Developmental Biology

Publications

Adhikari, N; Wu, Z; Huang, Y; Lan, Y; Jiang, R. Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the Mammalian Jaw. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 2025; 104:310-319.

Bartusel, M; Kim, SX; Rehimi, R; Darnell, AM; Nikolić, M; Heggemann, J; Kolovos, P; van Ijcken, WF J; Varineau, J; Crispatzu, G; Laugsch, M; Ludwig, KU; Rada-Iglesias, A; Calo, E. A non-syndromic orofacial cleft risk locus links tRNA splicing defects to neural crest cell pathologies. The American Journal of Human Genetics. 2025; 112:1097-1116.

Bhaskar, S; Gowda, J; Hegde, A; Thumu, SC R; Banerjee, S; M Bellchambers, H; Ramanan, N; Sala, PM; Campbell, K; Ware, S; Prasanna, J; Kumar, A. Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons. Cell Death Discovery. 2025; 11:165.

Bischoff, ME; Shamsaei, B; Yang, J; Secic, D; Vemuri, B; Reisz, JA; D’alessandro, A; Bartolacci, C; Adamczak, R; Schmidt, L; Landero Figueroa, JA; Meller, J; Cunningham, JT; Czyzyk-Krzeska, MF. Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma. Cancer Discovery. 2025; 15:401-426.

Cai, H; Tian, C; Chen, L; Yang, Y; Sun, AX; McCracken, K; Tchieu, J; Gu, M; Mackie, K; Guo, F. Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids. Cell Stem Cell. 2025; 32:824-837.e5.

Cain, B; Yuan, Z; Thoman, E; Kovall, RA; Gebelein, B. The ALX4 dimer structure provides insight into how disease alleles impact function. Nature Communications. 2025; 16:4800.

Cederquist, GY; Oberst, P; Chang, X; Tchieu, J; Studer, L. Generation of Prefrontal Cortex Neurons from Human Pluripotent Stem Cells Under Chemically Defined Conditions. Synapse Development. : Springer US; Springer US; 2025.

Chang, X; Li, W; Matsui, S; Huynh, C; Erickson, C; Guo, F; Cederquist, GY; Studer, L; Iwafuchi, M; Shillington, A; Chronis, C; Tchieu, J. ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis. Nature Communications. 2025; 16:9010.

Chen, Z; Zhang, C; Zhang, Y. Chromatin Analyses in Mouse Oocytes and Preimplantation Embryos. Methods in molecular biology (Clifton, N.J.). 2025; 2923:33-44.

Chung, E; Nosrati, F; Adam, M; Potter, A; Sayed, M; Ahn, C; Humphreys, BD; Lim, HW; Hu, YC; Potter, SS; Park, JS. Proximal Tubule Cells Contribute to the Thin Descending Limb of the Loop of Henle during Mouse Kidney Development. Journal of the American Society of Nephrology : JASN. 2025; 36:1928-1938.

Crossen, MJ; Jia, S; Jorgensen, JS; Kelleher, AM; Jiang, R; Zhao, F. Wnt9b enables androgen action to maintain Wolffian ducts in mice. Molecular Human Reproduction. 2025; 31:gaaf035.

Edwards, NA; Rankin, SA; Kashyap, A; Warren, A; Agricola, ZN; Kenny, AP; Kofron, M; Shen, Y; Chung, WK; Zorn, AM. Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis. Developmental Cell. 2025; 60:2487-2502.e4.

Feuermann, M; Mi, H; Gaudet, P; Muruganujan, A; Lewis, SE; Ebert, D; Mushayahama, T; Westerfield, M; Ruzicka, L; Ramachandran, S; Skrzypek, MS; Nash, RS; Miyasato, SR; Karra, K. A compendium of human gene functions derived from evolutionary modelling. Nature. 2025; 640:146-154.

Halurkar, MS; Inoue, O; Singh, A; Mukherjee, R; Ginugu, M; Ahn, C; Bonatto Paese, CL; Duszynski, M; Brugmann, SA; Lim, HW; Sanchez-Gurmaches, J. The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes. Nature Communications. 2025; 16:770.

