The Redington lab has recently moved from Toronto, and will be continuing its work investigating myocardial ischemia-reperfusion injury, particularly as it relates to the phenomenon of remote ischemic conditioning (RIC).

Remote Ischemic Conditioning (RIC) Research

This interesting phenomenon (inducing myocardial protection using transient limb ischemia) was first reported by our lab and our collaborators in 2001, and has already translated into clinical trials. We have shown that RIC can limit, acutely, the reperfusion injury associated with treatment for myocardial infarction (MI). We’ve also demonstrated that RIC can abrogate adverse left ventricular remodeling when delivered daily after MI. However, its mechanisms of action have yet to be fully elucidated.

Future Research Efforts

The lab recently reported microRNA-144 as an effector of the acute and delayed cardioprotection associated with RIC. Our future work will concentrate on the biology of mir-144, particularly as it relates to the modification of post-MI remodeling.