Zingarelli Lab

Publications

Stanski, NL; Zhang, B; Ouyang, J; Standage, SW; Cvijanovich, NZ; Fitzgerald, JC; Bigham, MT; Jain, PN; Lutfi, R; Allen, GL; Atreya, MR; Sanchez-Pinto, LN; Goldstein, SL; Liu, KD. External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes. Critical Care Medicine. 2026; 54(7):1680-1690.

Zingarelli, B. Mitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin. American Journal of Respiratory Cell and Molecular Biology. 2026.

Bonnefil, V; Standage, S; Lautz, AJ; Stanski, NL; Harmon, K; Lahni, P; Fitzgerald, JC; Schwarz, AJ; Thomas, NJ; Haileselassie, B; Zingarelli, B; Kaplan, JM; Atreya, MR. PPARγ Variant rs10865710 and Mortality in Pediatric Septic Shock Stratified by Corticosteroid Exposure. Critical Care Explorations. 2026; 8(6):e1410.

Atreya, MR; Zingarelli, B. Mapping the sepsis immune landscape across age and source of infection: lessons from single-cell multi-omics. Journal of Leukocyte Biology. 2026; 118(4).

Zingarelli, B. Shock Synopsis February 2026. Shock. 2026; 65(2):119-122.

Frazier, M; Edwards, A; Shahreki, E; Joshi, R; Porter, C; Zingarelli, B; Varisco, B. Increased transpulmonary pressure from partial tracheal occlusion potentiates tissue destruction in a mouse model of emphysema. American Journal of the Medical Sciences. 2026; 371:s339-s340.

Edwards, AD; Shahreki, E; Frazier, MK; Joshi, R; Porter, C; Zingarelli, B; Varisco, BM. Novel murine partial tracheal occlusion model with altered respiratory dynamics. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2025; 329(6):L749-L755.

Repici, A; Piraino, G; Wolfe, V; Kaplan, J; Nakamura, T; Zingarelli, B. Role of Extracellular Vesicles as Mediators of Cell Communication and Novel Biomarkers in Sepsis. Journal of Clinical Medicine. 2025; 14(18).

Zingarelli, B. SHOCK SYNOPSIS MAY 2025. Shock. 2025; 63(5):665-667.

Williams, JG; Whitney, JE; Weiss, SL; Varisco, BM; Yehya, N; Atreya, MR. Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction. CHEST Critical Care. 2025; 3(1).

Zingarelli, B. SHOCK SYNOPSIS FEBRUARY 2025. Shock. 2025; 63(2):179-181.

Devine, AJ; Smith, NJ; Joshi, R; Brooks-Patton, B; Dunham, J; Varisco, AN; Goodman, EM; Fan, Q; Zingarelli, B; Varisco, BM. KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency. Chronic Obstructive Pulmonary Diseases. 2025; 12(1):12-22.

Dunwoodie, L; Huang, M; Moore, AR; Stanski, NL; Standage, SW; Kaplan, JM; Zingarelli, B; Harmon, K; Fitzgerald, JC; Weiss, SL; Sweeney, TE; Kamaleswaran, R; Atreya, MR; Lautz, AJ. Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses. Frontiers in Immunology. 2025; 16:1663704.

Zingarelli, B. SHOCK SYNOPSIS DECEMBER 2024. Shock. 2024; 62(6):737.

Amman, AM; Wolfe, V; Piraino, G; Ziady, A; Zingarelli, B. Humanin-G Ameliorates Hemorrhage-Induced Acute Lung Injury in Mice Through AMPKα1-Dependent and -Independent Mechanisms. Biomedicines. 2024; 12(11).

Stanski, NL; Zhang, B; Cvijanovich, NZ; Fitzgerald, JC; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Allen, GL; Thomas, NJ; Zingarelli, B; Standage, SW; Kaplan, J; Goldstein, SL. Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock. Pediatric Critical Care Medicine. 2024; 25(11):1005-1016.

