center. 2015-2016.

Nick Pratap, MB BChir, MRCPCH, FRCA Congenital Cardiac Anesthesiologist, Department of Anesthesia

investigates the use of monitoring in the operating room and cardiac intensive care unit. The goal of his research is to improve clinical outcomes after open heart surgery in young infants. He is also working on novel ways of partnering with families to prepare their children for surgery.

513-803-0645 jayant.pratap@cchmc.org

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Nick Pratap, MB BChir, MRCPCH, FRCA

Congenital Cardiac Anesthesiologist, Department of Anesthesia

Attending Cardiac Intensivist, Heart Institute

Academic Affiliation

Assistant Professor

Phone 513-803-0645

Email jayant.pratap@cchmc.org

Show All

Clinical

Congenital cardiac anesthesia; general pediatric anesthesia; pediatric liver transplant anesthesia; cardiac intensive care medicine

Research
Improving outcomes after pediatric cardiac surgery; reducing surgical cancelations; improving safety in pediatric anesthesia using high-fidelity simulation training and checklists

Biography

Nick Pratap, MB BChir, is an assistant professor of anesthesia and pediatrics with the University of Cincinnati College of Medicine.

A native of England, Dr. Pratap graduated with first class honors from the University of Cambridge. He earned his medical degree from the University of Cambridge, United Kingdom. He undertook pediatric and anesthesia training, along with fellowships in pediatric anesthesia, pediatric critical care and congenital cardiac anesthesia in London, England.

Dr. Pratap has been an attending staff member of the Department of Anesthesia at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine since 2011. He joined the CICU in 2013.

Dr. Pratap's academic interests relate to reducing cancelation on the day of scheduled pediatric surgery and to improving outcomes after pediatric surgery through the use of novel technology.

Dr. Pratap has been active in the pediatric and cardiac anesthesia and pediatric critical care communities. He is a member of the American Society of Anesthesiologists, the Society for Pediatric Anesthesia, the Congenital Cardiac Anesthesia Society and the Society of Cardiovascular Anesthesiologists, as well as the Royal College of Paediatrics & Child Health and the Royal College of Anaesthetists in the United Kingdom.

Dr. Pratap serves on the Society for Pediatric Anesthesia's Quality and Safety Committee and the Sedation Taskforce of the Society for Critical Care Medicine. He is on the faculty for the Master of Science program in perioperative medicine at University College London, contributing to the Quality, Safety and Leadership module.

Dr. Pratap is an instructor and provider in Basic, Advanced Cardiac and Pediatric Advanced Life Support for the American Heart Association.

MA (Cantab): University of Cambridge, UK, 1998.

MB BChir: University of Cambridge, UK, 1998.

Pediatric Residency: Royal College of Paediatrics and Child Health, London, UK, 2002.

Anesthesia Residency: Royal College of Anaesthetists, London, UK, 2006.

Pediatric Anesthesia Fellowship: Great Ormond Street Hospital, London, UK, 2008.

Congenital Cardiac Anesthesia Fellowship: Royal Brompton Hospital, London, UK, 2009.

Pediatric Intensive Care Fellowship: Birmingham Children's and Great Ormond Street Hospitals, UK, 2010.

Pratap JN, Varughese AM, Mercurio P, Lynch T, Lonnemann T, Ellis A, Rugg J, Stone WR, Bedinghaus C. Reducing cancelations on the day of scheduled surgery at a children’s hospital. Pediatrics. 2015;135(5):e1-8.

Pratap JN. Ventilation. In: Skone R, Reynolds F, Bagshaw O, Cray S & Berry K, eds. Managing the Critically Ill Child: A Guide for Anesthetists and Emergency Physicians. Cambridge: Cambridge University Press. 2013.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: psychology and leadership issues in quality improvement. Br J Hosp Med (Lond). 2013 Feb;74(2):104-8.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: the model in practice. Br J Hosp Med (Lond). 2013 Jan;74(1):42-6.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: introduction and understanding variation. Br J Hosp Med (Lond). 2012 Dec;73(12):701-5.

