Projects
Lab Projects (3)
Targeting energy production in LSCs
Cells produce energy, which is required for cells to survive, through glycolysis and oxidative phosphorylation. In most cells, when one of these processes is inhibited the other increases to compensate for all in energy production. In leukemia stem cells (LSCs) when oxidative phosphorylation is inhibited, the cells do not have the ability to upregulate glycolysis which results in reduced energy production and LSC death. Therefore, targeting oxidative phosphorylation is a promising approach to better eradicate LSCs. Our lab is doing research to uncover leukemia-specific mechanisms that regulate oxidative phosphorylation.
Lipid metabolism in LSCs
We and others have shown that lipid metabolism is important for LSC survival and therapy resistance. Our lab is investigating how lipids are important for energy production, cell growth, and therapy resistance in LSCs. Our long-term goal is to develop novel therapeutic approaches to target lipid metabolism in order to kill LSCs.
Metabolites regulation protein function
Post translational modifications on proteins regulate many cellular functions including energy metabolism, cell signaling, and cell growth. The molecules that modify proteins are or are derived from metabolites. Our lab seeks to understand how unique metabolic properties of LSCs regulate post translational modifications on proteins within LSCs. These studies could lead to new approaches to target LSCs.
3333 Burnet Avenue, Cincinnati, Ohio 45229-3026
© 1999-2025 Cincinnati Children's Hospital Medical Center. All rights reserved.