Hendrickson, CL; Blitz, IL; Hussein, A; Paraiso, KD; Cho, JS; Klymkowsky, MW; Kofron, MJ; Cho, KW Y. Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus. Editor, Bronner ME. PLoS Biology. 2025; 23:e3003476.

Huang, F; Wang, Y; Zhang, X; Gao, W; Li, J; Yang, Y; Mo, H; Prince, E; Long, Y; Hu, J; Chen, CW; Chen, J; Huang, H; Weng, H. m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability. Nature Communications. 2025; 16:4214.

Hyatt, BA; Lundberg, E; Eye, R; Rankin, SA; Zorn, AM. Temporal induction of the homeodomain transcription factor Nkx2-1 is sufficient to respecify foregut and hindgut endoderm to a pulmonary fate in Xenopus laevis. microPublication Biology. 2025; 2025:10.17912/micropub.biology.

Jia, Z; Li, B; Matsuo, M; Dewar, A; Mustafaraj, A; Dey, SK; Yuan, J; Sun, X. Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation. Nature Communications. 2025; 16:2465.

Lai, C; Chen, K; Huang, HZ; Huang, X; Zhang, J; Wang, YB; Chen, Z; Hu, F; Guo, Z; Man, HY; Du, HY; Lu, YM; Shu, K; Liu, D; Zhu, LQ. Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics. Cell Discovery. 2025; 11:16.

Li, SY; Whiteside, S; Li, B; Sun, X; DeFalco, T. Mesenchymal-to-epithelial transition of perivascular cells contributes to endometrial re-epithelialization. Nature Communications. 2025; 16:10174.

Matentzoglu, N; Bello, SM; Stefancsik, R; Alghamdi, SM; Anagnostopoulos, AV; Balhoff, JP; Balk, MA; Bradford, YM; Bridges, Y; Callahan, TJ; Haendel, MA; Mungall, CJ; McLaughlin, JA; Osumi-Sutherland, D. The Unified Phenotype Ontology : a framework for cross-species integrative phenomics. Editor, Baryshnikova A. Genetics: a periodical record of investigations bearing on heredity and variation. 2025; 229:iyaf027.

Matsuyama, S; DeFalco, T. Leydig Cell Interaction with Macrophages, Peritubular Cells, and Sertoli Cells. Leydig Cells. : Springer Nature; Springer Nature; 2025.

Miao, Y; Pek, NM; Tan, C; Jiang, C; Yu, Z; Iwasawa, K; Shi, M; Kechele, DO; Sundaram, N; Pastrana-Gomez, V; Zorn, AM; Chen, YW; Guo, M; Gu, M. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025; 188:4295-4313.e27.

Michaels, JR; Iyyanar, PP R; Husami, A; Vontell, AM; Brugmann, SA; Stottmann, RW. Genetic analysis and functional assessment of a TGFBR2 variant in micrognathia and cleft palate. Editor, Cray JJ. PloS one. 2025; 20:e0324803.

Mirizio, G; Sampson, S; Iwafuchi, M. Interplay between pioneer transcription factors and epigenetic modifiers in cell reprogramming. Regenerative Therapy. 2025; 28:246-252.

Mongan, M; Xiao, B; Christianto, A; Hu, YC; Xia, Y. Mitogen-Activated Protein Kinase Kinase Kinase 1 Overexpression Disrupts Development of the Ocular Surface Epithelium. Cells. 2025; 14:894.

Nunley, H; Xue, X; Fu, J; Lubensky, DK. Generation of fate patterns via intercellular forces. Physical Review Research. 2025; 7:l022051.

Peter, J; Caldwell, KC N; McClain, L; Tchieu, J; Ross, AE; Luo, Y. Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway. Neurobiology of Disease. 2025; 213:107023.

Pimentel, L; Ha, S; Yang, Y; Cochran, K; Chang, CF; Houghtaling, S; Gombart, SK; Beier, DR; Brugmann, SA. Centriolar protein PIBF1 is required for craniofacial and forebrain development. Developmental Biology. 2025; 527:55-64.

