Publications

Dillman, JR; Tkach, JA; Imbus, R; Towbin, AJ; Denson, LA. MRI-Based Characterization of Intestinal Motility in Children and Young Adults With Newly Diagnosed Ileal Crohn Disease Treated by Biologic Therapy: A Controlled Prospective Study. American Journal of Roentgenology. 2022.

Lipstein, EA; Brinkman, WB; Zhang, Y; Hommel, KA; Ittenbach, RF; Liu, C; Denson, LA. Decision making about anti-TNF therapy: A pilot trial of a shared decision-making intervention. Patient Education and Counseling. 2022; 105:1075-1081.

Shoda, T; Collins, MH; Rochman, M; Wen, T; Caldwell, JM; Mack, LE; Osswald, GA; Besse, JA; Haberman, Y; Aceves, SS; et al. Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study. Gastroenterology. 2022; 162:1635-1649.

Ata, NA; Dillman, JR; Gandhi, D; Dudley, JA; Trout, AT; Imbus, R; Towbin, AJ; Denson, LA; Tkach, JA. Velocity-Encoded Phase-Contrast MRI for Measuring Mesenteric Blood Flow in Patients With Newly Diagnosed Small-Bowel Crohn Disease. American Journal of Roentgenology. 2022; 1-10.

Venkateswaran, S; Somineni, HK; Kilaru, V; Katrinli, S; Prince, J; Okou, DT; Hyams, JS; Denson, LA; Kellermayer, R; Gibson, G; et al. Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease. G3: Genes, Genomes, Genetics. 2022; 12.

Jurickova, I; Bonkowski, E; Angerman, E; Novak, E; Huron, A; Akers, G; Iwasawa, K; Braun, T; Hadar, R; Hooker, M; et al. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. 2022.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, B; D’Haens, GR; van Limbergen, J; Chun, K; Yang, J; et al. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55:593-603.

Wang, YM; Abdullah, S; Luebbering, N; Duell, A; Lake, KE; Denson, LA; Jodele, S; Haslam, D; Faubion Jr., WA; Davies, SM; et al. 18 Alterations in Day+30 Intestinal Permeability As Measured By a Novel Lactulose:Rhamonose Test Predicts Adverse Outcomes in Children: A Prospective Study. Transplantation and cellular therapy. 2022; 28:s17-s18.

Hyams, JS; Brimacombe, M; Haberman, Y; Walters, T; Gibson, G; Mo, A; Mack, D; Griffiths, A; Boyle, B; Leleiko, N; et al. Clinical and Host Biological Factors Predict Colectomy Risk in Children Newly Diagnosed With Ulcerative Colitis. Inflammatory Bowel Diseases. 2022; 28:151-160.

Haberman Ziv, Y; Braun, T; Sosnovski, K; Amir, A; VanDussen, K; Igor Ulitsky, IU; Griffiths, A; Walters, T; Mack, D; Boyle, B; et al. P089 Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic Functions. Journal of Crohn's and Colitis. 2022; 16:i187-i189.

Verburgt, C; Dunn, KA; Bielawski, JP; Otley, AR; Heyman, MB; Sunseri, W; Shouval, D; Levine, A; de Meij, T; Hyams, JS; et al. P711 Stool microbiome communities predict remission in pediatric Crohn’s disease patients even after start of treatment. Journal of Crohn's and Colitis. 2022; 16:i608-i608.

Sosnovski, K; BenShoShan, M; Braun, T; Barshack, I; Denson, L; Haberman, Y. P054 LHFPL3-AS2 long non-coding (lncRNA) is reduced in mucosal biopsies of Crohn Disease, and its reduction in tissue culture disrupts epithelial polarity. Journal of Crohn's and Colitis. 2022; 16:i164-i166.

Krishnakumar, C; Ananthakrishnan, AN; Boyle, BM; Griffiths, AM; LeLeiko, NS; Mack, DR; Markowitz, JF; Rosh, JR; Sauer, CG; Walters, TD; et al. Early Change in Fecal Calprotectin Predicts One-Year Outcome in Children Newly Diagnosed With Ulcerative Colitis. Journal of Pediatric Gastroenterology and Nutrition. 2022; 74:72-78.

