I chose to specialize in hospital medicine because it allows me to collaborate with other subspecialties in the care of pediatric patients. I enjoy the acute-care aspect of hospital medicine and have the opportunity to develop relationships with the families of children with medically complex illnesses admitted to our inpatient unit.
Early on, I realized information regarding appropriate drug dosing in medically complex or critically ill children was lacking. So, my research explores how to personalize the dosing of antibiotics and other medications in critically ill patients and patients with complex diseases.
I focus on the pharmacokinetics and pharmacodynamics of antibiotics, specifically beta-lactams, in critically ill children. Additionally, I strive to better understand the timely transition of intravenous to enteral antibiotics in hospitalized children. Today, my clinical work informs my research so that any newly discovered information can impact my patient’s care.
As a clinical fellow, I received several notable awards, including:
As a faculty member, in addition to serving on the American Society of Clinical Pharmacology and Therapeutics Career Development Committee, I am also a member of their Scientific Programming Committee for the national conference. Locally, I am a co-director of the Genetic Pharmacology Service and the T32 Pediatric Clinical Pharmacology Fellowship.
During my first two years on faculty, I was supported by the National Institute of Child Health and Human Development (NICHD) K12 Child Health Research Career Development Award to study the impact of piperacillin/tazobactam pharmacokinetics on kidney injury. I’m currently funded by a National Institute of General Medicine Sciences (NIGMS) R35 Maximizing Investigators' Research Award to continue building the evidence of precision dosing of antibiotics in critically ill children.
BS: Massachusetts Institute of Technology, Cambridge, MA, 2004.
MD: Johns Hopkins University, Baltimore, MD, 2013.
PhD: Johns Hopkins University, Baltimore, MD, 2013.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.
Chief Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2017.
Fellowship: Pediatric Hospital Medicine & T32 NICHD Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2020.
Hospital medicine; complex care inpatient team
Hospital Medicine, Genetic Pharmacology, Genetic Pharmacology Service
Pediatric clinical pharmacology; sepsis; model-informed precision dosing; IV to enteral antibiotic transition
Clinical Pharmacology
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment. Journal of Intensive Care. 2024; 12:38.
Optimizing Piperacillin Dosing in Pediatric Liver Transplant Recipients: A Case Series. Pediatric Transplantation. 2024; 28:e14860.
Identifying optimal dosing strategies for meropenem in the paediatric intensive care unit through modelling and simulation. Journal of Antimicrobial Chemotherapy. 2024; 79:2668-2677.
Impact of fluid balance on beta-lactam antibiotics target attainment: Insights from a simulation-based meropenem study. International Journal of Antimicrobial Agents. 2024; 64:107267.
From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education. Clinical Pharmacology and Therapeutics. 2024; 116:515-517.
Cystatin C Outperforms Creatinine in Predicting Cefepime Clearance in Pediatric Stem Cell Transplant Recipients. Transplantation and Cellular Therapy. 2024; 30:614.e1-614.e11.
Ceftriaxone Pharmacokinetics and Pharmacodynamic Target Attainment for Three Pediatric Patients Receiving Continuous Kidney Replacement Therapy. Journal of Pediatric Pharmacology and Therapeutics. 2024; 29:180-187.
Piperacillin pharmacokinetics and pharmacodynamics in paediatric patients who received high frequency intra-operative piperacillin/tazobactam dosing. International Journal of Antimicrobial Agents. 2024; 63:107079.
Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid. JAMA network open. 2024; 7:e2355707.
Cefepime-Associated Neurotoxicity in a Pediatric Patient With Stage V Chronic Kidney Disease. Journal of Pharmacy Practice. 2024; 37:243-247.
Sonya Tang Girdwood, MD, PhD3/9/2022
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