Denson Lab

Publications

Dillman, JR; Tkach, JA; Fletcher, JG; Bruining, DH; Lu, A; Kugathasan, S; Alazraki, AL; Knight-Scott, J; Stidham, RW; Adler, J; Anton, CG; Imbus, RA; Dudley, JA; Denson, LA. Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease. Inflammatory Bowel Diseases. 2025; 31:1380-1391.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31:s59-s60.

Jurickova, I; Dreskin, BW; Angerman, E; Bonkowski, E; Nguyen, J; Villarreal, R; Tominaga, K; Iwasawa, K; Braun, T; Takebe, T; Helmrath, MA; Haberman, Y; Wells, JM; Denson, LA. Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease. Journal of Crohn's and Colitis. 2025; 19:jjae139.

Lee, SH; Bushra, M; Qiu, L; Griffiths, AM; Turpin, W; Croitoru, K; Shao, J; Olivera, PA; Leibovitzh, H; Xue, M; Rosh, J; Rubin, D; Schultz, M; Siegel, C. Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease. Gastroenterology. 2025; 168:385-388.e3.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168:s84-s85.

Haberman Ziv, Y; Braun, T; Levhar, N; Efroni, G; Hadar, R; Jessula Levy, D; Talan Asher, A; Unger, B; Picard, O; Yablecovitch, D; Kopylov, U; Denson, L; Eliakim, R; Ben-Horin, S; Amir, A. P1314 Multi-omics analysis of Crohn’s Disease trajectory from active to remission reveals that the altered ileal anti-bacterial epithelial signals and pathogenic microbial composition and metabolomics persist despite normalizing ileal immune signals during remission. Journal of Crohn's and Colitis. 2025; 19:i2365-i2367.

Ahn, JH; da Silva Pedrosa, M; Lopez, LR; Tibbs, TN; Jeyachandran, JN; Vignieri, EE; Rothemich, A; Cumming, I; Irmscher, AD; Haswell, CJ; Zamboni, WC; Yu, YR A; Ellermann, M; Denson, LA; Arthur, JC. Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease. Cell Host and Microbe. 2025; 33:71-88.e9.

Olivera, PA; Martinez-Lozano, H; Leibovitzh, H; Xue, M; Neustaeter, A; Espin-Garcia, O; Xu, W; Madsen, KL; Guttman, DS; Bernstein, CN; Turpin, W; Lee, S; Croitoru, K; Crohn’s and Colitis Canada (CCC) Genetic, Environm, . Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease. Gastroenterology. 2025; 168:99-110.e2.

Lee, SH; Turpin, W; Espin-Garcia, O; Xu, W; Croitoru, K; Leibovitzh, H; Xue, M; Raygoza Garay, JA; Graña-Miraglia, L; Smith, MI; Higgins, P; Hyams, J; McGrath, J; Otley, A. Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study. Gastroenterology. 2025; 168:150-153.e4.

Tominaga, K; Kechele, DO; Sanchez, JG; Vales, S; Jurickova, I; Roman, L; Asai, A; Enriquez, JR; McCauley, HA; Kishimoto, K; Zorn, AM; Helmrath, MA; Denson, LA; Wells, JM. Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2025; 19:101444.

Braun, T; Feng, R; Amir, A; Levhar, N; Shacham, H; Mao, R; Hadar, R; Toren, I; Algavi, Y; Abu-Saad, K; Elinav, E; Chen, M; Ben-Horin, S; Haberman, Y. Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort. Nature Communications. 2024; 15:3764.

Abu-El-Haija, M; Zhang, W; Karns, R; Ginzburg, G; Vitale, D; Farrell, P; Nasr, A; Ibrahim, S; Bellin, M; Thompson, T; Garlapally, V; Woo, JG; Husain, SZ; Denson, LA. The role of pancreatitis risk genes in diabetes development post index admission of acute pancreatitis in children. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2024; 24:e10-e11.

Zhao, Q; Duck, LW; Killian, JT; Rosenberg, AF; Mannon, PJ; King, RG; Denson, LA; Kugathasan, S; Janoff, EN; Jenmalm, MC; Elson, CO. Crohn's Patients and Healthy Infants Share Immunodominant B Cell Response to Commensal Flagellin Peptide Epitopes. Gastroenterology. 2024; 167:1415-1428.

