Zorn Lab

Han, L; Chaturvedi, P; Kishimoto, K; Koike, H; Nasr, T; Iwasawa, K; Giesbrecht, K; Witcher, PC; Eicher, A; Haines, L; et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature Communications. 2020; 11.

Mukherjee, S; Chaturvedi, P; Rankin, SA; Fish, MB; Wlizla, M; Paraiso, KD; MacDonald, M; Chen, X; Weirauch, MT; Blitz, IL; et al. Sox17 and b-catenin co-occupy wntresponsive enhancers to govern the endoderm gene regulatory network. eLife. 2020; 9:1-26.

Nasr, T; Mancini, P; Rankin, SA; Edwards, NA; Agricola, ZN; Kenny, AP; Kinney, JL; Daniels, K; Vardanyan, J; Han, L; et al. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Developmental Cell. 2019; 51:665-674.e6.

Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature. 2019; 574:112-116.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Ruiz-Torres, S; Rankin, SA; Han, L; Nasr, T; Chaturvedi, P; Rothenberg, ME; et al. Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Cell Stem Cell. 2018; 23:501-515.e7.

Stevens, ML; Chaturvedi, P; Rankin, SA; Macdonald, M; Jagannathan, S; Yukawa, M; Barski, A; Zorn, AM. Genomic integration of Wnt/beta-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development (Cambridge). 2017; 144:1283-1295.

Rankin, SA; Han, L; McCracken, KW; Kenny, AP; Anglin, CT; Grigg, EA; Crawford, CM; Wells, JM; Shannon, JM; Zorn, AM. A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification. Cell Reports. 2016; 16:66-78.

Rankin, SA; Gallas, AL; Neto, A; Luis Gomez-Skarmeta, J; Zorn, AM. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/beta-catenin-mediated lung specification in Xenopus. Development (Cambridge). 2012; 139:3010-3020.

Kenny, AP; Rankin, SA; Allbee, AW; Prewitt, AR; Zhang, Z; Tabangin, ME; Shifley, ET; Louza, MP; Zorn, AM. Sizzled-Tolloid Interactions Maintain Foregut Progenitors by Regulating Fibronectin-Dependent BMP Signaling. Developmental Cell. 2012; 23:292-304.

Spence, JR; Mayhew, CN; Rankin, SA; Kuhar, MF; Vallance, JE; Tolle, K; Hoskins, EE; Kalinichenko, VV; Wells, SI; Zorn, AM; et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011; 470:105-U120.

Kormish, JD; Sinner, D; Zorn, AM. Interactions Between SOX Factors and Wnt/beta-Catenin Signaling in Development and Disease. Developmental Dynamics. 2010; 239:NA-NA.

Zorn, AM; Wells, JM. Vertebrate Endoderm Development and Organ Formation. Annual Review of Cell and Developmental Biology. 2009; 25:221-251.

Li, Y; Rankin, SA; Sinner, D; Kenny, AP; Krieg, PA; Zorn, AM. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes and Development. 2008; 22:3050-3063.

McLin, VA; Rankin, SA; Zorn, AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development (Cambridge). 2007; 134:2207-2217.

Sinner, D; Kirilenko, P; Rankin, S; Wei, E; Howard, L; Kofron, M; Heasman, J; Woodland, HR; Zorn, AM. Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development (Cambridge). 2006; 133:1955-1966.

Sinner, D; Rankin, S; Lee, M; Zorn, AM. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development (Cambridge). 2004; 131:3069-3080.

Zorn, AM; Barish, GD; Williams, BO; Lavender, P; Klymkowsky, MW; Varmus, HE. Regulation of Wnt signaling by sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular Cell. 1999; 4:487-498.

Kishimoto, K; Furukawa, KT; Luz-Madrigal, A; Yamaoka, A; Matsuoka, C; Habu, M; Alev, C; Zorn, AM; Morimoto, M. Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells. Nature Communications. 2020; 11.

Han, L; Chaturvedi, P; Kishimoto, K; Koike, H; Nasr, T; Iwasawa, K; Giesbrecht, K; Witcher, PC; Eicher, A; Haines, L; et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature Communications. 2020; 11.

Naert, T; Tulkens, D; Edwards, NA; Carron, M; Shaidani, NI; Wlizla, M; Boel, A; Demuynck, S; Horb, ME; Coucke, P; et al. Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos. Scientific Reports. 2020; 10.

Mukherjee, S; Chaturvedi, P; Rankin, SA; Fish, MB; Wlizla, M; Paraiso, KD; MacDonald, M; Chen, X; Weirauch, MT; Blitz, IL; et al. Sox17 and b-catenin co-occupy wntresponsive enhancers to govern the endoderm gene regulatory network. eLife. 2020; 9:1-26.

Fortriede, JD; Pells, TJ; Chu, S; Chaturvedi, P; Wang, D; Fisher, ME; James-Zorn, C; Wang, Y; Nenni, MJ; Burns, KA; et al. Xenbase: Deep integration of GEO & SRA RNA-seq and ChIP-seq data in a model organism database. Nucleic Acids Research. 2020; 48:D776-D782.

Nasr, T; Mancini, P; Rankin, SA; Edwards, NA; Agricola, ZN; Kenny, AP; Kinney, JL; Daniels, K; Vardanyan, J; Han, L; et al. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Developmental Cell. 2019; 51:665-674.e6.

Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature. 2019; 574:112-116.

Sterner, ZR; Rankin, SA; Wlizla, M; Choi, JA; Luedeke, DM; Zorn, AM; Buchholz, DR. Novel vectors for functional interrogation of Xenopus ORFeome coding sequences. Genesis: the Journal of Genetics and Development. 2019; 57.

Nenni, MJ; Fisher, ME; James-Zorn, C; Pells, TJ; Ponferrada, V; Chu, S; Fortriede, JD; Burns, KA; Wang, Y; Lotay, VS; et al. Xenbase: Facilitating the Use of Xenopus to Model Human Disease. Frontiers in Physiology. 2019; 10.

Steimle, JD; Rankin, SA; Slagle, CE; Bekeny, J; Rydeen, AB; Chan, SS-K; Kweon, J; Yang, XH; Ikegami, K; Nadadur, RD; et al. Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proceedings of the National Academy of Sciences of USA. 2018; 115:E10615-E10624.

Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Developmental Biology. 2018; 443:50-63.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Ruiz-Torres, S; Rankin, SA; Han, L; Nasr, T; Chaturvedi, P; Rothenberg, ME; et al. Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Cell Stem Cell. 2018; 23:501-515.e7.

Takebe, T; Wells, JM; Helmrath, MA; Zorn, AM. Organoid Center Strategies for Accelerating Clinical Translation. Cell Stem Cell. 2018; 22:806-809.

Rankin, SA; McCracken, KW; Luedeke, DM; Han, L; Wells, JM; Shannon, JM; Zorn, AM. Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis. Developmental Biology. 2018; 434:121-132.

Karimi, K; Fortriede, JD; Lotay, VS; Burns, KA; Wang, DZ; Fisher, ME; Pells, TJ; James-Zorn, C; Wang, Y; Ponferrada, VG; et al. Xenbase: a genomic, epigenomic and transcriptomic model organism database. Nucleic Acids Research. 2018; 46:D861-D868.

James-Zorn, C; Ponferrada, V; Fisher, ME; Burns, K; Fortriede, J; Segerdell, E; Karimi, K; Lotay, V; Wang, DZ; Chu, S; et al. Navigating xenbase: An integrated xenopus genomics and gene expression database. Methods in molecular biology (Clifton, N.J.). 2018; 1757:251-305.

Pells, T; Fisher, ME; Segerdell, E; Fortnede, JD; James-Zorn, C; Burns, KA; Ponferrada, V; Chaturvedi, P; Lotay, V; Nenni, M; et al. (2018) Visualization of gene expression and expression as a phenotype with the XPO, XAO and DO using a combination of experimental data sources. CEUR-WS.org. 2285.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Rankin, SA; Han, L; Nasr, T; Chatuvedi, P; Mandegar, MA; Zorn, AM; et al. Generation of Esophageal Organoids from Human Pluripotent Stem Cells and Their Use to Study Human Development. 2018.

Aslan, Y; Tadjuidje, E; Zorn, AM; Cha, S. High-efficiency non-mosaic CRISPR-mediated knock-in and indel mutation in F0 Xenopus. Development (Cambridge). 2017; 144:2852-2858.

Munera, JO; Sundaram, N; Rankin, SA; Hill, D; Watson, C; Mahe, M; Vallance, JE; Shroyer, NF; Sinagoga, KL; Zarzoso-Lacoste, A; et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017; 21:51-64.e6.

Han, L; Xu, J; Grigg, E; Slack, M; Chaturvedi, P; Jiang, R; Zorn, AM. Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Developmental Biology. 2017; 427:72-83.

Vize, PD; Zorn, AM. Xenopus genomic data and browser resources. Developmental Biology. 2017; 426:194-199.

Zorn, AM. Development of the digestive system. Seminars in Cell and Developmental Biology. 2017; 66:1-2.

Stevens, ML; Chaturvedi, P; Rankin, SA; Macdonald, M; Jagannathan, S; Yukawa, M; Barski, A; Zorn, AM. Genomic integration of Wnt/beta-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development (Cambridge). 2017; 144:1283-1295.

Session, AM; Uno, Y; Kwon, T; Hapman, JA C; Toyoda, A; Takahashi, S; Fukui, A; Hikosaka, A; Suzuki, A; Kondo, M; et al. Genome evolution in the allotetraploid frog Xenopus laevis. Nature. 2016; 538:336-343.

Nolan, K; Kattamuri, C; Rankin, SA; Read, RJ; Zorn, AM; Thompson, TB. Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism. Cell Reports. 2016; 16:2077-2086.

Zhang, Z; Rankin, SA; Zorn, AM. Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development. Developmental Biology. 2016; 416:187-199.

Rankin, SA; Han, L; McCracken, KW; Kenny, AP; Anglin, CT; Grigg, EA; Crawford, CM; Wells, JM; Shannon, JM; Zorn, AM. A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification. Cell Reports. 2016; 16:66-78.

Hawkins, F; Rankin, SA; Kotton, DN; Zorn, AM. The genetic programs regulating embryonic lung development and induced pluripotent stem cell differentiation. Fetal and Neonatal Lung Development: Clinical Correlates and Technologies for the Future. 2016.