Publications

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020; 19.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 2020; 105:925-936.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica. 2020; 105:573-584.

Grogg, MW; Zheng, Y. Rho GTPase-Activating Proteins in Cancer. The Rho GTPases in Cancer. 2010.

Nalapareddy, K; Zheng, Y; Geiger, H. Aging of intestinal stem cells. Stem Cell Reports. 2022; 17:734-740.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; et al. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Akwii, RG; Sajib, MS; Zahra, FT; Tullar, P; Zabet-Moghaddam, M; Zheng, Y; Silvio Gutkind, J; Doci, CL; Mikelis, CM. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis. 2022.

Zhang, Z; Zhang, F; Davis, AK; Xin, M; Walz, G; Tian, W; Zheng, Y. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell Reports. 2022; 38.

Zhang, Z; Liu, M; Zheng, Y. Role of Rho GTPases in stem cell regulation. Biochemical Society Transactions. 2021; 49:2941-2955.

Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. Journal of Neuroscience. 2021; 41:10247-10260.

Kandi, R; Senger, K; Grigoryan, A; Soller, K; Sakk, V; Schuster, T; Eiwen, K; Menon, MB; Gaestel, M; Zheng, Y; et al. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO Reports. 2021; 22.

Duan, X; Perveen, R; Dandamudi, A; Adili, R; Johnson, J; Funk, K; Berryman, M; Davis, AK; Holinstat, M; Zheng, Y; et al. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific Reports. 2021; 11.

Zhang, B; Nguyen, LX T; Zhao, D; Frankhouser, DE; Wang, H; Hoang, DH; Qiao, J; Abundis, C; Brehove, M; Su, YL; et al. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of Hematology and Oncology. 2021; 14.

Chlon, TM; Stepanchick, E; Hershberger, CE; Daniels, NJ; Hueneman, KM; Kuenzi Davis, A; Choi, K; Zheng, Y; Gurnari, C; Haferlach, T; et al. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021; 28:1966-1981.e6.

Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in Immunology. 2021; 12.

Mori, Y; Takashima, S; Kanatsu-Shinohara, M; Yi, Z; Shinohara, T. Cdc42 is required for male germline niche development in mice. Cell Reports. 2021; 36.

Guidi, N; Marka, G; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem Cells. 2021; 39:1101-1106.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; et al. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13.

Tu, Z; Wang, C; Davis, AK; Hu, M; Zhao, C; Xin, M; Lu, QR; Zheng, Y. Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood. 2021.

Lin, Y; Watanabe-Chailland, M; Zheng, Y. Protocol for structural and biochemical analyses of RhoA GTPase. STAR Protocols. 2021; 2.

Lin, Y; Lu, S; Zhang, J; Zheng, Y. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure with Folding & design. 2021; 29:553-563.e5.

Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience. 2021; 24.

Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood. 2021.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; et al. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021; 17:1-382.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020; 19.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 2020; 105:925-936.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica. 2020; 105:573-584.

Nayak, RC; Hegde, S; Althoff, MJ; Wellendorf, AM; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, MT; et al. The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nature Communications. 2019; 10.

Zahra, FT; Sajib, MS; Ichiyama, Y; Akwii, RG; Tullar, PE; Cobos, C; Minchew, SA; Doci, CL; Zheng, Y; Kubota, Y; et al. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific Reports. 2019; 9.

Papaioannou, D; Petri, A; Dovey, OM; Terreri, S; Wang, E; Collins, FA; Woodward, LA; Walker, AE; Nicolet, D; Pepe, F; et al. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature Communications. 2019; 10.

Nassar, N; Hegde, SN; Gasilina, A; Wunderlich, M; Premnauth, G; Merino, E; Lin, Y; Ahmadian, R; Zheng, Y; Mizukawa, B; et al. The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph+(BCR-ABL1) B-ALL. Blood. 2019; 134:4647-4647.

Tu, Z; Wang, C; Zhao, C; Huang, L; Salomonis, N; Lu, RQ; Zheng, Y. Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells. Blood. 2019; 134:1191-1191.

Yang, JQ; Kalim, KW; Li, Y; Zheng, Y; Guo, F. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of Leukocyte Biology. 2019; 106:1139-1151.

Hochstetler, CL; Feng, Y; Sacma, M; Davis, AK; Rao, M; Kuan, C; You, L; Geiger, H; Zheng, Y. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental Hematology. 2019; 79:3-15.e4.

