Wang Lab

Publications

Wang, Y; Adeleke, D; Xie, X; Yang, ZF; Wang, X; Loi, G; Yang Vom Hofe, A; Singh, M; Malik, A; Kudira, R; Dillman, JR; Trout, AT; Miraldi, ER; Miethke, AG. Macrophage signaling associates with fibrogenic program activation in periductal fibroblasts in pediatric primary sclerosing cholangitis. JCI Insight. 2026.

Caldwell, J; Wang, Y; Shi, T; Burg, A; Koby, A; Steve, KE; Roskin, W; Hildeman, DA. 37 Injured proximal tubule cells are increased in kidney transplant rejection and are spatially located in distinct niches containing mixed immune cells. Journal of Clinical and Translational Science. 2026; 10(s1):11-11.

Guirao-Abad, JP; Kasprovic, DA; Seo, D; Ozdemir, M; Shearer, SM; Wen, B-Y; Bowden, JJ; Grisham, C; Wang, Y; Tranter, M; Askew, DS; Kanisicak, O. Pulmonary fibroblast activation during Aspergillus fumigatus infection enhances lung defense via immunomodulation and tissue remodeling. Nature Communications. 2026; 17(1).

Napolitano, F; Wang, Y; Sudhan, DR; Gonzalez-Ericsson, PI; Formisano, L; Unni, N; Shakeel, S; Zhu, JZ; Ahuja, K; Guo, L; Mills, GB; Labrie, M; Hanker, AB; Arteaga, CL. CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer. Journal of Clinical Investigation. 2026; 136(3).

Guo, J; Liang, R; Chung, A; Li, Z; Li, B; Chen, E; Li, L; Wang, J; Hsieh, M-H; Fang, IX; Gopal, P; Xiao, G; Wang, T; Zhu, H. The origin of hepatocellular carcinoma depends on metabolic zonation. Science. 2026; 391(6784):eadv7129.

Nguyen, V; Harper, A; Azuero, M; Castellanos, I; He, S; Hochman, ML; Wenceslau, CF; Chen, D-B; Jegga, AG; Wang, Y; Fan, D; Nelson, JS; Tan, W. Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes. Stem Cell Reviews and Reports. 2026; 22(1):668-675.

Ahmed, F; Zhao, X; Setchell, KDR; Abu-El-Haija, M. Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics. Metabolites. 2025; 15(10).

Zhao, X; Pandey, MK. Central Roles of Glucosylceramide in Driving Cancer Pathogenesis. International Journal of Molecular Sciences. 2025; 26(20).

Dike, CR; Duan, Q; Ahmed, F; Denson, LA; Haslam, D; Minar, P; Ollberding, NJ; Papachristou, GI; Setchell, KDR; Thompson, T; Vitale, DS; Zhao, X; Abu-El-Haija, M. Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes. Journal of Pediatric Gastroenterology and Nutrition. 2025; 81(3):690-698.

Ruffolo, B; Vicente-Muñoz, S; Mehta, KY; Rivera-Cruz, CM; Zhao, X; Romick, L; Setchell, KDR; Lane, A; Wells, SI. The Fanconi Anemia Pathway Inhibits mTOR Signaling and Prevents Accelerated Translation in Head and Neck Cancer Cells. Cancers. 2025; 17(15).

Zhao, J; Zhao, X; Mizuno, T; Irie, K; Devarajan, P; Brunner, HI; Setchell, KDR. Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. Journal of Applied Laboratory Medicine. 2025; 10(4):806-819.

Agarwal, P; Sampson, A; Hueneman, K; Choi, K; Jakobsen, NA; Uible, E; Ishikawa, C; Yeung, J; Bolanos, L; Zhao, X; Galloway-Pena, J; Byrd, JC; Vyas, P; Starczynowski, DT. Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature. 2025; 642(8066):201-211.

Ahmed, F; Zhao, X; Beres, R; Garlapally, V; Mouzaki, M; Setchell, KD; Husain, SZ; Abu-El-Haija, M. Sa1442: LIPIDOMIC AND METABOLOMIC INSIGHTS INTO PEDIATRIC CHRONIC PANCREATITIS: DECIPHERING THE METABOLIC LANDSCAPE. Gastroenterology. 2025; 169(1):s-471.

Schenker, RB; Ramirez, CB; Jang, C; Allayee, H; Zhao, X; Setchell, KDR; Kohli, R; Goran, MI. Dihydroxyacetone phosphate is a novel predictor of hepatic fibrosis in Latino adolescents with obesity. Journal of Pediatric Gastroenterology and Nutrition. 2025; 80(1):174-181.

Zhu, J; Wang, Y; Chang, WY; Malewska, A; Napolitano, F; Gahan, JC; Unni, N; Zhao, M; Yuan, R; Wu, F; Desai, N; Wang, X; Xie, Y; Wang, T. Mapping cellular interactions from spatially resolved transcriptomics data. Nature Methods. 2024; 21(10):1830-1842.

