Courtney Jones Lab

Publications

O'brien, C; Nursimulu, N; Tyagi, A; Culp-Hill, R; Arruda, A; Murphy, T; Minden, MD; Kent, A; Stevens, B; Pollyea, DA; Hope, K; Kumar, S; Reisz, JA; D'alessandro, A; Jones, CL. Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia. Blood. 2025; 146(21):2589-2596.

Ling, T; O'brien, C; St-Germain, J; Rondeau, V; Shi, M; Berman, JM; Cepa, AK; Saez Raez, P; Wunderlich, M; Carter, K; Hope, K; D'alessandro, A; Raught, B; Jones, CL. Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation. Blood. 2025.

O'brien, C; Jones, CL. Unraveling lipid metabolism for acute myeloid leukemia therapy. Current Opinion in Hematology. 2025; 32(2):77-86.

Gower, M; Li, X; Aguilar-Navarro, AG; Lin, B; Fernandez, M; Edun, G; Nader, M; Rondeau, V; Arruda, A; Tierens, A; Jones, CL; Dolgalev, I; Jahangiri, S; Tikhonova, AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup. Science Translational Medicine. 2025; 17(779):eadr2012.

Sheth, AI; Althoff, MJ; Tolison, H; Engel, K; Amaya, ML; Krug, AE; Young, TN; Minhajuddin, M; Pei, S; Patel, SB; Smith, CA; Pollyea, DA; Stevens, BM; Jordan, CT. Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium. Cancer Discovery. 2024; 14(10):1922-1939.

Lee, SC-ES; Pyo, AHA; Mohammadi, H; Zhang, J; Dvorkin-Gheva, A; Malbeteau, L; Chung, S; Khan, S; Ciudad, MT; Rondeau, V; Culp-Hill, R; D'alessandro, A; Jones, CL; Koritzinsky, M. Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism. Science Advances. 2024; 10(40):eadq0355.

Rondeau, V; Berman, JM; Ling, T; O'brien, C; Culp-Hill, R; Reisz, JA; Wunderlich, M; Chueh, Y; Jiménez-Camacho, KE; Sexton, C; Minden, MD; Raught, B; D'alessandro, A; Jones, CL. Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models. Science Translational Medicine. 2024; 16(766):eadn1285.

O'brien, C; Ling, T; Berman, JM; Culp-Hill, R; Reisz, JA; Rondeau, V; Jahangiri, S; St-Germain, J; Macwan, V; Astori, A; Minden, MD; Raught, B; D'alessandro, A; Jones, CL. Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity. Haematologica. 2023; 108(9):2343-2357.

Jones, CL. Turning Down the Temperature on Leukemia Stem Cells. Cancer Research. 2023; 83(15):2441-2442.

Culp-Hill, R; Stevens, BM; Jones, CL; Pei, S; Dzieciatkowska, M; Minhajuddin, M; Jordan, CT; D'alessandro, A. Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2. Metabolites. 2023; 13(4).

Jones, CL. NOX2: a determinant of acute myeloid leukemia survival. Haematologica. 2022; 107(11):2530-2531.

Thomas, GE; Egan, G; García-Prat, L; Botham, A; Voisin, V; Patel, PS; Hoff, FW; Chin, J; Nachmias, B; Kaufmann, KB; Hakem, R; Kornblau, S; Dick, JE; Schimmer, AD. The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness. Nature Cell Biology. 2022; 24(6):872-884.

Amaya, ML; Inguva, A; Pei, S; Jones, C; Krug, A; Ye, H; Minhajuddin, M; Winters, A; Furtek, SL; Gamboni, F; Stevens, B; D'alessandro, A; Pollyea, DA; Reigan, P; Jordan, CT. The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation. Blood. 2022; 139(4):584-596.

Zhou, C; Uluisik, R; Rowley, JW; David, C; Jones, CL; Scharer, CD; Noetzli, L; Fisher, MH; Kirkpatrick, GD; Bark, K; Boss, JM; Henry, CJ; Pietras, EM; Di Paola, J; Porter, CC. Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Experimental Hematology. 2022; 112-113:24-34.