Pratap JN, Wilmshurst S. Anaesthetic management of children with in situ Berlin Heart EXCOR. Pediatr Anesth. 2010 Sep;20(9):812-20.

Pratap JN, McEwan AI. Failure to wean from cardiopulmonary bypass due to left atrial compression by periaortic hematoma. Anesth Analg. 2009 Jul;109(1):35-7.

Pratap JN, Sekhri C, Lloyd-Thomas AR. Anaesthetic management for adenotonsillectomy of a child with severe obesity due to homozygous melanocortin-4 receptor gene mutations. Paediatr Anaesth. 2009 Feb;19(2):195-6.

Pratap JN, Shankar RK, Goroszeniuk T. Co-injection of clonidine prolongs the analgesic effect of lidocaine skin infiltration by a peripheral action. Anesth Analg. 2007 Apr;104(4):982-3.

Pratap JN, Down JF. Posterior reversible encephalopathy syndrome: a report of a case with atypical features. Anaesthesia. 2008 Nov;63(11):1245-8.

Grants

Targeting family support to children coming for surgery. Principal Investigator. Place Outcomes Research Award. Jul 2014-Jun 2016.

Joseph P. Previte, MD, FAAP Director, Anesthesia Information and Communication Services

513-636-4408 joseph.previte@cchmc.org

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Joseph P. Previte, MD, FAAP

Director, Anesthesia Information and Communication Services

Academic Affiliation

Associate Professor

Phone 513-636-4408

Fax 513-636-7337

Email joseph.previte@cchmc.org

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Fetal surgery anesthesia; liver transplant anesthesia; spine and neuro-surgery; medical information system management

Biography

Joseph Previte, MD, FAAP, performs all types of pediatric anesthesia, except cardiac. He is also part of the Fetal Anesthesia Care Team, Spine Surgery Care Team and Bariatric Team, and he is the neurosurgery champion for the Department of Anesthesia.

Dr. Previte is interested in information technology in the health care setting and manages and directs several IT projects in the Department of Anesthesia. He is currently directing the implementation of Centricity, a perioperative-wide (from the preoperative evaluation through the postoperative note) computerized documentation system tailored for the anesthetic care of the pediatric patient. This system will be integrated with a perioperative-wide documentation system.

MD: West Virginia University School of Medicine, Morgantown, WV, 1989.

Internship: West Virginia University Medical Center, Morgantown, WV, 1990.

Residency: The Hospital of the University of Pennsylvania, Philadelphia, PA, 1993.

Fellowship: The Children's Hospital of Philadelphia, Philadelphia, PA, 1993.

Certification: Anesthesiology, 1995.

Meyer M, Previte JP. Aspiration Pneumonitis in Children. Complications in Anesthesia, 2nd Edition. 2007 641-43.

Robinson M, Previte JP. Complications of EXIT Procedure. Complications in Anesthesia, 2nd Edition. 2007 607-10.

Previte JP. Information and communication system implementation in anesthesia. Int Anesthesiol Clin. 2006 Winter;44(1):179-97. Review.

Wu J, Previte JP, Adler E, Myers T, Ball J, Gunter JB. Spontaneous ignition, explosion, and fire with sevoflurane and barium hydroxide lime. Anesthesiology. 2004 Aug;101(2):534-7.

Cook-Sather SD, Liacouras CA, Previte JP, Markakis DA, Schreiner MS. Gastric fluid measurement by blind aspiration in paediatric patients: a gastroscopic evaluation. Can J Anaesth. 1997 Feb;44(2):168-72.

John B. Rose, MD Co-Director, Inpatient Pain Rehabilitation Program

is a pediatric anesthesiologist with clinical expertise and research interest in the management of chronic pain in children and adolescents. His research interests also include quality improvement in chronic pediatric pain management and opiate safety in children.

