Takahisa Nakamura, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Associate Professor, Tohoku University

Phone 513-803-9230

Email takahisa.nakamura@cchmc.org

RNA-related inflammation in obesity and metabolic diseases 

Visit the Nakamura Lab.

Dr. Nakamura received his PhD from the University of Tokyo in 2003. He completed postdoctoral training in the laboratory of Dr. Gökhan S. Hotamisligil at Harvard School of Public Health in 2013, followed by his faculty appointment at Cincinnati Children's Hospital Medical Center within the UC Department of Pediatrics in 2013.

PhD: University of Tokyo, 2003.

Postdoctoral training: Harvard School of Public Health

View PubMed Publications

Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra V, Choi K, Yuan CL, Chan C, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T*. Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology. Nature Communications. 2018 Sep 10;9(1):3658.

Salem ESB, Murakami K, Takahashi T, Bernhard E, Borra V, Bethi M, Nakamura T*. Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-Radioactive L-Azidohomoalanine Labeling Method. Journal of Visualized Experiments. 2018 Oct 23;140.

Peng J, Li Y, Deng S, Holland J, Yates E, Chen J, Gu H, Wang X, Essandoh K, Mu X, McNamara RK, Peng T, Jegga AG, Nakamura T*, Huang K*, Perez-Tilve D*, Fan G*. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination. Cell Reports. 2018 June 19;23(12):3607-3620.

Yamazaki T, Li W, Yang L, Li P, Cao H, Motegi SI, Udey MC, Bernhard E, Nakamura T, Mukouyama YS. Whole-mount adult ear skin imaging reveals defective neuro-vascular branching morphogenesis in obese and type 2 diabetic mouse models. Sci Rep. 2018 Jan 11;8(1):430.

Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL. A potential role for snoRNAs in PKR activation during metabolic stress. Proc Natl Acad Sci U S A. 2015 Apr;112(16):5023-5028.

Nakamura T*, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki, Y, Gygi SP, Hotamisligil GS*. A critical role of PKR complexes with TRBP in immunometabolic regulation and eIF2alpha phosphorylation in obesity. Cell Reports. 2015 Apr 14;11(2): 295-307. 

Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes. 2014 Feb;63(2):526-34.

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell. 2010 Feb 5;140(3):338-48.

Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T. Oligoasthenoteratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33.

Yoshida Y*, Nakamura T*, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev. 2003 May 15;17(10):1201-6. *These authors contributed equally to this work.

Role of hepatic RNA silencing in insulin resistance and obesity. Principal Investigator. National Institutes of Health. RO1 DK107530.

Role of hepatocyte-derived extracellular vesicles in metabolic inflammation and glycemic control of obesity. Principal Investigator. DoD. PR182028.