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Our lab’s primary interest is the pathogenesis of obesity and metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). We are specifically interested in molecular mechanisms by which alternations in cellular and circulating RNA networks disrupt systemic glucose and lipid metabolism in the development and progression of these diseases. We have established a variety of mouse and cell culture models to study glucose and lipid metabolism, and miRNA-regulatory machinery in the pathogenesis of obesity. Our goal is to find novel therapeutic approaches targeting RNA networks for treating such diseases.
Our Research interests include:
Nayak, G; Zhang, KX; Vemaraju, S; Odaka, Y; Buhr, ED; Holt-Jones, A; Kernodle, S; Smith, AN; Upton, BA; D'Souza, S; et al.
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.
Shi, L; Kuhnell, D; Borra, VJ; Langevin, SM; Nakamura, T; Esfandiari, L.
Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device.
Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering.
Salem, ES B; Vonberg, AD; Borra, VJ; Gill, RK; Nakamura, T.
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.
Frontiers in Cardiovascular Medicine.
Yamazaki, T; Li, W; Yang, L; Li, P; Cao, H; Motegi, S; Udey, MC; Bernhard, E; Nakamura, T; Mukouyama, Y.
Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models.
Zhang, C; Seo, J; Murakami, K; Salem, ES B; Bernhard, E; Borra, VJ; Choi, K; Yuan, CL; Chan, CC; Chen, X; et al.
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.
Kim, A; Shah, AS; Nakamura, T.
Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications.
Salem, ES B; Murakami, K; Takahashi, T; Bernhard, E; Borra, V; Bethi, M; Nakamura, T.
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method.
Jove-Journal of Visualized Experiments.
Peng, J; Li, Y; Wang, X; Deng, S; Holland, J; Yates, E; Chen, J; Gu, H; Essandoh, K; Mu, X; et al.
An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination.
Zhang, C; Seo, J; Nakamura, T.
Cellular Approaches in Investigating Argonaute2-Dependent RNA Silencing.
Methods in Molecular Biology.
Springer New York;
Springer New York;