Publications from the Cincinnati Center for Eosinophilic Disorders
Pfefferle M, Stojkov D, Simon D, Gueguen E, Wawrzyniak M, Collins MH, Chehade M, Dellon ES, Furuta GT, Hirano I, Gonsalves N, Moawad FJ, Biedermann L, Schoepfer AM, Straumann A, Simon HU, Greuter T. Molecular Characterization of Non-Specific Esophagitis Reveals a Distinct Non-Eosinophilic Phenotype With Fibrotic Traits. Allergy. 2026 May 1. doi: 10.1111/all.70364. PMID: 42067399.
Azouz NP, Klingler AM, Beach SS, Rossey KA, Rochman M, Paul M, Caldwell JM, Brusilovsky M, Dwyer AT, Chen X, Miller D, Forney C, Kottyan LC, Weirauch MT, Rothenberg ME. IL-13 and calpain-14 suppress the expression of SPINK7 by regulating OVOL1 in eosinophilic esophagitis. JCI Insight. 2026 Apr 28:e204687. doi: 10.1172/jci.insight.204687. Epub ahead of print. PMID: 42048165.
Reigle J, Liu X, Lopez-Nunez O, Drysdale E, Qtaish D, Walters TD, Mack D, Boyle BM, Kugathasan S, Denson N, Erdman L, Prasath S, Collins MH, Hyams JS, Denson LA, Griffiths AM, Siddiqui I, Dhaliwal J. Automated Eosinophil Quantification Using Deep Learning to Predict Therapy Escalation in Pediatric Ulcerative Colitis. Clin Transl Gastroenterol. 2026 Apr 27. doi: 10.14309/ctg.0000000000001031. PMID: 42044208.
Lim WK, Wipperman MF, Rothenberg ME, Collins MH, Hamon SC, Chehade M, Spergel JM, Gayvert KM, Ehmann PJ, Horowitz JE, Farrell AB, Dellon ES, Maloney J, Radin A, Louisias M, Wolfe K, Akinlade B, Ajithdoss DK, Herman G, Yancopoulos GD, Hamilton JD. Dupilumab normalizes the eosinophilic esophagitis disease transcriptome. J Allergy Clin Immunol. 2026 Apr 22:S0091-6749(26)00263-0. doi: 10.1016/j.jaci.2026.01.033. PMID: 42031097.
Schwartz J, Pilipenko V, He H, Bolton S, Collins MH, Felton JM, Oswald GA, Zehnder LJ, Kemtur P, Mukkada VA, Martin LJ, Rothenberg ME, Zhang S. Peripheral blood markers of pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2026 Apr;157(4):1002-1005. doi: 10.1016/j.jaci.2026.01.013. PMID: 41711613.
Chang WC, Martin LJ, Satish L, Williams L, Hammonds M, Jenkins S, Osswald G, Caldwell J, Rothenberg ME, Khurana Hershey GK, Biagini JM. Longitudinal enrichment of eosinophilic esophagitis in children with AD: The MPAACH cohort. J Allergy Clin Immunol. 2026 Apr;157(4):999-1001. doi: 10.1016/j.jaci.2026.01.012. PMID: 41665573.
Trimarchi MP, Namjou-Khales B, Ben-Baruch Morgenstern N, Rochman M, Chen X, Osswald GA, Besse JA, Shook MS, Caldwell JM, Lape M, Shoda T, Weirauch MT, Ruffner MA, Constantine GM, Martin LJ, Kottyan LC, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators. Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores. J Allergy Clin Immunol. 2026 Mar 20:S0091-6749(26)00194-6. doi: 10.1016/j.jaci.2026.03.008. PMID: 41865802.
Dellon ES, Katzka DA, Mukkada VA, Falk GW, Tahir MJ, Gugiu PC, Blau J, Terreri B. Effect of Budesonide Oral Suspension on Time to First Dysphagia Symptom Response and Dysphagia Symptom Resolution Outcomes in Patients With Eosinophilic Esophagitis. J Gastroenterol Hepatol. 2026 Mar;41(3):927-936. doi: 10.1111/jgh.70205. PMID: 41711386; PMCID: PMC12969252.
Dellon ES, Falk GW, Katzka DA, Lightdale J, Muir AB, Bredenoord AJ, Bailey DD, Chang JW, Furuta GT, Gonsalves N, Greuter T, Gupta SK, Hiremath G, Horsley-Silva JL, Lucendo AJ, Lynch KL, Menard-Katcher C, Moawad F, Oliva S, Peterson KA, Philpott H, Putnam PE, Schoepfer AM, Snyder DL, Straumann A, Wechsler JB, Sharma P. American Society for Gastrointestinal Endoscopy consensus recommendations on the endoscopic management of eosinophilic esophagitis-part 2: disease assessment, monitoring, and pediatric considerations. Gastrointest Endosc. 2026 Mar;103(3):396-417. doi: 10.1016/j.gie.2025.10.032. PMID: 41504688.
Sharlin CS, Yamada S, Maekawa Y, Osonoi K, Matsuyama K, Osswald GA, Rochman M, Taylor RJ, Yamaguchi M, Tanaka Y, Wen T, Dellon ES, Rothenberg ME, Shoda T. Effects of proton pump inhibitors on remodeling and fibrosis in eosinophilic esophagitis. J Allergy Clin Immunol. 2026 May;157(5):1114-1126. doi: 10.1016/j.jaci.2026.02.025. PMID: 41765110.
Rochman M, Rothenberg ME. Immune functions of the esophagus. J Allergy Clin Immunol. 2026 Feb;157(2):316-328. doi: 10.1016/j.jaci.2025.12.001. PMID: 41386478; PMCID: PMC12805589.
Mahoney LB, Lightdale JR, Rubinstein E, Carman N, Kim J, Altaf MA, Bhardwaj V, Bolton SM, CaJacob N, Chiou E, Khalili AS, Koral A, Krasaelap A, Leinwand KL, Lerner DG, Mark JA, Mukkada VA, Nguyen N, Pitman RT, Ramraj R, Ryan MJ, Sabe R, Schroeder S, Thavamani A, Vaidy K, Venkatesh RD, Wechsler JB, Walsh CM. Assessing competence in unsedated transnasal endoscopy: Development of the TransNasal Endoscopy Skills Assessment Tool. J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):858-866. doi: 10.1002/jpn3.70323. PMID: 41502083.
Ketchem CJ, Gabryszewski SJ, Rothenberg ME. Artificial intelligence in the detection and management of eosinophilic gastrointestinal diseases: Applications, challenges, and future outlook. J Allergy Clin Immunol. 2026 Jan;157(1):56-58. doi: 10.1016/j.jaci.2025.08.020. PMID: 40914297; PMCID: PMC12543360.
Caldwell JM, Ballaban AY, Li J, Maddux R, Harris S, Dellon ES, Rothenberg ME. Cendakimab (anti-IL-13) administration improves esophageal gene expression in eosinophilic esophagitis. J Allergy Clin Immunol. 2026 Jan;157(1):118-130.e7. doi: 10.1016/j.jaci.2025.08.032. PMID: 41067281.