Zhao, X; Setchell, KD R; Huang, R; Mallawaarachchi, I; Ehsan, L; Dobrzykowski, E; Zhao, J; Syed, S; Ma, JZ; Iqbal, NT; et al. Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction. Journal of Nutrition. 2021; 151:3689-3700.

Soomro, S; Venkateswaran, S; Vanarsa, K; Kharboutli, M; Nidhi, M; Susarla, R; Zhang, T; Sasidharan, P; Lee, KH; Rosh, J; et al. Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen. Nature Communications. 2021; 12.

Pelia, R; Venkateswaran, S; Matthews, JD; Haberman, Y; Cutler, DJ; Hyams, JS; Denson, LA; Kugathasan, S. Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn's disease. BMC Medical Genomics. 2021; 14.

Moorman, EL; Farrell, M; Santucci, N; Denson, L; Le, C; Cunningham, NR. Elevated fecal calprotectin is linked to psychosocial complexity in pediatric functional abdominal pain disorders. BMC Research Notes. 2021; 14.

Ta, AD; Ollberding, NJ; Karns, R; Haberman, Y; Alazraki, AL; Hercules, D; Baldassano, R; Markowitz, J; Heyman, MB; Kim, S; et al. Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease. Inflammatory Bowel Diseases. 2021; 27:1707-1718.

Denson, LA. Application of mucosal functional genomics to childhood undernutrition and stunting: Insights into mechanisms and targeted interventions. EBioMedicine. 2021; 71.

Mo, A; Nagpal, S; Gettler, K; Haritunians, T; Giri, M; Haberman, Y; Karns, R; Prince, J; Arafat, D; Hsu, NY; et al. Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression. American Journal of Human Genetics. 2021; 108:1765-1779.

Niklinska-Schirtz, BJ; Venkateswaran, S; Anbazhagan, M; Kolachala, VL; Prince, J; Dodd, A; Chinnadurai, R; Gibson, G; Denson, LA; Cutler, DJ; et al. Ileal Derived Organoids From Crohn's Disease Patients Show Unique Transcriptomic and Secretomic Signatures. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1267-1280.

Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; et al. PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1479-1502.

Colman, RJ; Tsai, YT; Jackson, K; Boyle, BM; Noe, JD; Hyams, JS; D'Haens, GR A M; Van Limbergen, J; Rosen, MJ; Denson, LA; et al. Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:1045-1051.

Aschenbrenner, D; Quaranta, M; Banerjee, S; Ilott, N; Jansen, J; Steere, B; Chen, YH; Ho, S; Cox, K; Arancibia-Cárcamo, CV; et al. Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance. Gut. 2021; 70:1023-1036.

Xiong, Y; Mizuno, T; Colman, R; Hyams, J; Noe, JD; Boyle, B; Tsai, YT; Dong, M; Jackson, K; Punt, N; et al. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical Pharmacology and Therapeutics. 2021; 109:1639-1647.

Hellmann, J; Etter, RK; Denson, LA; Minar, P; Hill, D; Dykes, DM; Rosen, MJ. Quality Improvement Methodology Optimizes Infliximab Levels in Pediatric Patients with Inflammatory Bowel Disease. Pediatric Quality and Safety. 2021; 6.

Grasberger, H; Magis, AT; Sheng, E; Conomos, MP; Zhang, M; Garzotto, LS; Hou, G; Bishu, S; Nagao-Kitamoto, H; El-Zaatari, M; et al. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. Journal of Clinical Investigation. 2021; 131.

Haberman, Y; Iqbal, NT; Ghandikota, S; Mallawaarachchi, I; Tzipi Braun, ; Dexheimer, PJ; Rahman, N; Hadar, R; Sadiq, K; Ahmad, Z; et al. Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction. Gastroenterology. 2021; 160:2055-2071.e0.

Lyles, JL; Mulgund, AA; Bauman, LE; Su, W; Fei, L; Chona, DL; Sharma, P; Etter, RK; Hellmann, J; Denson, LA; et al. Effect of a Practice-wide Anti-TNF Proactive Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2021; 27:482-492.

Short, SP; Pilat, JM; Barrett, CW; Reddy, VK; Haberman, Y; Hendren, JR; Marsh, BJ; Keating, CE; Motley, AK; Hill, KE; et al. Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. Gastroenterology. 2021; 160:1694-1708.e3.

