Zheng Lab

Publications

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; Azam, M; Tian, W; Lu, QR; Zheng, Y. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2020102118.

Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; Diaz-Meco, MT; Moscat, J; Cancelas, JA. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020; 136:1824-1836.

Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; Mulaw, M; Wagner, W; Zheng, Y; Geiger, H. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging Cell. 2020; 19:e13208.

Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature Immunology. 2020; 21:535-545.

Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; Tang, J; Zheng, Y; Zhou, Y; Shen, S. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica: the hematology journal. 2020; 105:925-936.

Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica: the hematology journal. 2020; 105:573-584.

Grogg, MW; Zheng, Y. Rho GTPase-Activating Proteins in Cancer. The Rho GTPases in Cancer. : Springer Nature; Springer Nature; 2010.

Hsu, AY; Huang, Q; Pi, X; Fu, J; Raghunathan, K; Ghimire, L; Balasubramanian, A; Xie, X; Yu, H; Loison, F; Thiagarajah, JR; Wu, H; Feng, S; Luo, HR. Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025; 188:1623-1641.e26.

Miao, L; Lu, Y; Nusrat, A; Fan, G; Zhang, S; Zhao, L; Wu, CL; Guo, H; Huyen, TL N; Zheng, Y; Wan, LQ; Zhou, B; Evans, SM; Wu, M. Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Science. 2025; 387:eadd3417.

Lin, Y; Zheng, Y. Structural Dynamics of Rho GTPases. Journal of Molecular Biology. 2025; 437:168919.

Lin, Y; Ramelot, TA; Senyuz, S; Gursoy, A; Jang, H; Nussinov, R; Keskin, O; Zheng, Y. Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature Communications. 2024; 15:7176.

Hofstetter, KS; Haas, PM; Kuntz, JP; Zheng, Y; Fuhrmann, S. Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse. Frontiers in Cellular Neuroscience. 2024; 18:1474010.

Hegde, S; Akbar, H; Wellendorf, AM; Nestheide, S; Johnson, JF; Zhao, X; Setchell, KD; Zheng, Y; Cancelas, JA. Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets. Blood. 2024; 144:1732-1746.

Thorman, AW; Reigle, J; Chutipongtanate, S; Yang, J; Shamsaei, B; Pilarczyk, M; Fazel-Najafabadi, M; Adamczak, R; Kouril, M; Bhatnagar, S; Hildeman, DA; Medvedovic, M; Herr, AB; Meller, J. Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking. Science Advances. 2024; 10:eadj3010.

Chang, YH; Yamamoto, K; Fujino, T; Wang, TW; Sugimoto, E; Zhang, W; Yabushita, T; Suzaki, K; Pietsch, EC; Weir, BA; Enomoto, Y; Imai, Y; Kitamura, T; Goyama, S. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation. Cell Reports. 2024; 43:114536.

Zheng, Y. Conditioning for alloengraftment in FA. Blood. 2024; 143:2120-2122.

Zhang, D; Tang, W; Niu, H; Tse, W; Ruan, HB; Dolznig, H; Knösel, T; Karl-Heinz, F; Themanns, M; Wang, J; Kenner, L; Moriggl, R; Zheng, Y; Han, X. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes and Diseases. 2024; 11:413-429.

Yang, Y; Huang, Q; Cheng, M; Deng, L; Liu, X; Zheng, X; Wei, J; Lei, Y; Li, X; Guo, F; Deng, Y; Zheng, Y; Bi, F; Wang, G; Liu, M. Efficacy and advantage of immunotherapy for melanoma via intramuscular co-expression of plasmid-encoded PD-1 and CTLA-4 scFvs. AMERICAN JOURNAL OF CANCER RESEARCH. 2024; 14:2626-2642.

Zhang, C; Cui, X; Liu, Y; Wang, F; Signer, R; Nattamai, K; Zhou, D; Zheng, Y; Geiger, H; Wan, F; Liang, Y. Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica: the hematology journal. 2023; 108:3464-3470.

Wang, C; Zheng, Y; Fan, C; Tu, Z; Cai, X; Wu, J; Huang, G. Conserved and Unique Regulatory Mechanisms of RUNX1 in Hematopoietic Stem/Progenitor Cell Subpopulations in Both Normal Hematopoiesis and FPD/AML Development. Blood. 2023; 142:1314.

Fan, C; Wunderlich, M; Cai, X; Yan, Z; Zhang, F; Davis, AK; Xu, L; Guo, F; Lu, QR; Azam, M; Tian, W; Zheng, Y. Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor. Leukemia. 2023; 37:2073-2081.

