Developmental Biology


Bedard, MC; Brusadelli, MG; Carlile, A; Ruiz-Torres, S; Lodin, H; Lee, D; Kofron, M; Lambert, PF; Lane, A; Ameziane, N; et al. Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. Viruses. 2021; 13.

Bonatto Paese, CL; Hawkins, MB; Brugmann, SA; Harris, MP. Atavisms in the avian hindlimb and early developmental polarity of the limb. Developmental Dynamics. 2021; 250:1358-1367.

Brooks, EC; Paese, CL B; Carroll, AH; Struve, JN; Nagy, N; Brugmann, SA. Mutation in the Ciliary Protein C2CD3 Reveals Organ-Specific Mechanisms of Hedgehog Signal Transduction in Avian Embryos. Journal of Developmental Biology. 2021; 9.

Brugmann, S; Clouthier, DE; Saint-Jeannet, JP; Taneyhill, LA; Moody, SA. The society for craniofacial genetics and developmental biology 43rd annual meeting. American Journal of Medical Genetics, Part A. 2021; 185:1932-1939.

Cain, B; Gebelein, B. Mechanisms Underlying Hox-Mediated Transcriptional Outcomes. Frontiers in Cell and Developmental Biology. 2021; 9.

Chang, CF; Brown, KM; Yang, Y; Brugmann, SA. Centriolar Protein C2cd3 Is Required for Craniofacial Development. Frontiers in Cell and Developmental Biology. 2021; 9.

Deng, X; Tchieu, J; Higginson, DS; Hsu, KS; Feldman, R; Studer, L; Shaham, S; Powell, SN; Fuks, Z; Kolesnick, R. Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability. Cancer Research. 2021; 81:3706-3716.

Edwards, NA; Shacham-Silverberg, V; Weitz, L; Kingma, PS; Shen, Y; Wells, JM; Chung, WK; Zorn, AM. Developmental basis of trachea-esophageal birth defects. Developmental Biology. 2021; 477:85-97.

Edwards, NA; Zorn, AM. Modeling endoderm development and disease in Xenopus. Current Topics in Developmental Biology. 2021; 145:61-90.

Fischesser, DM; Meyer, EC; Sargent, M; Molkentin, JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments. 2021.

Gu, M; Zorn, AM. Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids. Cell Stem Cell. 2021; 28:2037-2038.

Guttikonda, SR; Sikkema, L; Tchieu, J; Saurat, N; Walsh, RM; Harschnitz, O; Ciceri, G; Sneeboer, M; Mazutis, L; Setty, M; et al. Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease. Nature Neuroscience. 2021; 24:343-354.

Hass, MR; Brissette, D; Parameswaran, S; Pujato, M; Donmez, O; Kottyan, LC; Weirauch, MT; Kopan, R. Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets. PLoS Genetics. 2021; 17.

Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16:309-323.

Hinze, C; Karaiskos, N; Boltengagen, A; Walentin, K; Redo, K; Himmerkus, N; Bleich, M; Potter, SS; Potter, AS; Eckardt, K; et al. Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients. Journal of the American Society of Nephrology : JASN. 2021; 32:291-306.

Hortells, L; Meyer, EC; Thomas, ZM; Yutzey, KE. Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth. Journal of Molecular and Cellular Cardiology. 2021; 154:124-136.

Imai, F; Adam, M; Potter, SS; Yoshida, Y. HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord. Development (Cambridge). 2021.

Jarmas, AE; Brunskill, EW; Chaturvedi, P; Salomonis, N; Kopan, R. Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis. Nature Communications. 2021; 12.

Kuang, Y; Pyo, A; Eafergan, N; Cain, B; Gutzwiller, LM; Axelrod, O; Gagliani, EK; Weirauch, MT; Kopan, R; Kovall, RA; et al. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. PLoS Genetics. 2021; 17.

Kuerbitz, J; Madhavan, M; Ehrman, LA; Kohli, V; Waclaw, RR; Campbell, K. Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse. Cerebral Cortex. 2021; 31:1744-1762.

Liu, H; Xu, J; Lan, Y; Lim, HW; Jiang, R. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Frontiers in Cell and Developmental Biology. 2021; 9.

Makayes, Y; Resnick, E; Hinden, L; Aizenshtein, E; Shlomi, T; Kopan, R; Nechama, M; Volovelsky, O. Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney. Journal of the American Society of Nephrology : JASN. 2021; 32:1898-1912.

May-Zhang, AA; Tycksen, E; Southard-Smith, AN; Deal, KK; Benthal, JT; Buehler, DP; Adam, M; Simmons, AJ; Monaghan, JR; Matlock, BK; et al. Combinatorial Transcriptional Profiling of Mouse and Human Enteric Neurons Identifies Shared and Disparate Subtypes In Situ. Gastroenterology. 2021; 160:755-770.e26.

Nasr, T; Holderbaum, AM; Chaturvedi, P; Agarwal, K; Kinney, JL; Daniels, K; Trisno, SL; Ustiyan, V; Shannon, JM; Wells, JM; et al. Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes. DMM Disease Models and Mechanisms. 2021.

