Publications

Dai, M; Lin, Y; El-Amouri, SS; Kohls, M; Pan, D. Comprehensive evaluation of blood-brain barrier-forming micro-vasculatures: Reference and marker genes with cellular composition. PLoS ONE. 2018; 13.

El-Amouri, SS; Dai, M; Han, J; Brady, RO; Pan, D. Normalization and improvement of CNS deficits in mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted iduronidase. Molecular Therapy. 2014; 22:2028-2037.

Dai, M; Han, J; El-Amouri, SS; Brady, RO; Pan, D. Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111:2680-2685.

Wang, D; El-Amouri, SS; Dai, M; Kuan, C; Hui, DY; Brady, RO; Pan, D. Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110:2999-3004.

Pan, D; Kalfa, TA; Wang, D; Risinger, M; Crable, S; Ottlinger, A; Chandra, S; Mount, DB; Huebner, CA; Franco, RS; et al. K-Cl cotransporter gene expression during human and murine erythroid differentiation. Journal of Biological Chemistry. 2011; 286:30492-30503.

Wang, D; Zhang, W; Kalfa, TA; Grabowski, G; Davies, S; Malik, P; Pan, D. Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:19958-19963.

Worsham, DN; Schuesler, T; von Kalle, C; Pan, D. In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector. Molecular Therapy. 2006; 14:514-524.

Pan, D; Gunther, R; Duan, WM; Wendell, S; Kaemmerer, W; Kafri, T; Verma, IM; Whitley, CB. Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Molecular Therapy. 2002; 6:19-29.

Pan, D; Shankar, R; Stroncek, DF; Whitley, CB. Combined ultrafiltration-transduction in a hollow-fiber bioreactor facilitates retrovirus-mediated gene transfer into peripheral blood lymphocytes from patients with mucopolysaccharidosis type II. Human Gene Therapy. 1999; 10:2799-2810.

Lin, Y; Wang, X; Rose, KP; Dai, M; Han, J; Xin, M; Pan, D. miR-143 Regulates Lysosomal Enzyme Transport across the Blood-Brain Barrier and Transforms CNS Treatment for Mucopolysaccharidosis Type I. Molecular Therapy. 2020; 28:2161-2176.

Che, L; Yang, X; Ge, C; El-Amouri, SS; Wang, Q; Pan, D; Herzog, TJ; Du, C. Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis. PLoS ONE. 2019; 14.

Hall, A; Choi, K; Liu, W; Rose, J; Zhao, C; Yu, Y; Na, Y; Cai, Y; Coover, RA; Lin, Y; et al. RUNX represses Pmp22 to drive neurofibromagenesis. Science advances. 2019; 5.

Pan, D; Buening, H; Ling, C. Rational Design of Gene Therapy Vectors. Molecular Therapy - Methods and Clinical Development. 2019; 12:246-247.

Han, J; El-Amouri, SS; Dai, M; Cao, P; Pan, D. Getting the Most: Enhancing Efficacy by Promoting Erythropoiesis and Thrombopoiesis after Gene Therapy in Mice with Hurler Syndrome. Molecular Therapy - Methods and Clinical Development. 2018; 11:52-64.

Dai, M; Lin, Y; El-Amouri, SS; Kohls, M; Pan, D. Comprehensive evaluation of blood-brain barrier-forming micro-vasculatures: Reference and marker genes with cellular composition. PLoS ONE. 2018; 13.

Zhang, W; Oehrle, M; Prada, CE; Schwartz, IV D; Chutipongtanate, S; Wattanasirichaigoon, D; Inskeep, V; Dai, M; Pan, D; Sun, Y; et al. A convenient approach to facilitate monitoring Gaucher disease progression and therapeutic response. The Analyst. 2017; 142:3380-3387.