Jiang Lab

Publications

Lofrano-Porto, A; Pereira, SA; Dauber, A; Bloom, JC B; Fontes, AN; Asimow, N; de Moraes, OL; Araujo, PA T; Abreu, AP; Guo, MH; Coelho, MS; Carroll, RS; Jiang, R; Kaiser, UB. OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. The Journal of Clinical Investigation. 2023; 133:e161701.

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development (Cambridge). 2022; 149:dev200667.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9:654397.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9:665109.

Xu, J; Liu, H; Lan, Y; Park, JS; Jiang, R. Genome-wide Identification of Foxf2 Target Genes in Palate Development. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2020; 99:463-471.

Liu, Z; Li, C; Xu, J; Lan, Y; Liu, H; Li, X; Maire, P; Wang, X; Jiang, R. Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2019; 98:572-579.

Liu, H; Xu, J; Jiang, R. Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons. Journal of Bone and Mineral Research. 2019; 34:557-569.

Xu, J; Liu, H; Lan, Y; Adam, M; Clouthier, DE; Potter, S; Jiang, R. Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. eLife. 2019; 8:e40315.

Li, C; Lan, Y; Krumlauf, R; Jiang, R. Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2017; 96:1273-1281.

Kwon, HE; Jia, S; Lan, Y; Liu, H; Jiang, R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2017; 96:1145-1152.

Jia, S; Kwon, HE; Lan, Y; Zhou, J; Liu, H; Jiang, R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Developmental Biology. 2016; 420:110-119.

Lan, Y; Zhang, N; Liu, H; Xu, J; Jiang, R. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development (Cambridge). 2016; 143:2344-2355.

Xu, J; Liu, H; Lan, Y; Aronow, BJ; Kalinichenko, VV; Jiang, R. A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. Editor, Chai Y. PLoS Genetics. 2016; 12:e1005769.

Lan, Y; Xu, J; Jiang, R. Cellular and Molecular Mechanisms of Palatogenesis. In: Chai Y, Ed. Current Topics in Developmental Biology. Waltham, MA: ELSEVIER ACADEMIC PRESS INC; 2015.

Liu, H; Xu, J; Liu, C; Lan, Y; Wylie, C; Jiang, R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. Journal of Orthopaedic Research. 2015; 33:840-848.

Xu, J; Liu, H; Park, J; Lan, Y; Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development (Cambridge). 2014; 141:1442-1452.

Lan, Y; Jia, S; Jiang, R. Molecular patterning of the mammalian dentition. Seminars in Cell and Developmental Biology. 2014; 25-26:61-70.

Zhou, J; Gao, Y; Lan, Y; Jia, S; Jiang, R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development (Cambridge). 2013; 140:4709-4718.

Liu, H; Lan, Y; Xu, J; Chang, C; Brugmann, SA; Jiang, R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences of USA. 2013; 110:18555-18560.

Jia, S; Zhou, J; Gao, Y; Baek, J; Martin, JF; Lan, Y; Jiang, R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development (Cambridge). 2013; 140:423-432.

Bush, JO; Jiang, R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (Cambridge). 2012; 139:231-243.

Zhou, J; Gao, Y; Zhang, Z; Zhang, Y; Maltby, KM; Liu, Z; Lan, Y; Jiang, R. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Developmental Biology. 2011; 353:344-353.

Baek, J; Lan, Y; Liu, H; Maltby, KM; Mishina, Y; Jiang, R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Developmental Biology. 2011; 350:520-531.

Liu, W; Watson, SS; Lan, Y; Keene, DR; Ovitt, CE; Liu, H; Schweitzer, R; Jiang, R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Molecular and Cellular Biology. 2010; 30:4797-4807.

Crossen, MJ; Jia, S; Jorgensen, JS; Kelleher, AM; Jiang, R; Zhao, F. Wnt9b enables androgen action to maintain Wolffian ducts in mice. Molecular Human Reproduction. 2025; 31:gaaf035.

Adhikari, N; Wu, Z; Huang, Y; Lan, Y; Jiang, R. Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2025; 104:310-319.

Lee, SJ; Kim, JA; Ihn, HJ; Choi, JY; Kwon, TY; Shin, HI; Cho, ES; Bae, YC; Jiang, R; Kim, JE; Park, EK. The transcription factor BBX regulates phosphate homeostasis through the modulation of FGF23. Experimental and Molecular Medicine. 2024; 56:2436-2448.

Lan, Y; Wu, Z; Liu, H; Jiang, R. Lineage-specific requirements of Alx4 function in craniofacial and hair development. Developmental Dynamics. 2024; 253:940-948.

Perl, AJ; Liu, H; Hass, M; Adhikari, N; Chaturvedi, P; Hu, YC; Jiang, R; Liu, Y; Kopan, R. Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer-Promoter Interactions in the Transgene. Journal of the American Society of Nephrology : JASN. 2024; 35:566-577.

Lofrano-Porto, A; Pereira, SA; Dauber, A; Bloom, JC B; Fontes, AN; Asimow, N; de Moraes, OL; Araujo, PA T; Abreu, AP; Guo, MH; Coelho, MS; Carroll, RS; Jiang, R; Kaiser, UB. OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. The Journal of Clinical Investigation. 2023; 133:e161701.

Iyyanar, PP R; Qin, C; Adhikari, N; Liu, H; Hu, YC; Jiang, R; Lan, Y. Developmental origin of the mammalian premaxilla. Developmental Biology. 2023; 503:1-9.

Xu, J; Iyyanar, PP R; Lan, Y; Jiang, R. Sonic hedgehog signaling in craniofacial development. Differentiation; Research in Biological Diversity. 2023; 133:60-76.

Wurmser, M; Madani, R; Chaverot, N; Backer, S; Borok, M; Dos Santos, M; Comai, G; Tajbakhsh, S; Relaix, F; Santolini, M; Sambasivan, R; Jiang, R; Maire, P. Overlapping functions of SIX homeoproteins during embryonic myogenesis. Editor, Cox GA. PLoS Genetics. 2023; 19:e1010781.

Liu, L; Zhou, Y; Liu, Z; Li, J; Hu, L; He, L; Gao, G; Kidd, B; Walsh, A; Jiang, R; Wu, C; Zhang, K; Xie, L. Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2023; 15:1117-1133.

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development (Cambridge). 2022; 149:dev200667.

Lee, JM; Qin, C; Chai, OH; Lan, Y; Jiang, R; Kwon, HJ E. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2022; 101:832-839.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9:654397.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9:665109.

Yue, M; Lan, Y; Liu, H; Wu, Z; Imamura, T; Jiang, R. Tissue-specific analysis of Fgf18 gene function in palate development. Developmental Dynamics. 2021; 250:562-573.

Ihn, HJ; Kim, JA; Lim, J; Nam, SH; Hwang, SH; Kim, YK; Kim, JY; Kim, JE; Cho, ES; Jiang, R; Park, EK. Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. Journal of Cellular Physiology. 2021; 236:480-488.