513-636-7768 john.rose@cchmc.org

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John B. Rose, MD

Co-Director, Inpatient Pain Rehabilitation Program

Academic Affiliation

Professor

Phone 513-636-7768

Email john.rose@cchmc.org

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MD: University of Pennsylvania, School of Medicine, Philadelphia, PA, 1980.

Residency: Pediatrics, Children’s Hospital National Medical Center, Washington, DC; Anesthesiology, Hospital of the University of Pennsylvania, Philadelphia, PA.

Fellowship: Pediatric Anesthesiology & Critical Care Medicine; Children’s Hospital of Philadelphia, Philadelphia, PA.

Certifications: Pediatrics, 1984; Anesthesiology, 1987.

Guite JW, Logan DE, McCue R, Sherry DD, Rose JB. Parental beliefs and worries regarding adolescent chronic pain. Clinical Journal Pain. 2009;25:223-32.

Zempsky WT, Bean-Lijewski J, Kauffman RE, Koh JL, Malviya SV, Rose JB, Richards PT, Gennevois DJ. Needle-free powder lidocaine delivery system provides rapid effective analgesia for venipuncture or cannulation pain in children: randomized, double-blind Comparison of Venipuncture and Venous Cannulation Pain After Fast-Onset Needle-Free Powder Lidocaine or Placebo Treatment trial. Pediatrics. 2008 May;121(5):979-87.

Ganesh A, Rose JB, Wells L, Ganley T, Gurnaney H, Maxwell LG, DiMaggio T, Milovcich K, Scollon M, Feldman JM, Cucchiaro G. Continuous peripheral nerve blockade for inpatient and outpatient postoperative analgesia in children. Anesth Analg. 2007 Nov;105(5):1234-42.

Guite JW, Logan DE, Sherry DD, Rose JB. Adolescent self-perception: associations with chronic musculoskeletal pain and functional disability. J Pain. 2007 May;8(5):379-86.

Harty TP, Dib-Hajj SD, Tyrrell L, Blackman R, Hisama FM, Rose JB, Waxman SG. Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. J Neurosci. 2006 Nov 29;26(48):12566-75.

Logan DE, Guite JW, Sherry DD, Rose JB. Adolescent-parent relationships in the context of adolescent chronic pain conditions. Clin J Pain. 2006 Jul-Aug;22(6):576-83.

Cucchiaro G, Adzick SN, Rose JB, Maxwell L, Watcha M. A comparison of epidural bupivacaine-fentanyl and bupivacaine-clonidine in children undergoing the Nuss procedure. Anesth Analg. 2006 Aug;103(2):322-7.

Nathan A, Rose JB, Guite JW, Hehir D, Milovcich K. Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment. Pediatrics. 2005 Apr;115(4):e504-7.

Logan DE, Rose JB. Is postoperative pain a self-fulfilling prophecy? Expectancy effects on postoperative pain and patient-controlled analgesia use among adolescent surgical patients. J Pediatr Psychol. 2005 Mar;30(2):187-96.

Senthilkumar Sadhasivam, MD, MPH

is director of Perioperative Pain Service, has clinical interests in regional anesthesia, fetal anesthesia and perioperative pain management. His funded clinical research aims to improve anesthetic outcomes and personalizing pain management. He mentors junior faculty with clinical research, especially pharmacogenetic and pharmacokinetic research to improve perioperative outcomes in children.

513-636-4408 senthilkumar.sadhasivam@cchmc.org

Nancy Samol, MD

513-636-4408 nancy.samol@cchmc.org

Paul J. Samuels, MD Director of Education, Department of Anesthesia

is a pediatric anesthesiologist and the director of education in the Department of Anesthesia. His clinical and research interests include measurement of technical skill acquisition, pediatric obesity, and medical simulation.

513-636-4408 paul.samuels@cchmc.org

Ximena Soler, MD Staff Anesthesiologist, Department of Anesthesia

513-636-4408 ximena.soler@cchmc.org

James P. Spaeth, MD Director, Cardiac Anesthesia

is a pediatric cardiac anesthesiologist and the director of Cardiac Anesthesia. His clinical research interests include the effect of congenital cardiac disease and cardiac surgery on neurodevelopmental outcomes, and the use of cerebral monitoring during the perioperative period. He is also involved in quality improvement work focused on improving the safety of pediatric anesthesia.