Uddin, J; Sharma, A; Wu, D; Tomar, S; Ganesan, V; Reichel, PE; Thota, LN R; Cabrera-Silva, RI; Marella, S; Idelman, G; Divanovic, S; Nusrat, A; Weaver, TE; Hogan, SP. STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis. JCI insight. 2024; 9:e172978.

Heekin, S; Lopez-Nunez, O; Smith, J; Denson, N; Denson, L; Miethke, A; Dillman, J; Miraldi, E; Kofron, JM; Dhaliwal, J; Erdman, L. (2024) Trade-Offs in Deep Learning Model Loss and Configuration for Sparse Histological Segmentation: A Case Study in Pediatric Ileal Histology. Institute of Electrical and Electronics Engineers (IEEE). 00:1-8.

Dillman, JR; Tkach, JA; Fletcher, JG; Bruining, DH; Lu, A; Kugathasan, S; Alazraki, AL; Knight-Scott, J; Stidham, RW; Adler, J; Anton, CG; Imbus, RA; Dudley, JA; Denson, LA. MRI and Blood-based Biomarkers Are Associated With Surgery in Children and Adults With Ileal Crohn's Disease. Inflammatory Bowel Diseases. 2024; 30:2181-2190.

Debnath, P; Epstein, KN; Kocaoglu, M; Towbin, AJ; Denson, LA; Dillman, JR. Imaging and clinical predictors of surgery in stricturing ileal Crohn's disease: a retrospective study from a large pediatric hospital. Abdominal Radiology. 2024; 49:3354-3363.

Alves, VD P V; Mahalingam, N; Tkach, JA; Towbin, AJ; Imbus, R; Denson, LA; Dillman, JR. Prospective characterization of intestinal MRI intravoxel incoherent motion in pediatric and young adult patients with newly diagnosed small bowel Crohn's disease. Abdominal Radiology. 2024; 49:3325-3336.

Abu-El-Haija, M; Zhang, W; Karns, R; Ginzburg, G; Vitale, DS; Farrell, P; Nasr, A; Ibrahim, S; Bellin, MD; Thompson, T; Garlapally, V; Woo, JG; Husain, SZ; Denson, LA. The Role of Pancreatitis Risk Genes in Endocrine Insufficiency Development After Acute Pancreatitis in Children. Clinical Gastroenterology and Hepatology. 2024; 22:2033-2043.e2.

VanBuskirk, K; Mweetwa, M; Kolterman, T; Raghavan, S; Ahmed, T; Ali, SA; Nahar Begum, SK; Besa, E; Denno, DM; Jamil, Z; Tarr, PI; Sullivan, PB; Moskaluk, CA; EEDBI Consortium, . Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S31-S40.

Jamil, Z; VanBuskirk, K; Mweetwa, M; Mouksassi, S; Smith, G; Ahmed, T; Chandwe, K; Denno, DM; Fahim, SM; Kelly, P; Tarr, PI; Tearney, GJ; Umrani, F; Yilmaz, OH. Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S65-S72.

Ehsan, L; Coomes, D; Kelly, P; Greene, AR; Ali, SA; Mulenga, C; Denno, DM; VanBuskirk, K; Raghib, MF; Mahfuz, M; Sullivan, PB; Moskaluk, CA; Syed, S; EEDBI Consortium, . Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S41-S50.

Denno, DM; Ahmed, S; Ahmed, T; Ali, SA; Amadi, B; Kelly, P; Lawrence, S; Mahfuz, M; Marie, C; Moore, SR; Ramakrishnan, G; Sadiq, K; Sarker, SA; Umrani, F. The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S4-S14.

Kelly, P; VanBuskirk, K; Coomes, D; Mouksassi, S; Smith, G; Jamil, Z; Hossain, MS; Syed, S; Marie, C; Tarr, PI; Sadiq, K; Sarker, SA; Umrani, F; Zyambo, K. Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S15-S30.

