Mersha Lab

Publications

Ye, Z; Harrar, SW; Beyene, J; Mersha, TB. Incorporating type 2 inflammation status with clinical diagnosis and transcriptomics data in asthma risk classification. Annals of Allergy, Asthma and Immunology. 2025; 135(3):329-332.

Mendy, A; Mersha, TB. Epigenetic age acceleration and mortality risk prediction in US adults. GeroScience. 2025; 47(4):6029-6038.

Zewale, TA; Wondmagegn, LY; Getahun, HA; Tariku, MK; Achamyeleh, AA; Asemahagn, MA; Enbiale, W; Mersha, TB; Muluneh, EK; Temesgen, AM. Trends of malaria incidence, prevalence, mortality, and disability-adjusted life years in Eastern Africa region from 1990 to 2021: a systematic analysis from Global Burden of Disease 2021 study. Malaria Journal. 2025; 24(1):207.

Aguree, S; Silveyra, P; Liu, N; Mersha, TB. Cardiometabolic and Inflammatory Profiles in Individuals With Asthma and Diabetes Comorbidity. Current Developments in Nutrition. 2025; 9:107006.

Tegegne, AS; Yenesew, MA; Asemahagn, MA; Mersha, TB; Deribew, A; Belete, MB; Mekonnen, A; Enquobahrie, DA; Awoke, W; Minas, TZ; Taye, B; Fentahun, N. Trends and spatio temporal distribution of HIV related programmatic indicators in North West Ethiopia from July 2018 up to June 2024. Scientific Reports. 2025; 15(1):15234.

Assa'ad, AH; Ding, L; Duan, Q; Mersha, TB; Warren, C; Bilaver, L; Ullrich, M; Wlodarski, M; Jiang, J; Choi, JJ; Tobin, MC; Mahdavinia, M; Sharma, H; Gupta, RS. Total Serum IgE in a Cohort of Children With Food Allergy. Journal of Allergy and Clinical Immunology: In Practice. 2025; 13(4):803-813.e3.

Derbie, A; Maier, M; Amare, B; Misgan, E; Nibret, E; Biadglegne, F; Liebert, UG; Minas, TZ; Yenesew, MA; Nigatu, D; Mersha, TB; Enquobahrie, DA; Woldeamanuel, Y; Abebe, T. HPV E6 and E7 mRNA Test for the Detection of High-Grade Cervical Lesions. JAMA Network Open. 2025; 8(2):e2459698.

Chang, WC; Burkle, JW; Williams, LR; Hammonds, MK; Weheba, FA; Satish, L; Martin, LJ; Guilbert, TW; Sherenian, MG; Mersha, TB; Biagini, JM; Khurana Hershey, GK. Race-Specific and Race-Neutral Equations for Lung Function and Asthma Diagnosis in Black Children. JAMA Network Open. 2025; 8(2):e2462176.

Alemu, R; Sharew, NT; Arsano, YY; Ahmed, M; Tekola-Ayele, F; Mersha, TB; Amare, AT. Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues. Human Genomics. 2025; 19(1):8.

Gautam, Y; Satish, L; Ramirez, S; Grashel, B; Biagini, JM; Martin, LJ; Rothenberg, ME; Khurana Hershey, GK; Mersha, TB. Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population. HGG Advances. 2024; 5(4):100350.

Correa-Agudelo, E; Ding, L; Beck, AF; Kahn, RS; Mersha, TB. Analyzing Racial Disparities in Pediatric Atopic Comorbidity Emergency Department Visitation Using Electronic Health Records. Journal of Allergy and Clinical Immunology: In Practice. 2024; 12(10):2826-2837.e10.

Correa-Agudelo, E; Ding, L; Beck, AF; Kahn, RS; Mersha, TB. Reply to ''Racial disparities in pediatric atopic comorbidity". Journal of Allergy and Clinical Immunology: In Practice. 2024; 12(10):2881-2882.

Dessie, EY; Ding, L; Satish, L; Mersha, TB. Co-Expression Network and Machine Learning Analysis of Transcriptomics Data Identifies Distinct Gene Signatures and Pathways in Lesional and Non-Lesional Atopic Dermatitis. Journal of Personalized Medicine. 2024; 14(9).