513-636-4408 james.spaeth@cchmc.org

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James P. Spaeth, MD

Director, Cardiac Anesthesia

Staff Anesthesiologist, Department of Anesthesia

Academic Affiliation

Associate Professor

Phone 513-636-4408

Fax 513-636-7337

Email james.spaeth@cchmc.org

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Cardiac anesthesia; neurologic injury in children with congenital heart disease; improving perioperative safety

MD: University of Virginia School of Medicine, Charlottesville, VA, 1993.

Internship: Internal Medicine, University of Virginia Medical Center, Charlottesville, VA, 1994.

Residency: Anesthesiology, University of California, San Diego Medical Center, San Diego, CA, 1997.

Fellowship: Pediatric Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA, 1998.

Certification: Anesthesiology, 1998.

Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006 Nov;16(11):1153-65.

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2006 Jan;131(1):190-7.

Aronson LA, Spaeth JP. Frontiers in pediatric anesthesia: cardiac anesthesia. Int Anesthesiol Clin. 2006 Winter;44(1):33-49.

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2005 Dec;130(6):1523-30.

Loepke AW, Spaeth JP. Glucose and Heart Surgery: Neonates Are Not Just Small Adults. Anesthesiology. 2004 Jun;100(6):1345-52.

Baker RC, Schubert CJ, Kirwan KA, Lenkauskas SM, Spaeth JT. After-hours telephone triage and advice in private and nonprivate pediatric populations. Arch Pediatr Adolesc Med. 1999 Mar;153(3):292-6.

Rajeev Subramanyam, MD, MS

is a health services and outcomes researcher in children undergoing surgery and anesthesia or sedation. He has a special interest in tonsillectomy and sleep apnea population. Health economics is a second research focus.

513-568-8994 rajeev.subramanyam@cchmc.org

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Rajeev Subramanyam, MD, MS

Academic Affiliation

Assistant Professor

Phone 513-568-8994

Email rajeev.subramanyam@cchmc.org

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Clinical

Pediatric anesthesia

Research

Clinical and translational outcomes research; tonsillectomy and sleep apnea; health economics

MBBS: Bangalore Medical College, India, 1999.

MD: Chandigarh, India, 2006.

Residency: Anesthesia, Post Graduate Institute of Medical Education and Research, India, 2006.

Pediatric Anesthesia Fellowship: Hospital for Sick Children, Toronto, Canada, 2011.

Advanced Fellowship in Pediatric Anesthesia: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013.

MS: Clinical and Translational Research, University of Cincinnati, Cincinnati, OH, 2013.

Certification: Anesthesiology, 2006.

Subramanyam R, Varughese A, Kurth CD, Eckman MH. Cost-effectiveness of intravenous acetaminophen for pediatric tonsillectomy. Paediatr Anaesth. 2014 May;24(5):467-75.

Subramanyam R, Chidambaran V, Ding L, Myer CM 3^rd, Sadhasivam S. Anesthesia and opioid related malpractice claims in the United States: LexisNexis Claims database – 1984 to 2012. Paediatr Anaesth. 2014 Apr;24(4):412-20.

Subramanyam R, Varughese A, Willging JP, Sadhasivam S. Future of pediatric tonsillectomy and perioperative outcomes. Int J Pediatr Otorhinolaryngol. 2013 Feb;77(2):194-9.

Chung F, Subramanyam R, Liao P, Sasaki E, Shapiro C, Sun Y. A higher score of STOP-Bang score indicates a high probability of obstructive sleep apnea. Br J Anaesth. 2012 May;108(5):768-75.

Mehta V, Subramanyam R, Shapiro CM, Chung F. Health effects of identifying patients with undiagnosed obstructive sleep apnea in the preoperative clinic: a follow-up study. Can J Anaesth. 2012 Jun;59(6):544-55.

