Denson Lab

Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS. Increased Effectiveness of Early Therapy with Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease. Gastroenterology. 2014 Feb;146(2):383-91.

Pai AL, Tackett A, Hente EA, Ernst MM, Denson LA, Hommel KA. Assessing Psychosocial Risk in Pediatric Inflammatory Bowel Disease: Validation of the Psychosocial Assessment Tool 2.0_General. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):51-6.

D Gevers, S Kugathasan, LA Denson, Y Vázquez-Baeza, W Van Treuren, B Ren, E Schwager, D Knights, S Song, M Yassour, X Morgan, A Kostic, C Luo, A González, D McDonald, Y Haberman, T Walters, S Baker, J Rosh, M Stephens, M Heyman, J Markowitz, R Baldassano, A Griffiths, S Francisco, D Mack, S Kim, W Crandall, J Hyams, C Huttenhower, R Knight, RJ Xavier. The treatment-naïve microbiome in new-onset Crohn’s disease. Cell Host Microbe. 2014 Mar 12;15(3):382-92.

Augustine MV, Leonard MB, Thayu M, Baldassano RN, de Boer IH, Shults J, Denson LA, DeBoer MD, Herskovitz R, Denburg MR. Changes in Vitamin D-Related Mineral Metabolism After Induction With Anti Tumor Necrosis Factor-α Therapy in Crohn's Disease. J Clin Endocrinol Metab. 2014 Jun;99(6):E991-8.

Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48.

Okou DT, Mondal K, Faubion WA, Kobrynski LJ, Denson LA, Mulle JG, Ramachandran D, Xiong Y, Svingen P, Patel V, Bose P, Waters JP, Prahalad S, Cutler DJ, Zwick ME, Kugathasan S. Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2014 May;58(5):561-8.

Y. Haberman, T. Tickle, P. Dexheimer, M. Kim, D. Tang, R. Karns, R. Baldassano, J. Noe, J. Rosh, J. Markowitz, M. Heyman, A. Griffiths, W. Crandall, D. Mack, S. Baker, C. Huttenhower, D. Keljo, J. Hyams, S. Kugathasan, T. Walters, B. Aronow, R. Xavier, D. Gevers, and L. Denson. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014 Aug 1;124(8):3617-33.

Lipstein EA, Dodds CM, Lovell DJ, Denson LA, Britto MT. Making decisions about chronic disease treatment: a comparison of parents and their adolescent children. Health Expect. 2014 Jun 3.

Hommel KA, Hente E, Herzer M, Ingerski LM, Denson LA. Telehealth behavioral treatment for medication nonadherence: a pilot and feasibility study. Eur J Gastroenterol Hepatol. 2013 Apr;25(4):469- 73.

Nylund CM, Goudie A, Garza JM, Crouch G, Denson LA. Venous Thrombotic Events in Hospitalized Children and Adolescents with Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2013 May;56(5):485-91.

Prosnitz AR, Leonard MB, Shults J, Zemel BS, Hollis BW, Denson LA, Baldassano RN, Cohen AB, Thayu, M. Changes in Vitamin D and PTH Metabolism in Incident Pediatric Crohn Disease. Inflamm Bowel Dis. 2013 Jan;19(1):45-53.

Lipstein EA, Lovell DJ, Denson LA, Moser DW, Saeed SA, Dodds CM, Britto MT. Parents' Information Needs in Tumor Necrosis Factor-α Inhibitor Treatment Decisions. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):244-50.

Gathungu G, Kim M, Ferguson J, Sharma Y, Zhang W, Ng S, Bonkowski E, Ning K, Simms L, Croft A, Stempak J, Walker N, Huang N, Xiao Y, Silverberg M, Trapnell B, Cho J, Radford-Smith G, Denson L. Granulocyte-Macrophage Colony-Stimulating Factor Auto-Antibodies: A Marker of Aggressive Crohn’s Disease. Inflamm Bowel Dis. 2013 Jul;19(8):1671-80.

Jurickova I, Collins M, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer J, Falcone R, Trapnell B, and Denson L. Pediatric Crohn’s Disease Patients with Stricturing Behavior Exhibit Ileal Granulocyte-Macrophage Colony Stimulating Factor Auto-antibody Production and Reduced Neutrophil Bacterial Killing and GM-CSF Bioactivity. Clin Exp Immunol. 2013 Jun;172(3):455-65.

Dykes D, Towbin A, Bonkowski E, Chalk C, Bezold R, Lake K, Kim M, Heubi J, Trapnell B, Podberesky D, and Denson L. Increased Prevalence of Luminal Narrowing and Stricturing by Enterography in Pediatric Crohn’s Disease Patients with Elevated Granulocyte-Macrophage Colony Stimulating Factor Auto-antibodies. Inflamm Bowel Dis. 2013 Sep;19(10):2146-54.

