Endocrinology Research
Nakamura Lab

Nakamura Research Lab

Our lab’s primary interest is the pathogenesis of obesity and metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). We are specifically interested in molecular mechanisms by which alternations in cellular and circulating RNA networks disrupt systemic glucose and lipid metabolism in the development and progression of these diseases. We have established a variety of mouse and cell culture models to study glucose and lipid metabolism, and miRNA-regulatory machinery in the pathogenesis of obesity. Our goal is to find novel therapeutic approaches targeting RNA networks for treating such diseases.

Our Research interests include:


Yagai, T; Nakamura, T. Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor. Frontiers in Medicine. 2022; 9:1060244.

Zhang, Y; Murakami, K; Borra, VJ; Ozen, MO; Demirci, U; Nakamura, T; Esfandiari, L. A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties. Biosensors. 2022; 12:104.

Bhattacharjee, J; Borra, VJ; Salem, ES B; Zhang, C; Murakami, K; Gill, RK; Kim, A; Kim, JK; Salazar-Gonzalez, R; Warren, M; et al. Hepatic Ago2 Regulates PPARα for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery. Endocrinology. 2021; 162:bqab007.

Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16:309-323.

Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al. Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing. Cell Reports. 2020; 30:672-686.e8.

Shi, L; Kuhnell, D; Borra, VJ; Langevin, SM; Nakamura, T; Esfandiari, L. Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering. 2019; 19:3726-3734.

Salem, ES B; Vonberg, AD; Borra, VJ; Gill, RK; Nakamura, T. RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases. Frontiers in Cardiovascular Medicine. 2019; 6:106.

Nakamura Lab.

Contact Us

Takahisa Nakamura, Ph.D.
Email: takahisa.nakamura@cchmc.org
Phone: 513-803-9230

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