Denson Lab

Lipstein, EA; Brinkman, WB; Zhang, Y; Hommel, KA; Ittenbach, RF; Liu, C; Denson, LA. Decision making about anti-TNF therapy: A pilot trial of a shared decision-making intervention. Patient Education and Counseling. 2021.

Denson, LA. Application of mucosal functional genomics to childhood undernutrition and stunting: Insights into mechanisms and targeted interventions. EBioMedicine. 2021; 71.

Mo, A; Nagpal, S; Gettler, K; Haritunians, T; Giri, M; Haberman, Y; Karns, R; Prince, J; Arafat, D; Hsu, NY; et al. Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression. American Journal of Human Genetics. 2021; 108:1765-1779.

Krishnakumar, C; Ananthakrishnan, AN; Boyle, BM; Griffiths, AM; LeLeiko, NS; Mack, DR; Markowitz, JF; Rosh, JR; Sauer, CG; Walters, TD; et al. Early Change in Fecal Calprotectin Predicts One-Year Outcome in Children Newly Diagnosed with Ulcerative Colitis. Journal of Pediatric Gastroenterology and Nutrition. 2021.

Niklinska-Schirtz, BJ; Venkateswaran, S; Anbazhagan, M; Kolachala, VL; Prince, J; Dodd, A; Chinnadurai, R; Gibson, G; Denson, LA; Cutler, DJ; et al. Ileal Derived Organoids From Crohn's Disease Patients Show Unique Transcriptomic and Secretomic Signatures. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1267-1280.

Uddin, J; Tomar, S; Sharma, A; Waggoner, L; Ganesan, V; Marella, S; Yang, Y; Noah, T; Vanoni, S; Patterson, A; et al. PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1479-1502.

Colman, RJ; Tsai, YT; Jackson, K; Boyle, BM; Noe, JD; Hyams, JS; D'Haens, GR A M; Van Limbergen, J; Rosen, MJ; Denson, LA; et al. Achieving Target Infliximab Drug Concentrations Improves Blood and Fecal Neutrophil Biomarkers in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:1045-1051.

Aschenbrenner, D; Quaranta, M; Banerjee, S; Ilott, N; Jansen, J; Steere, B; Chen, YH; Ho, S; Cox, K; Arancibia-Cárcamo, CV; et al. Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance. Gut. 2021; 70:1023-1036.

Xiong, Y; Mizuno, T; Colman, R; Hyams, J; Noe, JD; Boyle, B; Tsai, YT; Dong, M; Jackson, K; Punt, N; et al. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical Pharmacology and Therapeutics. 2021; 109:1639-1647.

Hellmann, J; Etter, RK; Denson, LA; Minar, P; Hill, D; Dykes, DM; Rosen, MJ. Quality Improvement Methodology Optimizes Infliximab Levels in Pediatric Patients with Inflammatory Bowel Disease. Pediatric Quality and Safety. 2021; 6.

Grasberger, H; Magis, AT; Sheng, E; Conomos, MP; Zhang, M; Garzotto, LS; Hou, G; Bishu, S; Nagao-Kitamoto, H; El-Zaatari, M; et al. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. Journal of Clinical Investigation. 2021; 131.

Haberman, Y; Iqbal, NT; Ghandikota, S; Mallawaarachchi, I; Tzipi Braun, ; Dexheimer, PJ; Rahman, N; Hadar, R; Sadiq, K; Ahmad, Z; et al. Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction. Gastroenterology. 2021; 160:2055-2071.e0.

Hyams, JS; Brimacombe, M; Haberman, Y; Walters, T; Gibson, G; Mo, A; Mack, D; Griffiths, A; Boyle, B; LeLeiko, N; et al. Clinical and Host Biological Factors Predict Colectomy Risk in Children Newly Diagnosed With Ulcerative Colitis. Inflammatory Bowel Diseases. 2021.

