Developmental Biology

Publications

Brugmann, SA; Merrill, AE; Saint-Jeannet, JP; Stottmann, RW; Clouthier, DE. The Society for Craniofacial Genetics and Developmental Biology 44th Annual Meeting. American Journal of Medical Genetics, Part A. 2022; 188:2258-2266.

Chang, X; Gu, M; Tchieu, J. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. Cells. 2022; 11:460.

Chimote, AA; Mayhew, C; Thornton, S; Wetzel, C; White, AN. Implementing Research Shared (Core) Facility Billing Systems. Journal of biomolecular techniques : JBT. 2022; 33:3fc1f5fe.1a877626.

Chowdhury, CS; Wareham, E; Xu, J; Kumar, S; Kofron, M; Lakshmikanthan, S; Chrzanowska, M; Filippi, MD. Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo. Frontiers in Immunology. 2022; 13:1061544.

Clements, D; Miller, S; Babaei-Jadidi, R; Adam, M; Potter, SS; Johnson, SR. Cross talk between LAM cells and fibroblasts may influence alveolar epithelial cell behavior in lymphangioleiomyomatosis. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2022; 322:L283-L293.

Del Águila, Á; Adam, M; Ullom, K; Shaw, N; Qin, S; Ehrman, J; Nardini, D; Salomone, J; Gebelein, B; Lu, QR; et al. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge). 2022; 149:dev200028.

Dong, C; Zhao, C; Chen, X; Berry, K; Wang, J; Zhang, F; Liao, Y; Han, R; Ogurek, S; Xu, L; et al. Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:8373-8392.

Duvall, K; Crist, L; Perl, AJ; Shakked, NP; Chaturvedi, P; Kopan, R. Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis. Development (Cambridge). 2022; 149:dev200446.

Ehrman, JM; Merchan-Sala, P; Ehrman, LA; Chen, B; Lim, HW; Waclaw, RR; Campbell, K. Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:3344-3364.

Eicher, AK; Kechele, DO; Sundaram, N; Berns, HM; Poling, HM; Haines, LE; Sanchez, JG; Kishimoto, K; Krishnamurthy, M; Han, L; et al. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.

Enriquez, JR; McCauley, HA; Zhang, KX; Sanchez, JG; Kalin, GT; Lang, RA; Wells, JM. A dietary change to a high-fat diet initiates a rapid adaptation of the intestine. Cell Reports. 2022; 41:111641.

Erickson, JJ; Archer-Hartmann, S; Yarawsky, AE; Miller, JL C; Seveau, S; Shao, TY; Severance, AL; Miller-Handley, H; Wu, Y; Pham, G; et al. Pregnancy enables antibody protection against intracellular infection. Nature. 2022; 606:769-775.

Fisher, ME; Segerdell, E; Matentzoglu, N; Nenni, MJ; Fortriede, JD; Chu, S; Pells, TJ; Osumi-Sutherland, D; Chaturvedi, P; James-Zorn, C; et al. The Xenopus phenotype ontology: bridging model organism phenotype data to human health and development. BMC Bioinformatics. 2022; 23:99.

Gagliani, EK; Gutzwiller, LM; Kuang, Y; Odaka, Y; Hoffmeister, P; Hauff, S; Turkiewicz, A; Harding-Theobald, E; Dolph, PJ; Borggrefe, T; et al. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. Editor, Wappner P. PLoS Genetics. 2022; 18:e1010335.

Iwasawa, E; Brown, FN; Shula, C; Kahn, F; Lee, SH; Berta, T; Ladle, DR; Campbell, K; Mangano, FT; Goto, J. The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022; 42:1820-1844.

Iyyanar, PP R; Wu, Z; Lan, Y; Hu, YC; Jiang, R. Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia. Frontiers in Cell and Developmental Biology. 2022; 10:777887.

Jansen, C; Paraiso, KD; Zhou, JJ; Blitz, IL; Fish, MB; Charney, RM; Cho, JS; Yasuoka, Y; Sudou, N; Bright, AR; et al. Uncovering the mesendoderm gene regulatory network through multi-omic data integration. Cell Reports. 2022; 38:110364.

