Developmental Biology

Publications

Ali, S; Ehrman, JM; Merchan-Sala, P; Matthew Kofron, J; Waclaw, RR; Campbell, K. A central role for Islr2 (Linx) in direct pathway striatal projection neurons for the correct formation of the internal capsule and cerebral peduncle. Developmental Biology. 2026; 538:56-73.

Arumugam, PI; Williams, C; Guo, M; Wessendarp, M; Carey, BC; Kumaragurubaran, R; Trapnell, C; Trapnell, BC. B28-23 Gm-csf Signaling Deficiency Causes Marked Pulmonary Lymphocytosis Due to Alveolar Macrophage-mediated Recruitment, Altered Lymphoid-myeloid Lineage Commitment, and Local Proliferation. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.1143.

Bok, J; Kim, YS; Cheng, F; Gao, C; Zhou, Z; Kobayashi, N; Sun, S; Tang, A; Xue, X; Nguyen, DH; Li, P; Fu, J. A controllable human spinal cord model with full dorsoventral patterning. Nature Communications. 2026; 17(1).

Brassard, JA; Wells, JM. Designing complex organoids through developmental principles. Cell Stem Cell. 2026; 33(7):1084-1097.

Chen, A; Avadhani, U; Ngo, K; Corona, RI; Neto, GDVC; Figueroa, KP; Perlman, S; Pulst, SM; Nelson, SF; Wong, D; Fogel, BL. Frequency of ZFHX3-Mediated Spinocerebellar Ataxia 4 in a US Undiagnosed Ataxia Cohort. Movement Disorders. 2026.

Chu, S; Bell, AJ; Lotay, V; Ly, N; Pells, TJ; Kwon, T; Agalakov, S; Ponferrada, V; Lenz, C; James-Zorn, C; Fisher, M; Karimi, K; Zorn, AM; Vize, PD. Xenbase: 25 years of integrating molecular and biomedical data from Xenopus. Genetics. 2026; 232(4).

Farrow, E; Rao, S; Han, SJY; Chang, X; Huynh, C; Brugmann, SA; Lim, H-W; Tchieu, J; Campbell, K; Gebelein, B. An inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors. Developmental Biology. 2026; 532:35-51.

Han, SJY; Adani, V; Farrow, E; Parmar, B; Chang, C-F; Cochran, K; Horne, RR; Ramkissoon, PJK; Esteban, E; Elliott, KH; Peterson, KA; Gebelein, B; García-Castro, MI; Brugmann, SA. A dual role for GLI3 signaling in neural crest development. Development. 2026; 153(1).

Heekin, S; Lopez-Nunez, O; Smith, J; Denson, N; Denson, L; Miethke, A; Collins, MH; Dillman, J; Miraldi, E; Kofron, JM; Dhaliwal, J; Erdman, L. Implications of Model Loss and Configuration for Sparse Histological Segmentation. In: Machine Learning Methods in Biomedical Field. Springer Nature; 2026:189-217.

Huang, Y; Iyyanar, PPR; Xu, J; Adhikari, N; Wu, Z; Lan, Y; Jiang, R. A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development. Developmental Biology. 2026; 534:88-100.

Iyyanar, PPR; Adhikari, N; Lan, Y; Jiang, R. The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation. Disease Models & Mechanisms. 2026; 19(2).

Kang, J; Liu, P; Ichimura, S; Cook, L; Hu, M; Namekawa, SH; Chen, Z. Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity. Nature Communications. 2026; 17(1).

Kechele, DO; Enriquez, JR; Eicher, AK; Thorner, K; Chaturvedi, P; Kishimoto, K; Adair, B; Sanchez, JG; Tominaga, K; Zorn, AM; Wells, JM. Single-cell transcriptomic comparison of the developing human fetal stomach and pluripotent stem cell-derived gastric organoids. Development. 2026; 153(4).