Short, SP; Pilat, JM; Barrett, CW; Reddy, VK; Haberman, Y; Hendren, JR; Marsh, BJ; Keating, CE; Motley, AK; Hill, KE; et al. Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. Gastroenterology. 2021; 160:1694-1708.e3.

Lyles, JL; Mulgund, AA; Bauman, LE; Su, W; Fei, L; Chona, DL; Sharma, P; Etter, RK; Hellmann, J; Denson, LA; et al. Effect of a Practice-wide Anti-TNF Proactive Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2021; 27:482-492.

Somineni, HK; Nagpal, S; Venkateswaran, S; Cutler, DJ; Okou, DT; Haritunians, T; Simpson, CL; Begum, F; Datta, LW; Quiros, AJ; et al. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. American Journal of Human Genetics. 2021; 108:431-445.

Haberman, Y; Minar, P; Karns, R; Dexheimer, PJ; Ghandikota, S; Tegge, S; Shapiro, D; Shuler, B; Venkateswaran, S; Braun, T; et al. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. Journal of Crohn's and Colitis. 2021.

Potdar, AA; Dube, S; Naito, T; Li, K; Botwin, G; Haritunians, T; Li, D; Casero, D; Yang, S; Bilsborough, J; et al. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. Gastroenterology. 2021; 160:809-822.e7.

Gray, WN; Wagoner, ST; Schaefer, MR; Reed, B; Morgan, P; Holbrook, E; Yacyshyn, B; MacKner, L; Young, M; Maddux, M; et al. Transition to Adult IBD Care: A Pilot Multi-Site, Telehealth Hybrid Intervention. Journal of Pediatric Psychology. 2021; 46:1-11.

Ungaro, RC; Hu, L; Ji, J; Nayar, S; Kugathasan, S; Denson, LA; Hyams, J; Dubinsky, MC; Sands, BE; Cho, JH. Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2021; 53:281-290.

Sali, R; Adewole, S; Ehsan, L; Denson, LA; Kelly, P; Amadi, BC; Holtz, L; Ali, SA; Moore, SR; Syed, S; et al. Hierarchical Deep Convolutional Neural Networks for Multi-category Diagnosis of Gastrointestinal Disorders on Histopathological Images. 2020 IEEE International Conference on Healthcare Informatics (ICHI). 2020; 00:1-6.

Lam, S; Singh, R; Dillman, JR; Trout, AT; Serai, SD; Sharma, D; Sheridan, R; Su, W; Fei, L; Karns, R; et al. Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease. Hepatology Communications. 2020; 4:1680-1693.

Wu, S; Hashimoto-Hill, S; Woo, V; Eshleman, EM; Whitt, J; Engleman, L; Karns, R; Denson, LA; Haslam, DB; Alenghat, T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature: New biology. 2020; 586:108-112.

Plevinsky, JM; Denson, LA; Hellmann, J; Minar, P; Rosen, MJ; Hommel, KA. A Micro-longitudinal Approach to Measuring Medication Adherence in Pediatric Inflammatory Bowel Diseases. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:366-370.

Mack, DR; Saul, B; Boyle, B; Griffiths, A; Sauer, C; Markowitz, J; LeLeiko, N; Keljo, D; Rosh, JR; Baker, SS; et al. Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:354-360.

Abu-El-Haija, M; Hornung, L; Lin, TK; Nathan, JD; Thompson, T; Vitale, DS; Nasr, A; Husain, SZ; Denson, L. Drug induced pancreatitis is the leading known cause of first attack acute pancreatitis in children. Pancreatology. 2020; 20:1103-1108.

Hellmann, J; Andersen, H; Fei, L; Linn, A; Bezold, R; Lake, K; Jackson, K; Meyer, D; Dirksing, K; Bonkowski, E; et al. Microbial Shifts and Shorter Time to Bowel Resection Surgery Associated with C. difficile in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2020; 26:1212-1221.

