Genetic Pharmacology

Genetic Pharmacology | Test and Drug Information

Customized Patient Care Through Pharmacogenetics

The Genetic Pharmacology Service for children and adults uses pharmacogenetics to help clinicians customize patient care. We offer pharmacogenetic tests for drugs significantly metabolized by major cytochrome (CYP) P450 drug metabolizing enzymes (CYP2D6, CYP2C9, CYP2C19, CYP3A5) and drugs metabolized by TPMT. 

> Download the Genetic Pharmacology Service test requisition.

> Download the Genetic Pharmacology Service report references.

The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for many commonly prescribed psychiatry medications.

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Psychiatry Pharmacogenetics Expanded Panel is ordered at Cincinnati Children’s.

  • Amitriptyline
  • Aripiprazole
  • Atomoxetine
  • Citalopram
  • Clomipramine
  • Desipramine
  • Doxepin
  • Escitalopram
 
  • Fluoxetine
  • Fluvoxamine
  • Haloperidol
  • Imipramine
  • Maprotiline
  • Nortriptyline
  • Olanzapine
  • Paroxetine
 
  • Perphenazine
  • Risperidone
  • Sertraline
  • Thioridazine
  • Trimipramine
  • Venlafaxine
 

The Genetic Pharmacology Service for children and adults offers a pharmacogenetics panel for many commonly prescribed opioids.

The table below lists the medications for which general dosing recommendations will be made when a Genetic Pharmacology Service’s Opioid CYP2D6 Pharmacogenetics Panel is ordered at Cincinnati Children’s. 

  • Codeine
  • Tramadol
 
  • Hydrocodone
  • Oxycodone
 

Genotyping only tests are available for:

  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP2D6 / CYP2C19
  • TPMT

An individual drug test is available for warfarin (CYP2C9 & VKORC1). 

Drug Information

The tables below list many commonly prescribed drugs that are metabolized through major cytochrome (CYP) P450 drug metabolizing enzymes (CYP2D6, CYP2C9, CYP2C19, CYP3A5) and drugs metabolized by TPMT.
  • 6-mercaptopurine  
  • 6-thioguanine  
  • amitriptyline  
  • aripiprazole
  • atomoxetine  
  • azathioprine  
  • carvedilol  
  • celecoxib
  • citalopram
  • clomipramine  
  • codeine  
 
  • desipramine  
  • doxepin
  • escitalopram
  • flecainide  
  • fluoxetine  
  • fluvastatin
  • fluvoxamine  
  • glimepiride  
  • glipizide  
  • glyburide  
  • haloperidol  
 
  • imipramine  
  • lansoprazole  
  • losartan  
  • maprotiline  
  • metoprolol  
  • nortriptyline  
  • olanzapine
  • omeprazole  
  • pantoprazole  
  • paroxetine
  • perphenazine 
 
  • phenytoin  
  • propafenone  
  • risperidone
  • sertraline
  • tacrolimus
  • tamoxifen  
  • thioridazine
  • tolbutamide  
  • trimipramine  
  • venlafaxine  
  • warfarin  
 
  • Abilify
  • Amaryl  
  • Anafranil  
  • Celebrex
  • Celexa
  • Codeine products  
  • Coreg  
  • Coumadin  
  • Cozaar  
  • DiaBeta  
  • Dilantin
  • Effexor 
 
  • Elavil  
  • Glucotrol  
  • Glynase  
  • Haldol  
  • Imuran  
  • Lescol
  • Lexapro
  • Lopressor  
  • Luvox  
  • Mellaril
  • Micronase
  • Norpramin 
 
  • Orinase  
  • Pamelor  
  • Paxil  
  • Pexeva  
  • Phenytek  
  • Prevacid  
  • Prilosec  
  • Prograf
  • Protonix  
  • Prozac
  • Purinethol
  • Risperdal  
 
  • Rythmol  
  • Sarafem  
  • Sinequan  
  • Strattera  
  • Surmontil  
  • Tambocor  
  • Tofranil  
  • Toprol  
  • Zyprexa
  • Zoloft