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Kopan Lab
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Developmental Biology
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Kopan Lab
Notch Wisdom
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Kopan Lab
Mechanisms of Notch Signaling
Kidney Development
Meet the Lab
Notch Wisdom
Publications
Notch Wisdom
Contents:
Contributors
xi
Prologue
xv
1.
Notch: The Past, the Present, and the Future
Spyros Artavanis-Tsakonas and Marc A. T. Muskavitch
1
2.
Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies
Rhett A. Kovall and Stephen C. Blacklow
31
3.
Canonical and Non-Canonical Notch Ligands
Brendan D’Souza, Laurence Meloty-Kapella, and Gerry Weinmaster
73
4.
Roles of Glycosylation in Notch Signaling
Pamela Stanley and Tetsuya Okajima
131
5.
Endocytosis and Intracellular Trafficking of Notch and Its Ligands
Shinya Yamamoto, Wu-Lin Charng, and Hugo J. Bellen
165
6.
g-Secretase and the Intramembrane Proteolysis of Notch
Ellen Jorissen and Bart De Strooper
201
7.
Two Opposing Roles of RBP-J in Notch Signaling
Kenji Tanigaki and Tasuku Honjo
231
8.
Notch targets and Their Regulation
Sarah Bray and Fred Bernard
253
9.
Notch Signaling in the Vasculature
Thomas Gridley
277
10.
Ultradian Oscillations in Notch Signaling Regulate Dynamic Biological Events
Ryoichiro Kageyama, Yasutaka Niwa, Hiromi Shimojo, Taeko Kobayashi, and Toshiyuki Ohtsuka
311
11.
Notch Signaling in Cardiac Development and Disease
Donal MacGrogan, Meritxell Nus, and Jose´ Luis de la Pompa
333
12.
Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
Jianing Liu, Chihiro Sato, Massimiliano Cerletti, and Amy Wagers
367
13.
Notch Signaling in Solid Tumors
Ute Koch and Freddy Radtke
411
14.
Biodiversity and Noncanonical Notch Signaling
Pascal Heitzler
457
Recommended Reviews
Kopan R, Ilagan MX.
SnapShot: notch signaling pathway.
Cell
. 2007 Mar 23;128(6):1246.
Kopan R, Ilagan, MX.
The canonical Notch signaling pathway: unfolding the activation mechanism.
Cell
. 2009 Apr 17;137(2):216-33.