Jiang Lab
Publications

Publications

Selected Publications

Lofrano-Porto, A; Pereira, SA; Dauber, A; Bloom, JC; Fontes, AN; Asimow, N; De Moraes, OL; Araujo, PAT; Abreu, AP; Guo, MH; Coelho, MS; Carroll, RS; Jiang, R; Kaiser, UB. OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. Journal of Clinical Investigation. 2023; 133(23).

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development. 2022; 149(21).

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Iyyanar, PPR; Wu, Z; Lan, Y; Hu, Y-C; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

Liu, H; Xu, J; Lan, Y; Lim, H-W; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9:654397.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9:665109.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Journal of Dental Research. 2020; 99(4):463-471.

Liu, Z; Li, C; Xu, J; Lan, Y; Liu, H; Li, X; Maire, P; Wang, X; Jiang, R. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. Journal of Dental Research. 2019; 98(5):572-579.

Liu, H; Xu, J; Jiang, R. Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons. Journal of Bone and Mineral Research. 2019; 34(3):557-569.

Xu, J; Liu, H; Lan, Y; Adam, M; Clouthier, DE; Potter, S; Jiang, R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. eLife. 2019; 8.

Li, C; Lan, Y; Krumlauf, R; Jiang, R. Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. Journal of Dental Research. 2017; 96(11):1273-1281.

Kwon, H-JE; Jia, S; Lan, Y; Liu, H; Jiang, R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. Journal of Dental Research. 2017; 96(10):1145-1152.

Jia, S; Kwon, H-JE; Lan, Y; Zhou, J; Liu, H; Jiang, R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Developmental Biology. 2016; 420(1):110-119.

Lan, Y; Zhang, N; Liu, H; Xu, J; Jiang, R. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development. 2016; 143(13):2344-2355.

Xu, J; Liu, H; Lan, Y; Aronow, BJ; Kalinichenko, VV; Jiang, R. A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genetics. 2016; 12(1):e1005769.

Liu, H; Xu, J; Liu, C-F; Lan, Y; Wylie, C; Jiang, R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. Journal of Orthopaedic Research. 2015; 33(6):840-848.

Lan, Y; Xu, J; Jiang, R. Cellular and Molecular Mechanisms of Palatogenesis. 2015:59-84.

Xu, J; Liu, H; Park, J-S; Lan, Y; Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014; 141(7):1442-1452.

Lan, Y; Jia, S; Jiang, R. Molecular patterning of the mammalian dentition. Seminars in Cell and Developmental Biology. 2014; 25-26:61-70.

Zhou, J; Gao, Y; Lan, Y; Jia, S; Jiang, R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013; 140(23):4709-4718.

Liu, H; Lan, Y; Xu, J; Chang, C-F; Brugmann, SA; Jiang, R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(46):18555-18560.

Jia, S; Zhou, J; Gao, Y; Baek, J-A; Martin, JF; Lan, Y; Jiang, R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013; 140(2):423-432.

Bush, JO; Jiang, R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012; 139(2):231-243.

Zhou, J; Gao, Y; Zhang, Z; Zhang, Y; Maltby, KM; Liu, Z; Lan, Y; Jiang, R. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Developmental Biology. 2011; 353(2):344-353.

Baek, J-A; Lan, Y; Liu, H; Maltby, KM; Mishina, Y; Jiang, R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Developmental Biology. 2011; 350(2):520-531.

Liu, W; Watson, SS; Lan, Y; Keene, DR; Ovitt, CE; Liu, H; Schweitzer, R; Jiang, R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Molecular and Cellular Biology. 2010; 30(20):4797-4807.

Huang, Y; Iyyanar, PPR; Xu, J; Adhikari, N; Wu, Z; Lan, Y; Jiang, R. A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development. Developmental Biology. 2026.

Iyyanar, PPR; Adhikari, N; Lan, Y; Jiang, R. The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation. Disease Models & Mechanisms. 2026; 19(2).

Liu, L; Li, J; Cheng, H; Xiang, M; Liu, J; Kidd, B; Li, J; Qin, Y; Peng, H; Ji, J-Y; Kelly, RG; Jiang, R; Zhang, K; Xie, L. Osr1 orchestrates posterior second heart field cell migration for outflow tract formation. Communications Biology. 2025; 8(1):1770.

Crossen, MJ; Jia, S; Jorgensen, JS; Kelleher, AM; Jiang, R; Zhao, F. Wnt9b enables androgen action to maintain Wolffian ducts in mice. Molecular Human Reproduction. 2025; 31(3).

Adhikari, N; Wu, Z; Huang, Y; Lan, Y; Jiang, R. Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw. Journal of Dental Research. 2025; 104(3):310-319.

Lee, SJ; Kim, JA; Ihn, HJ; Choi, J-Y; Kwon, T-Y; Shin, H-I; Cho, E-S; Bae, YC; Jiang, R; Kim, J-E; Park, EK. The transcription factor BBX regulates phosphate homeostasis through the modulation of FGF23. Experimental and Molecular Medicine. 2024; 56(11):2436-2448.

Lan, Y; Wu, Z; Liu, H; Jiang, R. Lineage-specific requirements of Alx4 function in craniofacial and hair development. Developmental Dynamics. 2024; 253(10):940-948.

Perl, AJ; Liu, H; Hass, M; Adhikari, N; Chaturvedi, P; Hu, Y-C; Jiang, R; Liu, Y; Kopan, R. Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer-Promoter Interactions in the Transgene. Journal of the American Society of Nephrology. 2024; 35(5):566-577.

Lofrano-Porto, A; Pereira, SA; Dauber, A; Bloom, JC; Fontes, AN; Asimow, N; De Moraes, OL; Araujo, PAT; Abreu, AP; Guo, MH; Coelho, MS; Carroll, RS; Jiang, R; Kaiser, UB. OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. Journal of Clinical Investigation. 2023; 133(23).

Iyyanar, PPR; Qin, C; Adhikari, N; Liu, H; Hu, Y-C; Jiang, R; Lan, Y. Developmental origin of the mammalian premaxilla. Developmental Biology. 2023; 503:1-9.

Wurmser, M; Madani, R; Chaverot, N; Backer, S; Borok, M; Dos Santos, M; Comai, G; Tajbakhsh, S; Relaix, F; Santolini, M; Sambasivan, R; Jiang, R; Maire, P. Overlapping functions of SIX homeoproteins during embryonic myogenesis. PLoS Genetics. 2023; 19(6):e1010781.

Xu, J; Iyyanar, PPR; Lan, Y; Jiang, R. Sonic hedgehog signaling in craniofacial development. Differentiation. 2023; 133:60-76.

Liu, L; Zhou, Y; Liu, Z; Li, J; Hu, L; He, L; Gao, G; Kidd, B; Walsh, A; Jiang, R; Wu, C; Zhang, K; Xie, L. Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression. Cellular and Molecular Gastroenterology and Hepatology (CMGH). 2023; 15(5):1117-1133.

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development. 2022; 149(21).

Lee, J-M; Qin, C; Chai, OH; Lan, Y; Jiang, R; Kwon, H-JE. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. Journal of Dental Research. 2022; 101(7):832-839.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Iyyanar, PPR; Wu, Z; Lan, Y; Hu, Y-C; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

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