Denson, LA. Mitochondrial Networks: A New Therapeutic Target in Colitis. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 10:426-427.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Rosen, MJ; Denson, LA; et al. 613 ANTIBODIES TO INFLIXIMAB ACCELERATE DRUG CLEARANCE WHILE INTENSIFICATION STRATEGIES REVERSE IMMUNOGENICITY AND RECAPTURE CLINICAL RESPONSE. Gastroenterology. 2020; 158.

Minar, PP; Xiong, Y; Mizuno, T; Colman, RJ; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Tsai, YT; et al. 1160 REAL-WORLD PEDIATRIC INFLIXIMAB PHARMACOKINETIC MODEL VERIFIES CRITICAL NEED FOR PRECISION DOSING SOFTWARE. Gastroenterology. 2020; 158.

Shapiro, JM; El-Serag, HB; Gandle, C; Peacock, C; Denson, LA; Fishman, LN; Hernaez, R; Hou, JK. Recommendations for Successful Transition of Adolescents With Inflammatory Bowel Diseases to Adult Care. Clinical Gastroenterology and Hepatology. 2020; 18:276-289.e2.

Haberman Ziv, Y; Minar, P; Karns, R; Dexheimer, P; Ghandikota, S; Tegge, S; Shapiro, D; Shuler, B; Venkateswaran, S; Braun, T; et al. DOP89 Pre-treatment mucosal inflammatory and wound healing gene programmes reveal mechanisms associated with future stricturing behaviour during 5-year follow-up in paediatric Crohn’s disease. Journal of Crohn's and Colitis. 2020; 14:s127-s127.

Haberman Ziv, Y; Loberman-Nachum, N; Katya, S; Di Segni, A; Efroni, G; Braun, T; BenShoshan, M; Shouval, D; Denson, LA; Amir, A; et al. OP06 Comparison between Crohn and coeliac diseases small intestine transcriptomics and microbial data define similarities and divergent pathways linked to pathogenesis. Journal of Crohn's and Colitis. 2020; 14:s006-s006.

Venkateswaran, S; Denson, LA; Jurickova, I; Dodd, A; Zwick, ME; Cutler, DJ; Kugathasan, S; Okou, DT. Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants. Scientific Reports. 2019; 9.

Iqbal, NT; Syed, S; Sadiq, K; Khan, MN; Iqbal, J; Ma, JZ; Umrani, F; Ahmed, S; Maier, EA; Denson, LA; et al. Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation. BMC Pediatrics. 2019; 19.

Schuler, CL; Dodds, C; Hommel, KA; Ittenbach, RF; Denson, LA; Lipstein, EA. Shared decision making in IBD: A novel approach to trial consent and timing. Contemporary Clinical Trials Communications. 2019; 16.

Loberman-Nachum, N; Sosnovski, K; Di Segni, A; Efroni, G; Braun, T; BenShoshan, M; Anafi, L; Avivi, C; Barshack, I; Shouval, DS; et al. Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis. Scientific Reports. 2019; 9.

Vaz, KK H; Carmody, JK; Zhang, Y; Denson, LA; Hommel, KA. Evaluation of a Novel Educational Tool in Adolescents With Inflammatory Bowel Disease: The NEAT Study. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:564-569.

Naramore, SK; Jr, BW E; Jiang, G; Kugathasan, S; Denson, LA; Hyams, JS; Steiner, SJ; Grp, PR O-K I I D. Serologic, but Not Genetic, Markers Are Associated With Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:e129-e134.

Tokarz, R; Hyams, JS; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Shah, S; Markowitz, J; Baker, SS; et al. Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflammatory Bowel Diseases. 2019; 25:1656-1662.

Carmody, JK; Plevinsky, J; Peugh, JL; Denson, LA; Hyams, JS; Lobato, D; LeLeiko, NS; Hommel, KA. Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis. Alimentary Pharmacology and Therapeutics. 2019; 50:911-918.

Minar, P; Lehn, C; Tsai, YT; Jackson, K; Rosen, MJ; Denson, LA. Elevated Pretreatment Plasma Oncostatin M Is Associated With Poor Biochemical Response to Infliximab. Crohn's && Colitis 360. 2019; 1.

