Minar Lab

Publications

Garlapally, V; Ahmed, F; Lynch, K; Minar, P; Bruce, J; Abu-El-Haija, M. Markers of Gut Inflammation in Pediatric Acute Pancreatitis. Pancreas. 2025.

Irie, K; Minar, P; Reifenberg, J; Boyle, BM; Noe, JD; Hyams, JS; Mizuno, T. Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease. Clinical Pharmacokinetics. 2025; 64(11):1669-1679.

Debnath, P; Acord, MR; Anton, CG; Courtier, J; El-Ali, AM; Forbes-Amrhein, MM; Gee, MS; Greer, M-LC; Guillerman, RP; Kocaoglu, M; Zhang, B; Frischer, JS; Minar, P; Dillman, JR. Magnetic resonance imaging for suspected perianal Crohn's disease in children: a multi-reader agreement study. European Radiology. 2025; 35(9):5856-5863.

Dike, CR; Duan, Q; Ahmed, F; Denson, LA; Haslam, D; Minar, P; Ollberding, NJ; Papachristou, GI; Setchell, KDR; Thompson, T; Vitale, DS; Zhao, X; Abu-El-Haija, M. Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes. Journal of Pediatric Gastroenterology and Nutrition. 2025; 81(3):690-698.

Moses, J; Adler, J; Saeed, SA; Firestine, AM; Galanko, JA; Ammoury, RF; Bass, DM; Bass, JA; Bastidas, M; Benkov, KJ; Wohl, DA; Zikry, M; Boyle, BM; Kappelman, MD. Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn's Disease. Inflammatory Bowel Diseases. 2025; 31(7):1841-1850.

Colman, RJ; Dotson, JL; Mock, M; Sandberg, K; Saeed, S; Margolis, P; Dhaliwal, J. Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease: A Nationwide Survey of Anti-TNF Therapy Practices, Attitudes, and Barriers. Crohn's & Colitis 360. 2025; 7(3):otaf050.

Dillman, JR; Tkach, JA; Fletcher, JG; Bruining, DH; Lu, A; Kugathasan, S; Alazraki, AL; Knight-Scott, J; Stidham, RW; Adler, J; Anton, CG; Imbus, RA; Dudley, JA; Denson, LA. Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease. Inflammatory Bowel Diseases. 2025; 31(5):1380-1391.

Adler, J; Galanko, JA; Ammoury, R; Benkov, KJ; Bousvaros, A; Boyle, B; Cabrera, JM; Chun, KY; Dorsey, J; Ebach, DR; Strople, JA; Sullivan, JS; Wali, PD; Kappelman, MD. HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease. American Journal of Gastroenterology. 2025; 120(5):1076-1086.

Sifuentes-Dominguez, L; Bauman, LE; Subedi, S; Chevalier, RL; Niklinska-Schirtz, BJ; Hoffenberg, EJ; De Zoeten, E; Shapiro, J; Goyal, A; Albenberg, L; Sauer, C; Huang, JS; Kahn, SA; Rosen, MJ. Tu2094: COHORT FOR PEDIATRIC TRANSLATIONAL AND CLINICAL RESEARCH IN IBD (CAPTURE IBD): INITIAL ENROLLMENT OF A DIVERSE AND ADVANCED THERAPY-EXPOSED PROSPECTIVE COHORT. Gastroenterology. 2025; 169(1):s-1607.

Colman, RJ; Lopez-Rivera, J; Pinto, Y; Hyams, JS; Boyle, BM; Noe, JD; Minar, PP; Rosen, MJ. 36: LONGITUDINAL MICROBIAL SIGNATURES PREDICT DRUG CONCENTRATIONS, IMMUNOGENICITY, AND ENDOSCOPIC HEALING IN PEDIATRIC PATIENTS WITH CROHN’S DISEASE TREATED WITH ANTI-TNF THERAPY. Gastroenterology. 2025; 169(1):s-13-s-14.

Bartel, C; Minar, P. Editorial: Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab. Alimentary Pharmacology and Therapeutics. 2025; 61(6):1063-1064.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Inflammatory Bowel Diseases. 2025; 31(Supplement_1):s59-s60.

