Andreassen Lab

Publications

Hater, N; Iwaniuk, KM; Leifeld, C; Grüten, P; Wiek, C; Raba, K; Zhang, F; Fischer, JC; Andreassen, PR; Hanenberg, H; Trompeter, HI. Identification of new RAD51D-regulating microRNAs that also emerge as potent inhibitors of the Fanconi anemia/homologous recombination pathways. Human Molecular Genetics. 2022; 31:4241-4254.

Abe, H; Yeh, YH; Munakata, Y; Ishiguro, KI; Andreassen, PR; Namekawa, SH. Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation. Nature Communications. 2022; 13:7212.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; Romick-Rosendale, LE; Wells, SI. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14:2040.

Alavattam, KG; Maezawa, S; Andreassen, PR; Namekawa, SH. Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis. Cellular and Molecular Life Sciences. 2022; 79:18.

Abe, H; Meduri, R; Li, Z; Andreassen, PR; Namekawa, SH. RNF8 is not required for histone-to-protamine exchange in spermiogenesis†. Biology of Reproduction. 2021; 105:1154-1159.

Andreassen, PR; Seo, J; Wiek, C; Hanenberg, H. Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses. Genes. 2021; 12:1034.

Zhang, Y; Park, JY; Zhang, F; Olson, SH; Orlow, I; Li, Y; Kurtz, RC; Ladanyi, M; Chen, J; Toland, AE; Zhang, L; Andreassen, PR. The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. Human Mutation. 2021; 42:150-163.

Abe, H; Alavattam, KG; Hu, Y; Pang, Q; Andreassen, PR; Hegde, RS; Namekawa, SH. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology. 2020; 30:408-420.e5.

Yu, Y; Choi, K; Wu, J; Andreassen, PR; Dexheimer, PJ; Keddache, M; Brems, H; Spinner, RJ; Cancelas, JA; Martin, LJ; Wallace, MR; Legius, E; Vogel, KS; Ratner, N. NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation. Acta Neuropathologica. 2020; 139:157-174.

Jayavaradhan, R; Pillis, DM; Goodman, M; Zhang, F; Zhang, Y; Andreassen, PR; Malik, P. CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Nature Communications. 2019; 10:2866.

Hanenberg, H; Andreassen, PR. PALB2 (partner and localizer of BRCA2). Atlas of genetics and cytogenetics in oncology and haematology. 2018; 22:484-490.

Toland, AE; Andreassen, PR. DNA repair-related functional assays for the classification of BRCA1 and BRCA2 variants: a critical review and needs assessment. Journal of medical genetics. 2017; 54:721-731.

Alavattam, KG; Kato, Y; Sin, H; Maezawa, S; Kowalski, IJ; Zhang, F; Pang, Q; Andreassen, PR; Namekawa, SH. Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Cell Reports. 2016; 17:1141-1157.

Park, J; Virts, EL; Jankowska, A; Wiek, C; Othman, M; Chakraborty, SC; Vance, GH; Alkuraya, FS; Hanenberg, H; Andreassen, PR. Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene. Journal of medical genetics. 2016; 53:672-680.

Hanenberg, H; Zhang, F; Malev, N; Wiek, C; Klamer, BG; Nassar, N; Hesselbrock, T; Hanenberg, JH; Aeilts, AM; Hentschel, J; Hauke, J; Niederacher, D; Toland, AE; Andreassen, PR. Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points-Based Framework. Clinical Cancer Research. 2025; 31:2426-2440.

Li, J; Bai, J; Pham, VT; Hashimoto, M; Sezaki, M; Shi, Q; Jin, Q; He, C; Armstrong, A; Li, T; Luan, Y; Zeng, H; Andreassen, PR; Huang, G. Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells. The Journal of Clinical Investigation. 2025; 135:e184069.

Li, J; Hashimoto, M; Pan, M; Zeng, H; Andreassen, PR; Huang, G. Loss of Cpt1a Results in Elevated Mitochondrial Reactive Oxygen Species from Glucose-Fueled Mitochondrial Oxidative Phosphorylation and Defective Hematopoietic Stem Cells. Blood. 2024; 144:4035.

Alavattam, KG; Esparza, JM; Hu, M; Shimada, R; Kohrs, AR; Abe, H; Munakata, Y; Otsuka, K; Yoshimura, S; Kitamura, Y; Kim, J; Andreassen, PR; Ishiguro, KI; Namekawa, SH. ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline. Genes and Development. 2024; 38:115-130.

Luo, Z; Xin, D; Liao, Y; Berry, K; Ogurek, S; Zhang, F; Zhang, L; Zhao, C; Rao, R; Dong, X; Zhou, W; Weiss, WA; Andreassen, P; Lu, QR. Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nature Communications. 2023; 14:762.

Hashimoto, M; Li, J; Andreassen, PR; Huang, G. CPT1a Controls the Function of Long-Term Hematopoietic Stem Cells By Regulating the Balance between Fatty Acid Oxidation and Oxphos in Mitochondria. Blood. 2023; 142:4089.

Radulovic, I; Schündeln, MM; Müller, L; Ptok, J; Honisch, E; Niederacher, D; Wiek, C; Scheckenbach, K; Leblanc, T; Larcher, L; Soulier, J; Reinhardt, D; Schaal, H; Andreassen, PR; Hanenberg, H. A novel cancer risk prediction score for the natural course of FA patients with biallelic BRCA2/FANCD1 mutations. Human Molecular Genetics. 2023; 32:1836-1849.

Hashimoto, M; Li, J; Andreassen, P; Huang, G. 3079 – CPT1A MAINTAINS LONG-TERM HEMATOPOIETIC STEM CELLS BY REGULATING THE BALANCE BETWEEN FATTY ACID OXIDATION AND OXPHOS IN MITOCHONDRIA. Experimental Hematology. 2023; 124:s89.

Hater, N; Iwaniuk, KM; Leifeld, C; Grüten, P; Wiek, C; Raba, K; Zhang, F; Fischer, JC; Andreassen, PR; Hanenberg, H; Trompeter, HI. Identification of new RAD51D-regulating microRNAs that also emerge as potent inhibitors of the Fanconi anemia/homologous recombination pathways. Human Molecular Genetics. 2022; 31:4241-4254.

Abe, H; Yeh, YH; Munakata, Y; Ishiguro, KI; Andreassen, PR; Namekawa, SH. Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation. Nature Communications. 2022; 13:7212.

Chihanga, T; Vicente-Muñoz, S; Ruiz-Torres, S; Pal, B; Sertorio, M; Andreassen, PR; Khoury, R; Mehta, P; Davies, SM; Lane, AN; Romick-Rosendale, LE; Wells, SI. Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia. Cancers. 2022; 14:2040.

Alavattam, KG; Maezawa, S; Andreassen, PR; Namekawa, SH. Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis. Cellular and Molecular Life Sciences. 2022; 79:18.

Abe, H; Meduri, R; Li, Z; Andreassen, PR; Namekawa, SH. RNF8 is not required for histone-to-protamine exchange in spermiogenesis†. Biology of Reproduction. 2021; 105:1154-1159.

Andreassen, PR; Seo, J; Wiek, C; Hanenberg, H. Understanding BRCA2 Function as a Tumor Suppressor Based on Domain-Specific Activities in DNA Damage Responses. Genes. 2021; 12:1034.

Zhang, Y; Park, JY; Zhang, F; Olson, SH; Orlow, I; Li, Y; Kurtz, RC; Ladanyi, M; Chen, J; Toland, AE; Zhang, L; Andreassen, PR. The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response. Human Mutation. 2021; 42:150-163.