Lee, H; Jaquish, A; Fernandes, S; Zhao, B; Elitz, A; Cook, K; Trovillion, S; Bottasso-Arias, N; Han, SJY; Goodwin, S; Sinner, D; Sun, X; Swarr, DT; Zacharias, WJ. Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity. Nature Communications. 2026; 17(1).

Leon Tenorio, AA; Sugio, T; Cheng, J; Bonner, DE; Esfahani, MS; Kasinathan, S; Hsu, JJ; Moyer, A; Pimentel Vera, L; Carter, J; Wheeler, MT; Bernstein, JA; Alizadeh, A; Gomez-Ospina, N. DNASE1L3 Deficiency With Novel Missense Variant: Enzymatic and Plasma Fragmentomic Evidence of Pathogenicity and Partial Response to JAK Blockade. ACR Open Rheumatology. 2026; 8(2):e70184.

Li, S-Y; Matsuyama, S; Whiteside, S; Gu, X; Cool, J; Capel, B; Defalco, T. Platelet-derived growth factor receptor alpha regulates fetal testis differentiation via an ERK-CREB axis. Proceedings of the National Academy of Sciences of the United States of America. 2026; 123(4):e2515138123.

Lin, Y; Liou, B; Fannin, V; Adler, S; Mayhew, CN; Hammonds, JE; Hu, Y-C; Tchieu, J; Zhang, W; Zhao, X; Kaynak, A; Qi, X; Feldman, RA; Sun, Y. Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies. eLife. 2026; 15.

Matsui, S; Sampson, S; Mirizio, G; Granitto, M; Maeda, R; Tachibana, M; Ahn, C; Lim, H-W; Iwafuchi, M. MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competence. Nucleic Acids Research (NAR). 2026; 54(12).

Matsuyama, S; Bhushan, S; Defalco, T. Role of macrophages in testis function. 2026:51-96.

Nguyen, NNM; Brady, AE; Russi, A; Pham, G; Li, B; Turner, LH; Kotliar, M; Barski, A; Sun, X; Way, SS. Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance. Proceedings of the National Academy of Sciences of the United States of America. 2026; 123(13):e2519393123.

Paulding, D; Han, SJY; Timmons, J; Caye, M; Riedel, A; Brugmann, SA; Barske, L. Cranial neural crest shortage leads to extensive craniofacial anomalies in mice mutant for the NR2F1/2 nuclear receptors. Developmental Biology. 2026; 530:102-118.

Poling, HM; Noël, T; Singh, A; Fisher, GW; Thorner, K; Chaturvedi, P; Nattamai, K; Srivastava, K; Batie, MR; Hausfeld, T; Takebe, T; Wells, JM; Helmrath, MA; Mahe, MM. Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement. Nature Biomedical Engineering. 2026.

Rezvani, M; Quach, S; Lewis, K; Saiki, N; Xue, C; Kimura, M; Iwasawa, K; Weihs, J; Elzobair, T; Al Reza, H; Zorn, AM; Wells, JM; Yoshimoto, M; Takebe, T. Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids. Journal of Hepatology. 2026; 84(5):946-961.

Roy, K; Warmflash, A. Pattern Formation in Cell Cultures. Annual Review of Biophysics. 2026; 55(1):199-224.

Schulz, K; Botts, SR; Ellis, K; Scipione, CA; Khyzha, N; Ho, C; Kumaragurubaran, R; Yuki, KE; Wythe, JD; Miller, CL; Wilson, MD; Howe, KL; Fish, JE. ERG is a regulator of dynamic and reversible endothelial plasticity. Genome Medicine. 2026; 18(1).

Showpnil, IA; Feinstein-Goren, N; Greenbaum, L; Barel, O; Koboldt, DC; Brugmann, SA; Weaver, KN; Slavotinek, A; Pode-Shakked, B; Stottmann, RW. Detection of the Heterozygous Recurrent MAX p.(Arg60Gln) Variant in Two Females Confirms and Expands the Phenotypic Spectrum of Polydactyly-Macrocephaly Syndrome. Clinical Genetics. 2026; 109(4):788-795.