Somineni, HK; Nagpal, S; Venkateswaran, S; Cutler, DJ; Okou, DT; Haritunians, T; Simpson, CL; Begum, F; Datta, LW; Quiros, AJ; et al. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. American Journal of Human Genetics. 2021; 108:431-445.

Haberman, Y; Minar, P; Karns, R; Dexheimer, PJ; Ghandikota, S; Tegge, S; Shapiro, D; Shuler, B; Venkateswaran, S; Braun, T; et al. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. Journal of Crohn's and Colitis. 2021.

Potdar, AA; Dube, S; Naito, T; Li, K; Botwin, G; Haritunians, T; Li, D; Casero, D; Yang, S; Bilsborough, J; et al. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. Gastroenterology. 2021; 160:809-822.e7.

Gray, WN; Wagoner, ST; Schaefer, MR; Reed, B; Morgan, P; Holbrook, E; Yacyshyn, B; MacKner, L; Young, M; Maddux, M; et al. Transition to Adult IBD Care: A Pilot Multi-Site, Telehealth Hybrid Intervention. Journal of Pediatric Psychology. 2021; 46:1-11.

Ungaro, RC; Hu, L; Ji, J; Nayar, S; Kugathasan, S; Denson, LA; Hyams, J; Dubinsky, MC; Sands, BE; Cho, JH. Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2021; 53:281-290.

Sali, R; Adewole, S; Ehsan, L; Denson, LA; Kelly, P; Amadi, BC; Holtz, L; Ali, SA; Moore, SR; Syed, S; et al. Hierarchical Deep Convolutional Neural Networks for Multi-category Diagnosis of Gastrointestinal Disorders on Histopathological Images. 2020 IEEE International Conference on Healthcare Informatics (ICHI). 2020; 00:1-6.

Lam, S; Singh, R; Dillman, JR; Trout, AT; Serai, SD; Sharma, D; Sheridan, R; Su, W; Fei, L; Karns, R; et al. Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease. Hepatology Communications. 2020; 4:1680-1693.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. 2020; 586:108-112.

Plevinsky, JM; Denson, LA; Hellmann, J; Minar, P; Rosen, MJ; Hommel, KA. A Micro-longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:366-370.

Mack, DR; Saul, B; Boyle, B; Griffiths, A; Sauer, C; Markowitz, J; LeLeiko, N; Keljo, D; Rosh, JR; Baker, SS; et al. Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:354-360.

Abu-El-Haija, M; Hornung, L; Lin, TK; Nathan, JD; Thompson, T; Vitale, DS; Nasr, A; Husain, SZ; Denson, L. Drug induced pancreatitis is the leading known cause of first attack acute pancreatitis in children. Pancreatology. 2020; 20:1103-1108.

Hellmann, J; Andersen, H; Fei, L; Linn, A; Bezold, R; Lake, K; Jackson, K; Meyer, D; Dirksing, K; Bonkowski, E; et al. Microbial Shifts and Shorter Time to Bowel Resection Surgery Associated with C. difficile in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2020; 26:1212-1221.

Denson, LA. Mitochondrial Networks: A New Therapeutic Target in Colitis. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 10:426-427.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Rosen, MJ; Denson, LA; et al. 613 ANTIBODIES TO INFLIXIMAB ACCELERATE DRUG CLEARANCE WHILE INTENSIFICATION STRATEGIES REVERSE IMMUNOGENICITY AND RECAPTURE CLINICAL RESPONSE. Gastroenterology. 2020; 158.

Minar, PP; Xiong, Y; Mizuno, T; Colman, RJ; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Tsai, YT; et al. 1160 REAL-WORLD PEDIATRIC INFLIXIMAB PHARMACOKINETIC MODEL VERIFIES CRITICAL NEED FOR PRECISION DOSING SOFTWARE. Gastroenterology. 2020; 158.

Shapiro, JM; El-Serag, HB; Gandle, C; Peacock, C; Denson, LA; Fishman, LN; Hernaez, R; Hou, JK. Recommendations for Successful Transition of Adolescents With Inflammatory Bowel Diseases to Adult Care. Clinical Gastroenterology and Hepatology. 2020; 18:276-289.e2.

Haberman Ziv, Y; Minar, P; Karns, R; Dexheimer, P; Ghandikota, S; Tegge, S; Shapiro, D; Shuler, B; Venkateswaran, S; Braun, T; et al. DOP89 Pre-treatment mucosal inflammatory and wound healing gene programmes reveal mechanisms associated with future stricturing behaviour during 5-year follow-up in paediatric Crohn’s disease. Journal of Crohn's and Colitis. 2020; 14:s127-s127.

