Dr. Mersha is a Professor of Pediatrics in the Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, and University of Cincinnati College of Medicine, where he leads the Population Genetics, Ancestry and Bioinformatics Laboratory (pGAB). His research combines genetic ancestry, bioinformatics, and statistical and functional genomics to unravel genetic and non-genetic contributions to complex diseases in human populations, particularly in allergic disorders. Much of his research is at the intersection of basic, clinical, and translational research, and he is interested in crossline disciplines to dissect how biologic predisposition and environmental exposures interact to shape racial disparities in asthma and other complex disorders. Dr. Mersha is recognized in the field of genetic ancestry, race, ethnicity, admixture mapping and functional genomics related to complex diseases. His current research has focused on understanding the complex interplay surrounding environmental exposures, genomics, race, ethnicity, ancestry, multi-omics, and health, especially in underrepresented populations. He is a strong advocate of reimagining health equity in the era of precision medicine. Specifically addressing the lack of equity (or racial disparities) in genomic research through inclusion of diverse populations.
Esteban received his PhD from the University of Cincinnati in 2021. Before moving to Cincinnati Children’s in 2021 as a research fellow, Esteban worked as a software engineer at LiveVox (CA, USA), and as a medical imaging engineer at CREATIS-UMR, Université Lyon 1 (Lyon, FR). Esteban focuses on automating data pipelines, remote sensing, and risk prediction models around unconventional datasets such as electronic medical records for clinical research. Outside of the lab, Esteban enjoys motorsports and goes for bike rides.
Eskezeia earned a MS in biostatistics from Addis Ababa University in Ethiopia and a PhD in bioinformatics and medical engineering from Asia University in Taiwan. Eskezeia is interested in developing and applying statistical, machine learning and bioinformatics methods into biomedical data. In 2021, Eskezeia joined Dr. Mersha’s Lab as a Research Fellow to uncover genetic, epigenetic, and environmental exposer risk factors in asthma and asthma-associated allergic diseases. Eskezeia is also interested in improving the predictive performance of polygenic risk scores in complex human diseases including asthma and cancer.
Yadu Gautam received his PhD in statistics from Central Michigan University, MI in 2014. He joined Mersha Lab in 2017 as a postdoctoral fellow. At Mersha Lab, he is working on genomics projects aimed at detecting predisposing genes and environmental exposer risk factors in asthma and related phenotypes. He is interested in both application and computational tools development in big biological data to investigate the genetics and environment risk factors for common and complex diseases. Currently, he is developing a novel tool called AdmixPower for power and sample size analysis of admixture mapping studies. Besides working in the Lab, he spends some time reading news and watching cartoons with his kids.
Stephen was born and raised in Florence, KY. He received his bachelor's degree in biological sciences from Cornell University in December 2021. He joined the Hershey Lab in June 2022 as a research assistant II. He will be involved in sample processing for the MPAACH and CREW studies as well as various other research projects. Outside of the lab, he enjoys travelling, music and eating good food.