Folger, AT; Ding, L; Mersha, TB; Bowers, K. Community-level and maternal individual-level social support and offspring epigenetic aging. Annals of Epidemiology. 2024; 97:144.

Ko, E; Kim, Y; Shokoohi, F; Mersha, TB; Kang, M. SPIN: sex-specific and pathway-based interpretable neural network for sexual dimorphism analysis. Briefings in Bioinformatics. 2024; 25(4).

Kirenga, BJ; Chakaya, J; Yimer, G; Nyale, G; Haile, T; Muttamba, W; Mugenyi, L; Katagira, W; Worodria, W; Aanyu-Tukamuhebwa, H; Green, CL; De Jong, C; Kamya, M; Van Der Molen, T. The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project. Journal of Allergy and Clinical Immunology: Global. 2024; 3(2):100209.

Mendy, A; Burcham, S; Merianos, AL; Mersha, TB; Yolton, K; Chen, A; Mahabee-Gittens, EM. Urinary Volatile Organic Compound Metabolites Are Associated with Reduced Lung Function in U.S. Children and Adolescents. Toxics. 2024; 12(4).

Hardy, DS; Garvin, JT; Mersha, TB. Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity, and Cardiovascular Disease. Nutrients. 2024; 16(4).

Mersha, TB. From Mendel to multi-omics: shifting paradigms. European Journal of Human Genetics. 2024; 32(2):139-142.

Lennon, NJ; Kottyan, LC; Kachulis, C; Abul-Husn, NS; Arias, J; Belbin, G; Below, JE; Berndt, SI; Chung, WK; Cimino, JJ; Weng, C; Wiesner, GL; Yin, X; Kenny, EE. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations. Nature Medicine. 2024; 30(2):480-487.

Dessie, EY; Ding, L; Mersha, TB. Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function. Clinical Epigenetics. 2024; 16(1):15.

Correa-Agudelo, E; Gautam, Y; Mendy, A; Mersha, TB. Racial differences in length of stay and readmission for asthma in the all of us research program. Journal of Translational Medicine. 2024; 22(1):22.

Tewabe, DS; Azage, M; Wubetu, GY; Fenta, SA; Worke, MD; Asres, AM; Getnet, WA; Kassie, GG; Menber, Y; Munea, AM; Dadi, AF; Enquobahrie, DA; Frissa, SM; Geda, YE. Gender-based violence in the context of armed conflict in Northern Ethiopia. Conflict and Health. 2024; 18(1):1.

Proper, SP; Dwyer, AT; Appiagyei, A; Felton, JM; Ben-Baruch Morgenstern, N; Marlman, JM; Kotliar, M; Barski, A; Troutman, TD; Rothenberg, ME; Mersha, TB; Azouz, NP. Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis. Frontiers in Allergy. 2024; 5:1323405.

Yenesew, MA; Krell-Roesch, J; Fekadu, B; Nigatu, D; Endalamaw, A; Mekonnen, A; Biyadgie, M; Wubetu, GY; Debiso, AT; Beyene, KM; Kelkile, TS; Enquobahrie, DA; Mersha, TB; Eagan, DE; Geda, YE. Prevalence of Dementia and Cognitive Impairment in East Africa Region: A Scoping Review of Population-Based Studies and Call for Further Research. Journal of Alzheimer's Disease. 2024; 100(4):1121-1131.

Ghosh, D; Mersha, TB. Atopic dermatitis and ocular allergy: common mechanisms and uncommon questions. Current Opinion in Allergy and Clinical Immunology. 2023; 23(5):383-389.

Dessie, EY; Gautam, Y; Ding, L; Altaye, M; Beyene, J; Mersha, TB. Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods. Scientific Reports. 2023; 13(1):11279.

Phelan, KJ; Dill-Mcfarland, KA; Kothari, A; Segnitz, RM; Burkle, J; Grashel, B; Jenkins, S; Spagna, D; Martin, LJ; Haslam, DB; Jackson, DJ; Mersha, TB; Altman, MC; Khurana Hershey, GK. Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children. Journal of Allergy and Clinical Immunology. 2023; 152(1):73-83.

Correa-Agudelo, E; Beck, AF; Mersha, TB. Racial differences in emergency encounters related to pediatric allergic diseases during the COVID-19 pandemic. Journal of Allergy and Clinical Immunology: In Practice. 2023; 11(7):2232-2234.e1.