Subramanyam R, Vaishnav V, Chan VWS, Brown-Shreves D, Brull R. Lateral vs. Medial Needle Approach for ultrasound-guided supraclavicular block: A Randomized Controlled Trial. Reg Anesth Pain Med. 2011 Jul-Aug;36(4):387-92.

Batra YK, Rakesh SV, Panda NB, Lokesh VC, Subramanyam R. Intrathecal clonidine decreases sedation requirements during spinal anesthesia in infants. Pediatr Anesth. 2010 Jul;20(7):625-32.

Harjeet K, Aggarwal A, Sahni D, Batra YK, Rakesh SV, Subramanyam R. Anatomical dimensions of larynx, epiglottis and cricoid cartilage in fetuses and their relationship with crown rump length. Surg Radiol Anat. 2010 Aug;32(7):675-81.

Aggarwal A, Kaur H, Batra YK, Aggarwal AK, Subramanyam R, Sahni D. Anatomic consideration of caudal epidural space: A cadaver study. Clin Anat. 2009 Sep;22(6):730-7.

Batra YK, Rajeev S, Subramanyam R, Panda NB, Lokesh VC, Rao KL. Intrathecal neostigmine with bupivacaine for infants undergoing lower abdominal and urogenital procedures: dose response. Acta Anaesthesiol Scand. 2009 Apr;53(4):470-5.

Alexandra Szabova, MD Director, Pain Management Fellowship

is a pediatric anesthesiologist with interest in chronic pediatric pain medicine. She is on staff at the Pain Management Center and a program director of the Pediatric Pain Medicine Fellowship at Cincinnati Children’s. Her area of expertise includes musculoskeletal/back pain in children and young adults and related clinical outcome research.

513-636-7768 alexandra.szabova@cchmc.org

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Alexandra Szabova, MD

Director, Pain Management Fellowship

Academic Affiliation

Assistant Professor

Phone 513-636-7768

Fax 513-636-2920

Email alexandra.szabova@cchmc.org

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Chronic pediatric pain management; chronic pediatric and adolescent back and musculoskeletal pain management; acute pain management; pediatric regional anesthesia techniques; interventional pain management; pediatric anesthesia

Biography

Alexandra Szabova, MD, joined the staff of Cincinnati Children's Hospital Medical Center in 2006. She has worked as a pediatric anesthesiologist but also became a team member of the multidisciplinary chronic pediatric pain clinic.

Dr. Szabova demonstrated strong interest in pediatric chronic pain management during her training.
She graduated from a combined pediatric and adult chronic pain management fellowship which was a result of close collaboration between the Cincinnati Children's and Cleveland Clinic Foundation, Cleveland, OH.

Dr. Szabova received her medical degree from the Comenius University in Bratislava, Slovakia, and completed her residency in anesthesia at the Cleveland Clinic Foundation, Cleveland, OH.

Dr. Szabova completed her combined pediatric and adult chronic pain management at Cincinnati Children's and Cleveland Clinic Foundation where is served as a chief fellow. She graduated with The Pain Fellow of the Year Award. Dr. Szabova completed pediatric anesthesia fellowship at the Cincinnati Children's.

Dr. Szabova's interests include chronic pediatric pain management, musculoskeletal pain in children and adolescents, acute pain management of surgical and non surgical pediatric patients, regional nerve blocks, and pediatric anesthesia.

MD: Comenius University, Bratislava, Slovakia, 1995.

Residency: Anesthesiology, Cleveland Clinic Foundation, Cleveland, OH.

Fellowship: Pain Management, Cleveland Clinic Foundation, Cleveland, OH; Pediatric Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Anesthesiology, 2005; ABA Pain Medicine, 2005.

Rachel Thienprayoon, MD, MSCS Medical Director, StarShine Hospice

is a clinical researcher focusing on racial/ethnic disparities in hospice enrollment in children, quality indicators in pediatric hospice care, and systems delivery of hospice care to children.