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK; Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium; International IBD Genetics Consortium, D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet. 2013 Sep;9(9):e1003723.

Maier EA, Weage KJ, Guedes MM, Denson LA, McNeal MM, Bernstein DI, Moore SR. Protein-energy malnutrition alters IgA responses to rotavirus vaccination and infection but does not impair vaccine efficacy in mice. Vaccine. 2013 Dec 17;32(1):48-53.

Ryan JL, Mellon MW, Junger KW, Hente EA, Denson LA, Saeed SA, Hommel KA. The clinical utility of health-related quality of life screening in a pediatric inflammatory bowel disease clinic. Inflamm Bowel Dis. 2013 Nov;19(12):2666-72.

Däbritz J, Bonkowski E, Chalk C, Trapnell BC, Langhorst J, Denson LA, Foell D. Granulocyte Macrophage Colony-Stimulating Factor Auto-Antibodies and Disease Relapse in Inflammatory Bowel. Am J Gastroenterol. 2013 Dec;108(12):1901-10.

Riis JL, Out D, Dorn LD, Beal SJ, Denson LA, Pabst S, Jaedicke K, Granger DA. Salivary cytokines in healthy adolescent girls: Intercorrelations, stability, and associations with serum cytokines, age, and pubertal stage. Dev Psychobiol. 2013 Jul 19.

Wu YP, Pai AL, Gray WN, Denson LA, Hommel KA. Development and reliability of a correction factor for family-reported medication adherence: pediatric inflammatory bowel disease as an exemplar. J Pediatr Psychol. 2013 Sep;38(8):893-901.

Waddell A, Ahrens R, Tsai YT, Sherrill JD, Denson LA, Steinbrecher KA, Hogan SP. Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice. J Immunol. 2013 May 1;190(9):4773-85.

Willson TA, Jurickova I, Collins M, Denson LA.Deletion of intestinal epithelial cell STAT3 promotes T-lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice. Inflamm Bowel Dis. 2013 Mar;19(3):512-25.

Melmed GY, Siegel CA, Spiegel BM, Allen JI, Cima R, Colombel JF, Dassopoulos T, Denson LA,Dudley-Brown S, Garb A, Hanauer SB, Kappelman MD, Lewis JD, Lynch I, Moynihan A, Rubin DT, Sartor RB, Schwartz RM, Wolf DC, Ullman TA. Quality indicators for inflammatory bowel disease: development of process and outcome measures. Inflamm Bowel Dis. 2013 Mar;19(3):662-8. Erratum in: Inflamm Bowel Dis. 2013 Aug;19(9):2040.

S. D’Mello, A. Trauernicht, A. Ryan, E. Bonkowski, T. Willson, B. Trapnell, S. Frank, S. Kugasathan, and L. Denson.Innate Dysfunction Promotes Linear Growth Failure in Pediatric Crohn Disease and Growth Hormone Resistance in Murine Ileitis. Inflamm Bowel Dis. 2012 Feb;18(2):236-45.

Hommel KA, Hente EA, Odell S, Herzer M, Ingerski LM, Guilfoyle SM, Denson LA. Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2012 Jan;24(1):64-9.

Chernoguz A, Crawford K, Vandersall A, Rao M, Willson T, Denson LA, Frischer JS. Pretreatment with anti-VEGF therapy may exacerbate inflammation in experimental acute colitis. J Pediatr Surg. 2012 Feb;47(2):347-54.

Gilbert S, Zhang R, Denson L, Moriggl R, Steinbrecher K, Shroyer N, Lin J, Han X. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med. 2012 Feb;4(2):109-24.

Willson TA, Kuhn BR, Jurickova I, Gerad S, Moon D, Bonkowski E, Carey R, Collins M, Xu H, Jegga AG, Guthery SL, Denson LA. STAT3 Genotypic Variation and Cellular STAT3 Activation and Colon Leukocyte Recruitment in Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. 2012 Jul;55(1):32-43.

Samson CM, Morgan P, Williams E, Beck L, Addie-Carson R, McIntire S, Booth A, Mendez E, Luzader C, Tomer G, Saeed S, Donovan E, Bucuvalas J, Denson LA. Improved Outcomes with Quality Improvement Interventions in Pediatric Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2012 Dec;55(6):679-88.

Wallihan DB, Towbin AJ, Denson LA, Salisbury S, Podberesky DJ. Inflammatory Bowel Disease in Children and Adolescents: Assessing the Diagnostic Performance and Interreader Agreement of Magnetic Resonance Enterography Compared to Histopathology. Acad Radiol. 2012 Jul;19(7):819-26.

