Cardiology

Redington Lab

Redington Research Lab

The Redington lab has recently moved from Toronto, and will be continuing its work investigating myocardial ischemia-reperfusion injury, particularly as it relates to the phenomenon of remote ischemic conditioning (RIC).

Remote Ischemic Conditioning (RIC) Research

This interesting phenomenon (inducing myocardial protection using transient limb ischemia) was first reported by our lab and our collaborators in 2001, and has already translated into clinical trials. We have shown that RIC can limit, acutely, the reperfusion injury associated with treatment for myocardial infarction (MI). We’ve also demonstrated that RIC can abrogate adverse left ventricular remodeling when delivered daily after MI. However, its mechanisms of action have yet to be fully elucidated.

Future Research Efforts

The lab recently reported microRNA-144 as an effector of the acute and delayed cardioprotection associated with RIC. Our future work will concentrate on the biology of mir-144, particularly as it relates to the modification of post-MI remodeling.

 

Publications

Grants

2014/03/01-2017/02/28
MOP133469, Canadian Institute of Health Research
Redington, Andrew (PI)
The role of miR-144 in the cardioprotection associated with remote pre-conditioning

2012/03/01-2016/03/31
MOP123355, Canadian Institute of Health Research
Redington, Andrew (PI)
A proof of Principal Randomized Controlled Trial of Chronic Remote Ischemic Conditioning to Modify post-MI remodeling

2013/03/01-2016/02/28
MOP125947, Canadian Institute of Health Research
Redington, Andrew (PI)
TLR4 signaling in acute and chronic responses to remote ischemic conditioning

Contact Us

Andrew Redington, MD's head shot photo.
Andrew Redington, MD
Executive Co-Director, Heart Institute; Chief, Pediatric Cardiology
Professor, UC Department of Pediatrics

 Email: andrew.redington@cchmc.org

Postdoctoral Position Available

Our lab has an open position for a recent PhD graduate with a strong publication record and special interest in cardioprotection/ischemia-reperfusion injury. To apply for the position, send (via email) a current CV, a research statement briefly describing past work and current interests, and the names of at least three references with contact information.