Zheng Lab

Publications

Yang, Y; Liu, X; Wei, J; Qin, J; Tan, Q; Ji, J; Guo, F; Zheng, Y; Bi, F; Liu, M; Wang, G. In vivo expression of CD3/CD19 bispecific T-cell engager and α-PD-L1-Fc enables effective and durable immunotherapy for CD19+/PD-L1+ leukemia. Leukemia. 2026; 40(2):348-359.

Nalapareddy, K; Haslam, DB; Kissmann, A-K; Alenghat, T; Stahl, S; Rosenau, F; Zheng, Y; Geiger, H. Microbiota from young mice restore the function of aged ISCs. Stem Cell Reports. 2026; 102788.

Kirstein, A; Ionascu, D; Lamba, MAS; Ruffolo, BM; Crail, KJ; Mascia, AE; Sertorio, MG; Hinrichs, BH; Zender, C; Lehn, MA; Wise-Draper, TM; Perentesis, JP; Zheng, Y; Wells, SI. In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy. Clinical and Translational Radiation Oncology. 2026; 56:101046.

Mejía-Ramírez, E; Picazo, PI; Walter, B; Montserrat-Vazquez, S; Affuso, F; Wieser, S; Pezzano, F; Reymond, L; Castillo-Robles, J; Matteini, F; Ruprecht, V; Zheng, Y; Petrone, P; Florian, MC. Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells. Nature Aging. 2026; 6(1):68-87.

Iwata, W; Adachi, Y; West, JJ; Ewald, AJ; Zheng, Y; Wood, LD; Anders, RA; Sesaki, H; Iijima, M. Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix. Cell reports. 2025; 44(12):116649.

Cai, M; Adam, M; Duan, X; Guo, F; Zheng, Y. Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor. Science Advances. 2025; 11(44):eaea1212.

Dionisio, LM; Zheng, Y; Cancelas, JA. Redox Control in Platelet Activity and Therapy. Antioxidants. 2025; 14(11).

Li, Q; Liao, Y; Zeng, J; Hu, S; Li, C; Whitsett, JA; Zheng, Y; Luo, F; Xu, C; He, T; Lin, X; Wan, H. KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. 2025; 72(6):663-677.

Yang, J-Q; Wang, C; Nayak, RC; Kolla, M; Cai, M; Pujato, M; Zheng, Y; Lu, QR; Guo, F. Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8. Cellular & Molecular Biology Letters. 2025; 30(1):36.

Hsu, AY; Huang, Q; Pi, X; Fu, J; Raghunathan, K; Ghimire, L; Balasubramanian, A; Xie, X; Yu, H; Loison, F; Thiagarajah, JR; Wu, H; Feng, S; Luo, HR. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025; 188(6):1623-1641.e26.

Miao, L; Lu, Y; Nusrat, A; Fan, G; Zhang, S; Zhao, L; Wu, C-L; Guo, H; Huyen, TLN; Zheng, Y; Wan, LQ; Zhou, B; Evans, SM; Wu, M. Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Science. 2025; 387(6739):eadd3417.

Lin, Y; Zheng, Y. Structural Dynamics of Rho GTPases. Journal of Molecular Biology. 2025; 437(3):168919.

Khanal, N; Summey, V; Bailey, J; Duan, X; Zheng, Y; Zhu, L; Stringer, K; Rao, M; Banerjee, RK. Development of Mouse-Tumor Model Using Prostate Cancer (PC3) Cell Line for High-Intensity Focused Ultrasound (HIFU) Ablation. Prostate Cancer. 2025; 2025:5678314.

Hegde, S; Akbar, H; Wellendorf, AM; Nestheide, S; Johnson, JF; Zhao, X; Setchell, KD; Zheng, Y; Cancelas, JA. Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets. Blood. 2024; 144(16):1732-1746.

