The Zingarelli Laboratory is focused on the investigation of the pathophysiologic mechanisms of sepsis, trauma and hemorrhagic shock, which are leading causes of morbidity and mortality in intensive care units. Dr. Zingarelli has identified putative anti-inflammatory nuclear receptors, the peroxisome proliferator activated receptors (PPARγ , PPARα and PPARδ ), and liver X receptors (LXRs), which regulate gene transcription of several cytotoxic modulators and may be important defense factors. Recent research efforts also focus on understanding the role of aging on the clinical course of infections, severe hemorrhage and trauma. The laboratory employs a multidisciplinary approach combining in vivo and in vitro experimental models in genetically modified rodents and cell lines. These models are also utilized as a translational research platform to screen novel pharmacological compounds that can modulate the molecular mechanisms of organ function. The goal is to identify specific therapeutic interventions for pediatric, adult and elderly patients.

The Zingarelli Laboratory is also collaborating with several basic science and translational studies in the Division of Critical Care Medicine. In collaboration with Dr. Hector Wong, the Zingarelli Laboratory investigates novel biomarkers and pathways involved in sepsis pathobiology, including the role of the matrix metallo-proteinase 8 (MMP-8). In collaboration with Dr. Jennifer Kaplan, the Zingarelli Laboratory evaluates the effects of obesity on the increased risk of complications after infections.

Dr. Zingarelli also collaborates on basic science studies with Dr. James A. Cook of the Medical University of South Carolina on the molecular mechanisms by which Gram-negative or Gram-positive bacteria interact with the host cells and mediate the pathological effects of infections.

Ongoing projects are primarily funded by multiple grants from the National Institutes of Health.