Correa-Agudelo, E; Ding, L; Beck, AF; Mendy, A; Mersha, TB. Multilevel Analysis of Racial and Ethnic Disparities in COVID-19 Hospitalization among Children with Allergies. Annals of the American Thoracic Society. 2023; 20(6):843-853.

Gautam, Y; Caldwell, J; Kottyan, L; Chehade, M; Dellon, ES; Rothenberg, ME; Mersha, TB. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. Journal of Allergy and Clinical Immunology. 2023; 151(5):1337-1350.

Devonshire, A; Gautam, Y; Johansson, E; Mersha, TB. Multi-omics profiling approach in food allergy. World Allergy Organization Journal. 2023; 16(5):100777.

Linder, JE; Allworth, A; Bland, HT; Caraballo, PJ; Chisholm, RL; Clayton, EW; Crosslin, DR; Dikilitas, O; Divietro, A; Esplin, ED; Weng, C; Wiesner, GL; Wiley, K; Peterson, JF. Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genetics in Medicine. 2023; 25(4):100006.

Gautam, Y; Mersha, TB. Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population. Thorax. 2023; 78(3):220-221.

Pennington, J; Rasnick, E; Martin, LJ; Biagini, JM; Mersha, TB; Parsons, A; Khurana Hershey, GK; Ryan, P; Brokamp, C. Racial Fairness in Precision Medicine: Pediatric Asthma Prediction Algorithms. American Journal of Health Promotion. 2023; 37(2):239-242.

Hardy, DS; Garvin, JT; Mersha, TB. Analysis of ancestry-specific polygenic risk score and diet composition in type 2 diabetes. PLoS ONE. 2023; 18(5):e0285827.

Correa-Agudelo, E; Ding, L; Beck, AF; Brokamp, C; Altaye, M; Kahn, RS; Mersha, TB. Understanding racial disparities in childhood asthma using individual- and neighborhood-level risk factors. Journal of Allergy and Clinical Immunology. 2022; 150(6):1427-1436.e5.

Mendy, A; Burcham, S; Merianos, AL; Mersha, TB; Mahabee-Gittens, EM; Chen, A; Yolton, K. Urinary volatile organic compound metabolites and reduced lung function in U.S. adults. Respiratory Medicine. 2022; 205:107053.

Namjou, B; Lape, M; Malolepsza, E; Devore, SB; Weirauch, MT; Dikilitas, O; Jarvik, GP; Kiryluk, K; Kullo, IJ; Liu, C; Biagini, JM; Khurana Hershey, GK; Martin, LJ; Kottyan, L. Multiancestral polygenic risk score for pediatric asthma. Journal of Allergy and Clinical Immunology. 2022; 150(5):1086-1096.

Ghosh, D; Mersha, TB. Publicly available cytokine data: Limitations and opportunities. Journal of Allergy and Clinical Immunology. 2022; 150(5):1053-1056.

Mendy, A; Merianos, AL; Mersha, TB; Mahabee-Gittens, EM. Blood volatile organic compounds associated with non-reversible and reversible airflow obstruction in US adults. European Respiratory Journal. 2022; 60(5).

Parikh, MN; Brokamp, C; Rasnick, E; Ding, L; Mersha, TB; Bowers, K; Folger, AT. Epigenome-wide association of neonatal methylation and trimester-specific prenatal PM2.5 exposure. Environmental Epidemiology. 2022; 6(5):e227.

Mendy, A; Mersha, TB. Comorbidities in childhood-onset and adult-onset asthma. Annals of Allergy, Asthma and Immunology. 2022; 129(3):327-334.

Cao, X; Ding, L; Mersha, TB. Development and validation of an RNA-seq-based transcriptomic risk score for asthma. Scientific Reports. 2022; 12(1):8643.

Cao, X; Ding, L; Mersha, TB. Development and validation of an RNA-seq-based transcriptomic risk score for asthma. Scientific Reports. 2022; 12(1).

Stevens, ML; Mersha, TB; Zhang, Z; Kothari, A; Khurana Hershey, GK. Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile. Human Molecular Genetics. 2022; 31(10):1588-1598.

Dadi, AF; Mersha, TB. WHO's surveillance system for attacks on health care is failing Ethiopia. The Lancet. 2022; 399(10331):1225-1226.