Wang, C; Tu, Z; Cai, X; Wang, W; Davis, AK; Nattamai, K; Paranjpe, A; Dexheimer, P; Wu, J; Huang, FL; Geiger, H; Huang, G; Zheng, Y. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation. Blood Advances. 2023; 7:2590-2605.

Modur, V; Muhammad, B; Yang, JQ; Zheng, Y; Komurov, K; Guo, F. Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects. Cell Reports. 2023; 42:112364.

Katayama, KI; Zheng, Y; Inoue, N. Rac is required for the survival of cortical neurons. Experimental Neurology. 2023; 361:114316.

Dandamudi, A; Seibel, W; Tourdot, B; Cancelas, JA; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents. International Journal of Molecular Sciences. 2023; 24:4167.

Li, Y; Martin, TE; Hancock, JM; Li, R; Viswanathan, S; Lydon, JP; Zheng, Y; Ye, X. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor™ 488 Hydrazide†. Biology of Reproduction. 2023; 108:204-217.

Dandamudi, A; Akbar, H; Cancelas, J; Zheng, Y. Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies. International Journal of Molecular Sciences. 2023; 24:2519.

Lin, Y; Zheng, Y. Rho Family GTPases and their Modulators. NADPH Oxidases Revisited: From Function to Structure. : Springer Nature; Springer Nature; 2023.

Hegde, S; Nestheide, S; Wellndorf, A; Zheng, Y; Cancelas, J. 3080 – RHOA SIGNALING IS REQUIRED FOR THE COLD-INDUCED PLATELET LESION AND REVERSIBLE TARGETING OF RHOA IN A NEW PLATELET ADDITIVE SOLUTION EXTENDS DONOR-DERIVED PLATELET SHELF-LIFE TO FOURTEEN DAYS. Experimental Hematology. 2023; 124:s90.

Montserrat-Vazquez, S; Ali, NJ; Matteini, F; Lozano, J; Zhaowei, T; Mejia-Ramirez, E; Marka, G; Vollmer, A; Soller, K; Sacma, M; Plass, M; Zheng, Y; Geiger, H; Florian, MC. Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice. npj Regenerative Medicine. 2022; 7:78.

Kim, YW; Zara, G; Kang, HJ; Branciamore, S; O’Meally, D; Feng, Y; Kuan, CY; Luo, Y; Nelson, MS; Brummer, AB; Rockne, R; Chen, ZB; Zheng, Y; Cardoso, AA; Carlesso, N. Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium. Nature Communications. 2022; 13:7235.

Katayama, KI; Zheng, Y; Inoue, N. Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer. Scientific Reports. 2022; 12:14848.

Kalim, KW; Yang, JQ; Wunderlich, M; Modur, V; Nguyen, P; Li, Y; Wen, T; Davis, AK; Verma, R; Lu, QR; Jegga, AG; Zheng, Y; Guo, F. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. Journal for ImmunoTherapy of Cancer. 2022; 10:e004806.

Kim, KB; Kim, DW; Kim, Y; Tang, J; Kirk, N; Gan, Y; Kim, B; Fang, B; Park, JL; Zheng, Y; Park, KS. WNT5A-RHOA Signaling Is a Driver of Tumorigenesis and Represents a Therapeutically Actionable Vulnerability in Small Cell Lung Cancer. Cancer Research. 2022; 82:4219-4233.

Hegde, S; Zheng, Y; Cancelas, JA. Novel blood derived hemostatic agents for bleeding therapy and prophylaxis. Current Opinion in Hematology. 2022; 29:281-289.

Romano, L; Seu, KG; Papoin, J; Muench, DE; Konstantinidis, D; Olsson, A; Schlum, K; Chetal, K; Chasis, JA; Mohandas, N; Grimes, HL; Salomonis, N; Blanc, L; Kalfa, TA. Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood. 2022; 140:1621-1634.

Akwii, RG; Sajib, MS; Zahra, FT; Tullar, P; Zabet-Moghaddam, M; Zheng, Y; Silvio Gutkind, J; Doci, CL; Mikelis, CM. Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Angiogenesis. 2022; 25:373-396.

Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell Reports. 2022; 40:111072.

Tu, Z; Zheng, Y. Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Current Opinion in Hematology. 2022; 29:174-180.

Nalapareddy, K; Zheng, Y; Geiger, H. Aging of intestinal stem cells. Stem Cell Reports. 2022; 17:734-740.

