Heart Institute

Dr. Redington comes to Cincinnati Children’s from The Hospital for Sick Children in Toronto, Ontario. His research interests include ventricular function, integrated physiology of congenital heart disease, and ischemic preconditioning. Dr. Redington has written more than 300 peer-reviewed publications, more than 30 book chapters, and has co-edited seven textbooks. He currently holds over 15 US and international patents.

Working with colleagues throughout the Heart Institute, his plans include building on the remarkable developments achieved in the recent past to establish a world-leading multidisciplinary team providing the highest quality clinical care and practice-changing research for children and adults with congenital heart disease.

Education and Training

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Medical School: University of London.

Research Training: Doctorate of Medicine, University of London.

Fellowship: Adult cardiology, pediatric cardiology, The Royal Brompton Hospital, London, England.

Publications

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Li J, Rohaila S, Gelber N, Rutka J, Sabah N, Gladstone R, Wei C, Kharbanda R, Redington AN. MicroRNA-144 is a circulating effector of remote ischemic preconditioning. Basic Research in Cardiology 2014: 109 (5): pp 423. (Sept)

Burns KM, Byrne BJ, Gelb BD, Kuhn B, Leinwand LA, Mital S, Pearson GD, Rodefeld M, Rossano JW, Stauffer BL, Taylor MD, Towbin JA, Redington AN. New mechanistic and therapeutic targets for pediatric heart failure: report from a national heart, lung, and blood institute working group. Circulation 2014: 130 (1): pp 79-86. (July)

Friedberg MK, Redington AN. Right versus left ventricular failure: differences, similarities, and interactions. Circulation 2014: 129 (9): pp 1033-1044. (Mar)

Friedberg MK, Cho MY, Li J, Assad RS, Sun M, Rohailla S, Honjo O, Apitz C, Redington AN. Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased TGFβ1 signaling and is abrogated by angiotensin receptor blockade. American Journal of Respirology Cell Molecular Biology 2013: 49 (6): pp 1019-1028. (Dec)

Roche SL, Redington AN. Right ventricle: wrong targets? Another blow for pharmacotherapy in congenital heart diseases. Circulation 2013: 127 (3): pp 314-316. (Jan)

Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: A novel therapy for evolving stroke? Stroke 2011: 42 (10) pp 2960-2962.

Jean-St-Michel E, Manlhiot C, Li J, Tropak M, Michelsen MM, Schmidt MR, McCrindle BW, Slievert G, Wells GD, Redington AN. Remote Ischemic Preconditioning improves maximal performance in elite athletes. Medicine & Science of Sports & Exercise 2011: 43 (7): pp 1280-1286.

Wei M, Xin P, Li Y, Li J, Ma S, Wang L, Liu M, Li J, Zhu W, Redington AN. Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circulation Research 2011: 108 (10): pp 1220-1225.

Roche SL, Vogel M, Pitkanen O, Grant B, Slorach C, Fackoury C, Stephens D, Smallhorn J, Benson LN, Kantor PF, Redington AN. Isovolumic acceleration at rest and during exercise in children normal values for the left ventricle and first non-invasive demonstration of exercise-induced force-frequency relationships. Journal of American College of Cardiology 2011: 57 (9): pp 1100-1107.

Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK, Terkelsen CJ, Munk K, Anderson NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Neilseu TT: Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomized trial. Lancet 2010: 375 (9716): pp 727-734.

Jeffrey Robbins, PhD Executive Co-Director, Heart Institute

Jeffrey Robbins, PhD, established the means to direct the heart to synthesize normal and mutant proteins. They can turn these on and off at will and this allows them to establish cause-and-effect relationships between mutant proteins and the development of cardiac disease. The lab is particularly interested in how protein aggregation can cause cardiac disease but also studies the contractile protein mutations that cause hypertrophic cardiomyopathy and heart failure.
Visit the Robbins Lab.

513-636-8098 jeffrey.robbins@cchmc.org

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Jeffrey Robbins, PhD

Executive Co-Director, Heart Institute

Director, Molecular Cardiovascular Biology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8098

Email jeffrey.robbins@cchmc.org

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Specialties

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Structure function relationships for the contractile proteins; cardiac-specific gene manipulation in transgenic rabbits; the contractile protein myosin and human heart failure; molecular studies of human valve disease

Visit the Robbins Lab.