Martin, JC; Chang, C; Boschetti, G; Ungaro, R; Giri, M; Grout, JA; Gettler, K; Chuang, L; Nayar, S; Greenstein, AJ; et al. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019; 178:1493-1508.e20.

Gettler, K; Giri, M; Kenigsberg, E; Martin, J; Chuang, L; Hsu, N; Denson, LA; Hyams, JS; Griffiths, A; Noe, JD; et al. Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets. Genes and Immunity. 2019; 20:577-588.

Ballengee, CR; Stidham, RW; Liu, C; Kim, M; Prince, J; Mondal, K; Baldassano, R; Dubinsky, M; Markowitz, J; Leleiko, N; et al. Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Clinical Gastroenterology and Hepatology. 2019; 17:1799-1806.

Gray, WN; Holbrook, E; Dykes, D; Morgan, PJ; Saeed, SA; Denson, LA. Improving IBD Transition, Self-management, and Disease Outcomes With an In-clinic Transition Coordinator. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:194-199.

Clarkston, K; Tsai, Y; Jackson, K; Rosen, MJ; Denson, LA; Minar, P. Development of Infliximab Target Concentrations During Induction in Pediatric Crohn Disease Patients. Journal of Pediatric Gastroenterology and Nutrition. 2019; 69:68-74.

Wright, M; Chandrakasan, S; Okou, DT; Yin, H; Jurickova, I; Denson, LA; Kugathasan, S. Early Onset Granulomatous Colitis Associated with a Mutation in NCF4 Resolved with Hematopoietic Stem Cell Transplantation. Journal of Pediatrics. 2019; 210:220-225.

Krishnakumar, C; Ballengee, CR; Liu, C; Kim, M; Baker, SS; Baldassano, RN; Cohen, SA; Crandall, WV; Denson, LA; Dubinsky, MC; et al. Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Inflammatory Bowel Diseases. 2019; 25:1208-1217.

Somineni, HK; Venkateswaran, S; Kilaru, V; Marigorta, UM; Mo, A; Okou, DT; Kellermayer, R; Mondal, K; Cobb, D; Walters, TD; et al. Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology. 2019; 156:2254-2265.e3.

Abu-El-Haija, M; Valencia, CA; Hornung, L; Youssef, N; Thompson, T; Barasa, NW; Wang, X; Denson, LA. Genetic variants in acute, acute recurrent and chronic pancreatitis affect the progression of disease in children. Pancreatology. 2019; 19:535-540.

Lloyd-Price, J; Arze, C; Ananthakrishnan, AN; Schirmer, M; Avila-Pacheco, J; Poon, TW; Andrews, E; Ajami, NJ; Bonham, KS; Brislawn, CJ; et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature: New biology. 2019; 569:655-662.

Denson, LA; Curran, M; McGovern, DP B; Koltun, WA; Duerr, RH; Kim, SC; Sartor, RB; Sylvester, FA; Abraham, C; de Zoeten, EF; et al. Challenges in IBD Research: Precision Medicine. Inflammatory Bowel Diseases. 2019; 25:S31-S39.

Wu, J; Lubman, DM; Kugathasan, S; Denson, LA; Hyams, JS; Dubinsky, MC; Griffiths, AM; Baldassano, RN; Noe, JD; Rabizadeh, S; et al. Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease. American Journal of Gastroenterology. 2019; 114:777-785.

Hajjat, T; Mosha, MH; Bonkowski, E; Denson, LA; Hyams, JS. 882 – Normalization of Fecal Calprotectin Requires Higher Trough Infliximab Levels in Children with Inflammatory Bowel Disease. Gastroenterology. 2019; 156:s-200.

Lyles, JL; Mulgund, AA; Bauman, LE; Su, W; Fei, L; Chona, D; Sharma, P; Etter, R; Hellmann, J; Denson, LA; et al. 303 – Effect of a Practice-Wide Anti-TNF Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. Gastroenterology. 2019; 156:s-60.

