I chose to specialize in hospital medicine because it allows me to collaborate with other subspecialties in the care of pediatric patients. I enjoy the acute-care aspect of hospital medicine and have the opportunity to develop relationships with the families of children with medically complex illnesses admitted to our inpatient unit.
Early on, I realized information regarding appropriate drug dosing in medically complex or critically ill children was lacking. So, my research explores how to personalize the dosing of antibiotics and other medications in critically ill patients and patients with complex diseases.
I focus on the pharmacokinetics and pharmacodynamics of antibiotics, specifically beta-lactams, in critically ill children. Additionally, I strive to better understand the timely transition of intravenous to enteral antibiotics in hospitalized children. Today, my clinical work informs my research so that any newly discovered information can impact my patient’s care.
As a clinical fellow, I received several notable awards, including:
As a faculty member, in addition to serving on the American Society of Clinical Pharmacology and Therapeutics Career Development Committee, I am also a member of their Scientific Programming Committee for the national conference. Locally, I am a co-director of the Genetic Pharmacology Service and the T32 Pediatric Clinical Pharmacology Fellowship.
During my first two years on faculty, I was supported by the National Institute of Child Health and Human Development (NICHD) K12 Child Health Research Career Development Award to study the impact of piperacillin/tazobactam pharmacokinetics on kidney injury. I’m currently funded by a National Institute of General Medicine Sciences (NIGMS) R35 Maximizing Investigators' Research Award to continue building the evidence of precision dosing of antibiotics in critically ill children.
BS: Massachusetts Institute of Technology, Cambridge, MA, 2004.
MD: Johns Hopkins University, Baltimore, MD, 2013.
PhD: Johns Hopkins University, Baltimore, MD, 2013.
Residency: Cincinnati Children's, Cincinnati, OH, 2016.
Chief Residency: Cincinnati Children's, Cincinnati, OH, 2017.
Fellowship: Pediatric Hospital Medicine & T32 NICHD Clinical Pharmacology, Cincinnati Children's, Cincinnati, OH, 2020.
Hospital medicine; complex care inpatient team
Pediatric clinical pharmacology; sepsis; model-informed precision dosing; IV to enteral antibiotic transition
Building a Beta-Lactam Model-Informed Precision Dosing Service in a Quaternary Care Children's Hospital. Clinical and Translational Science. 2025; 18:e70438.
Precision Dosing of Meropenem in a Neonate on CARPEDIEM Dialysis: A Grand Round. Therapeutic Drug Monitoring. 2025; 47:701-704.
Oral Cephalexin Population Pharmacokinetics and Target Attainment Analysis in Infants 7-60 Days Old. Journal of the Pediatric Infectious Diseases Society. 2025; 14:piaf088.
The influence of intergenerational trauma in families of Chinese descent on perceptions of microaggressions. Journal of hospital medicine (Online). 2025; 20:1127-1129.
Piperacillin Pharmacokinetics in a Pediatric Patient With Primary Hyperoxaluria Receiving High-Dose Continuous Dialysis Post Liver-Kidney Transplant. Journal of Pediatric Pharmacology and Therapeutics. 2025; 30:673-679.
Complexity in assessing acute kidney injury and cefepime exposure in critically ill patients. Pediatric Nephrology. 2025; 40:2101-2102.
Empowering Early-Career Scientists: Opportunities Through ASCPT Programs, Networks, and Communities. Clinical Pharmacology and Therapeutics. 2025; 117:1495-1498.
Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64:553-564.
Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients. Antimicrobial Agents and Chemotherapy. 2025; 69:e0122724.
Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40:513-521.
Sonya Tang Girdwood, MD, PhD3/9/2022
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