Zheng Lab

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020; 19.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 2020; 105:925-936.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica. 2020; 105:573-584.

Grogg, MW; Zheng, Y. Rho GTPase-Activating Proteins in Cancer. The Rho GTPases in Cancer. 2010.

Lin, Y; Watanabe-Chailland, M; Zheng, Y. Protocol for structural and biochemical analyses of RhoA GTPase. STAR Protocols. 2021; 2.

Lin, Y; Lu, S; Zhang, J; Zheng, Y. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure with Folding & design. 2021; 29:553-563.e5.

Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience. 2021; 24.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, R; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021.

Guidi, N; Marka, G; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem Cells. 2021.

Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood. 2021.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; et al. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020; 19.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 2020; 105:925-936.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica. 2020; 105:573-584.

Zahra, FT; Sajib, MS; Ichiyama, Y; Akwii, RG; Tullar, PE; Cobos, C; Minchew, SA; Doci, CL; Zheng, Y; Kubota, Y; et al. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific Reports. 2019; 9.

Papaioannou, D; Petri, A; Dovey, OM; Terreri, S; Wang, E; Collins, FA; Woodward, LA; Walker, AE; Nicolet, D; Pepe, F; et al. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature Communications. 2019; 10.

Nassar, N; Hegde, SN; Gasilina, A; Wunderlich, M; Premnauth, G; Merino, E; Lin, Y; Ahmadian, R; Zheng, Y; Mizukawa, B; et al. The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph+(BCR-ABL1) B-ALL. Blood. 2019; 134:4647-4647.

Tu, Z; Wang, C; Zhao, C; Huang, L; Salomonis, N; Lu, RQ; Zheng, Y. Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells. Blood. 2019; 134:1191-1191.

Yang, JQ; Kalim, KW; Li, Y; Zheng, Y; Guo, F. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of Leukocyte Biology. 2019; 106:1139-1151.

Hochstetler, CL; Feng, Y; Sacma, M; Davis, AK; Rao, M; Kuan, C; You, L; Geiger, H; Zheng, Y. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental Hematology. 2019; 79:3-15.e4.

Zhou, W; Yang, Y; Mei, C; Dong, P; Mu, S; Wu, H; Zhou, Y; Zheng, Y; Guo, F; Yang, J. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells. 2019; 8.

Nguyen, P; Chakrabarti, J; Li, Y; Kalim, KW; Zhang, M; Zhang, L; Zheng, Y; Guo, F. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in Oncology. 2019; 9.

Qiu, S; Fan, X; Yang, Y; Dong, P; Zhou, W; Xu, Y; Zhou, Y; Guo, F; Zheng, Y; Yang, J. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PLoS ONE. 2019; 12.

Sertorio, M; Perentesis, JP; Vatner, RE; Mascia, AE; Zheng, Y; Wells, SI. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy. 2019; 5:40-48.

Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia. 2019; 33:749-761.

Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and Experimental Allergy. 2019; 49:92-107.

Lv, J; Zeng, J; Guo, F; Li, Y; Xu, M; Cheng, Y; Zhang, L; Cai, S; Chen, Y; Zheng, Y; et al. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory Research. 2018; 19.

Grigoryan, A; Guidi, N; Senger, K; Liehr, T; Soller, K; Marka, G; Vollmer, A; Markaki, Y; Leonhardt, H; Buske, C; et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biology. 2018; 19.

Hayashi, Y; Zhang, Y; Yokota, A; Yan, X; Liu, J; Choi, K; Li, B; Sashida, G; Peng, Y; Xu, Z; et al. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery. 2018; 8:1438-1457.

Hegde, S; Akbar, H; Zheng, Y; Cancelas, JA. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current Opinion in Hematology. 2018; 25:500-508.

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, AK; Tandon, NN; Bergmeier, W; Zheng, Y. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of Thrombosis and Haemostasis. 2018; 16:2083-2096.

Florian, MC; Klose, M; Sacma, M; Jablanovic, J; Knudson, L; Nattamai, KJ; Marka, G; Vollmer, A; Soller, K; Sakk, V; et al. Aging alters the epigenetic asymmetry of HSC division. PLoS Biology. 2018; 16.

Maliken, BD; Kanisicak, O; Karch, J; Khalil, H; Fu, X; Boyer, JG; Prasad, V; Zheng, Y; Molkentin, JD. Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018; 138:1012-1024.

Du, W; Liu, W; Mizukawa, B; Shang, X; Sipple, J; Wunderlich, M; Geiger, H; Davies, S; Mulloy, J; Pang, Q; et al. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia. 2018; 32:2041-2046.