Haberman Ziv, Y; Loberman-Nachum, N; Katya, S; Di Segni, A; Efroni, G; Braun, T; BenShoshan, M; Shouval, D; Denson, LA; Amir, A; et al. OP06 Comparison between Crohn and coeliac diseases small intestine transcriptomics and microbial data define similarities and divergent pathways linked to pathogenesis. Journal of Crohn's and Colitis. 2020; 14:s006-s006.

Venkateswaran, S; Denson, LA; Jurickova, I; Dodd, A; Zwick, ME; Cutler, DJ; Kugathasan, S; Okou, DT. Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants. Scientific Reports. 2019; 9.

Iqbal, NT; Syed, S; Sadiq, K; Khan, MN; Iqbal, J; Ma, JZ; Umrani, F; Ahmed, S; Maier, EA; Denson, LA; et al. Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation. BMC Pediatrics. 2019; 19.

Schuler, CL; Dodds, C; Hommel, KA; Ittenbach, RF; Denson, LA; Lipstein, EA. Shared decision making in IBD: A novel approach to trial consent and timing. Contemporary Clinical Trials Communications. 2019; 16.

Loberman-Nachum, N; Sosnovski, K; Di Segni, A; Efroni, G; Braun, T; BenShoshan, M; Anafi, L; Avivi, C; Barshack, I; Shouval, DS; et al. Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis. Scientific Reports. 2019; 9.

Vaz, KK H; Carmody, JK; Zhang, Y; Denson, LA; Hommel, KA. Evaluation of a Novel Educational Tool in Adolescents With Inflammatory Bowel Disease: The NEAT Study. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:564-569.

Naramore, SK; Jr, BW E; Jiang, G; Kugathasan, S; Denson, LA; Hyams, JS; Steiner, SJ; Grp, PR O-K I I D. Serologic, but Not Genetic, Markers Are Associated With Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:e129-e134.

Tokarz, R; Hyams, JS; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Shah, S; Markowitz, J; Baker, SS; et al. Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflammatory Bowel Diseases. 2019; 25:1656-1662.

Carmody, JK; Plevinsky, J; Peugh, JL; Denson, LA; Hyams, JS; Lobato, D; LeLeiko, NS; Hommel, KA. Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis. Alimentary Pharmacology and Therapeutics. 2019; 50:911-918.

Minar, P; Lehn, C; Tsai, YT; Jackson, K; Rosen, MJ; Denson, LA. Elevated Pretreatment Plasma Oncostatin M Is Associated With Poor Biochemical Response to Infliximab. Crohn's && Colitis 360. 2019; 1.

Martin, JC; Chang, C; Boschetti, G; Ungaro, R; Giri, M; Grout, JA; Gettler, K; Chuang, L; Nayar, S; Greenstein, AJ; et al. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019; 178:1493-1508.e20.

Gettler, K; Giri, M; Kenigsberg, E; Martin, J; Chuang, L; Hsu, N; Denson, LA; Hyams, JS; Griffiths, A; Noe, JD; et al. Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets. Genes and Immunity. 2019; 20:577-588.

Ballengee, CR; Stidham, RW; Liu, C; Kim, M; Prince, J; Mondal, K; Baldassano, R; Dubinsky, M; Markowitz, J; Leleiko, N; et al. Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Clinical Gastroenterology and Hepatology. 2019; 17:1799-1806.

Gray, WN; Holbrook, E; Dykes, D; Morgan, PJ; Saeed, SA; Denson, LA. Improving IBD Transition, Self-management, and Disease Outcomes With an In-clinic Transition Coordinator. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:194-199.

Clarkston, K; Tsai, Y; Jackson, K; Rosen, MJ; Denson, LA; Minar, P. Development of Infliximab Target Concentrations During Induction in Pediatric Crohn Disease Patients. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:68-74.

Wright, M; Chandrakasan, S; Okou, DT; Yin, H; Jurickova, I; Denson, LA; Kugathasan, S. Early Onset Granulomatous Colitis Associated with a Mutation in NCF4 Resolved with Hematopoietic Stem Cell Transplantation. Journal of Pediatrics. 2019; 210:220-225.

