Publications

Selected Publications

Adams, JM; Huppert, KA; Castro, EC; Lopez, MF; Niknejad, N; Subramanian, S; Zarrin-Khameh, N; Finegold, MJ; Huppert, SS; Jafar-Nejad, H. Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020; 71(4):1331-1349.

Huppert, SS; Iwafuchi-Doi, M. Molecular regulation of mammalian hepatic architecture. Current Topics in Developmental Biology. 2019; 132:91-136.

Schaub, JR; Huppert, KA; Kurial, SNT; Hsu, BY; Cast, AE; Donnelly, B; Karns, RA; Chen, F; Rezvani, M; Luu, HY; Mattis, AN; Rougemont, A-L; Rosenthal, P; Huppert, SS; Willenbring, H. De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation. Nature. 2018; 557(7704):247-251.

Broadus, MR; Chen, TW; Neitzel, LR; Ng, VH; Jodoin, JN; Lee, LA; Salic, A; Robbins, DJ; Capobianco, AJ; Patton, JG; Huppert, SS; Lee, E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell reports. 2016; 15(9):1920-1929.

2025

Kudira, R; Yang, ZF; Osuji, I; Damen, MSMA; Yang Vom Hofe, A; Singh, M; Karns, R; Bariya, P; Pfuhler, L; Mullen, M; Subramanian, S; Salomonis, N; Miraldi, ER; Miethke, AG. Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies. Journal of Hepatology. 2025; 83(5):1128-1141.

Fox, D; Xie, J; Burwinkel, JL; Adams, JM; Chetal, K; Keivandarian, M; Faingelernt, Y; Subramanian, S; Lopez, MF; Peters, AL; Salomonis, N; Zarrin-Khameh, N; Gao, G; Huppert, SS; Jafar-Nejad, H. Adeno-associated Virus-mediated Silencing of Sox4 Leads to Long-Term Amelioration of Liver Phenotypes in Mouse Models of Alagille Syndrome. Gastroenterology. 2025; 169(5):1000-1016.

Peters, AL; Depasquale, E; Begum, G; Seraphine, K; Steinkamp, S; Huppert, S; Woodle, E; Hildeman, D. Multiome Sequencing of Chronic Ductopenic Rejection Reveals Roles for Th2 Immunity and Activated Fibroblasts in Cholangiocyte Injury. American Journal of Transplantation. 2025; 25(8):s245.

Lee, S; Ren, L; Li, W; Paranjpe, A; Zhou, P; Potter, A; Huppert, SS; Shin, S. Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice. Hepatology Communications. 2025; 9(7).

Mcdaniel, CG; Fox, D; Pastura, P; Alharbi, S; Huppert, SS; Cras, TDL. Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and Hepatic Vascular Defects in Embryonic Mice. Pediatric Blood and Cancer. 2025; 72(3):e31492.

2024

Hellen, DJ; Fay, ME; Lee, DH; Klindt-Morgan, C; Bennett, A; Pachura, KJ; Grakoui, A; Huppert, SS; Dawson, PA; Lam, WA; Karpen, SJ. BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2024; 327(1):G1-G15.

Huppert, SS; Balistreri, WF. Morphogenesis of the Liver and Biliary System. In: Nelson Textbook of Pediatrics Volume 1 2. 2024:2434-2437.e1.

2023

Niknejad, N; Fox, D; Burwinkel, JL; Zarrin-Khameh, N; Cho, S; Soriano, A; Cast, AE; Lopez, MF; Huppert, KA; Rigo, F; Huppert, SS; Jafar-Nejad, P; Jafar-Nejad, H. ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome. Hepatology. 2023; 78(5):1337-1351.

Huppert, SS; Schwartz, RE. Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver. Annual Review of Physiology. 2023; 85:469-493.

2021

Gillen, MC; Huppert, SS. Liver Development. In: Liver Disease in Children. Cambridge University Press (CUP); 2021:1-11.

Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; Mayhew, C; Setchell, K; Takebe, T; Asai, A. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16(2):309-323.

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