Biography

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Jeff Robbins CV (.pdf)

Publications

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Gupta MK, Robbins J. Post-translational control of cardiac hemodynamics through myosin binding protein C. Pflugers Arch: European journal of physiology. 2014 Feb;466(2):231-6.

Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R. Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2170-5.

Sandri M, Robbins J. Proteotoxicity: An underappreciated pathology in cardiac disease. J Mol Cell Cardiol. 2014 Jun;71c:3-10.

Wang X, Robbins J. Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol. 2014 Jun;71c:16-24.

James J, Robbins J. Ablating a cardiac protein: Causality at last. Circ Res. 2013;112:1415-1419.

Razzaque MA, Gupta M, Osinska H, Gulick J, Blaxall BC, Robbins J. An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure. Circ Res. 2013 Aug 16;113(5):553-61.

Gupta MK, Gulick J, James J, Osinska H, Lorenz JN, Robbins J. Functional dissection of myosin binding protein C phosphorylation. J Mol Cell Cardiol. 2013;64C:39-50.

Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013;123(12):5284-97.

Pattison JS, Robbins J. Desmin and heart disease. In: Kavallaris M, ed. Cytoskeleton and human disease. New York, NY: Humana Press; 2012:411-424.

Bhuiyan MS, Gulick J, Osinska H, Gupta M, Robbins J. Determination of the critical residues responsible for cardiac myosin binding protein C's interactions. J Mol Cell Cardiol. 2012;53:838-847.

Grants

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Cardiac Signaling in the Normal and Abnormal Heart. Principal Investigator. National Heart, Lung, and Blood Institute. Sep 2013-May 2018. #P01 HL69779.

Proteotoxicity: an underappreciated factor in cardiac disease. North American Coordinator. Leducq Transatlantic Alliance For Cardiovascular Disease. 2011-2016.

James S. Tweddell, MD Executive Co-Director, Heart Institute

James S. Tweddell, MD, concentrates his clinical and research efforts on the care of the neonate before, during and after complex congenital heart surgery. Together with his colleagues, Dr. Tweddell has established a multi-institutional, multi-disciplinary group studying bleeding and antithrombotic strategies among pediatric cardiac surgical patients with a special focus on neonates and patients requiring mechanical circulatory support.

513-803-8824 james.tweddell@cchmc.org

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James S. Tweddell, MD

Executive Co-Director, Heart Institute

Surgical Director, Heart Institute

Academic Affiliations

Professor, UC Department of Surgery

Phone 513-803-8824

Email james.tweddell@cchmc.org

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Clinical & Research Interests

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Clinical

Surgical emphases include congenital heart surgery in neonates, infants, children, teenagers and adults. Heart transplantation and mechanical circulatory support.

Research

Developing reliable and reproducible evidence-based perioperative management strategies to improve survival and developmental outcomes; novel monitoring techniques such as continuous venous oximetry and near infrared spectroscopy.

Biography

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Dr. Tweddell leads the Heart Institute’s surgical team providing unparalleled surgical care and innovation for our patients and their families. Over the last 20 years, he built the pediatric cardiothoracic surgery program at the Medical College of Wisconsin, where he held the S. Bert Litwin Chair for Cardiothoracic Surgery position, served as medical director of pediatric cardiothoracic surgery at Children’s Hospital of Wisconsin and professor and chief for the Division of Cardiothoracic Surgery. Dr. Tweddell has an extensive list of vital research contributions, having authored more than 125 peer reviewed articles, published numerous books, chapters, invited reviews and editorials, and serving on multiple editorial boards and national committees.

Dr. Tweddell is the elite surgeon of his generation and has earned a worldwide reputation for outstanding clinical results based on team contributions to his outcomes. He decreased mortality following the Norwood procedure through the use of venous saturation monitoring and afterload reduction. In addition, Dr. Tweddell reduced interstage mortality of a single ventricle patient through the development of a home monitoring program.

Education and Training

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MD: University of Cincinnati, Cincinnati, OH, 1985.

Residency: Intern and Second Year Resident in General Surgery, New York Medical Center, New York, NY, 1987.