Krishnakumar, C; Ballengee, CR; Liu, C; Kim, M; Baker, SS; Baldassano, RN; Cohen, SA; Crandall, WV; Denson, LA; Dubinsky, MC; et al. Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Inflammatory Bowel Diseases. 2019; 25:1208-1217.

Somineni, HK; Venkateswaran, S; Kilaru, V; Marigorta, UM; Mo, A; Okou, DT; Kellermayer, R; Mondal, K; Cobb, D; Walters, TD; et al. Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology. 2019; 156:2254-2265.e3.

Abu-El-Haija, M; Valencia, CA; Hornung, L; Youssef, N; Thompson, T; Barasa, NW; Wang, X; Denson, LA. Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children. Pancreatology. 2019; 19:535-540.

Lloyd-Price, J; Arze, C; Ananthakrishnan, AN; Schirmer, M; Avila-Pacheco, J; Poon, TW; Andrews, E; Ajami, NJ; Bonham, KS; Brislawn, CJ; et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019; 569:655-662.

Denson, LA; Curran, M; McGovern, DP B; Koltun, WA; Duerr, RH; Kim, SC; Sartor, RB; Sylvester, FA; Abraham, C; de Zoeten, EF; et al. Challenges in IBD Research: Precision Medicine. Inflammatory Bowel Diseases. 2019; 25:S31-S39.

Wu, J; Lubman, DM; Kugathasan, S; Denson, LA; Hyams, JS; Dubinsky, MC; Griffiths, AM; Baldassano, RN; Noe, JD; Rabizadeh, S; et al. Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease. American Journal of Gastroenterology. 2019; 114:777-785.

Hajjat, T; Mosha, MH; Bonkowski, E; Denson, LA; Hyams, JS. 882 – Normalization of Fecal Calprotectin Requires Higher Trough Infliximab Levels in Children with Inflammatory Bowel Disease. Gastroenterology. 2019; 156:s-200.

Lyles, JL; Mulgund, AA; Bauman, LE; Su, W; Fei, L; Chona, D; Sharma, P; Etter, R; Hellmann, J; Denson, LA; et al. 303 – Effect of a Practice-Wide Anti-TNF Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. Gastroenterology. 2019; 156:s-60.

Hyams, JS; Thomas, SD; Gotman, N; Haberman, Y; Karns, R; Schirmer, M; Mo, A; Mack, DR; Boyle, B; Griffiths, AM; et al. Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. The Lancet. 2019; 393:1708-1720.

Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Science Alliance. 2019; 2.

Carmody, JK; Denson, LA; Hommel, KA. Content and Usability Evaluation of Medication Adherence Mobile Applications for Use in Pediatrics. Journal of Pediatric Psychology. 2019; 44:333-342.

Haberman, Y; Schirmer, M; Dexheimer, PJ; Karns, R; Braun, T; Kim, M; Walters, TD; Baldassano, RN; Noe, JD; Rosh, J; et al. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunology. 2019; 12:491-502.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, D; Valencia, CA; Dodd, A; Mondal, K; Aronow, BJ; et al. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2019; 25:547-560.

Shaw, KA; Cutler, DJ; Okou, D; Dodd, A; Aronow, BJ; Haberman, Y; Stevens, C; Walters, TD; Griffiths, A; Baldassano, RN; et al. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes and Immunity. 2019; 20:131-142.

Picoraro, JA; Lee, D; Heller, CA; Weaver, A; Hyams, JS; Conklin, LS; Otley, A; Ziring, D; Kugathasan, S; Rosh, JR; et al. Pediatric Inflammatory Bowel Disease Clinical Innovations Meeting of the Crohn's & Colitis Foundation: Charting the Future of Pediatric IBD. Inflammatory Bowel Diseases. 2019; 25:27-32.

Sweeny, KF; Lin, TK; Nathan, JD; Denson, LA; Husain, SZ; Hornung, L; Thompson, T; Abu-El-Haija, M. Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. Journal of Pediatric Gastroenterology and Nutrition. 2019; 68:104-109.

Momozawa, Y; Dmitrieva, J; Theatre, E; Deffontaine, V; Rahmouni, S; Charloteaux, B; Crins, F; Docampo, E; Elansary, M; Gori, A; et al. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications. 2018; 9.