513-827-7954 rachel.thienprayoon@cchmc.org

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Rachel Thienprayoon, MD, MSCS

Medical Director, StarShine Hospice

Attending Physician, Palliative Care Team

Attending Physician, Hemangioma and Vascular Malformation Program

Academic Affiliation

Assistant Professor

UC Department of Pediatrics

Phone 513-827-7954

Email rachel.thienprayoon@cchmc.org

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Pediatric oncology; pediatric hospice and palliative medicine

Biography

Dr. Thienprayoon was a St. Baldrick's Fellows Grant recipient from 2011 to 2013. She was an ASH Clinical Research Training Institute participant in 2012. In 2014 she was part of the James M. Anderson Center for Health Systems Excellence Quality Scholars Program.

BS: Chemistry, Georgia Institute of Technology, Atlanta, GA, 2003.

MD: Medical College of Georgia, Augusta, GA, 2007.

Residency: General Pediatrics, Children's Medical Center Dallas, Dallas, TX, 2010.

Fellowship: Pediatric Hematology-Oncology, UT Southwestern, Dallas, TX, 2013.

Fellowship: Pediatric Hospice and Palliative Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2014.

Board certification: General Pediatrics, 2012; Hospice and Palliative Medicine, 2014; Pediatric Hematology-Oncology, 2015.

Thienprayoon R, Porter K, Tate M, Ashby M, Meyer M. Risk stratification for opioid misuse in children, adolescents and young adults: a quality improvement project. Pediatrics. Accepted for publication, June 30, 2016.

Thienprayoon R, Marks E, Funes M, Martinez L, Lee SC, Winick NJ. Perceptions of the pediatric hospice experience among English and Spanish speaking families. J Palliat Med. 2016 Jan;19(1):30-41.

Thienprayoon R, LeBlanc T. Early Integration of Palliative Care in the Care of Patients with Cancer. Hematology Am Soc Hematol Educ Program. 2015 Dec 5;2015(1):479-83.

Thienprayoon R, Lee SC Leonard D, Winick NJ. Hospice care for children with cancer: where do these children die? J Pediatr Hematol Oncol. 2015 Jul;37(5):373-7.

Thienprayoon R, Campbell R, Winick NJ. Attitudes and practices in the bereavement care offered by children’s hospitals: a survey of the Pediatric Chaplains Network. Omega: Journal of Death and Dying. Accepted for publication.

Thienprayoon R, Lee SC, Leonard D, Winick NJ. Racial and ethnic differences in hospice enrollment among children with cancer. Pediatr Blood and Cancer. 2013 Oct;60(10):1662-6.

Thienprayoon R, Heym KM, Pelfrey L, Bowers DC. Accidental cytarabine overdose in childhood: a case series. Annals of Pharmacotherapy. 2013 May;47(5):e24.

Anna M. Varughese, MD, MPH Anesthesia Divisional Chief, Department of Anesthesia

is a pediatric anesthesiologist with an interest in quality improvement, outcomes and health services research. Her current work is centered on measuring perioperative quality outcomes and developing predictive models to improve outcomes as well as optimizing resources, efficiency and flow in the perioperative arena.

513-636-4408 anna.varughese@cchmc.org

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Anna M. Varughese, MD, MPH

Anesthesia Divisional Chief, Department of Anesthesia

Senior Medical Director, Perioperative Services

Academic Affiliation

Professor

Phone 513-636-4408

Fax 513-636-7337

Email anna.varughese@cchmc.org

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Clinical

Anesthesia for complex surgery, liver transplantation, fetal surgery and radiology

Research

Quality improvement; safety and outcomes research

MD: University of Madras, Vellore, India, 1989.

Residency: Anesthesiology, Christian Medical College Hospital, Vellore, India, 1989; Anesthesiology, Queen Elizabeth Hospital, Birmingham, England, 1994; Anesthesiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1995.

Fellowship: Pediatric Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1996.