Xue, M; Leibovitzh, H; Jingcheng, S; Neustaeter, A; Dong, M; Xu, W; Espin-Garcia, O; Griffiths, AM; Steinhart, AH; Turner, D; Higgins, P; Mack, D; McGrath, J; Panancionne, R. Environmental Factors Associated With Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project. Clinical Gastroenterology and Hepatology. 2024; 22:1889-1897.e12.

Marie, C; Das, S; Coomes, D; Ahmed, T; Ali, SA; Iqbal, J; Kelly, P; Mahfuz, M; Moore, SR; Petri, WA; Tarr, PI; Denson, LA. Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers. American Journal of Clinical Nutrition. 2024; 120 Suppl 1:S51-S64.

Briggs, K; Tomar, V; Ollberding, N; Haberman, Y; Bourgonje, AR; Hu, S; Chaaban, L; Sunuwar, L; Weersma, RK; Denson, LA; Melia, JM P. Crohn's Disease-Associated Pathogenic Mutation in the Manganese Transporter ZIP8 Shifts the Ileal and Rectal Mucosal Microbiota Implicating Aberrant Bile Acid Metabolism. Inflammatory Bowel Diseases. 2024; 30:1379-1388.

Zulqarnain, F; Zhao, X; Setchell, KD R; Sharma, Y; Fernandes, P; Srivastava, S; Shrivastava, A; Ehsan, L; Jain, V; Raghavan, S; Brown, DE; Moore, SR; Ali, SA; Syed, S. Machine-learning-based integrative -'omics analyses reveal immunologic and metabolic dysregulation in environmental enteric dysfunction. iScience. 2024; 27:110013.

Ando, T; Takazawa, I; Spencer, ZT; Ito, R; Tomimori, Y; Mikulski, Z; Matsumoto, K; Ishitani, T; Denson, LA; Kawakami, Y; Kawakami, Y; Kitaura, J; Ahmed, Y; Kawakami, T. Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway. Cells. 2024; 13:986.

Hommel, KA; Noser, AE; Plevinsky, J; Gamwell, K; Denson, LA. Pilot and feasibility of the SMART IBD mobile app to improve self-management in pediatric inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition. 2024; 78:1273-1278.

Nasr, A; Mizuno, T; Irie, K; Dillman, J; Jackson, K; Lynch, K; Horrell, A; Chun, KY; Yang, JM; Hyams, JS; Boyle, BM; Noe, JD; Denson, LA; Minar, PP. 958 ATTAINING EARLY ANTI-TNF EXPOSURE TARGETS IS ASSOCIATED WITH IMPROVED RATES OF ENDOSCOPIC HEALING AND TRANSMURAL HEALING IN CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166:s-226-s-227.

Briggs, K; Tomar, V; Ollberding, N; Haberman, Y; Bourgonje, AR; Hu, S; Chaaban, L; Sunuwar, L; Weersma, RK; Denson, LA; Melia, JP. Mo1794 CROHN'S DISEASE-ASSOCIATED PATHOGENIC MUTATION IN MANGANESE TRANSPORTER ZIP8 SHIFTS THE ILEAL AND RECTAL MUCOSAL MICROBIOTA IMPLICATING ABERRANT BILE ACID METABOLISM. Gastroenterology. 2024; 166:s-1114.

Minar, PP; Karns, R; Lynch, K; Jackson, K; Horrell, A; Boyle, BM; Hyams, JS; Noe, JD; Denson, LA. 748 EXTENSIVE PROTEOMIC ANALYSIS IDENTIFIES A CROHN'S DISEASE CORE PROTEOME AND ANTI-TNF TREATMENT RESPONSE PROFILE FOR CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166:s-177-s-178.

Liu, X; Prasath, S; Siddiqui, I; Walters, TD; Denson, LA; Hyams, JS; Kugathasan, S; Griffiths, AM; Collins, MH; Baldassano, RN; Sudel, B; Wali, P; Ziring, D; Dhaliwal, J. Machine Learning-Based Prediction of Pediatric Ulcerative Colitis Treatment Response Using Diagnostic Histopathology. Gastroenterology. 2024; 166:921-924.e4.