Jurickova, I; Bonkowski, E; Angerman, E; Novak, E; Huron, A; Akers, G; Iwasawa, K; Braun, T; Hadar, R; Hooker, M; et al. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. 2022; 28:988-1003.

Kimura, M; Iguchi, T; Iwasawa, K; Dunn, A; Thompson, WL; Yoneyama, Y; Chaturvedi, P; Zorn, AM; Wintzinger, M; Quattrocelli, M; et al. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Cell. 2022; 185:4216-4232.e16.

Kishimoto, K; Iwasawa, K; Sorel, A; Ferran-Heredia, C; Han, L; Morimoto, M; Wells, JM; Takebe, T; Zorn, AM. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Nature Protocols. 2022; 17:2699-2719.

Krishnamurthy, M; Kechele, DO; Broda, T; Zhang, X; Enriquez, JR; McCauley, HA; Sanchez, JG; McCracken, K; Palermo, J; Bernieh, A; et al. Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations. Gastroenterology. 2022; 163:1053-1063.e7.

Lan, Y; Jiang, R. Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis. Current Topics in Developmental Biology. 2022; 148:13-50.

Lee, JM; Qin, C; Chai, OH; Lan, Y; Jiang, R; Kwon, HJ E. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2022; 101:832-839.

Li, CZ; Ogawa, H; Ng, SS; Chen, X; Kishimoto, E; Sakabe, K; Fukami, A; Hu, YC; Mayhew, CN; Hellmann, J; et al. Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. JHEP Reports. 2022; 4:100446.

Michiue, T; Kato, T; Ochi, H; Zorn, A; Hayashi, T; Inoue, T; Kondo, M; Taira, M. Versatile utilities of amphibians (Part 3). Development, Growth and Differentiation. 2022; 64:472-473.

Michiue, T; Zorn, AM; Kato, T; Ochi, H; Hayashi, T; Inoue, T. Versatile Utilities of Amphibians (part 1). Development, Growth and Differentiation. 2022; 64:264-265.

Michiue, T; Zorn, AM; Kato, T; Ochi, H; Hayashi, T; Inoue, T. Versatile utilities of amphibians (part 2). Development, Growth and Differentiation. 2022; 64:346.

Mukherjee, S; Luedeke, DM; McCoy, L; Iwafuchi, M; Zorn, AM. SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells. Cell Reports. 2022; 40:111247.

Murray, JI; Preston, E; Crawford, JP; Rumley, JD; Amom, P; Anderson, BD; Sivaramakrishnan, P; Patel, SD; Bennett, BA; Lavon, TD; et al. The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo. Editor, Nance J. PLoS Genetics. 2022; 18:e1010187.

Murrison, LB; Ren, X; Preusse, K; He, H; Kroner, J; Chen, X; Jenkins, S; Johansson, E; Biagini, JM; Weirauch, MT; et al. TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. Journal of Allergy and Clinical Immunology. 2022; 149:79-88.

Neilson, DE; Zech, M; Hufnagel, RB; Slone, J; Wang, X; Homan, S; Gutzwiller, LM; Leslie, EJ; Leslie, ND; Xiao, J; et al. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Movement Disorders. 2022; 37:375-383.

Paese, CL B; Chang, CF; Kristeková, D; Brugmann, SA. Pharmacological intervention of the FGF-PTH axis as a potential therapeutic for craniofacial ciliopathies. DMM Disease Models and Mechanisms. 2022; 15:dmm049611.

Pilarczyk, M; Fazel-Najafabadi, M; Kouril, M; Shamsaei, B; Vasiliauskas, J; Niu, W; Mahi, N; Zhang, L; Clark, NA; Ren, Y; et al. Connecting omics signatures and revealing biological mechanisms with iLINCS. Nature Communications. 2022; 13:4678.