Neilson, DE; Zech, M; Hufnagel, RB; Slone, J; Wang, X; Homan, S; Gutzwiller, LM; Leslie, EJ; Leslie, ND; Xiao, J; et al. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Movement Disorders. 2021.

Oatman, N; Dasgupta, N; Arora, P; Choi, K; Gawali, MV; Gupta, N; Parameswaran, S; Salomone, J; Reisz, JA; Lawler, S; et al. Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science advances. 2021; 7.

Padmanabhan Nair, V; Liu, H; Ciceri, G; Jungverdorben, J; Frishman, G; Tchieu, J; Cederquist, GY; Rothenaigner, I; Schorpp, K; Klepper, L; et al. Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3. Cell Stem Cell. 2021; 28:1566-1581.e8.

Paese, CL B; Brooks, EC; Aarnio-Peterson, M; Brugmann, SA. Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling. Development (Cambridge). 2021; 148.

Pagliaroli, L; Porazzi, P; Curtis, AT; Scopa, C; Mikkers, HM M; Freund, C; Daxinger, L; Deliard, S; Welsh, SA; Offley, S; et al. Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders. Nature Communications. 2021; 12.

Rankin, SA; Steimle, JD; Yang, XH; Rydeen, AB; Agarwal, K; Chaturvedi, P; Ikegami, K; Herriges, MJ; Moskowitz, IP; Zorn, AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. eLife. 2021; 10.

Roychoudhury, K; Hegde, RS. The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases. International Journal of Molecular Sciences. 2021; 22.

Salomone, J; Qin, S; Fufa, TD; Cain, B; Farrow, E; Guan, B; Hufnagel, RB; Nakafuku, M; Lim, HW; Campbell, K; et al. Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice. Genes and Development. 2021; 35:157-174.

Schuh, MP; Alkhudairy, L; Potter, A; Potter, SS; Chetal, K; Thakkar, K; Salomonis, N; Kopan, R. The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis. Journal of the American Society of Nephrology : JASN. 2021; 32:1097-1112.

Simsek, MF; Özbudak, EM. A 3-D Tail Explant Culture to Study Vertebrate Segmentation in Zebrafish. Journal of Visualized Experiments. 2021.

Soni, UK; Roychoudhury, K; Hegde, RS. The Eyes Absent proteins in development and in developmental disorders. Biochemical Society Transactions. 2021; 49:1397-1408.

Sun, F; Wang, G; Pradhan, A; Xu, K; Gomez-Arroyo, J; Zhang, Y; Kalin, GT; Deng, Z; Vagnozzi, RJ; He, H; et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021; 144:539-555.

Trisno, SL; Higano, NS; Kechele, D; Nasr, T; Chung, W; Zorn, AM; Woods, JC; Wells, JM; Kingma, PS. Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis. Frontiers in Pediatrics. 2021; 9.

Wang, T; Zhu, H; Guo, Z; Li, T. (2021) A Robust Microfabrication Process for Microfluidic Devices with High Resolution and Aspect Ratio Features for Neural Circuitry Modeling. 00:529-532.

Wang, X; Ye, F; Wen, Z; Guo, Z; Yu, C; Huang, W; Rojas Ringeling, F; Su, Y; Zheng, W; Zhou, G; et al. Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. Molecular Psychiatry. 2021; 26:1346-1360.

Wang, Y; Pandey, RN; Roychoudhury, K; Milewski, D; Kalin, TV; Szabo, S; Pressey, JG; Hegde, RS. Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis. Molecular Cancer Therapeutics. 2021; 20:803-815.

Wu, G; Lee, YY; Gulla, EM; Potter, A; Kitzmiller, J; Ruben, MD; Salomonis, N; Whitsett, JA; Francey, LJ; Hogenesch, JB; et al. Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease. eLife. 2021; 10.

Xia, S; Bozóky, Z; Di Paola, M; Laselva, O; Ahmadi, S; Jiang, JX; Pitstick, AL; Jiang, C; Rotin, D; Mayhew, CN; et al. High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Cells. 2021; 10.

Xu, J; Liu, H; Lan, Y; Jiang, R. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Frontiers in Cell and Developmental Biology. 2021; 9.

Yue, M; Lan, Y; Liu, H; Wu, Z; Imamura, T; Jiang, R. Tissue-specific analysis of Fgf18 gene function in palate development. Developmental Dynamics. 2021; 250:562-573.

Zhang, J; Wu, Q; Johnson, CB; Pham, G; Kinder, JM; Olsson, A; Slaughter, A; May, M; Weinhaus, B; D’Alessandro, A; et al. In situ mapping identifies distinct vascular niches for myelopoiesis. Nature: New biology. 2021; 590:457-462.

Zheng, J; Ru, W; Adolacion, JR; Spurgat, MS; Liu, X; Yuan, S; Liang, RX; Dong, J; Potter, AS; Potter, SS; et al. Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia. iScience. 2021; 24.

Zinani, OQ H; Keseroglu, K; Ay, A; Özbudak, EM. Pairing of segmentation clock genes drives robust pattern formation. Nature: New biology. 2021; 589:431-436.