Residency: Research Fellow in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1989.

Residency: Senior Resident and Chief Resident in General Surgery, Washington University Medical Center, St. Louis, MO, 1991.

Residency: Resident in Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.

Fellowship: Fellow in Pediatric Cardiothoracic Surgery, Washington University Medical Center, St. Louis, MO, 1993.

Publications

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View PubMed Publications

Jacobs JP, O'Brien SM, Pasquali SK, Gaynor JW, Mayer JE Jr, Karamlou T, Welke KF, Filardo G, Han JM, Kim S, Quintessenza JA, Pizarro C, Tchervenkov CI, Lacour-Gayet F, Mavroudis C, Backer CL, Austin EH 3rd, Fraser CD, Tweddell JS, Jonas RA, Edwards FH, Grover FL, Prager RL, Shahian DM, Jacobs ML. The Society of Thoracic Surgeons Congenital Heart Surgery Database Mortality Risk Model: Part 2-Clinical Application. Ann Thorac Surg. 2015 Aug 3.

Tweddell JS. The Atrial Level Switch Operation: Lessons Old and New. Circulation. 2015 Jul 16.

Niebler RA, Shah TK, Mitchell ME, Woods RK, Zangwill SD, Tweddell JS, Berger S, Ghanayem NS. Ventricular Assist Device in Single-Ventricle Heart Disease and a Superior Cavopulmonary Anastomosis. Artif Organs. 2015 Jul 6.

Jacobsen RM, Earing MG, Hill GD, Barnes M, Mitchell ME, Woods RK, Tweddell JS. The Externally Supported Ross Operation: Early Outcomes and Intermediate Follow-Up. Ann Thorac Surg. 2015 Aug;100(2):631-8.

Ginde S, Lam J, Hill GD, Cohen S, Woods RK, Mitchell ME, Tweddell JS, Earing MG. Long-term outcomes after surgical repair of complete atrioventricular septal defect. J Thorac Cardiovasc Surg. 2015 Aug;150(2):369-74.

Buelow MW, Earing MG, Hill GD, Cohen SB, Bartz PJ, Tweddell JS, Ginde S. Tricuspid repair at pulmonary valve replacement does not alter outcomes in tetralogy of Fallot. Ann Thorac Surg. 2015 Mar;99(3):899-904.

Cox DA, Ginde S, Tweddell JS, Earing MG. Outcomes of a hepatitis C screening protocol in at-risk adults with prior cardiac surgery. World J Pediatr Congenit Heart Surg. 2014 Oct;5(4):503-6.

Samyn MM, Plymale JM, Cousineau AJ, Tweddell JS. TAPVR in a kindergartner presenting with fatigue. BMJ Case Rep. 2014 Oct 9;2014.

McCrindle BW, Li JS, Manlhiot C, Tweddell JS, Giglia TM, Massicotte MP, Monagle P, Krishnamurthy R, Mahaffey KW, Michelson AD, Verdun N, Almond CS, Newburger JW, Brandão LR, Esmon CT, Manco-Johnson MJ, Ichord R, Ortel TL, Chan AK, Portman R, Rose M, Strony J, Kaltman JR. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. Circulation. 2014 Sep 30;130(14):1192-203.

Mitchell ME, Rumman N, Chun RH, Rao A, Martin T, Beste DJ, Berens RJ, Parakininkas DE, Ghanayem NS, Hubert MJ, Uhing M, Simpson P, Sato TT, Tweddell JS, Kerschner JE. Anterior tracheal suspension for tracheobronchomalacia in infants and children. Ann Thorac Surg. 2014 Oct;98(4):1246-53.

Grants

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PumpKIN Trial. Principal Surgical Investigator. National Institutes of Health. 2013-ongoing.

Targeted, Highly Sensitive, Non-Invasive Cardiac Transplant Rejection Monitoring. Co-Principal Investigator. National Institutes of Health. 2013-2018.

Berlin Heart Post Approval Study. Co-Principal Investigator. Berlin Heart Inc. Aug 2013-ongoing.

Faculty

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Jeffrey B. Anderson, MD, MPH, MBA Chief Quality Officer, Heart Institute

Jeffrey B. Anderson, MD, MPH, MBA, has research interests that include nutrition in congenital heart disease, syncope in the pediatric population and application of quality improvement methodology to improve outcomes and value in congenital heart disease.