Samuels, A; Irie, K; Mizuno, T; Reifenberg, J; Punt, N; Vinks, AA; Minar, P. Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. Clinical and Translational Science. 2025; 18(2):e70086.

Bartel, C; Mizuno, T; Irie, K; Samuels, A; Lynch, K; Jackson, K; Hyams, J; Boyle, B; Saeed, S; Kurowski, J; Noe, J; Chun, K; Yang, J; Denson, L; Minar, P. AN EVALUATION OF ENDOSCOPIC HEALING IN PEDIATRIC CROHN’S DISEASE USING MULTIPLE ENDOSCOPIC SCORING METHODS IDENTIFIES SIMILARITIES IN BLOOD AND STOOL BIOMARKERS. Gastroenterology. 2025; 168(3):s84-s85.

Adler, J; Galanko, JA; Ammoury, R; Benkov, KJ; Bousvaros, A; Boyle, B; Cabrera, JM; Chun, KY; Dorsey, J; Ebach, DR; Strople, JA; Sullivan, JS; Wali, PD; Kappelman, MD. HLA DQA1*05 and risk of anti-TNF treatment failure and anti-drug antibody development in children with Crohn's Disease: HLA DQA1*05 and Pediatric Crohn's Disease. American Journal of Gastroenterology. 2024.

Colman, RJ; Vuijk, SA; Mathôt, RAA; Van Limbergen, J; Jongsma, MME; Schreurs, MWJ; Minar, P; De Ridder, L; D'haens, GRAM. Infliximab Monotherapy vs Combination Therapy for Pediatric Crohn's Disease Exhibit Similar Pharmacokinetics. Inflammatory Bowel Diseases. 2024; 30(10):1678-1685.

Ebach, DR; Jester, TW; Galanko, JA; Firestine, AM; Ammoury, R; Cabrera, J; Bass, J; Minar, P; Olano, K; Margolis, P; Molle-Rios, Z; Saeed, SA; Bousvaros, A; Kappelman, MD. High Body Mass Index and Response to Anti-Tumor Necrosis Factor Therapy in Pediatric Crohn's Disease. American Journal of Gastroenterology. 2024; 119(6):1110-1116.

Allegretti, JR; Bordeianou, LG; Damas, OM; Eisenstein, S; Greywoode, R; Minar, P; Singh, S; Harmon, S; Lisansky, E; Malone-King, M; Litwin, NS; Weaver, A; Heller, CA; Moss, AC; Adler, J. Challenges in IBD Research 2024: Pragmatic Clinical Research. Inflammatory Bowel Diseases. 2024; 30(Suppl 2):S55-S66.

Nasr, A; Mizuno, T; Irie, K; Dillman, J; Jackson, K; Lynch, K; Horrell, A; Chun, KY; Yang, JM; Hyams, JS; Boyle, BM; Noe, JD; Denson, LA; Minar, PP. 958 ATTAINING EARLY ANTI-TNF EXPOSURE TARGETS IS ASSOCIATED WITH IMPROVED RATES OF ENDOSCOPIC HEALING AND TRANSMURAL HEALING IN CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166(5):s-226-s-227.

Minar, PP; Karns, R; Lynch, K; Jackson, K; Horrell, A; Boyle, BM; Hyams, JS; Noe, JD; Denson, LA. 748 EXTENSIVE PROTEOMIC ANALYSIS IDENTIFIES A CROHN'S DISEASE CORE PROTEOME AND ANTI-TNF TREATMENT RESPONSE PROFILE FOR CHILDREN WITH CROHN'S DISEASE. Gastroenterology. 2024; 166(5):s-177-s-178.

Minar, PP; Colman, RJ; Zhang, N; Mizuno, T; Vinks, AA. Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohn's disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA. BMJ Open. 2024; 14(3):e077193.

Dike, CR; Ollberding, NJ; Thompson, T; Kotha, N; Minar, P; Vitale, DS; Lin, TK; Nasr, A; Denson, LA; Haslam, DB; Abu-El-Haija, M. Acute pancreatitis is associated with gut dysbiosis in children. Digestive and Liver Disease. 2024; 56(3):444-450.