Sun, S; Zheng, Y; Kim, YS; Zhong, Z; Kobayashi, N; Xue, X; Liu, Y; Zhou, Z; Xu, Y; Zhai, J; Wang, H; Fu, J. A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures. Nature Cell Biology. 2026; 28(5):1049-1065.

Sun, X; Dey, SK. Aspects of Rodent Implantation. In: Encyclopedia of Reproduction. Elsevier; 2026:403-412.

Ushuhuda, EG; Nguyen, JT; Pfaltzgraff, NG; Wenner, SM; Kofron, M; Mikedis, MM. MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis. Development. 2026; 153(1).

Ushuhuda, EG; Nguyen, JT; Pfaltzgraff, NG; Wenner, SM; Kofron, M; Mikedis, MM. MEIOC prevents continued mitotic cycling and promotes meiotic entry during mouse oogenesis. Development. 2026; 153(1).

Wang, C; Zhou, Y; Wang, Y; Guha, TK; Luo, Z; Mustafaraj, A; Mcintyre, TI; Schwab, ME; Davidson, BR; Reeder, GC; Sun, X; Winn, VD; Fisher, SJ; Li, J. Single-cell spatiotemporal dissection of the human maternal-fetal interface. Nature. 2026; 653(8113):167-179.

Weatherbee, BAT; Rankin, SA; Zorn, AM. Vertebrate endoderm development. Development. 2026; 153(9).

Weaver, KN; Broeckel, JW; Brown, K; Wasserman, H; Wu, J; Neal, A; Prada, CE; Kleinschmidt, NL; Machal, EMF; Bertinetti, D; Ruiz-Perez, VL; Taylor, SS; Brugmann, SA; Herberg, FW. Combined skeletal dysplasia and vasculopathy phenotypes associated with in-frame intragenic deletion in PRKACA. HGG Advances. 2026; 7(3):100626.

Xiao, B; Mongan, M; Ko, C-I; Hu, Y-C; Defalco, T; Greis, KD; Xia, Y. Generation and characterization of a Cre-inducible MAP3K1 gain-of-function model. Disease Models & Mechanisms. 2026; 19(2).

Xing, Y; Yang, Y; Hong, Z; Tian, C; Chu, H; Prokop, SC; Cai, H; Gu, M; Tchieu, J; Mackie, K; Guo, F. Organoid Brain-Machine-Interface Devices for Central Nervous System Repair. Advanced Science. 2026; e75444.

Xue, X; Rahman, OM; Sun, S; Bok, J; Tang, A; Fu, J. Generation of spatially patterned human neural tube-like structures using microfluidic gradient devices. Nature Protocols. 2026; 21(4):1730-1753.

Zhai, Y; Xue, X; Bok, J; Skidmore, J; Fu, J; Martin, D. P149: CHARGE 3D neural tube model recapitulating impaired cranial neural crest migration. Genetics in Medicine Open. 2026; 4:103643.

Zhou, C; Wang, M; Chen, Z; Zhang, Y. Decoding stage-specific functions of PRC2 in early embryogenesis uncovers roles in preimplantation development and primordial germ cell fate. Nature Cell Biology. 2026.

Zhou, Y; Li, W-L; Liu, Z-Q; Ai, W-Q; Kou, J-X; Fan, H-W; Han, Z-T; Hu, Y-Z; Zhang, H-H; Jia, J-J; Man, H-Y; Lu, Y-M; Liu, D; Zhu, L-Q. Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons. Nature Neuroscience. 2026; 29(2):358-373.

Zhu, Y; Warmflash, A. Dependence of cell fate potential and cadherin switching on the coordinate within the primitive streak during differentiation of human pluripotent stem cells. Development. 2026; 153(7).