513-636-3865 jeffrey.anderson@cchmc.org

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Jeffrey B. Anderson, MD, MPH, MBA

Chief Quality Officer, Heart Institute

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-3865

Fax 513-636-3952

Email jeffrey.anderson@cchmc.org

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Clinical & Research Interests

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Clinical

Pediatric electrophysiology; syncope; quality improvement and outcomes

Research

Syncope; nutrition and growth in congenital heart disease; large database analysis; quality improvement

Biography

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Following his cardiology fellowship, Dr. Anderson helped establish the Syncope Clinic in the Heart Institute at Cincinnati Children’s Hospital Medical Center, and he continues to direct the work in this clinic.

Dr. Anderson helped develop the Safety, Quality, Value program within the Heart Institute at Cincinnati Children's Hospital Medical Center. The Heart Institute’s Safety, Quality, and Value team provides a platform of core data management, analytic, quality improvement, and project management expertise focused specifically on the Heart Institute’s strategic priority areas related to safety, quality, and value. This team serves a supporting role to further the Heart Institute’s ability to achieve its mission of being the leader in clinical outcomes, experience, and value for patients and families who receive diagnostic and interventional services for congenital and acquired heart disease.

Education and Training

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MD: University of Utah School of Medicine, Salt Lake City, UT, 2002.

Masters of Public Health: University of Utah School of Medicine, Salt Lake City, UT, 2002.

Residency: Pediatrics, University of North Carolina,Chapel Hill, NC, 2002-2006.

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2006-2009.

Fellowship: Pediatric Electrophysiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2010.

Masters of Business Administration: Ross School of Business, University of Michigan, Ann Arbor, MI, 2013.

Publications

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View PubMed Publications

Anderson J, Grenier M, Edwards N, Madsen N, Czosek R, Spar D, Barnes A, Pratt J, King E, Knilans T. Usefulness of Combined History, Physical Examination, Electrocardiogram and Limited Echocardiogram in Screening Adolescent Athletes for Risk for Sudden Cardiac Death. Am J Cardiol. 2014 Dec 1;114(11):1763-7.

Anderson JB, Beekman RH 3rd, Kugler JD, Rosenthal GL, Jenkins KJ, Klitzner TS, Martin GR, Neish SR, Darbie L, King E, Lannon C. Improvement in growth in infants with single ventricle using a learning collaborative. National Pediatric Cardiology Quality Improvement Collaborative. Congenit Heart Dis. 2014 Nov;9(6):512-20.

Burch PT, Gerstenberger E, Ravishankar C, Hehir DA, Davies RR, Colan SD, Sleeper LA, Newburger JW, Clabby ML, Williams IA, Li JS, Uzark K, Cooper DS, Lambert LM, Pemberton VL, Pike NA, Anderson JB, Dunbar-Masterson C, Khaikin S, Zyblewski SC, Minich LL. Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial. J Am Heart Assoc. 2014 Jun 27;3(3).

Slicker J, Hehir DA, Horsley M, Monczka J, Stern KW, Roman B, Ocampo EC, Flanagan L, Keenan E, Lambert LM, Davis D, Lamonica M, Rollison N, Heydarian H, Anderson JB. Nutrition Algorithms for Infants with Hypoplastic Left Heart Syndrome; Birth Through the First Interstage Period. Congenital Heart Disease. 2013 Mar-April;8(2)89-102.

Anderson JB, Czosek RJ, Knilans TK, Marino BS. The Effect of Paediatric Syncope on Health-Related Quality of Life. Cardiol Young. 2012 Oct;22(5):583-588.

Anderson J, Czosek R, Cnota J, Meganathan K, Knilans T, Heaton P. Pediatric syncope: National Hospital Ambulatory Medical Care Survey results. J Emerg Med. 2012 Oct;43(4):575-83.

Anderson J, Iyer S, Schidlow D, Williams R, Varadarajan K, Horsley M, Slicker J, Pratt J, King E, Lannon C. Variation in growth of infants with a single ventricle. J Pediatr. 2012 Jul;161(1):16-21.

