Publications

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Journal of Dental Research. 2020; 99:463-471.

Liu, Z; Li, C; Xu, J; Lan, Y; Liu, H; Li, X; Maire, P; Wang, X; Jiang, R. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. Journal of Dental Research. 2019; 98:572-579.

Liu, H; Xu, J; Jiang, R. Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons. Journal of Bone and Mineral Research. 2019; 34:557-569.

Xu, J; Liu, H; Lan, Y; Adam, M; Clouthier, DE; Potter, S; Jiang, R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. eLife. 2019; 8.

Li, C; Lan, Y; Krumlauf, R; Jiang, R. Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. Journal of Dental Research. 2017; 96:1273-1281.

Kwon, HE; Jia, S; Lan, Y; Liu, H; Jiang, R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. Journal of Dental Research. 2017; 96:1145-1152.

Jia, S; Kwon, HE; Lan, Y; Zhou, J; Liu, H; Jiang, R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Developmental Biology. 2016; 420:110-119.

Lan, Y; Zhang, N; Liu, H; Xu, J; Jiang, R. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development (Cambridge). 2016; 143:2344-2355.

Xu, J; Liu, H; Lan, Y; Aronow, BJ; Kalinichenko, VV; Jiang, R. A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genetics. 2016; 12.

Lan, Y; Xu, J; Jiang, R. Cellular and Molecular Mechanisms of Palatogenesis. . 2015.

Liu, H; Xu, J; Liu, C; Lan, Y; Wylie, C; Jiang, R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. Journal of Orthopaedic Research. 2015; 33:840-848.

Xu, J; Liu, H; Park, J; Lan, Y; Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development (Cambridge). 2014; 141:1442-1452.

Lan, Y; Jia, S; Jiang, R. Molecular patterning of the mammalian dentition. Seminars in Cell and Developmental Biology. 2014; 25-26:61-70.

Zhou, J; Gao, Y; Lan, Y; Jia, S; Jiang, R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development (Cambridge). 2013; 140:4709-4718.

Liu, H; Lan, Y; Xu, J; Chang, C; Brugmann, SA; Jiang, R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110:18555-18560.

Jia, S; Zhou, J; Gao, Y; Baek, J; Martin, JF; Lan, Y; Jiang, R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development (Cambridge). 2013; 140:423-432.

Bush, JO; Jiang, R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (Cambridge). 2012; 139:231-243.

Zhou, J; Gao, Y; Zhang, Z; Zhang, Y; Maltby, KM; Liu, Z; Lan, Y; Jiang, R. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Developmental Biology. 2011; 353:344-353.

Baek, J; Lan, Y; Liu, H; Maltby, KM; Mishina, Y; Jiang, R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Developmental Biology. 2011; 350:520-531.

Liu, W; Watson, SS; Lan, Y; Keene, DR; Ovitt, CE; Liu, H; Schweitzer, R; Jiang, R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Molecular and Cellular Biology. 2010; 30:4797-4807.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Lee, JM; Qin, C; Chai, OH; Lan, Y; Jiang, R; Kwon, HJ E. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. Journal of Dental Research. 2022.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9.

Yue, M; Lan, Y; Liu, H; Wu, Z; Imamura, T; Jiang, R. Tissue-specific analysis of Fgf18 gene function in palate development. Developmental Dynamics. 2021; 250:562-573.

Ihn, HJ; Kim, JA; Lim, J; Nam, S; Hwang, SH; Kim, YK; Kim, J; Kim, J; Cho, E; Jiang, R; et al. Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. Journal of Cellular Physiology. 2021; 236:480-488.

Li, C; Liu, H; Hu, Y; Lan, Y; Jiang, R. Generation and characterization of Six2 conditional mice. Genesis. 2020; 58.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Journal of Dental Research. 2020; 99:463-471.

Lan, Y; Qin, C; Jiang, R. Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development. Journal of Dental Research. 2019; 98:1367-1375.

Liu, Z; Li, C; Xu, J; Lan, Y; Liu, H; Li, X; Maire, P; Wang, X; Jiang, R. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. Journal of Dental Research. 2019; 98:572-579.

Liu, H; Xu, J; Jiang, R. Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons. Journal of Bone and Mineral Research. 2019; 34:557-569.

Xu, J; Liu, H; Lan, Y; Adam, M; Clouthier, DE; Potter, S; Jiang, R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. eLife. 2019; 8.

Fu, X; Xu, J; Chaturvedi, P; Liu, H; Jiang, R; Lan, Y. Identification of Osr2 Transcriptional Target Genes in Palate Development. Journal of Dental Research. 2017; 96:1451-1458.

Li, C; Lan, Y; Krumlauf, R; Jiang, R. Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. Journal of Dental Research. 2017; 96:1273-1281.

Li, C; Lan, Y; Jiang, R. Molecular and Cellular Mechanisms of Palate Development. Journal of Dental Research. 2017; 96:1184-1191.

Kwon, HE; Jia, S; Lan, Y; Liu, H; Jiang, R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. Journal of Dental Research. 2017; 96:1145-1152.

Han, L; Xu, J; Grigg, E; Slack, M; Chaturvedi, P; Jiang, R; Zorn, AM. Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Developmental Biology. 2017; 427:72-83.

Contact Us

A photo of Rulang Jiang.
Rulang Jiang, PhD
Professor, UC Department of Pediatrics

Phone: 513-636-3212
Email: rulang.jiang@cchmc.org

Graduate Student and Postdoctoral Training Opportunities

The Jiang lab welcomes graduate students and postdoctoral fellows to join our team. Each graduate student or postdoctoral fellow carries out semi-independent research projects and is expected to generate high–quality, first-author publications.

Students and postdoctoral candidates interested in mammalian development and birth defect research are encouraged to contact Rulang Jiang, PhD, (rulang.jiang@cchmc.org) to discuss opportunities.