Zhou, W; Yang, Y; Mei, C; Dong, P; Mu, S; Wu, H; Zhou, Y; Zheng, Y; Guo, F; Yang, J. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells. 2019; 8.

Nguyen, P; Chakrabarti, J; Li, Y; Kalim, KW; Zhang, M; Zhang, L; Zheng, Y; Guo, F. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in Oncology. 2019; 9.

Qiu, S; Fan, X; Yang, Y; Dong, P; Zhou, W; Xu, Y; Zhou, Y; Guo, F; Zheng, Y; Yang, J. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PLoS ONE. 2019; 12.

Sertorio, M; Perentesis, JP; Vatner, RE; Mascia, AE; Zheng, Y; Wells, SI. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy. 2019; 5:40-48.

Liu, W; Du, W; Shang, X; Wang, L; Evelyn, C; Florian, MC; Ryan, MA; Rayes, A; Zhao, X; Setchell, K; et al. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia. 2019; 33:749-761.

Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and Experimental Allergy. 2019; 49:92-107.

Lv, J; Zeng, J; Guo, F; Li, Y; Xu, M; Cheng, Y; Zhang, L; Cai, S; Chen, Y; Zheng, Y; et al. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory Research. 2018; 19.

Grigoryan, A; Guidi, N; Senger, K; Liehr, T; Soller, K; Marka, G; Vollmer, A; Markaki, Y; Leonhardt, H; Buske, C; et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biology. 2018; 19.

Hayashi, Y; Zhang, Y; Yokota, A; Yan, X; Liu, J; Choi, K; Li, B; Sashida, G; Peng, Y; Xu, Z; et al. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery. 2018; 8:1438-1457.

Hegde, S; Akbar, H; Zheng, Y; Cancelas, JA. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current Opinion in Hematology. 2018; 25:500-508.

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, AK; Tandon, NN; Bergmeier, W; Zheng, Y. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of Thrombosis and Haemostasis. 2018; 16:2083-2096.

Florian, MC; Klose, M; Sacma, M; Jablanovic, J; Knudson, L; Nattamai, KJ; Marka, G; Vollmer, A; Soller, K; Sakk, V; et al. Aging alters the epigenetic asymmetry of HSC division. PLoS Biology. 2018; 16.

Maliken, BD; Kanisicak, O; Karch, J; Khalil, H; Fu, X; Boyer, JG; Prasad, V; Zheng, Y; Molkentin, JD. Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018; 138:1012-1024.

Du, W; Liu, W; Mizukawa, B; Shang, X; Sipple, J; Wunderlich, M; Geiger, H; Davies, S; Mulloy, J; Pang, Q; et al. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia. 2018; 32:2041-2046.

Cai, X; Zheng, Y; Speck, NA. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of Visualized Experiments. 2018.

Mizukawa, B; O'Brien, E; Mulloy, JC; Zheng, Y. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in Molecular Biology. 2018; 1821:257-266.

Cai, X; Zhou, X; Zheng, Y. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. . 2018.

Chadwick, ML; Lane, A; Thomas, D; Smith, AR; White, AR; Davidson, D; Feng, Y; Boscolo, E; Zheng, Y; Adams, DM; et al. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget. 2018; 9:24750-24765.

Kalim, KW; Yang, J; Li, Y; Meng, Y; Zheng, Y; Guo, F. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of Immunology. 2018; 200:2313-2326.

Yang, Y; Dong, P; Zhao, J; Zhou, W; Zhou, Y; Xu, Y; Mei, C; Guo, F; Zheng, Y; Yang, J. PKCλ/ι regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2018; 1864:934-941.

Wu, LM N; Deng, Y; Wang, J; Zhao, C; Wang, J; Rao, R; Xu, L; Zhou, W; Choi, K; Rizvi, TA; et al. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer Cell. 2018; 33:292-308.e7.

Fang, J; Muto, T; Kleppe, M; Bolanos, LC; Hueneman, KM; Walker, CS; Sampson, L; Wellendorf, AM; Chetal, K; Choi, K; et al. TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. Cell Reports. 2018; 22:1250-1262.

Contact Us

For information regarding the Zheng Lab and the Cell Signaling and Drug Discovery Program contact:

Yi Zheng, PhD
Phone: 513-636-0594
Email: yi.zheng@cchmc.org  

Experimental Hematology and Cancer Biology
Location R
Room R-7503