• Identifying neural signatures of juvenile chronic pain conditions

    Our large, adequately powered, study will leverage clinical methods (phenotyped cohort; treatments) and infrastructure of Dr. Kashikar-Zuck’s clinical trial (“Multisite Randomized Clinical Trial of FIT Teens for JFM”, R01AR070474) to identify neurophysiological mechanisms linked to the comprehensively characterized profile of pain symptoms, psychological and physical functioning in a large sample of JFM patients. If successful, the products of this work may be used to help understanding treatment mechanisms and tailoring intervention strategies for individual JFM patients as a function of underlying pathophysiology.
  • Distinguishing primary pain pathologies from primary depression and anxiety

  • Understanding the effects of social support and altruistic behavior as significant analgesic tools