Wang, Z; Song, X; Waitman, LR; Hyams, JS; Denson, LA. Fitness-for-use of Retrospective Multicenter Electronic Health Records to Conduct Outcome Analysis for Pediatric Ulcerative Colitis. Medicine (United Kingdom). 2024; 103:e37395.

Wang, Z; Nie, J; Song, X; Denson, LA; Hyams, JS. A comparison of Bayesian and frequentist approaches to incorporating clinical and biological information for the prediction of response to standardized pediatric colitis therapy. Editor, Tsuji Y. PloS one. 2024; 19:e0295814.

Dike, CR; Ollberding, NJ; Thompson, T; Kotha, N; Minar, P; Vitale, DS; Lin, TK; Nasr, A; Denson, LA; Haslam, DB; Abu-El-Haija, M. Acute pancreatitis is associated with gut dysbiosis in children. Digestive and Liver Disease. 2024; 56:444-450.

Schirmer, M; Stražar, M; Avila-Pacheco, J; Rojas-Tapias, DF; Brown, EM; Temple, E; Deik, A; Bullock, K; Jeanfavre, S; Pierce, K; Hyams, J; Denson, L; Clish, CB; Xavier, RJ. Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course. Cell Host and Microbe. 2024; 32:209-226.e7.

Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, HW; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024; 57:319-332.e6.

Ramos, KN; Lake, KE; Hoerth, C; Langenberg, L; Luebbering, N; Haslam, D; Newburg, D; Morrow, AL; Ollberding, NJ; Denson, LA; Watanabe-Chailland, M; Romick-Rosendale, L; Davies, SM; Khandelwal, P. Administration of Human Milk Oligosaccharide (2′-fucosyllactose) Reduces Dysbiosis and Increases Short Chain Fatty Acids in Children and Young Adults Following HSCT: A Prospective, Single-Center Study. Transplantation and Cellular Therapy. 2024; 30:s16.

Dillman, J; Fletcher, JG; Bruining, D; Kugathasan, S; Stidham, R; Adler, J; Tkach, J; Alazraki, A; Knight-Scott, J; Lu, A; Anton, C; Imbus, R; Dudley, J; Denson, L. MRI AND BLOOD-BASED BIOMARKERS ASSOCIATED WITH SURGICAL MANAGEMENT IN CHILDREN AND ADULTS WITH SMALL BOWEL CROHN'S DISEASE. Gastroenterology. 2024; 166:s19-s20.

Geem, D; Hercules, D; Pelia, RS; Venkateswaran, S; Griffiths, A; Noe, JD; Dotson, JL; Snapper, S; Rabizadeh, S; Rosh, JR; Sharma, G; Denson, LA; Hyams, JS; Kugathasan, S. Progression of Pediatric Crohn's Disease Is Associated With Anti-Tumor Necrosis Factor Timing and Body Mass Index Z-Score Normalization. Clinical Gastroenterology and Hepatology. 2024; 22:368-376.e4.

Dillman, J; Fletcher, JG; Bruining, D; Kugathasan, S; Stidham, R; Adler, J; Tkach, J; Alazraki, A; Knight-Scott, J; Lu, A; Anton, C; Imbus, R; Dudley, J; Denson, L. MRI AND BLOOD-BASED BIOMARKERS ASSOCIATED WITH SURGICAL MANAGEMENT IN CHILDREN AND ADULTS WITH SMALL BOWEL CROHN'S DISEASE. Inflammatory Bowel Diseases. 2024; 30:s14-s15.

Derinkuyu, BE; Bard, A; Naim, I; Tkach, JA; Denson, LA; Dillman, JR. P067 Volumetric Assessment of Treatment Response in Newly Diagnosed Crohn Disease: A Pilot Study. Journal of Crohn's and Colitis. 2024; 18:i337.

Zhang, D; Tang, W; Niu, H; Tse, W; Ruan, HB; Dolznig, H; Knösel, T; Karl-Heinz, F; Themanns, M; Wang, J; Kenner, L; Moriggl, R; Zheng, Y; Han, X. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. Genes and Diseases. 2024; 11:413-429.

Liu, RX; Li, H; Towbin, AJ; Ata, NA; Smith, EA; Tkach, JA; Denson, LA; He, L; Dillman, JR. Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data. American Journal of Roentgenology. 2024; 222:e2329812.