Certification: American Board of Anesthesiology, 1996; Subspecialty Certificate in Pediatric Anesthesia, 2013.

DA: Anesthesia, University of Madras, India, 1988.

FRCA: Fellowship of the Royal College of Anesthetists, United Kingdom, 1993.

MPH: Master in Public Health, Harvard School of Public Health, Boston, MA, 2003-2005.

Buck D, Varughese A, Subramanyam R, Adler E. A quality improvement project to reduce the intraoperative use of single dose fentanyl vials across multiple patients at a pediatric institution. Pediatric Anesthesia. 2015 August.

Pratap NJ, Varughese AM, Mercurio P, Lynch T, Lonnemann T, Ellis A, Rugg J, Stone R, Bedinghaus C. Reducing cancelations on the day of scheduled surgery at a Children’s Hospital. Pediatrics. 2015 May;135(5):e1292-9.

Wittkugel E, Varughese A. Development of a nurse-assisted preanesthesia evaluation program for pediatric outpatient anesthesia. Paediatr Anaesth. 2015 Jul;25(7):719-26.

Buck D, Kurth CD, Varughese AM. Perspectives on Quality and Safety in Pediatric Anesthesia. Anesthesiology Clinics. 2014 Mar;32(1):281-94.

Tjia IM, Rampersad S, Varughese AM, Heitmiller E, Tyler DC, Uejima T. Quality Improvement in Pediatric Anesthesia: Wake Up Safe and Safety Analytics. Anesthesia and Analgesia. 2014;119(1):122-36.

Varughese AM, Heitmiller E, Rampersad S, Whitney G, Flick R. Quality in Pediatric Anesthesia-A Review. Anesth Analg. 2013 Dec;117(6):1408-18.

Varughese AM, Adler E, Anneken A, Kurth CD. Improving On-Time Start of Day and End of Day for a Pediatric Surgical Service. Pediatrics. 2013 Jul;132(1):e219-28.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: psychology and leadership in quality improvement. Br J Hosp Med (Lond). 2013;74(2):104-108.

Varughese AM, Hagerman N, Townsend ME. Using quality improvement methods to optimize resources and maximize productivity in an anesthesia screening and consultation clinic. Paediatr Anaesth. 2013;23(7):597-606

Varughese AM, Hagerman NS, Kurth CD. Quality in pediatric anesthesia. Paediatr Anaesth. 2010 Aug;20(8):684-96.

Charlotte Walter, MD

513-636-4408 charlotte.walter@cchmc.org

Eric P. Wittkugel, MD Staff Anesthesiologist, Department of Anesthesia

is a pediatric anesthesiologist and a mentor with a research and education focus on quality improvement and safety in outpatient pediatric anesthesia. His research focuses on the use of quality improvement methods to optimize preanesthetic evaluation and clinical outcomes for children undergoing ambulatory surgery. His clinical interests include anesthesia for airway surgery and for children with epidermolysis bullosa.

513-636-4408 eric.wittkugel@cchmc.org

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Eric P. Wittkugel, MD

Staff Anesthesiologist, Department of Anesthesia

Academic Affiliation

Associate Professor

Phone 513-636-4408

Fax 513-636-7337

Email eric.wittkugel@cchmc.org

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Preoperative evaluation; anesthesia for airway surgery; latex allergy; epidermolysis bullosa

Biography

Eric Wittkugel, MD, has been a practicing pediatric anesthesiologist since 1989, when he joined the Department of Anesthesia at Cincinnati Children's Hospital Medical Center.

MD: State University of New York at Buffalo, NY, 1983.

Internship: Internal Medicine and Pediatrics, State University of New York at Buffalo, NY, 1983-1984;

Residency: Anesthesia, University of Pennsylvania Hospitals, Philadelphia, PA, 1986-1988; Pediatrics, Children's Hospital of Philadelphia, PA, 1984-1986.

Fellowship: Pediatric Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, PA, 1988-1989.

Certification: Anesthesiology, 1990; Pediatrics, 1987.