Genetic Pharmacology

Personalized Medicine Through Pharmacogenetics

Genetic Pharmacology Service logo.Scientific evidence indicates that pharmacogenetics − the study of drug interactions with an individual's genetic makeup − may improve patient safety.

Pharmacogenetic testing for some medications adds genetic information to the usual considerations of patient age, weight, disease process, use of other medications, health behaviors and environment.

The additional information gained from pharmacogenetics can help physicians and nurse practitioners choose and dose medication that best meets the needs of the individual patient.

Benefits of Pharmacogenetics

Pharmacogenetics uses molecular testing to analyze certain genes. A pharmacogenetic test can predict how a patient will metabolize a drug, allowing the clinician to adjust dosages for individual patients to get maximum efficacy from a drug with minimum side effects.

Helping Physicians Prescribe the Best Dose of the Best Medications

Our goal is to provide prescribing clinicians with state-of-the-art information to improve the effectiveness and safety of the medications they prescribe for your child. We achieve this goal through a comprehensive approach:

  • Rapid (two-day) pharmacogenetic testing
  • Education
  • Reports with dose recommendations, if applicable
  • Reports with important drug-drug interactions that can alter metabolism
  • Pharmacology consults as requested

Our service offers a number of unique features:

  • Tests ordered by gene or gene panel
  • Assistance with specimen transport (free within the Cincinnati metropolitan area)
  • Results from blood and cytobrush specimens are faxed in two business days
  • Genotype results stored in a safeguarded database that can be used for interpretation when your patient requires a different drug metabolized by the same enzyme
  • Interpretation from internationally recognized experts in clinical pharmacology and molecular genetics

Tests Offered

We offer genetic pharmacogenetic tests for drugs metabolized by major cytochrome (CYP) P450 drug metabolizing enzymes (CYP2D6, CYP2C9, CYP2C19, CYP3A5) and TPMT. Tests offered

Test Requisition Form

Download the test requisition form for the Genetic Pharmacology Service in the Molecular Genetics Laboratory at Cincinnati Children's.

Molecular Genetics Lab

The GPS works with the Molecular Genetics Lab to provide state-of-the-art testing with comprehensive interpretation of test results by experts. Read More