Anderson J, Eghtesady P, Kalkwarf HJ, Kehl JE, Marino BS. Low weight-for-age z-score and infection risk following Fontan procedure. Ann Thorac Surg. 2011 May;91(5):1460-6.

Anderson J, Beekman RH, Eghtesady P, Uzark K, Kalkwarf HJ, Kehl JE, Marino BS. Predictors of poor weight gain in infants with a single ventricle. J Pediatr. 2010 Sep;157(3):407-13, 413.e1.

Anderson JB, Beekman RH, 3rd, Border WL, Kalkwarf HJ, Khoury PR, Uzark K, Eghtesady P, Marino BS. Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg. 2009;138(2):397-404.

Burns C. Blaxall, PhD, FAHA, FACC, FAPS Director of Translational Science, Heart Institute

Burns C. Blaxall, PhD, FAHA, FACC, FAPS, is interested in understanding the molecular mechanisms associated with the development and progression of heart failure. We are particularly interested in developing novel heart failure therapeutics targeting myocardial function and fibrosis. To this end, we also seek to understand the pathologic role of cardiac myocyte and non-myocyte (i.e.. fibroblast) intercellular communication.

513-803-4005 burns.blaxall@cchmc.org

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Burns C. Blaxall, PhD, FAHA, FACC, FAPS

Director of Translational Science, Heart Institute

Co-Director, Heart Institute Research Core & Biorepository

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-4005

Email burns.blaxall@cchmc.org

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Specialties

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Molecular and signaling mechanisms of heart failure; cardiac fibrosis; drug and therapeutic discovery

Visit the Blaxall Lab.

Biography

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Dr. Burns C. Blaxall has focused his entire career on understanding the molecular mechanisms of heart failure. He received his PhD in pharmacology from the University of Colorado Health Sciences Center, and postdoctoral training at Duke University Medical Center. He then rose through the faculty ranks at the University of Rochester Medical Center and the Aab Cardiovascular Research Institute, where he also directed the Howard Hughes Medical Institute Med-into-Grad Fellowship in Cardiovascular Science.

In 2012, he was recruited to the Heart Institute of Cincinnati Children’s Hospital Medical Center, where he is director of translational science. Dr. Blaxall has received many academic honors, including the Early Career Investigator Award from the American Heart Association (AHA), the Outstanding Achievement Award from the Founder’s AHA Affiliate, the Merit Award for Research Achievement from Mended Hearts, and election as fellow of the AHA.

Education and Training

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PhD: University of Colorado HSC, Denver, CO, 1999.

Fellowship: Duke University Medical Center, Durham, NC.

Publications

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View PubMed Publications

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. J Am Coll Cardiol. 2014;63(23):2549-57.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2014;306(1):H154-9.

Belmonte SL, Ram R, Mickelsen DM, Gertler FB, Blaxall BC. Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice. Am J Physiol Heart Circ Physiol. 2013;305(6):H875-84.

Martin ML, Blaxall BC. Cardiac intercellular communication: are myocytes and fibroblasts fair-weather friends? J Cardiovasc Transl Res. 2012;5(6):768-82.

Aguilar F, Belmonte SL, Ram R, Noujaim SF, Dunaevsky O, Protack TL, Jalife J, Todd Massey H, Gertler FB, Blaxall BC. Mammalian enabled (Mena) is a critical regulator of cardiac function. Am J Physiol Heart Circ Physiol. 2011;300(5):H1841-52.

Belmonte S, Blaxall BC. G-protein coupled receptor kinases as therapeutic targets in cardiovascular disease. Circ Res. 2011;109(3):309-19.

Jaffré F, Friedman AE, Hu Z-Y, Mackman N and Blaxall BC. Beta-adrenergic receptor stimulation transactivates Protease-Activated Receptor 1 via MMP-13 in heart. Circulation. 2012;125(24):2993-3003.

Ram R, Mickelsen DM, Theodoropoulos C, Blaxall BC. New approaches in small animal echocardiography: imaging the sounds of silence. Amer J Pathol Heart Circ Physiol. 2011;301(5):H1765-80.