Hyams, JS; Thomas, SD; Gotman, N; Haberman, Y; Karns, R; Schirmer, M; Mo, A; Mack, DR; Boyle, B; Griffiths, AM; et al. Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. The Lancet. 2019; 393:1708-1720.

Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Science Alliance. 2019; 2.

Carmody, JK; Denson, LA; Hommel, KA. Content and Usability Evaluation of Medication Adherence Mobile Applications for Use in Pediatrics. Journal of Pediatric Psychology. 2019; 44:333-342.

Haberman, Y; Schirmer, M; Dexheimer, PJ; Karns, R; Braun, T; Kim, M; Walters, TD; Baldassano, RN; Noe, JD; Rosh, J; et al. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunology. 2019; 12:491-502.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, D; Valencia, CA; Dodd, A; Mondal, K; Aronow, BJ; et al. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2019; 25:547-560.

Shaw, KA; Cutler, DJ; Okou, D; Dodd, A; Aronow, BJ; Haberman, Y; Stevens, C; Walters, TD; Griffiths, A; Baldassano, RN; et al. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes and Immunity. 2019; 20:131-142.

Picoraro, JA; Lee, D; Heller, CA; Weaver, A; Hyams, JS; Conklin, LS; Otley, A; Ziring, D; Kugathasan, S; Rosh, JR; et al. Pediatric Inflammatory Bowel Disease Clinical Innovations Meeting of the Crohn's & Colitis Foundation: Charting the Future of Pediatric IBD. Inflammatory Bowel Diseases. 2019; 25:27-32.

Sweeny, KF; Lin, TK; Nathan, JD; Denson, LA; Husain, SZ; Hornung, L; Thompson, T; Abu-El-Haija, M. Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. Journal of Pediatric Gastroenterology and Nutrition. 2019; 68:104-109.

Momozawa, Y; Dmitrieva, J; Theatre, E; Deffontaine, V; Rahmouni, S; Charloteaux, B; Crins, F; Docampo, E; Elansary, M; Gori, A; et al. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications. 2018; 9.

Romick-Rosendale, LE; Haslam, DB; Lane, A; Denson, L; Lake, K; Wilkey, A; Watanabe, M; Bauer, S; Litts, B; Luebbering, N; et al. Antibiotic Exposure and Reduced Short Chain Fatty Acid Production after Hematopoietic Stem Cell Transplant. Biology of Blood and Marrow Transplantation. 2018; 24:2418-2424.

Abu-El-Haija, M; Hornung, L; Denson, LA; Husami, A; Lin, TK; Matlock, K; Nathan, JD; Palermo, JJ; Thompson, T; Valencia, CA; et al. Prevalence of abnormal glucose metabolism in pediatric acute, acute recurrent and chronic pancreatitis. PLoS ONE. 2018; 13.

Schirmer, M; Denson, L; Vlamakis, H; Franzosa, EA; Thomas, S; Gotman, NM; Rufo, P; Baker, SS; Sauer, C; Markowitz, J; et al. Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell Host and Microbe. 2018; 24:600-610.e4.

Chandradevan, R; Hofmekler, TT; Mondal, K; Harun, N; Venkateswaran, S; Somineni, HK; Ballengee, CR; Kim, M; Griffiths, A; Noe, JD; et al. Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles. Inflammatory Bowel Diseases. 2018; 24:2285-2290.

Lindoso, L; Mondal, K; Venkateswaran, S; Somineni, HK; Ballengee, C; Walters, TD; Griffiths, A; Noe, JD; Crandall, W; Snapper, S; et al. The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. American Journal of Gastroenterology. 2018; 113:1524-1529.

Kelly, D; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Aronow, BJ; Dubinsky, MC; Hyams, JS; Markowitz, JF; et al. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight. 2018; 3.