Romo, MV; Acharya, K; Shelman, NR; Minar, P; Denson, LA; Softic, S. De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics. 2024; 8:1-4.

Roberts, CM; Plevinsky, JM; Gamwell, KL; Noser, AE; Denson, LA; Hommel, KA. Self-Management assistance for recommended treatment (SMART) IBD app randomized control trial in adolescents with IBD: Design and methodology. Health Care Transitions. 2024; 2:100031.

Sosnovski, KE; Braun, T; Amir, A; BenShoshan, M; Abbas-Egbariya, H; Ben-Yishay, R; Anafi, L; Avivi, C; Barshack, I; Denson, LA; Haberman, Y. Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease. Scientific Reports. 2023; 13:20513.

Venkateswaran, S; Somineni, HK; Matthews, JD; Kilaru, V; Hyams, JS; Denson, LA; Kellamayer, R; Gibson, G; Cutler, DJ; Conneely, KN; Smith, AK; Kugathasan, S. Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC. Clinical Epigenetics. 2023; 15:50.

Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Neurogastroenterology and Motility. 2023; 35:e14681.

Wu, Y; Gettler, K; Kars, ME; Giri, M; Li, D; Bayrak, CS; Zhang, P; Jain, A; Maffucci, P; Sabic, K; Brant, SR; McGovern, DP B; Cho, JH; Itan, Y. Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature Communications. 2023; 14:2256.

Dike, C; Ollberding, N; Thompson, T; Kotha, N; Minar, P; Vitale, D; Lin, T; Nasr, A; Denson, L; Haslam, D; Abu-El-Haija, M. Acute pancreatitis is associated with gut dysbiosis in children. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2023; 23:e3-e4.

Wang, YM; Abdullah, S; Luebbering, N; Langenberg, L; Duell, A; Lake, K; Lane, A; Hils, B; Silva, OV; Trapp, M; Haslam, DB; Faubion, WA; Davies, SM; Khandelwal, P. Intestinal permeability in patients undergoing stem cell transplantation correlates with systemic acute phase responses and dysbiosis. Blood Advances. 2023; 7:5137-5151.

Raygoza Garay, JA; Turpin, W; Lee, SH; Smith, MI; Goethel, A; Griffiths, AM; Moayyedi, P; Espin-Garcia, O; Abreu, M; Aumais, GL; Herfarth, H; Higgins, P; McGrath, J; Panancionne, R. Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives. Gastroenterology. 2023; 165:670-681.

Smith, J; Liu, C; Beck, A; Fei, L; Brokamp, C; Meryum, S; Whaley, KG; Minar, P; Hellmann, J; Denson, LA; Margolis, P; Dhaliwal, J. Racial Disparities in Pediatric Inflammatory Bowel Disease Care: Differences in Outcomes and Health Service Utilization Between Black and White Children. The Journal of Pediatrics. 2023; 260:113522.

Braun, T; Sosnovski, KE; Amir, A; BenShoshan, M; VanDussen, KL; Karns, R; Levhar, N; Abbas-Egbariya, H; Hadar, R; Efroni, G; Ferrer, J; Hyams, JS; Denson, LA; Haberman, Y. Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease. JCI insight. 2023; 8:e170181.

Castillo, DF; Denson, LA; Haslam, DB; Hommel, KA; Ollberding, NJ; Sahay, R; Santucci, NR. The microbiome in adolescents with irritable bowel syndrome and changes with percutaneous electrical nerve field stimulation. Neurogastroenterology and Motility. 2023; 35:e14573.

Khandelwal, P; Lounder, DT; Bartlett, A; Haberman, Y; Jegga, AG; Ghandikota, S; Koo, J; Luebbering, N; Leino, D; Abdullah, S; Karns, R; Nelson, AS; Denson, LA; Davies, SM. Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease. Haematologica: the hematology journal. 2023; 108:1803-1816.

Sosnovski, KE; Braun, T; Amir, A; Moshel, D; Benshoshan, M; Vandussen, KL; Levhar, N; Abbas-Egbariya, H; Beider, K; Ben-Yishay, R; Ulitsky, I; Hyams, JS; Denson, LA; Haberman, Y. GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. Journal of Crohn's and Colitis. 2023; 17:960-971.