Romick-Rosendale, LE; Haslam, DB; Lane, A; Denson, L; Lake, K; Wilkey, A; Watanabe, M; Bauer, S; Litts, B; Luebbering, N; et al. Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant. Biology of Blood and Marrow Transplantation. 2018; 24:2418-2424.

Abu-El-Haija, M; Hornung, L; Denson, LA; Husami, A; Lin, TK; Matlock, K; Nathan, JD; Palermo, JJ; Thompson, T; Valencia, CA; et al. Prevalence of abnormal glucose metabolism in pediatric acute, acute recurrent and chronic pancreatitis. PLoS ONE. 2018; 13.

Schirmer, M; Denson, L; Vlamakis, H; Franzosa, EA; Thomas, S; Gotman, NM; Rufo, P; Baker, SS; Sauer, C; Markowitz, J; et al. Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell Host and Microbe. 2018; 24:600-610.e4.

Chandradevan, R; Hofmekler, TT; Mondal, K; Harun, N; Venkateswaran, S; Somineni, HK; Ballengee, CR; Kim, M; Griffiths, A; Noe, JD; et al. Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles. Inflammatory Bowel Diseases. 2018; 24:2285-2290.

Lindoso, L; Mondal, K; Venkateswaran, S; Somineni, HK; Ballengee, C; Walters, TD; Griffiths, A; Noe, JD; Crandall, W; Snapper, S; et al. The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. American Journal of Gastroenterology. 2018; 113:1524-1529.

Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight. 2018; 3.

Gutierrez, M; Scaglia, P; Keselman, A; Martucci, L; Karabatas, L; Domene, S; Martin, A; Pennisi, P; Blanco, M; Sanguineti, N; et al. Partial growth hormone insensitivity and dysregulatory immune disease associated with de novo germline activating STAT3 mutations. Molecular and Cellular Endocrinology. 2018; 473:166-177.

Chen, J; Hu, F; Kugathasan, S; Jorde, LB; Nix, D; Rutherford, A; Denson, L; Watkins, WS; Prahalad, S; Huff, C; et al. Targeted Gene Sequencing in Children with Crohn's Disease and Their Parents: Implications for Missing Heritability. G3: Genes, Genomes, Genetics. 2018; 8:2881-2888.

Ledder, O; Church, P; Cytter-Kuint, R; Martinez-Leon, M; Sladek, M; Coppenrath, E; Weiss, B; Yerushalmi, B; Martin de Carpi, J; Duchano, L; et al. A Simple Endoscopic Score Modified for the Upper Gastrointestinal Tract in Crohn's Disease [UGI-SES-CD]: A Report From the ImageKids Study. Journal of Crohn's and Colitis. 2018; 12:1073-1078.

Boyle, B; Collins, M; Denson, L; Hyams, J. Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed With Ulcerative Colitis. American Journal of Surgical Pathology. 2018; 42.

Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology. 2018; 155:501-513.

Venkateswaran, S; Marigorta, UM; Denson, LA; Hyams, JS; Gibson, G; Kugathasan, S. Bowel Location Rather Than Disease Subtype Dominates Transcriptomic Heterogeneity in Pediatric IBD. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:474-476.e3.

Orscheln, ES; Dillman, JR; Towbin, AJ; Denson, LA; Trout, AT. Penetrating Crohn disease: does it occur in the absence of stricturing disease?. Abdominal Radiology. 2018; 43:1583-1589.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, DT; Dodd, A; Quinn, K; Mondal, K; Aronow, BJ; et al. Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease. Gastroenterology. 2018; 154:2097-2110.

Spencer, EA; Davis, SM; Mack, DR; Boyle, BM; Griffiths, AM; LeLeiko, NS; Sauer, CG; Keljo, DJ; Markowitz, JF; Baker, SS; et al. Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children. Inflammatory Bowel Diseases. 2018; 24:1335-1343.

Wright, SS; Trauernicht, A; Bonkowski, E; McCall, CA; Maier, EA; Bezold, R; Lake, K; Chalk, C; Trapnell, BC; Kim, M; et al. Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition. 2018; 66:767-772.

Jurickova, I; Karns, R; Cutler, DJ; Okou, D; Dodd, A; Mondal, K; Aronow, BJ; Haberman, Y; Linn, A; Price, A; et al. 378 - Genomic Correlates of Reduced Neutrophil Granulocytemacrophage Colony Stimulating Factor Signaling in Stricturing Pediatric Crohn Disease. Gastroenterology. 2018; 154.