Gutierrez, M; Scaglia, P; Keselman, A; Martucci, L; Karabatas, L; Domene, S; Martin, A; Pennisi, P; Blanco, M; Sanguineti, N; et al. Partial growth hormone insensitivity and dysregulatory immune disease associated with de novo germline activating STAT3 mutations. Molecular and Cellular Endocrinology. 2018; 473:166-177.

Chen, J; Hu, F; Kugathasan, S; Jorde, LB; Nix, D; Rutherford, A; Denson, L; Watkins, WS; Prahalad, S; Huff, C; et al. Targeted Gene Sequencing in Children with Crohn's Disease and Their Parents: Implications for Missing Heritability. G3: Genes, Genomes, Genetics. 2018; 8:2881-2888.

Ledder, O; Church, P; Cytter-Kuint, R; Martinez-Leon, M; Sladek, M; Coppenrath, E; Weiss, B; Yerushalmi, B; Martin de Carpi, J; Duchano, L; et al. A Simple Endoscopic Score Modified for the Upper Gastrointestinal Tract in Crohn's Disease [UGI-SES-CD]: A Report From the ImageKids Study. Journal of Crohn's and Colitis. 2018; 12:1073-1078.

Boyle, B; Collins, M; Denson, L; Hyams, J. Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed With Ulcerative Colitis. American Journal of Surgical Pathology. 2018; 42.

Whitt, J; Woo, V; Lee, P; Moncivaiz, J; Haberman, Y; Denson, L; Tso, P; Alenghat, T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology. 2018; 155:501-513.

Venkateswaran, S; Marigorta, UM; Denson, LA; Hyams, JS; Gibson, G; Kugathasan, S. Bowel Location Rather Than Disease Subtype Dominates Transcriptomic Heterogeneity in Pediatric IBD. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 6:474-476.e3.

Orscheln, ES; Dillman, JR; Towbin, AJ; Denson, LA; Trout, AT. Penetrating Crohn disease: does it occur in the absence of stricturing disease?. Abdominal Radiology. 2018; 43:1583-1589.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, DT; Dodd, A; Quinn, K; Mondal, K; Aronow, BJ; et al. Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease. Gastroenterology. 2018; 154:2097-2110.

Spencer, EA; Davis, SM; Mack, DR; Boyle, BM; Griffiths, AM; LeLeiko, NS; Sauer, CG; Keljo, DJ; Markowitz, JF; Baker, SS; et al. Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children. Inflammatory Bowel Diseases. 2018; 24:1335-1343.

Wright, SS; Trauernicht, A; Bonkowski, E; McCall, CA; Maier, EA; Bezold, R; Lake, K; Chalk, C; Trapnell, BC; Kim, M; et al. Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition. 2018; 66:767-772.

Kelly, DR; Kotliar, M; Woo, V; Jagannathan, S; Whitt, J; Moncivaiz, J; Haberman, Y; Barski, A; Denson, LA; Alenghat, T. 635 - Intestinal Microbiota Direct an Epithelial Epigenetic Signature of Pediatric Crohn's Disease. Gastroenterology. 2018; 154.

Jurickova, I; Karns, R; Cutler, DJ; Okou, D; Dodd, A; Mondal, K; Aronow, BJ; Haberman, Y; Linn, A; Price, A; et al. 378 - Genomic Correlates of Reduced Neutrophil Granulocytemacrophage Colony Stimulating Factor Signaling in Stricturing Pediatric Crohn Disease. Gastroenterology. 2018; 154.

Carmody, J; Plevinsky, J; Peugh, J; Lobato, D; Leleiko, NS; Hyams, JS; Denson, LA; Baker, SS; Sauer, CG; Markowitz, J; et al. Su2018 - Longitudinal Adherence to Mesalamine in Pediatric Ulcerative Colitis: Results from the Protect Study. Gastroenterology. 2018; 154.