Thorman, AW; Reigle, J; Chutipongtanate, S; Yang, J; Shamsaei, B; Pilarczyk, M; Fazel-Najafabadi, M; Adamczak, R; Kouril, M; Bhatnagar, S; Hildeman, DA; Medvedovic, M; Herr, AB; Meller, J. Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking. Science Advances. 2024; 10(35):eadj3010.

Chang, Y-H; Yamamoto, K; Fujino, T; Wang, T-W; Sugimoto, E; Zhang, W; Yabushita, T; Suzaki, K; Pietsch, EC; Weir, BA; Enomoto, Y; Imai, Y; Kitamura, T; Goyama, S. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation. Cell reports. 2024; 43(8):114536.

Lin, Y; Ramelot, TA; Senyuz, S; Gursoy, A; Jang, H; Nussinov, R; Keskin, O; Zheng, Y. Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature Communications. 2024; 15(1):7176.

Zheng, Y. Conditioning for alloengraftment in FA. Blood. 2024; 143(21):2120-2122.

Zhang, D; Tang, W; Niu, H; Tse, W; Ruan, H-B; Dolznig, H; Knösel, T; Karl-Heinz, F; Themanns, M; Wang, J; Kenner, L; Moriggl, R; Zheng, Y; Han, X. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes and Diseases. 2024; 11(1):413-429.

Yang, Y; Huang, Q; Cheng, M; Deng, L; Liu, X; Zheng, X; Wei, J; Lei, Y; Li, X; Guo, F; Deng, Y; Zheng, Y; Bi, F; Wang, G; Liu, M. Efficacy and advantage of immunotherapy for melanoma via intramuscular co-expression of plasmid-encoded PD-1 and CTLA-4 scFvs. AMERICAN JOURNAL OF CANCER RESEARCH. 2024; 14(5):2626-2642.

Hofstetter, KS; Haas, PM; Kuntz, JP; Zheng, Y; Fuhrmann, S. Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse. Frontiers in Cellular Neuroscience. 2024; 18:1474010.

Zhang, C; Cui, X; Liu, Y; Wang, F; Signer, R; Nattamai, K; Zhou, D; Zheng, Y; Geiger, H; Wan, F; Liang, Y. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica. 2023; 108(12):3464-3470.

Wang, C; Zheng, Y; Fan, C; Tu, Z; Cai, X; Wu, J; Huang, G. Conserved and Unique Regulatory Mechanisms of RUNX1 in Hematopoietic Stem/Progenitor Cell Subpopulations in Both Normal Hematopoiesis and FPD/AML Development. Blood. 2023; 142(Supplement 1):1314.

Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; Tian, W; Zheng, Y. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia. 2023; 37(10):2073-2081.

Wang, C; Tu, Z; Cai, X; Wang, W; Davis, AK; Nattamai, K; Paranjpe, A; Dexheimer, P; Wu, J; Huang, FL; Geiger, H; Huang, G; Zheng, Y. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood advances. 2023; 7(11):2590-2605.

Modur, V; Muhammad, B; Yang, J-Q; Zheng, Y; Komurov, K; Guo, F. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell reports. 2023; 42(4):112364.

Katayama, K-I; Zheng, Y; Inoue, N. Rac is required for the survival of cortical neurons. Experimental Neurology. 2023; 361:114316.

Dandamudi, A; Seibel, W; Tourdot, B; Cancelas, JA; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023; 24(4).

Li, Y; Martin, TE; Hancock, JM; Li, R; Viswanathan, S; Lydon, JP; Zheng, Y; Ye, X. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of Reproduction. 2023; 108(2):204-217.

Dandamudi, A; Akbar, H; Cancelas, J; Zheng, Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023; 24(3).

Hegde, S; Nestheide, S; Wellndorf, A; Zheng, Y; Cancelas, J. 3080 – RHOA SIGNALING IS REQUIRED FOR THE COLD-INDUCED PLATELET LESION AND REVERSIBLE TARGETING OF RHOA IN A NEW PLATELET ADDITIVE SOLUTION EXTENDS DONOR-DERIVED PLATELET SHELF-LIFE TO FOURTEEN DAYS. Experimental Hematology. 2023; 124:s90.

