Pediatric Sepsis and Precision Therapeutics
Projects within the Kaplan lab seek to investigate critical mechanisms in pediatric sepsis and provide precision therapeutics to improve outcomes in critically ill patients.
Current Projects
Lab Projects (3)
Role of STAT3 in Sepsis-Induced Adipose Tissue Browning
Investigating the molecular mechanisms by which STAT3 signaling contributes to adipose tissue browning and inflammation in pediatric sepsis.
This work is supported by an NIH R01GM126551 award.
Precision Dosing of Beta-Lactam Antibiotics in Critically Ill Children
Developing pharmacometric models to optimize beta-lactam antibiotic dosing in pediatric patients, aiming to improve therapeutic outcomes and reduce resistance.
This work is supported by NIGMS R35 Maximizing Investigator Research Award to Dr. Tang Girdwood.
Project Collaborators
Biobank of Small Extracellular Vesicles in Pediatric Sepsis
In collaboration with Dr. Basilia Zingarelli, we are establishing a biobank of extracellular vesicles from pediatric sepsis patients to study their role in disease progression and potential as biomarkers.
This work is supported by NIH R33GM151734.
Project Collaborators
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