Romo, MV; Acharya, K; Shelman, NR; Minar, P; Denson, LA; Softic, S. De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics. J Pediatr Perinatol Child Health. 2024; 8(1):1-4.

Samuels, A; Whaley, KG; Minar, P. Precision Dosing of Anti-TNF Therapy in Pediatric Inflammatory Bowel Disease. Current Gastroenterology Reports. 2023; 25(11):323-332.

Dike, C; Ollberding, N; Thompson, T; Kotha, N; Minar, P; Vitale, D; Lin, T; Nasr, A; Denson, L; Haslam, D; Abu-El-Haija, M. Acute pancreatitis is associated with gut dysbiosis in children. Pancreatology. 2023; 23:e3-e4.

Smith, J; Liu, C; Beck, A; Fei, L; Brokamp, C; Meryum, S; Whaley, KG; Minar, P; Hellmann, J; Denson, LA; Margolis, P; Dhaliwal, J. Racial Disparities in Pediatric Inflammatory Bowel Disease Care: Differences in Outcomes and Health Service Utilization Between Black and White Children. Journal of Pediatrics. 2023; 260:113522.

Nasr, A; Minar, P. The Role of Therapeutic Drug Monitoring in Children. Gastroenterology Clinics of North America. 2023; 52(3):549-563.

Colman, RJ; Samuels, A; Mizuno, T; Punt, N; Vinks, AA; Minar, P. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2023; 29(8):1342-1346.

Khandelwal, P; Lounder, DT; Bartlett, A; Haberman, Y; Jegga, AG; Ghandikota, S; Koo, J; Luebbering, N; Leino, D; Abdullah, S; Karns, R; Nelson, AS; Denson, LA; Davies, SM. Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease. Haematologica. 2023; 108(7):1803-1816.

Kappelman, MD; Wohl, DA; Herfarth, HH; Firestine, AM; Adler, J; Ammoury, RF; Aronow, JE; Bass, DM; Bass, JA; Benkov, K; Zikry, M; Weinberger, M; Saeed, SA; Bousvaros, A. Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn's Disease: A Pragmatic Randomized Trial. Gastroenterology. 2023; 165(1):149-161.e7.

Whaley, KG; Xiong, Y; Karns, R; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; Kelsen, J; Leleiko, N; Shapiro, J; D'haens, GR; Denson, LA; Vinks, AA; Rosen, MJ. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21(5):1338-1347.

Dike, C; Ollberding, N; Thompson, T; Kotha, N; Minar, PP; Vitale, DS; Lin, TK; Nasr, A; Denson, LA; Haslam, D; Abu-El-Haija, M. Su1884 ACUTE PANCREATITIS IS ASSOCIATED WITH GUT DYSBIOSIS IN CHILDREN. Gastroenterology. 2023; 164(6):s-703.

Smith, J; Howard, CA; Etter, R; Hellmann, J; Whaley, KG; Minar, PP; Denson, LA; Margolis, P; Dhaliwal, J. Su1013 EVALUATION OF INSURANCE TYPE ON PRIOR AUTHORIZATION (PA) DELAYS IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD) PATIENTS PRESCRIBED BIOLOGIC THERAPIES. Gastroenterology. 2023; 164(6):s-504-s-505.

Gadepalli, S; Boyle, BM; Chavannes, M; Egberg, MD; Frischer, JS; Gayer, C; Kandavel, P; Kim, SC; Mcmahon, L; Minar, PP; Mollen, K; Nwomeh, B; Pasternak, B; Phillips, MR; Adler, J. 513 DISPARITIES IN OSTOMY CREATION FOR PERIANAL FISTULIZING COMPLICATIONS IN PEDIATRIC PATIENTS WITH CROHN'S DISEASE WITHIN A MULTI-INSTITUTIONAL COHORT. Gastroenterology. 2023; 164(6):s-1477.

Samuels, A; Punt, N; Mizuno, T; Vinks, AA; Minar, PP. 347 DISEASE PROGRESSION PHARMACOKINETIC MODELING IMPROVES THE ACCURACY OF EARLY INFLIXIMAB CONCENTRATION TARGETS. Gastroenterology. 2023; 164(6):s-59.