Dike, C; Ollberding, N; Thompson, T; Kotha, N; Minar, PP; Vitale, DS; Lin, TK; Nasr, A; Denson, LA; Haslam, D; Abu-El-Haija, M. Su1884 ACUTE PANCREATITIS IS ASSOCIATED WITH GUT DYSBIOSIS IN CHILDREN. Gastroenterology. 2023; 164:s-703.

Smith, J; Howard, CA; Etter, R; Hellmann, J; Whaley, KG; Minar, PP; Denson, LA; Margolis, P; Dhaliwal, J. Su1013 EVALUATION OF INSURANCE TYPE ON PRIOR AUTHORIZATION (PA) DELAYS IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD) PATIENTS PRESCRIBED BIOLOGIC THERAPIES. Gastroenterology. 2023; 164:s-504-s-505.

Liu, X; Reigle, J; Sharma, M; Lopez-Nunez, O; Walters, TD; Collins, MH; Hyams, JS; Siddiqui, I; Denson, LA; Jegga, A; Prasath, S; Dhaliwal, J. 783 DEVELOPMENT OF AN OPTIMAL MACHINE LEARNING MODEL USING TREATMENT NAÏVE DIAGNOSTIC PATHOLOGY IMAGES TO PREDICT STEROID-FREE CLINICAL REMISSION AT ONE YEAR IN PEDIATRIC ULCERATIVE COLITIS. Gastroenterology. 2023; 164:s-170.

Jurickova, I; Dreskin, B; Angerman, E; Bonkowski, E; Denson, LA. 675 EICOSATETRAYNOIC ACID REGULATES PRO-FIBROTIC PATHWAYS IN AN INDUCED PLURIPOTENT STEM CELL DERIVED MACROPHAGE:HUMAN INTESTINAL ORGANOID MODEL OF ILEAL CROHN'S DISEASE. Gastroenterology. 2023; 164:s-132-s-133.

Whaley, KG; Xiong, Y; Karns, R; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; Kelsen, J; LeLeiko, N; Shapiro, J; D'Haens, GR; Denson, LA; Vinks, AA; Rosen, MJ. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21:1338-1347.

Liu, Z; Liu, R; Gao, H; Jung, S; Gao, X; Sun, R; Liu, X; Kim, Y; Lee, HS; Kawai, Y; Guo, Z; Zhu, S; Li, D; Liu, J. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nature Genetics. 2023; 55:796-806.

Dreskin, B; Jurickova, I; Angerman, E; Bonkowski, E; Denson, L. EICOSATETRAYNOIC ACID REGULATES PRO-FIBROTIC PATHWAYS IN AN INDUCED PLURIPOTENT STEM CELL DERIVED MACROPHAGE:HUMAN INTESTINAL ORGANOID MODEL OF ILEAL CROHN’S DISEASE. Gastroenterology. 2023; 164:s97-s98.

Dhaliwal, J; Liu, X; Reigle, J; Sharma, M; Lopez-Nunez, O; Walters, T; Collins, M; Hyams, J; Siddiqui, I; Denson, L; Jegga, A; Prasath, S. DEVELOPMENT OF AN OPTIMAL MACHINE LEARNING MODEL USING TREATMENT NAÏVE DIAGNOSTIC PATHOLOGY IMAGES TO PREDICT STEROID-FREE CLINICAL REMISSION AT ONE YEAR IN PEDIATRIC ULCERATIVE COLITIS. Gastroenterology. 2023; 164:s72-s73.

Colman, RJ; Mizuno, T; Fukushima, K; Haslam, DB; Hyams, JS; Boyle, B; Noe, JD; D'Haens, GR; Van Limbergen, J; Chun, K; Yang, J; Denson, LA; Ollberding, NJ; Vinks, AA; Minar, P. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary Pharmacology and Therapeutics. 2023; 57:524-539.