Hajjat, T; Wang, Z; Rufo, PA; Strople, JA; Sauer, CG; Markowitz, J; Pfefferkorn, MD; Oliva-Hemker, M; Rosh, JR; Otley, A; et al. 497 - Irrespective of Initial Ulcerative Colitis Therapy Thiopurines Unlikely to Result in Corticosteroid-Free Remission One Year after Diagnosis. Gastroenterology. 2018; 154:s-113.

Venkateswaran, S; Prince, J; Cutler, DJ; Marigorta, UM; Okou, DT; Prahalad, S; Mack, D; Boyle, B; Walters, T; Griffiths, A; et al. Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis. Inflammatory Bowel Diseases. 2018; 24:829-838.

Schwerd, T; Bryant, RV; Pandey, S; Capitani, M; Meran, L; Cazier, J; Jung, J; Mondal, K; Parkes, M; Mathew, CG; et al. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease. Mucosal Immunology. 2018; 11:562-574.

DeBoer, MD; Lee, AM; Herbert, K; Long, J; Thayu, M; Griffin, LM; Baldassano, RN; Denson, LA; Zemel, BS; Denburg, MR; et al. Increases in IGF-1 After Anti-TNF-α Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease. Journal of Clinical Endocrinology and Metabolism. 2018; 103:936-945.

Schirmer, M; Franzosa, EA; Lloyd-Price, J; McIver, LJ; Schwager, R; Poon, TW; Ananthakrishnan, AN; Andrews, E; Barron, G; Lake, K; et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nature Microbiology. 2018; 3:337-346.

Gray, WN; Reed-Knight, B; Morgan, PJ; Holbrook, E; Kugathasan, S; Saeed, SA; Denson, LA; Hommel, KA. Multi-Site Comparison of Patient, Parent, and Pediatric Provider Perspectives on Transition to Adult Care in IBD. Journal of Pediatric Nursing. 2018; 39:49-54.

Sauer, CG; Loop, MS; Venkateswaran, S; Tangpricha, V; Ziegler, TR; Dhawan, A; McCall, C; Bonkowski, E; Mack, DR; Boyle, B; et al. Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naïve Ulcerative Colitis. Inflammatory Bowel Diseases. 2018; 24:641-650.

Gathungu, G; Zhang, Y; Tian, X; Bonkowski, E; Rowehl, L; Krumsiek, J; Nix, B; Chalk, C; Trapnell, B; Zhu, W; et al. Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. World Journal of Gastroenterology. 2018; 24:623-630.

Haberman, Y; BenShoshan, M; Di Segni, A; Dexheimer, PJ; Braun, T; Weiss, B; Walters, TD; Baldassano, RN; Noe, JD; Markowitz, J; et al. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflammatory Bowel Diseases. 2018; 24:346-360.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, D; Dodd, A; Mondal, K; Aronow, BJ; Haberman, Y; et al. 27 CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE. Inflammatory Bowel Diseases. 2018; 24:s7-s8.

Haberman, Y; BenShoshan, M; Di Segni, A; Dexheimer, PJ; Braun, T; Weiss, B; Avivi, C; Barshack, I; Anikster, Y; Aronow, B; et al. DOP015 Dysregulation of cell-type-specific long ncRNA in the ileum of treatment naïve early onset Crohn disease. Journal of Crohn's and Colitis. 2018; 12:s040-s040.

Minar, P; Jackson, K; Tsai, Y; Sucharew, H; Rosen, MJ; Denson, LA. Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2018; 24:198-208.

Hyams, JS; Davis, S; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Keljo, DJ; Markowitz, J; Baker, SS; et al. Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study. The Lancet Gastroenterology and Hepatology. 2017; 2:855-868.

Boyle, B; Collins, MH; Wang, Z; Mack, D; Griffiths, A; Sauer, C; Markowitz, J; LeLeiko, N; Keljo, D; Rosh, J; et al. Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed With Ulcerative Colitis. American Journal of Surgical Pathology. 2017; 41:1491-1498.