Cai, X; Zheng, Y; Speck, NA. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of Visualized Experiments. 2018.

Mizukawa, B; O'Brien, E; Mulloy, JC; Zheng, Y. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in Molecular Biology. 2018; 1821:257-266.

Cai, X; Zhou, X; Zheng, Y. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. . 2018.

Chadwick, ML; Lane, A; Thomas, D; Smith, AR; White, AR; Davidson, D; Feng, Y; Boscolo, E; Zheng, Y; Adams, DM; et al. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget. 2018; 9:24750-24765.

Kalim, KW; Yang, J; Li, Y; Meng, Y; Zheng, Y; Guo, F. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of Immunology. 2018; 200:2313-2326.

Yang, Y; Dong, P; Zhao, J; Zhou, W; Zhou, Y; Xu, Y; Mei, C; Guo, F; Zheng, Y; Yang, J. PKCλ/ι regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2018; 1864:934-941.

Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer Cell. 2018; 33:292-308.e7.

Fang, J; Muto, T; Kleppe, M; Bolanos, LC; Hueneman, KM; Walker, CS; Sampson, L; Wellendorf, AM; Chetal, K; Choi, K; et al. TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. Cell Reports. 2018; 22:1250-1262.

Jiang, X; Hu, C; Ferchen, K; Nie, J; Cui, X; Chen, C; Cheng, L; Zuo, Z; Seibel, W; He, C; et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature Communications. 2017; 8.

Liu, M; Zhang, Z; Sampson, L; Zhou, X; Nalapareddy, K; Feng, Y; Akunuru, S; Melendez, J; Davis, AK; Bi, F; et al. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem Cell Reports. 2017; 9:1961-1975.

Jiang, X; Hu, C; Ferchen, K; Nie, J; Cui, X; Chen, C; Cheng, L; Zuo, Z; Seibel, W; He, C; et al. Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia. Blood. 2017; 130:857-857.

Guo, F; Zheng, Y. Vav1: Friend and Foe of Cancer. Trends in Cell Biology. 2017; 27:879-880.

Sakabe, M; Fan, J; Odaka, Y; Liu, N; Hassan, A; Duan, X; Stump, P; Byerly, L; Donaldson, M; Hao, J; et al. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114:10918-10923.

Mizukawa, B; O'Brien, E; Moreira, DC; Wunderlich, M; Hochstetler, CL; Duan, X; Liu, W; Orr, E; Grimes, HL; Mulloy, JC; et al. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood. 2017; 130:1336-1346.

Kalim, KW; Zhang, S; Chen, X; Li, Y; Yang, JQ; Zheng, Y; Guo, F. mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PLoS ONE. 2017; 12.

Hato, T; Winfree, S; Day, R; Sandoval, RM; Molitoris, BA; Yoder, MC; Wiggins, RC; Zheng, Y; Dunn, KW; Dagher, PC. Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN. 2017; 28:2420-2430.

El Zowalaty, AE; Li, R; Zheng, Y; Lydon, JP; DeMayo, FJ; Ye, X. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology. 2017; 158:2168-2178.

Sinagoga, KL; Stone, WJ; Schiesser, JV; Schweitzer, JI; Sampson, L; Zheng, Y; Wells, JM. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge). 2017; 144:2402-2414.

Zandvakili, I; Lin, Y; Morris, JC; Zheng, Y. Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene. 2017; 36:3213-3222.

Chen, X; Clark, J; Wunderlich, M; Fan, C; Davis, A; Chen, S; Guan, J; Mulloy, JC; Kumar, A; Zheng, Y. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy. 2017; 13:955-966.

Li, J; Miao, L; Zhao, C; Qureshi, WM S; Shieh, D; Guo, H; Lu, Y; Hu, S; Huang, A; Zhang, L; et al. CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge). 2017; 144:1635-1647.

Hayashi, Y; Zhang, Y; Yan, X; Sashida, G; Chetal, K; Olsson, A; Harada, H; Shih, LY; Tse, W; Bridges, J; et al. 12 HIF1A Signaling is a Central Pathobiologic Mediator of MDS. Leukemia Research. 2017; 55.

Nalapareddy, K; Nattamai, KJ; Kumar, RS; Karns, R; Wikenheiser-Brokamp, KA; Sampson, LL; Mahe, MM; Sundaram, N; Yacyshyn, M; Yacyshyn, B; et al. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell Reports. 2017; 18:2608-2621.

Fang, J; Bolanos, LC; Choi, K; Liu, X; Christie, S; Akunuru, S; Kumar, R; Wang, D; Chen, X; Greis, KD; et al. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature Immunology. 2017; 18:236-245.