Adler, J; Tribble, AC; Boyle, BM; Chavannes, M; Egberg, MD; Frischer, JS; Gayer, C; Kandavel, P; Kim, SC; Mcmahon, L; Nwomeh, B; Pasternak, B; Phillips, MR; Gadepalli, S. 860 ANTIBIOTIC USE AMONG PEDIATRIC PATIENTS WITH PERIANAL COMPLICATIONS OF CROHN'S DISEASE IN A MULTICENTER COHORT: THE CASE FOR ANTIBIOTIC STEWARDSHIP. Gastroenterology. 2023; 164(6):s-188.

Colman, RJ; Mizuno, T; Fukushima, K; Haslam, DB; Hyams, JS; Boyle, B; Noe, JD; D'haens, GR; Van Limbergen, J; Chun, K; Yang, J; Denson, LA; Ollberding, NJ; Vinks, AA; Minar, P. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary Pharmacology and Therapeutics. 2023; 57(5):524-539.

Colman, RJ; Minar, P. Editorial: achievements and unresolved questions in improving the pharmacokinetics of vedolizumab in adolescents with inflammatory bowel disease-authors' reply. Alimentary Pharmacology and Therapeutics. 2023; 57(5):567-568.

Colman, RJ; Dykes, DMH; Arce-Clachar, AC; Saeed, SA; Minar, P. Infliximab Therapy for Pediatric Crohn Disease and Ulcerative Colitis. In: Pediatric Inflammatory Bowel Disease. Springer Nature; 2023:407-422.

Matula, KA; Minar, P; Daraiseh, NM; Lin, L; Recker, M; Lipstein, EA. Pilot trial of iBDecide: Evaluating an online tool to facilitate shared decision making for adolescents and young adults with ulcerative colitis. Health Expectations. 2022; 25(6):3105-3113.

Clarkston, K; Karns, R; Jegga, AG; Sharma, M; Fox, S; Ojo, BA; Minar, P; Walters, TD; Griffiths, AM; Mack, DR; Haberman, Y; Hyams, JS; Denson, LA; Rosen, MJ. Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis. Journal of Crohn's and Colitis. 2022; 16(11):1735-1750.

Daraiseh, NM; Black, A; Minar, P; Meisman, A; Saxe, M; Lipstein, EA. iBDecide: A web-based tool to promote engagement in shared decision-making among adolescents with ulcerative colitis. Patient Education and Counseling. 2022; 105(6):1628-1633.

Miller, TL; Schuchard, J; Carle, AC; Forrest, CB; Kappelman, MD. Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn's Disease. Journal of Pediatrics. 2022; 242:86-92.e3.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, B; D'haens, GR; Van Limbergen, J; Chun, K; Yang, J; Rosen, MJ; Denson, LA; Vinks, AA; Minar, P. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55(5):593-603.

Colman, R; Mizuno, T; Hyams, J; Noe, J; Boyle, B; Denson, L; Vinks, A; Minar, P. REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Gastroenterology. 2022; 162(3):s100.

Samuels, A; Punt, N; Reifenberg, J; Mizuno, T; Colman, R; Menke, F; Vogt, A; Vinks, A; Minar, P. PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Gastroenterology. 2022; 162(3):s99-s100.

Minar, P; Samuels, A; Mizuno, T; Menke, F; Vogt, A; Punt, N; Vinks, A. BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Gastroenterology. 2022; 162(3):s98-s99.

Colman, R; Mizuno, T; Hyams, J; Noe, J; Boyle, B; Denson, L; Vinks, A; Minar, P. REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s100-s100.

Samuels, A; Punt, N; Reifenberg, J; Mizuno, T; Colman, R; Menke, F; Vogt, A; Vinks, A; Minar, P. PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s99-s100.

Minar, P; Samuels, A; Mizuno, T; Menke, F; Vogt, A; Punt, N; Vinks, A. BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Inflammatory Bowel Diseases. 2022; 28(Supplement_1):s98-s99.