Jean, MR; Weaver, A; Mastin-Diebold, T; Kissinger, K; Smitherman, EA; Favier, L; Danziger-Isakov, L; Williams, E; Brady, RC; Huggins, J; et al. Improving a process to obtain hepatitis B serology among patients treated with infliximab at a large urban children's hospital. BMJ Open Quality. 2017; 6.

Marigorta, UM; Denson, LA; Hyams, JS; Mondal, K; Prince, J; Walters, TD; Griffiths, A; Noe, JD; Crandall, WV; Rosh, JR; et al. Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease. Nature Genetics. 2017; 49:1517-1521.

Hommel, KA; McGrady, ME; Peugh, J; Zacur, G; Loreaux, K; Saeed, S; Williams, E; Denson, LA. Longitudinal Patterns of Medication Nonadherence and Associated Health Care Costs. Inflammatory Bowel Diseases. 2017; 23:1577-1583.

Rosen, MJ; Karns, R; Vallance, JE; Bezold, R; Waddell, A; Collins, MH; Haberman, Y; Minar, P; Baldassano, RN; Hyams, JS; et al. Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Gastroenterology. 2017; 152:1345-1357.e7.

Kugathasan, S; Denson, LA; Walters, TD; Kim, M; Marigorta, UM; Schirmer, M; Mondal, K; Liu, C; Griffiths, A; Noe, JD; et al. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. The Lancet. 2017; 389:1710-1718.

Denson, LA; Jurickova, I; Shaw, K; Linn, A; Dodd, A; Okou, D; Chalk, C; Bonkowski, E; Griffiths, AM; Baldassano, RN; et al. Tu1748 Low Neutrophil Reactive Oxygen Species Production is Associated with Nicotinamide-Adenine Dinucleotide Phosphate (NADPH) Oxidase Gene Mutations and Refractory Colonic Involvement in Pediatric Crohn Disease. Gastroenterology. 2017; 152.

Denson, LA; Jurickova, I; Shaw, K; Linn, A; Dodd, A; Okou, D; Chalk, C; Bonkowski, E; Griffiths, AM; Baldassano, RN; et al. Tu1747 Reduced Neutrophil Granulocyte-Macrophage Colony Stimulating Factor Signaling is Associated with Granulocyte-Macrophage Colony Stimulating Factor Receptor Alpha Chain Gene Mutations and Stricturing Disease Complications in Pediatric Crohn Disease. Gastroenterology. 2017; 152.

Hyams, JS; Davis, S; Mack, DR; Boyle, BM; Griffiths, AM; Leleiko, NS; Sauer, CG; Keljo, DJ; Markowitz, J; Baker, SS; et al. 1090 Predicting Non-Response to Intravenous Corticosteroid Induction Therapy in Children Newly Diagnosed with Severely Active Ulcerative Colitis: The Protect Study. Gastroenterology. 2017; 152.

Denson, LA; McDonald, SA; Das, A; Schendel, DE; Skogstrand, K; Hougaard, DM; Shankaran, S; Higgins, RD; Carlo, WA; Ehrenkranz, RA; et al. Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. American Journal of Perinatology. 2017; 34:240-247.

Gray, W; Morgan, P; Holbrook, E; Rosen, M; Yacyshyn, B; Wise, C; Wagoner, S; Schaefer, M; Saeed, S; Denson, L; et al. P-223 The Self-management Transition Enhancement Program (STEP). Inflammatory Bowel Diseases. 2017; 23.

Moshkovits, I; Reichman, H; Karo-Atar, D; Rozenberg, P; Zigmond, E; Haberman, Y; Ben Baruch-Morgenstern, N; Lampinen, M; Carlson, M; Itan, M; et al. A key requirement for CD300f in innate immune responses of eosinophils in colitis. Mucosal Immunology. 2017; 10:172-183.

Brant, SR; Okou, DT; Simpson, CL; Cutler, DJ; Haritunians, T; Bradfield, JP; Chopra, P; Prince, J; Begum, F; Kumar, A; et al. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017; 152:206-217.e2.