Carmody, J; Plevinsky, J; Peugh, J; Lobato, D; Leleiko, NS; Hyams, JS; Denson, LA; Baker, SS; Sauer, CG; Markowitz, J; et al. Su2018 - Longitudinal Adherence to Mesalamine in Pediatric Ulcerative Colitis: Results from the Protect Study. Gastroenterology. 2018; 154.

Hajjat, T; Wang, Z; Rufo, PA; Strople, JA; Sauer, CG; Markowitz, J; Pfefferkorn, MD; Oliva-Hemker, M; Rosh, JR; Otley, A; et al. 497 - Irrespective of Initial Ulcerative Colitis Therapy Thiopurines Unlikely to Result in Corticosteroid-Free Remission One Year after Diagnosis. Gastroenterology. 2018; 154:s-113.

Venkateswaran, S; Prince, J; Cutler, DJ; Marigorta, UM; Okou, DT; Prahalad, S; Mack, D; Boyle, B; Walters, T; Griffiths, A; et al. Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis. Inflammatory Bowel Diseases. 2018; 24:829-838.

Schwerd, T; Bryant, RV; Pandey, S; Capitani, M; Meran, L; Cazier, J; Jung, J; Mondal, K; Parkes, M; Mathew, CG; et al. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunology. 2018; 11:562-574.

DeBoer, MD; Lee, AM; Herbert, K; Long, J; Thayu, M; Griffin, LM; Baldassano, RN; Denson, LA; Zemel, BS; Denburg, MR; et al. Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease. Journal of Clinical Endocrinology and Metabolism. 2018; 103:936-945.

Schirmer, M; Franzosa, EA; Lloyd-Price, J; McIver, LJ; Schwager, R; Poon, TW; Ananthakrishnan, AN; Andrews, E; Barron, G; Lake, K; et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nature Microbiology. 2018; 3:337-346.

Gray, WN; Reed-Knight, B; Morgan, PJ; Holbrook, E; Kugathasan, S; Saeed, SA; Denson, LA; Hommel, KA. Multi-Site Comparison of Patient, Parent, and Pediatric Provider Perspectives on Transition to Adult Care in IBD. Journal of Pediatric Nursing. 2018; 39:49-54.

Sauer, CG; Loop, MS; Venkateswaran, S; Tangpricha, V; Ziegler, TR; Dhawan, A; McCall, C; Bonkowski, E; Mack, DR; Boyle, B; et al. Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naïve Ulcerative Colitis. Inflammatory Bowel Diseases. 2018; 24:641-650.

Gathungu, G; Zhang, Y; Tian, X; Bonkowski, E; Rowehl, L; Krumsiek, J; Nix, B; Chalk, C; Trapnell, B; Zhu, W; et al. Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. World Journal of Gastroenterology. 2018; 24:623-630.

Haberman, Y; BenShoshan, M; Di Segni, A; Dexheimer, PJ; Braun, T; Weiss, B; Walters, TD; Baldassano, RN; Noe, JD; Markowitz, J; et al. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflammatory Bowel Diseases. 2018; 24:346-360.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, D; Dodd, A; Mondal, K; Aronow, BJ; Haberman, Y; et al. 27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE. Inflammatory Bowel Diseases. 2018; 24:s7-s8.

Haberman, Y; BenShoshan, M; Di Segni, A; Dexheimer, PJ; Braun, T; Weiss, B; Avivi, C; Barshack, I; Anikster, Y; Aronow, B; et al. DOP015 Dysregulation of cell-type-specific long ncRNA in the ileum of treatment naïve early onset Crohn disease. Journal of Crohn's and Colitis. 2018; 12:s040-s040.

Minar, P; Jackson, K; Tsai, Y; Sucharew, H; Rosen, MJ; Denson, LA. Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2018; 24:198-208.

Contact Us

A photo of Lee A. Denson.

Lee Denson, MD
Associate Professor
UC Department of Pediatrics


Mailing Address:
Division of Gastroenterology, Hepatology and Nutrition
3333 Burnet Ave.
MLC 2010
Cincinnati, OH 45229-3039

Phone: 513-636-7575
Fax: 513-636-5581
Email: lee.denson@cchmc.org