Courtney Jones Lab

Publications

O'Brien, C; Jones, CL. Unraveling lipid metabolism for acute myeloid leukemia therapy. Current Opinion in Hematology. 2025; 32:77-86.

Gower, M; Li, X; Aguilar-Navarro, AG; Lin, B; Fernandez, M; Edun, G; Nader, M; Rondeau, V; Arruda, A; Tierens, A; Jones, CL; Dolgalev, I; Jahangiri, S; Tikhonova, AN. An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup. Science Translational Medicine. 2025; 17:eadr2012.

Sheth, AI; Althoff, MJ; Tolison, H; Engel, K; Amaya, ML; Krug, AE; Young, TN; Minhajuddin, M; Pei, S; Patel, SB; Smith, CA; Pollyea, DA; Stevens, BM; Jordan, CT. Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium. Cancer Discovery. 2024; 14:1922-1939.

Lee, SC-E S; Pyo, AH A; Mohammadi, H; Zhang, J; Dvorkin-Gheva, A; Malbeteau, L; Chung, S; Khan, S; Ciudad, MT; Rondeau, V; Culp-Hill, R; D'Alessandro, A; Jones, CL; Koritzinsky, M. Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism. Science Advances. 2024; 10:eadq0355.

Rondeau, V; Berman, JM; Ling, T; O’Brien, C; Culp-Hill, R; Reisz, JA; Wunderlich, M; Chueh, Y; Jiménez-Camacho, KE; Sexton, C; Minden, MD; Raught, B; D’Alessandro, A; Jones, CL. Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models. Science Translational Medicine. 2024; 16:eadn1285.

O’Brien, C; Ling, T; Berman, JM; Culp-Hill, R; Reisz, JA; Rondeau, V; Jahangiri, S; St-Germain, J; Macwan, V; Astori, A; Minden, MD; Raught, B; DÁlessandro, A; Jones, CL. Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity. Haematologica: the hematology journal. 2023; 108:2343-2357.

Jones, CL. Turning Down the Temperature on Leukemia Stem Cells. Cancer Research. 2023; 83:2441-2442.

Culp-Hill, R; Stevens, BM; Jones, CL; Pei, S; Dzieciatkowska, M; Minhajuddin, M; Jordan, CT; D’Alessandro, A. Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2. Metabolites. 2023; 13:467.

Jones, CL. NOX2: a determinant of acute myeloid leukemia survival. Haematologica: the hematology journal. 2022; 107:2530-2531.

Zhou, C; Uluisik, R; Rowley, JW; David, C; Jones, CL; Scharer, CD; Noetzli, L; Fisher, MH; Kirkpatrick, GD; Bark, K; Boss, JM; Henry, CJ; Pietras, EM; Di Paola, J; Porter, CC. Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Experimental Hematology. 2022; 112-113:24-34.

Thomas, GE; Egan, G; García-Prat, L; Botham, A; Voisin, V; Patel, PS; Hoff, FW; Chin, J; Nachmias, B; Kaufmann, KB; Hakem, R; Kornblau, S; Dick, JE; Schimmer, AD. The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness. Nature Cell Biology. 2022; 24:872-884.

Amaya, ML; Inguva, A; Pei, S; Jones, C; Krug, A; Ye, H; Minhajuddin, M; Winters, A; Furtek, SL; Gamboni, F; Stevens, B; D'Alessandro, A; Pollyea, DA; Reigan, P; Jordan, CT. The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation. Blood. 2022; 139:584-596.

Yan, D; Franzini, A; Pomicter, AD; Halverson, BJ; Antelope, O; Mason, CC; Ahmann, JM; Senina, AV; Vellore, NA; Jones, CL; Rajabi, N; Olsen, CA; O’Hare, T; Deininger, MW. SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA. Blood Cancer Discovery. 2021; 2:266-287.

Agudo, J; Cheng, CW; Jones, CL; Avgustinova, A; Rodriguez-Fraticelli, AE; Storer, M. Introductions to the community: Early-career researchers in the time of COVID-19. Cell Stem Cell. 2021; 28:600-602.

Stevens, BM; O'Brien, C; Jordan, CT; Jones, CL. Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting. Star Protocols. 2021; 2:100248.

Jones, CL; Inguva, A; Jordan, CT. Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors. Cell Stem Cell. 2021; 28:378-393.