Genetic Pharmacology
Test and Drug Information

The Genetic Pharmacology Service for children and adults offers a comprehensive pharmacogenetics panel for many commonly prescribed psychiatry medications.

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Comprehensive Pharmacogenetics Panel, which analyzes CYP2C19, CYP2C9, CYP2D6, CYP3A5, NUDT15 and TPMT, is ordered at Cincinnati Children’s.

  • 6-mercaptopurine
  • 6-thioguanine
  • amitriptyline
  • aripiprazole
  • atomoxetine
  • azathioprine
  • citalopram
  • clomipramine
  • codeine
  • desipramine
 
  • doxepin
  • escitalopram
  • fluvoxamine
  • hydrocodone
  • imipramine
  • nortriptyline
  • paroxetine
  • perphenazine
  • sertraline
  • tacrolimus
 
  • thioridazine
  • tramadol
  • trimipramine
  • venlafaxine
  • voriconizole
 
The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for the immunosuppressant tacrolimus.

The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for many commonly prescribed psychiatry medications.

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Psychiatry Pharmacogenetics Expanded Panel is ordered at Cincinnati Children’s.

  • amitriptyline
  • aripiprazole
  • atomoxetine
  • citalopram
  • clomipramine
  • desipramine
  • doxepin
  • escitalopram
 
  • fluvoxamine
  • imipramine
  • nortriptyline
  • paroxetine
  • perphenazine
  • sertraline
  • thioridazine
  • trimipramine
 
  • venlafaxine
 

The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for many commonly prescribed opioids.

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Opioid CYP2D6 Pharmacogenetics Panel is ordered at Cincinnati Children’s. 

  • codeine
  • tramadol
 
  • hydrocodone
  • oxycodone
 
The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for three commonly prescribed thiopurines.
 

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Thiopurine Pharmacogenetics Analysis (TPMT/NUDT15) test is ordered at Cincinnati Children’s. 

  • azathioprine
  • cyclosporine
  • mercaptopurine
  • sirolimus
  • tacrolimus
  • thioguanine

Genotyping only tests are available for:

  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP2D6 / CYP2C19

An individual drug test is available for warfarin (CYP2C9 & VKORC1). 

Drug Information

The tables below list many commonly prescribed drugs that are metabolized through major cytochrome (CYP) P450 drug metabolizing enzymes (CYP2D6, CYP2C9, CYP2C19, CYP3A5) and drugs metabolized by TPMT/NUDT15.
  • 6-mercaptopurine  
  • 6-thioguanine  
  • amitriptyline  
  • aripiprazole
  • atomoxetine  
  • azathioprine  
  • carvedilol  
  • celecoxib
  • citalopram
  • clomipramine  
  • codeine  
 
  • desipramine  
  • doxepin
  • escitalopram
  • flecainide    
  • fluvastatin
  • fluvoxamine  
  • glimepiride  
  • glipizide  
  • glyburide 
  • imipramine
  • lansoprazole
 
  • losartan 
  • metoprolol 
  • nortriptyline 
  • omeprazole 
  • pantoprazole 
  • paroxetine
  • perphenazine
  • phenytoin
  • propafenone
  • sertraline
  • tacrolimus
 
  • thioridazine
  • tolbutamide 
  • trimipramine 
  • venlafaxine 
  • warfarin  
 
  • Abilify
  • Amaryl  
  • Anafranil  
  • Celebrex
  • Celexa
  • Codeine products  
  • Coreg  
  • Coumadin  
  • Cozaar  
  • DiaBeta  
  • Dilantin
  • Effexor 
 
  • Elavil  
  • Glucotrol  
  • Glynase   
  • Imuran  
  • Lescol
  • Lexapro
  • Lopressor  
  • Luvox  
  • Mellaril
  • Micronase
  • Norpramin 
  • Orinase
 
  • Pamelor 
  • Paxil 
  • Pexeva 
  • Phenytek 
  • Prevacid 
  • Prilosec 
  • Prograf
  • Protonix 
  • Purinethol
  • Rythmol
  • Sinequan
  • Strattera
 
  • Rythmol  
  • Sinequan  
  • Strattera  
  • Surmontil  
  • Tambocor  
  • Tofranil  
  • Toprol 
  • Zoloft