Zhu, M; Wang, Y; Lu, T; Guo, J; Li, L; Hsieh, M-H; Gopal, P; Han, Y; Fujiwara, N; Wallace, DP; Singal, AG; Yopp, A; Wang, T; Zhu, H. PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer. Cell Metabolism. 2024; 36(8):1711-1725.e8.

Lim, YZ; Zhu, M; Wang, Y; Sharma, T; Kelley, S; Oertling, E; Zhu, H; Corbitt, N. Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells. Journal of Hepatology. 2024; 81(1):62-75.

Li, X; Deng, S; Wang, C; Wang, Y; Mu, P. Abstract 4311: The interplay of SYNCRIP deficiency, APOBEC activity, and extrachromosomal DNA in castration-resistant prostate cancer drug resistance. Cancer Research. 2024; 84(6_Supplement):4311-4311.

Lin, C-C; Chang, T-C; Wang, Y; Guo, L; Gao, Y; Bikorimana, E; Lemoff, A; Fang, YV; Zhang, H; Zhang, Y; Xie, Y; Mendell, JT; Hanker, AB; Arteaga, CL. PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Nature Communications. 2024; 15(1):2287.

Rodriguez Tirado, C; Wang, C; Li, X; Deng, S; Gonzalez, J; Johnson, NA; Xu, Y; Metang, LA; Sundar Rajan, M; Yang, Y; Fan, J; Wang, Y; Wang, T; Mu, P. UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. Oncogene. 2024; 43(4):265-280.

Nguyen, V; Gao, C; Hochman, ML; Kravitz, J; Chen, EH; Friedman, HI; Wenceslau, CF; Chen, D; Wang, Y; Nelson, JS; Jegga, AG; Tan, W. Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark. British Journal of Dermatology. 2023; 189(6):780-783.

Nguyen, V; Gao, C; Hochman, ML; Friedman, HI; Chen, EH; Wang, Y; Jegga, A; Nelson, JS; Tan, W. Abstract 14173: Generation and Characterization of Clinically Relevant Disease Models for Port Wine Birthmark Using Induced Pluripotent Stem Cells. Circulation. 2023; 148(Suppl_1):a14173-a14173.

Nguyen, V; Kravitz, J; Gao, C; Hochman, ML; Meng, D; Chen, D; Wang, Y; Jegga, AG; Nelson, JS; Tan, W. Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells. Metabolites. 2023; 13(9).

Li, X; Wang, Y; Deng, S; Zhu, G; Wang, C; Johnson, NA; Zhang, Z; Tirado, CR; Xu, Y; Metang, LA; Mendell, JT; Li, B; Wang, T; Mu, P. Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer. Cancer Cell. 2023; 41(8):1427-1449.e12.

Rong, R; Wei, Y; Li, L; Wang, T; Zhu, H; Xiao, G; Wang, Y. Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System. EBioMedicine. 2023; 94:104698.

Lin, Y-H; Wei, Y; Zeng, Q; Wang, Y; Pagani, CA; Li, L; Zhu, M; Wang, Z; Hsieh, M-H; Corbitt, N; Zhang, Y; Sharma, T; Wang, T; Zhu, H. IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration. Cell Stem Cell. 2023; 30(5):665-676.e4.

Wang, Z; Zhu, S; Jia, Y; Wang, Y; Kubota, N; Fujiwara, N; Gordillo, R; Lewis, C; Zhu, M; Sharma, T; Hoare, M; Campbell, P; Hoshida, Y; Zhu, H. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell. 2023; 186(9):1968-1984.e20.

Lu, T; Park, S; Han, Y; Wang, Y; Hubert, SM; Futreal, PA; Wistuba, I; Heymach, JV; Reuben, A; Zhang, J; Wang, T. Netie: inferring the evolution of neoantigen-T cell interactions in tumors. Nature Methods. 2022; 19(11):1480-1489.

Celen, C; Chuang, J-C; Shen, S; Li, L; Maggiore, G; Jia, Y; Luo, X; Moore, A; Wang, Y; Otto, JE; Wang, SC; Scherer, PE; Kadoch, C; Zhu, H. Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling. Cell reports. 2022; 41(5):111581.

Gross, SM; Dane, MA; Smith, RL; Devlin, KL; Mclean, IC; Derrick, DS; Mills, CE; Subramanian, K; London, AB; Torre, D; Sorger, PK; Korkola, JE; Gray, JW; Heiser, LM. A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses. Communications Biology. 2022; 5(1):1066.

Deng, S; Wang, C; Wang, Y; Xu, Y; Li, X; Johnson, NA; Mukherji, A; Lo, U-G; Xu, L; Gonzalez, J; Li, B; Raj, G; Wang, T; Mu, P. Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Nature Cancer. 2022; 3(9):1071-1087.

Wang, Y; Song, B; Wang, S; Chen, M; Xie, Y; Xiao, G; Wang, L; Wang, T. Sprod for de-noising spatially resolved transcriptomics data based on position and image information. Nature Methods. 2022; 19(8):950-958.