Pitstick, AL; Poling, HM; Sundaram, N; Lewis, PL; Kechele, DO; Sanchez, JG; Scott, MA; Broda, TR; Helmrath, MA; Wells, JM; et al. Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation. Stem Cell Reports. 2022; 17:1889-1902.

Qiu, K; Yadav, A; Tian, Z; Guo, Z; Shi, D; Nandi, CK; Diao, J. Ultralong-Term Super-Resolution Tracking of Lysosomes in Brain Organoids by Near-Infrared Noble Metal Nanoclusters. 2022; 4:1565-1573.

Ramachandran, J; Zhou, W; Bardenhagen, AE; Nasr, T; Yates, ER; Zorn, AM; Ji, H; Vokes, SA. Hedgehog regulation of epithelial cell state and morphogenesis in the larynx. eLife. 2022; 11:e77055.

Rankin, SA; Zorn, AM. The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development. Development, Growth and Differentiation. 2022; 64:347-361.

Rosselot, AE; Park, M; Kim, M; Matsu-Ura, T; Wu, G; Flores, DE; Subramanian, KR; Lee, S; Sundaram, N; Broda, TR; et al. Ontogeny and function of the circadian clock in intestinal organoids. The EMBO Journal. 2022; 41:e106973.

Rumley, JD; Preston, EA; Cook, D; Peng, FL; Zacharias, AL; Wu, L; Jileaeva, I; Murray, JI. pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo. Developmental Biology. 2022; 489:34-46.

Sanchez, JG; Enriquez, JR; Wells, JM. Enteroendocrine cell differentiation and function in the intestine. Current Opinion in Endocrinology, Diabetes and Obesity. 2022; 29:169-176.

Simsek, MF; Özbudak, EM. Patterning principles of morphogen gradients. Open Biology. 2022; 12:220224.

Sinha, S; Sparks, HD; Labit, E; Robbins, HN; Gowing, K; Jaffer, A; Kutluberk, E; Arora, R; Raredon, MS B; Cao, L; et al. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell. 2022; 185:4717-4736.e25.

Swaminathan, B; Youn, SW; Naiche, LA; Du, J; Villa, SR; Metz, JB; Feng, H; Zhang, C; Kopan, R; Sims, PA; et al. Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration. Scientific Reports. 2022; 12:1655.

Wells, JM; Guo, Z. In preprints: humans, the new model organism. Development (Cambridge). 2022; 149:dev201395.

Wu, LM N; Zhang, F; Rao, R; Adam, M; Pollard, K; Szabo, S; Liu, X; Belcher, KA; Luo, Z; Ogurek, S; et al. Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy. Science Advances. 2022; 8:eabo5442.

Xu, J; Liu, H; Lan, Y; Jiang, R. The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis. Development (Cambridge). 2022; 149:dev200667.

Zahn, N; James-Zorn, C; Ponferrada, VG; Adams, DS; Grzymkowski, J; Buchholz, DR; Nascone-Yoder, NM; Horb, M; Moody, SA; Vize, PD; et al. Normal Table of Xenopus development: a new graphical resource. Development (Cambridge). 2022; 149:dev200356.

Zhong, G; Ahimaz, P; Edwards, NA; Hagen, JJ; Faure, C; Lu, Q; Kingma, P; Middlesworth, W; Khlevner, J; El Fiky, M; et al. Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas. HGG Advances. 2022; 3:100107.

Zinani, OQ H; Keseroglu, K; Dey, S; Ay, A; Singh, A; Özbudak, EM. Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes. iScience. 2022; 25:104579.

Zinani, OQ H; Keseroglu, K; Özbudak, EM. Regulatory mechanisms ensuring coordinated expression of functionally related genes. Trends in Genetics. 2022; 38:73-81.

Zoubovsky, SP; Williams, MT; Hoseus, S; Tumukuntala, S; Riesenberg, A; Schulkin, J; Vorhees, CV; Campbell, K; Lim, H; Muglia, LJ. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational Psychiatry. 2022; 12:22.