Rui, TY; Huang, HZ; Zheng, K; Fan, HW; Zhang, J; Guo, ZY; Man, HY; Brazhe, N; Semyanov, A; Lu, YM; Liu, D; Zhu, LQ. Tau Pathology Drives Disease-Associated Astrocyte Reactivity in Salt-Induced Neurodegeneration. Advanced Science. 2025; 12:e2410799.

Setayesh, T; Chi, M; Oestreicher, Z; Sakabe, M; Seu, K; Zhu, Z; Kaur, H; Tijani, A; Xin, M; Shova, A; Balla, J; VandenHeuvel, K; Hu, YC; Malik, P. A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea. Blood. 2025; 146:13-28.

Shen, C; Che, Y; Zhou, K; Wang, K; Li, W; Xue, D; Wu, T; Yang, L; Chen, M; Sheng, Y; Marcucci, G; He, C; Deng, X; Chen, J. ALKBH1 Drives Tumorigenesis and Drug Resistance via tRNA-decoding Reprogramming and Codon-biased Translation. Cancer Discovery. 2025; 15:2298-2325.

Shi, M; Crouse, B; Sundaram, N; Pode Shakked, N; Thorner, K; King, NM; Dutta, P; Ester, L; Zhang, W; Govindarajah, V; Mayhew, CN; Helmrath, MA; Bonventre, JV; McCracken, KW. Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud. Cell Stem Cell. 2025; 32:1055-1070.e8.

Singh, AK; D'Alessandro, A; Wellendorf, AM; Gonzalez-Nieto, D; Kofron, M; Dzieciatkowska, M; Mejia, L; Barrio, LC; Filippi, M; Cancelas, JA. Metabolic adaptation of regenerative hematopoiesis depends on docking-independent mitochondrial connexin 43. Blood. 2025; 146:2306-2321.

Solano, AF; Preusse, K; Cain, B; Hotz, R; Gavini, P; Yuan, Z; Bowen, B; Maco, G; Neal, H; Gagliani, EK; Southgate, L; Kovall, RA; Kopan, R; Gebelein, B. Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver Syndrome. The Journal of Clinical Investigation. 2025; 135:e187532.

Thapa, C; Walling, I; Chaturvedi, P; Baumgartner, S; Fleming, M; Biesiada, J; Salomonis, N; Crone, SA. Diverse Transcriptional Alterations in V2a Propriospinal Neurons Following Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025; 45:e1163242025.

Tominaga, K; Kechele, DO; Sanchez, JG; Vales, S; Jurickova, I; Roman, L; Asai, A; Enriquez, JR; McCauley, HA; Kishimoto, K; Zorn, AM; Helmrath, MA; Denson, LA; Wells, JM. Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2025; 19:101444.

Tweedie, L; Riccetti, MR; Cain, B; Qin, S; Salomone, J; Webb, JA; Riesenberg, A; Ehrman, LA; Waclaw, RR; Kovall, RA; Gebelein, B; Campbell, K. Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects. DMM Disease Models and Mechanisms. 2025; 18:dmm052110.

Weinhaus, B; Homan, S; Kincaid, M; Tadwalkar, A; Gu, X; Kumar, S; Slaughter, A; Zhang, J; Wu, Q; Kofron, JM; Troutman, TD; DeFalco, T; Lucas, D. Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells. Nature Communications. 2025; 16:4427.

Xue, X; Liu, Y; Fu, J. Bioengineering embryo models. 2025; 3:11-29.

Yoo, JJ; Serafin, EK; Kofron, JM; Baccei, ML. Early Life Injury Alters Spinal Astrocyte Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2025; 45:e1197252025.

Zhang, J; Yang, CQ; Liu, ZQ; Wu, SP; Li, ZG; Zhang, LM; Fan, HW; Guo, ZY; Man, HY; Li, X; Lu, YM; Zhu, LQ; Liu, D. Cpeb1 remodels cell type-specific translational program to promote fear extinction. Science Advances. 2025; 11:eadr8687.