Lin, Y; Zheng, Y. Rho Family GTPases and their Modulators. In: NADPH Oxidases Revisited: From Function to Structure. Springer Nature; 2023:287-310.

Florian, MC; Montserrat-Vazquez, S; Ali, N; Matteini, F; Lozano, J; Mejia-Ramirez, E; Sakk, V; Soller, K; Vollmer, A; Sacma, M; Zhaowei, T; Mallm, J-P; Plass, M; Zheng, Y; Geiger, H. 1003 – TRANSPLANTING REJUVENATED BLOOD STEM CELLS EXTENDS LIFESPAN OF AGED MICE. Experimental Hematology. 2023; 124:s21.

Montserrat-Vazquez, S; Ali, NJ; Matteini, F; Lozano, J; Zhaowei, T; Mejia-Ramirez, E; Marka, G; Vollmer, A; Soller, K; Sacma, M; Plass, M; Zheng, Y; Geiger, H; Florian, MC. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. npj Regenerative Medicine. 2022; 7(1):78.

Kim, Y-W; Zara, G; Kang, H; Branciamore, S; O'meally, D; Feng, Y; Kuan, C-Y; Luo, Y; Nelson, MS; Brummer, AB; Rockne, R; Chen, ZB; Zheng, Y; Cardoso, AA; Carlesso, N. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature Communications. 2022; 13(1):7235.

Kim, K-B; Kim, D-W; Kim, Y; Tang, J; Kirk, N; Gan, Y; Kim, B; Fang, B; Park, J-L; Zheng, Y; Park, K-S. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer Research. 2022; 82(22):4219-4233.

Hegde, S; Zheng, Y; Cancelas, JA. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current Opinion in Hematology. 2022; 29(6):281-289.

Kalim, KW; Yang, J-Q; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; Jegga, AG; Zheng, Y; Guo, F. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for ImmunoTherapy of Cancer. 2022; 10(11).

Romano, L; Seu, KG; Papoin, J; Muench, DE; Konstantinidis, D; Olsson, A; Schlum, K; Chetal, K; Chasis, JA; Mohandas, N; Grimes, HL; Salomonis, N; Blanc, L; Kalfa, TA. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood. 2022; 140(14):1621-1634.

Katayama, K-I; Zheng, Y; Inoue, N. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific Reports. 2022; 12(1):14848.

Akwii, RG; Sajib, MS; Zahra, FT; Tullar, P; Zabet-Moghaddam, M; Zheng, Y; Silvio Gutkind, J; Doci, CL; Mikelis, CM. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis. 2022; 25(3):373-396.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports. 2022; 40(2):111072.

Tu, Z; Zheng, Y. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current Opinion in Hematology. 2022; 29(4):174-180.

Nalapareddy, K; Zheng, Y; Geiger, H. Aging of intestinal stem cells. Stem Cell Reports. 2022; 17(4):734-740.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OHF; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; Perentesis, JP; Mizukawa, BE; Vinnedge, LP; Cancelas, JA; Nassar, NN. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36(3):637-647.

Amoah, A; Keller, A; Emini, R; Hoenicka, M; Liebold, A; Vollmer, A; Eiwen, K; Soller, K; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica. 2022; 107(2):393-402.

Zhang, Z; Zhang, F; Davis, AK; Xin, M; Walz, G; Tian, W; Zheng, Y. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell reports. 2022; 38(2):110009.

Matteini, F; Montserrat-Vazquez, S; Ali, N; Lozano, J; Zhaowei, T; De Arellano, EM-R; Marka, G; Vollmer, A; Soller, K; Saçma, M; Plass, M; Zheng, Y; Geiger, H; Florian, MC. 3010 – REJUVENATING BLOOD STEM CELLS EXTENDS LIFESPAN OF AGED IMMUNOCOMPROMISED MICE. Experimental Hematology. 2022; 111:s49.