Hegde, S; Gasilina, A; Wunderlich, M; Lin, Y; Buchholzer, M; Krumbach, OH F; Akbarzadeh, M; Ahmadian, MR; Seibel, W; Zheng, Y; Perentesis, JP; Mizukawa, BE; Vinnedge, LP; Cancelas, JA; Nassar, NN. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia. Leukemia. 2022; 36:637-647.

Amoah, A; Keller, A; Emini, R; Hoenicka, M; Liebold, A; Vollmer, A; Eiwen, K; Soller, K; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity. Haematologica: the hematology journal. 2022; 107:393-402.

Zhang, Z; Zhang, F; Davis, AK; Xin, M; Walz, G; Tian, W; Zheng, Y. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell Reports. 2022; 38:110009.

Zhang, Z; Liu, M; Zheng, Y. Role of Rho GTPases in stem cell regulation. Biochemical Society Transactions. 2021; 49:2941-2955.

Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021; 41:10247-10260.

Kandi, R; Senger, K; Grigoryan, A; Soller, K; Sakk, V; Schuster, T; Eiwen, K; Menon, MB; Gaestel, M; Zheng, Y; Florian, MC; Geiger, H. Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. EMBO Reports. 2021; 22:e52931.

Duan, X; Perveen, R; Dandamudi, A; Adili, R; Johnson, J; Funk, K; Berryman, M; Davis, AK; Holinstat, M; Zheng, Y; Akbar, H. Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis. Scientific Reports. 2021; 11:13170.

Zhang, B; Nguyen, LX T; Zhao, D; Frankhouser, DE; Wang, H; Hoang, DH; Qiao, J; Abundis, C; Brehove, M; Su, YL; Zheng, Y; Carlesso, N; Kuo, YH; Marcucci, G. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of Hematology and Oncology. 2021; 14:122.

Dandamudi, A; Seibel, W; Akbar, H; Zheng, Y. Structure-Activity Relationship Analysis of Analogs of Rhosin, a RhoA Inhibitor, Reveals a New Generation of Improved Antiplatelet Agents. Blood. 2021; 138:3989.

Chlon, TM; Stepanchick, E; Hershberger, CE; Daniels, NJ; Hueneman, KM; Kuenzi Davis, A; Choi, K; Zheng, Y; Gurnari, C; Haferlach, T; Padgett, RA; Maciejewski, JP; Starczynowski, DT. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021; 28:1966-1981.e6.

Kalim, KW; Yang, JQ; Modur, V; Nguyen, P; Li, Y; Zheng, Y; Guo, F. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Frontiers in Immunology. 2021; 12:726393.

Mori, Y; Takashima, S; Kanatsu-Shinohara, M; Yi, Z; Shinohara, T. Cdc42 is required for male germline niche development in mice. Cell Reports. 2021; 36:109550.

Guidi, N; Marka, G; Sakk, V; Zheng, Y; Florian, MC; Geiger, H. An aged bone marrow niche restrains rejuvenated hematopoietic stem cells. Stem Cells. 2021; 39:1101-1106.

Fan, Y; Teng, Y; Loison, F; Pang, A; Kasorn, A; Shao, X; Zhang, C; Ren, Q; Yu, H; Zheng, Y; Feng, S; Silberstein, LE; Ma, F; Luo, HR. Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Science Translational Medicine. 2021; 13:eabb1069.

Lin, Y; Watanabe-Chailland, M; Zheng, Y. Protocol for structural and biochemical analyses of RhoA GTPase. Star Protocols. 2021; 2:100541.

Lin, Y; Lu, S; Zhang, J; Zheng, Y. Structure of an inactive conformation of GTP-bound RhoA GTPase. Structure. 2021; 29:553-563.e5.

Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H. Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. iScience. 2021; 24:102362.

Sheng, Y; Ma, R; Yu, C; Wu, Q; Zhang, S; Paulsen, K; Zhang, J; Ni, H; Huang, Y; Zheng, Y; Qian, Z. Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice. Blood. 2021; 137:610-623.

Hegde, S; Wellendorf, AM; Zheng, Y; Cancelas, JA. Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage. Transfusion. 2021; 61:557-567.

Sertorio, M; Nowrouzi, A; Akbarpour, M; Chetal, K; Salomonis, N; Brons, S; Mascia, A; Ionascu, D; McCauley, S; Kupneski, T; Perentesis, JP; Abdollahi, A; Zheng, Y; Wells, SI. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiotherapy and Oncology. 2021; 155:293-303.

Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; Azam, M; Tian, W; Lu, QR; Zheng, Y. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of USA. 2021; 118:e2020102118.

Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; Au, AK; Auberger, P; Auner, HW; Aurelian, L. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021; 17:1-382.