Masebo, TM; Fikadu, BK; Mehari, E; Gelaye, B; Habte, A; Mersha, TB; Begna, K. The need for rigour and balance in reporting the health impacts of conflict in Tigray, Ethiopia. BMJ Global Health. 2022; 7(3).

Roman, YM; Mcclish, D; Price, ET; Sabo, RT; Woodward, OM; Mersha, TB; Shah, N; Armada, A; Terkeltaub, R. Cardiometabolic genomics and pharmacogenomics investigations in Filipino Americans: Steps towards precision health and reducing health disparities. American Heart Journal Plus. 2022; 15.

Kang, M; Ko, E; Mersha, TB. A roadmap for multi-omics data integration using deep learning. Briefings in Bioinformatics. 2022; 23(1).

Gautam, Y; Johansson, E; Mersha, TB. Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm. Journal of Personalized Medicine. 2022; 12(1).

Adejare, AA; Gautam, Y; Madzia, J; Mersha, TB. Unraveling racial disparities in asthma emergency department visits using electronic healthcare records and machine learning. Journal of Asthma. 2022; 59(1):79-93.

Hershey, GKK; Sherenian, MG; Mersha, TB. 2 Precision Medicine. In: Allergy Essentials. Elsevier; 2022:25-39.

Mendy, A; Wu, X; Keller, JL; Fassler, CS; Apewokin, S; Mersha, TB; Xie, C; Pinney, SM. Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients. Respirology. 2021; 26(12):1181-1187.

Mersha, TB; Qin, K; Beck, AF; Ding, L; Huang, B; Kahn, RS. Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors. Journal of Allergy and Clinical Immunology. 2021; 148(5):1210-1218.e4.

Chidambaran, V; Mersha, TB. A step towards understanding disparities - linking race, ancestry, epigenetics and pain. Epigenomics. 2021; 13(22):1791-1796.

Johansson, E; Mersha, TB. Genetics of Food Allergy. Immunology and Allergy Clinics of North America. 2021; 41(2):301-319.

Hardy, DS; Racette, SB; Garvin, JT; Gebrekristos, HT; Mersha, TB. Ancestry specific associations of a genetic risk score, dietary patterns and metabolic syndrome: a longitudinal ARIC study. BMC Medical Genomics. 2021; 14(1):118.

Correa-Agudelo, E; Mersha, TB; Branscum, AJ; Mackinnon, NJ; Cuadros, DF. Identification of Vulnerable Populations and Areas at Higher Risk of COVID-19-Related Mortality during the Early Stage of the Epidemic in the United States. International Journal of Environmental Research and Public Health. 2021; 18(8).

Mersha, TB; Afanador, Y; Johansson, E; Proper, SP; Bernstein, JA; Rothenberg, ME; Khurana Hershey, GK. Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. Clinical Reviews in Allergy and Immunology. 2021; 60(2):200-219.

Brandt, EB; Mersha, TB. Environmental Determinants of Coronavirus Disease 2019 (COVID-19). Current Allergy and Asthma Reports. 2021; 21(3):15.

Mendy, A; Wu, X; Keller, JL; Fassler, CS; Apewokin, S; Mersha, TB; Xie, C; Pinney, SM. Long-term exposure to fine particulate matter and hospitalization in COVID-19 patients. Respiratory Medicine. 2021; 178:106313.

Jones, DE; Park, JS; Gamby, K; Bigelow, TM; Mersha, TB; Folger, AT. Mental Health Epigenetics: A Primer With Implications for Counselors. Professional counselor. 2021; 11(1):102-121.

Proper, SP; Azouz, NP; Mersha, TB. Achieving Precision Medicine in Allergic Disease: Progress and Challenges. Frontiers in Immunology. 2021; 12:720746.

Beyene, J; Harrar, SW; Altaye, M; Astatkie, T; Awoke, T; Shkedy, Z; Mersha, TB. A Roadmap for Building Data Science Capacity for Health Discovery and Innovation in Africa. Frontiers in Public Health. 2021; 9:710961.

Enquobahrie, DA; Tekola-Ayele, F; Mersha, TB. Editorial: Genetic and Epigenetic Insights Into the Developmental Origins of Health and Disease. Frontiers in Genetics. 2021; 12:814126.