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Krishnakumar, C; Ananthakrishnan, AN; Boyle, BM; Griffiths, AM; LeLeiko, NS; Mack, DR; Markowitz, JF; Rosh, JR; Sauer, CG; Walters, TD; Bonkowski, E; Denson, LA; Hyams, JS; Kugathasan, S. Early Change in Fecal Calprotectin Predicts One-Year Outcome in Children Newly Diagnosed With Ulcerative Colitis. Journal of Pediatric Gastroenterology and Nutrition. 2022; 74:72-78.

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Haberman, Y; Iqbal, NT; Ghandikota, S; Mallawaarachchi, I; Tzipi Braun, ; Dexheimer, PJ; Rahman, N; Hadar, R; Sadiq, K; Ahmad, Z; Jegga, AG; Moore, SR; Ali, SA; Denson, LA. Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction. Gastroenterology. 2021; 160:2055-2071.e0.

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Somineni, HK; Nagpal, S; Venkateswaran, S; Cutler, DJ; Okou, DT; Haritunians, T; Simpson, CL; Begum, F; Datta, LW; Quiros, AJ; Gibson, G; McGovern, DP B; Brant, SR; Kugathasan, S. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. The American Journal of Human Genetics. 2021; 108:431-445.

Short, S; Pilat, J; Reddy, V; Haberman, Y; Hendren, J; Washington, M; Hyams, J; Denson, L; Rosen, M; Williams, C. COLON SPECIFIC ROLE FOR SELENOPROTEIN P IN COLITIS AND COLITIS-ASSOCIATED CARCINOMA. Gastroenterology. 2021; 160:s32-s33.

Whaley, K; Xiong, V; Karns, R; Hyams, J; Kugathasan, S; Boyle, B; Walters, T; Kelsen, J; LeLeiko, N; Shapiro, J; Denson, L; D’Haens, G; Vinks, A; Rosen, M. ANTI-TNF PHARMACOKINETICS AND RESPONSE TO THERAPY IN PEDIATRIC ACUTE SEVERE ULCERATIVE COLITIS (THE ARCH STUDY). Gastroenterology. 2021; 160:s75-s76.

Potdar, AA; Dube, S; Naito, T; Li, K; Botwin, G; Haritunians, T; Li, D; Casero, D; Yang, S; Bilsborough, J; Braun, J; Kugathasan, S; Stappenbeck, TS; McGovern, DP B. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease. Gastroenterology. 2021; 160:809-822.e7.

Haberman, Y; Minar, P; Karns, R; Dexheimer, PJ; Ghandikota, S; Tegge, S; Shapiro, D; Shuler, B; Venkateswaran, S; Braun, T; Hyams, JS; Kugathasan, S; Jegga, AG; Denson, LA. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. Journal of Crohn's and Colitis. 2021; 15:273-286.

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Short, S; Pilat, J; Reddy, V; Haberman, Y; Hendren, J; Washington, M; Hyams, J; Denson, L; Rosen, M; Williams, C. COLON SPECIFIC ROLE FOR SELENOPROTEIN P IN COLITIS AND COLITIS-ASSOCIATED CARCINOMA. Inflammatory Bowel Diseases. 2021; 27:s25.

Gray, WN; Wagoner, ST; Schaefer, MR; Reed, B; Morgan, P; Holbrook, E; Yacyshyn, B; MacKner, L; Young, M; Maddux, M; Saeed, SA; Denson, LA; Hommel, K. Transition to Adult IBD Care: A Pilot Multi-Site, Telehealth Hybrid Intervention. Journal of Pediatric Psychology. 2021; 46:1-11.

Niklinska-Schirtz, BJ; Venkateswaran, S; Anbazhagan, M; Kolachala, VL; Prince, J; Dodd, A; Chinnadurai, R; Gibson, G; Denson, LA; Cutler, DJ; Jegga, AG; Matthews, JD; Kugathasan, S. Ileal Derived Organoids From Crohn's Disease Patients Show Unique Transcriptomic and Secretomic Signatures. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2021; 12:1267-1280.

Ungaro, RC; Hu, L; Ji, J; Nayar, S; Kugathasan, S; Denson, LA; Hyams, J; Dubinsky, MC; Sands, BE; Cho, JH. Machine learning identifies novel blood protein predictors of penetrating and stricturing complications in newly diagnosed paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2021; 53:281-290.

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