Zingarelli, B. SHOCK SYNOPSIS AUGUST 2024. Shock. 2024; 62(4):459-460.

Zingarelli, B. SHOCK SYNOPSIS OCTOBER 2024. Shock. 2024; 62(4):459-460.

Zingarelli, B. SHOCK SYNOPSIS OCTOBER 2024. Shock. 2024; 62(4):459-460.

Atreya, MR; Huang, M; Moore, AR; Zheng, H; Hasin-Brumshtein, Y; Fitzgerald, JC; Weiss, SL; Cvijanovich, NZ; Bigham, MT; Jain, PN; Sweeney, TE; Khatri, P; Sanchez-Pinto, LN; Kamaleswaran, R. Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes. Critical Care. 2024; 28(1):246.

Kaplan, JM; Zingarelli, B. SHOCK SYNOPSIS MAY 2024. Shock. 2024; 61(5):647-649.

Kaplan, JM; Zingarelli, B. SHOCK SYNOPSIS MAY 2024. Shock. 2024; 61(5):647-649.

Kaplan, JM; Zingarelli, B. SHOCK SYNOPSIS MAY 2024. Shock. 2024; 61(5):647-649.

Lautz, A; Atreya, M; Zhang, S; Kempton, K; Alder, M; Zingarelli, B. 893: INDUCED PLURIPOTENT STEM CELL-DERIVED MONOCYTE RESPONSE TO RISK-STRATIFIED PEDIATRIC SEPTIC SERUM. Critical Care Medicine. 2024; 52(1):s419-s419.

Atreya, MR; Piraino, G; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; Thomas, NJ; Baines, T; Haileselassie, B; Zingarelli, B. SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME. Shock. 2024; 61(1):83-88.

Stanski, NL; Basu, RK; Cvijanovich, NZ; Fitzgerald, JC; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Thomas, NJ; Baines, T; Standage, SW; Kaplan, J; Chawla, LS; Goldstein, SL. External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock. Critical Care. 2023; 27(1):463.

Atreya, MR; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; Thomas, NJ; Quasney, M; Haileselassie, B; Baines, TD; Zingarelli, B. SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME. Shock. 2023; 60(3):379-384.

Wagner, ML; Ammann, A; Piraino, G; Wolfe, V; O'connor, M; Lahni, P; Ziady, A; Zingarelli, B. PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS. Shock. 2023; 60(1):64-74.

Davis, X; Williamson, L; Stuck, J; Howell, K; Lahni, P; Piraino, G; Wolfe, V; Mukherjee, R; Sanchez-Gurmaches, J; Zingarelli, B; Kaplan, J. SEX-DEPENDENT EFFECTS OF ADIPOCYTE STAT3 INHIBITION ON THE INFLAMMATORY RESPONSE DURING SEVERE SEPSIS. Shock. 2023; 59(5):779-790.

Li, P; Wu, Y; Goodwin, AJ; Wolf, B; Halushka, PV; Wang, H; Zingarelli, B; Fan, H. Circulating extracellular vesicles are associated with the clinical outcomes of sepsis. Frontiers in Immunology. 2023; 14:1150564.

Pei, F; Yao, R-Q; Ren, C; Bahrami, S; Billiar, TR; Chaudry, IH; Chen, D-C; Chen, X-L; Cui, N; Fang, X-M; Zingarelli, B; Guan, X-D; Wu, J-F; Yao, Y-M. Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression. Military Medical Research. 2022; 9(1):74.

Odum, JD; Standage, S; Alder, M; Zingarelli, B; Devarajan, P; Wong, HR. Candidate Biomarkers for Sepsis-Associated Acute Kidney Injury Mechanistic Studies. Shock. 2022; 57(5):687-693.

Urban, C; Hayes, HV; Piraino, G; Wolfe, V; Lahni, P; O'connor, M; Phares, C; Zingarelli, B. Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice. Frontiers in Immunology. 2022; 13:984298.