Crandall WV, Margolis PA, Kappelman MD, King EC, Pratt JM, Boyle BM, Duffy LF, Grunow JE, Kim SC, Leibowitz I, Schoen BT, Colletti RB; ImproveCareNow Collaborative. Improved Outcomes in a Quality Improvement Collaborative for Pediatric Inflammatory Bowel Disease. Pediatrics. 2012 Apr;129(4):e1030-41.

Gray WN, Denson LA, Baldassano RN, Hommel KA. Disease activity, behavioral dysfunction, and health-related quality of life in adolescents with inflammatory bowel disease. Inflamm Bowel Dis. Nov, 2010.

Lawal TA, Frischer JS, Falcone RA, Chatoorgoon K, Denson LA, Levitt MA. The transanal approach with laparoscopy or laparotomy for the treatment of rectal strictures in Crohn's disease. J Laparoendosc Adv Surg Tech A. 20(9):791-5. Nov, 2010.

Crandall W, Kappelman MD, Colletti RB, Leibowitz I, Grunow JE, Ali S, Baron HI, Berman JH, Boyle B, Cohen S, Del Rosario F, Denson LA, Duffy L, Integlia MJ, Kim SC, Milov D, Patel AS, Schoen BT, Walkiewicz D, Margolis P. ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network. Inflamm Bowel Dis. Jul, 2010.

Ingerski LM, Baldassano RN, Denson LA, Hommel KA. Barriers to oral medication adherence for adolescents with inflammatory bowel disease. J Pediatr Psychol. 35(6):683-91. Jul, 2010.

Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson H. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 15;19(10):2059-67. May, 2010.

Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A Randomized Controlled Trial of Growth Hormone in Active Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. May, 2010.

Pasternak BA, D'Mello S, Jurickova II, Han X, Willson T, Flick L, Petiniot L, Uozumi N, Divanovic S, Traurnicht A, Bonkowski E, Kugathasan S, Karp CL, Denson LA. Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohn's disease and murine colitis. Inflamm Bowel Dis. 16(5):856-69. May, 2010.

Nylund CM, Denson LA, Noel JM. Bacterial enteritis as a risk factor for childhood intussusception: a retrospective cohort study. J Pediatr. 156(5):761-5. May, 2010.

Thayu M, Denson LA, Shults J, Zemel BS, Burnham JM, Baldassano RN, Howard KM, Ryan A, Leonard MB. Determinants of Changes in Linear Growth and Body Composition in Incident Pediatric Crohn Disease. Gastroenterology. Apr, 2010.

Munitz A, Cole ET, Waddell A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like Receptor B (PIR-B) Negatively Regulates Macrophage Activation in Experimental Colitis. Gastroenterology. Apr, 2010.

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D; Western Regional Alliance for Pediatric IBD, Silber G, Wrobel I, Quiros A; International IBD Genetics Consortium, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 41(12):1335-40. Dec, 2009.

Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV, Crissinger KD, D'Amico MA, Day AS, Denson LA, Dubinsky M, Ebach DR, Hoffenberg EJ, Kader HA, Keljo DJ, Leibowitz IH, Mamula P, Pfefferkorn MD, Qureshi MA; Pediatric IBD Network for Research and Improvement. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 49(3):297-303. Sep, 2009.

Tomer G, Wetzler G, Keddache M, Denson LA. Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients. J Pediatr Gastroenterol Nutr. 48(5):531-7. May, 2009.

Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 136(4):1261-71, e1-3. Apr, 2009.

Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 113(11):2547-56. Mar, 2009.

Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet. 84(3):399-405. Mar, 2009.

Denson LA. Growth hormone therapy in children and adolescents: pharmacokinetic/pharmacodynamic considerations and emerging indications. Expert Opin Drug Metab Toxicol. 4(12):1569-80. Dec, 2008.

Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 181(10):7390-9. Nov, 2008.

Hommel KA, Denson LA, Crandall WV, Mackner LM. Behavioral Functioning and Treatment Adherence in Pediatric Inflammatory Bowel Disease: Review and Recommendations for Practice. Gastroenterol Hepatol (N Y). 4(11):785. Nov, 2008.

Hommel KA, Mackner LM, Denson LA, Crandall WV. Treatment regimen adherence in pediatric gastroenterology. J Pediatr Gastroenterol Nutr. 47(5):526-43. Nov, 2008.

Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy individuals. Blood. Oct, 2008.

Kugathasan S, Baldassano RN, Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Willson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, Grundmeier R, Mamula P, Tomer G, Piccoli DA, Monos DS, Annese V, Denson LA, Grant SF, Hakonarson H. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet. 40(10):1211-5. Oct, 2008.