Contents:
Contributors xi
Prologue xv
1. Notch: The Past, the Present, and the Future

Spyros Artavanis-Tsakonas and Marc A. T. Muskavitch		 1
2. Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies

Rhett A. Kovall and Stephen C. Blacklow		 31
3. Canonical and Non-Canonical Notch Ligands

Brendan D’Souza, Laurence Meloty-Kapella, and Gerry Weinmaster
 73
4. Roles of Glycosylation in Notch Signaling

Pamela Stanley and Tetsuya Okajima		 131
5. Endocytosis and Intracellular Trafficking of Notch and Its Ligands

Shinya Yamamoto, Wu-Lin Charng, and Hugo J. Bellen		 165
6. g-Secretase and the Intramembrane Proteolysis of Notch

Ellen Jorissen and Bart De Strooper		 201
7. Two Opposing Roles of RBP-J in Notch Signaling

Kenji Tanigaki and Tasuku Honjo		 231
8. Notch targets and Their Regulation

Sarah Bray and Fred Bernard		 253
9. Notch Signaling in the Vasculature 

Thomas Gridley		 277
10. Ultradian Oscillations in Notch Signaling Regulate Dynamic Biological Events

Ryoichiro Kageyama, Yasutaka Niwa, Hiromi Shimojo, Taeko Kobayashi, and Toshiyuki Ohtsuka		 311
11. Notch Signaling in Cardiac Development and Disease

Donal MacGrogan, Meritxell Nus, and Jose´ Luis de la Pompa		 333
12. Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation

Jianing Liu, Chihiro Sato, Massimiliano Cerletti, and Amy Wagers		 367
13. Notch Signaling in Solid Tumors

Ute Koch and Freddy Radtke		 411
14. Biodiversity and Noncanonical Notch Signaling

Pascal Heitzler		 457