Casey LM, Pistner AR, Belmonte S, Jaffre F, Migdalovic D, Stolpnik O, Nwakanma F, Vorobiof G, Dunaevsky O, Smrcka AV, Blaxall BC. Small molecule targeting of G beta gamma prevents heart failure progression. Circ Res. 2010;107(4):532-9.

Bullard TA, Protack TL, Aguilar F, Bagwe S, Massey HT, Blaxall BC. Identification of Nogo as a novel indicator of heart failure. Physiolog Genom. 2008;32(2):182-9.

James F. Cnota, MD Director of Fetal Echocardiography/Cardiology

James F. Cnota, MD, is a pediatric cardiologist with clinical focus in echocardiography and fetal cardiology. His research activities are in two areas: 1) fetal cardiology and perinatal risk factors in congenital heart disease and 2) multicenter clinical trials in pediatric cardiovascular disease.

513-636-1199 james.cnota@cchmc.org

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James F. Cnota, MD

Director of Fetal Echocardiography/Cardiology

Phone 513-636-1199

Email james.cnota@cchmc.org

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Clinical & Research Interests

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Clinical

Congenital heart disease; echocardiography; fetal cardiology; Cardiology Consult Service; General Cardiology Outpatient Clinic; Interstage Program

Research

Multicenter clinical studies; perinatal outcomes in congenital heart disease

Biography

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Dr. Cnota is an associate professor of pediatrics at the University of Cincinnati College of Medicine and Cincinnati Children's Hospital. His patient care activities focus on echocardiography and fetal cardiology. He is currently director of the Neonatal Cardiology service.

His clinical research focuses on two areas. He is the site principal investigator of the Prairieland Consortium within the NHLBI sponsored Pediatric Heart Network. He also studies growth and development in the fetus with congenital heart disease.

Education and Training

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BS: Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, 1991.

MD: Tulane University School of Medicine, New Orleans, Louisiana, 1995.

Residency: University of Arizona Health Sciences Center, Tucson, Arizona, 1998.

Fellowship: Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2001.

MS: Clinical Epidemiology and Health Services Research, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 2005.

Publications

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View PubMed Publications

Votava-Smith JK, Habli M, Cnota JF, Divanovic A, Polzin W, Lim FY, Michelfelder EC. Diastolic Dysfunction and Cerebrovascular Redistribution Precede Overt Recipient Twin Cardiomyopathy in Early-Stage Twin-Twin Transfusion Syndrome. J Am Soc Echocardiogr. 2015 Jan 7.

Frommelt PC, Gerstenberger E, Cnota JF, Cohen MS, Gorentz J, Hill KD, John JB, Levine JC, Lu J, Mahle WT, McCandless RT, Mertens L, Pearson GD, Spencer C, Thacker D, Williams IA, Wong PC, Newburger JW, Pediatric Heart Network Investigators. Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial. J Am Coll Cardiol. 2014 Nov 11;64(19):2026-35.

Weaver KN, Wang D, Cnota J, Gardner N, Stabley D, Sol-Church K, Gripp KW, Witte DP, Bove KE, Hopkin RJ. Early-lethal Costello syndrome due to rare HRAS Tandem Base substitution (c.35_36GC>AA; p.G12E)-associated pulmonary vascular disease. Pediatr Dev Pathol. 2014 Nov-Dec;17(6):421-30.

Czosek RJ, Cnota JF, Knilans TK, Pratt J, Guerrier K, Anderson JB. Relationship between echocardiographic LV mass and ECG based left ventricular voltages in an adolescent population: related or random? Pacing Clin Electrophysiol. 2014 Sep;37(9):1133-40.

Butts RJ, Zak V, Hsu D, Cnota J, Colan SD, Hehir D, Kantor P, Levine JC, Margossian R, Richmond M, Szwast A, Williams D, Williams R, Atz AM. Factors associated with serum B-type natriuretic peptide in infants with single ventricles. Pediatr Cardiol. 2014 Jun;35(5):879-87.

Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of fetal cardiomyopathy in early-stage twin-twin transfusion syndrome: comparison between commonly reported cardiovascular assessment scores. Ultrasound Obstet Gynecol. 2014 Jun;43(6):646-51.

Sekar P, Heydarian HC, Cnota JF, Hornberger LK, Michelfelder EC. Diagnosis of congenital heart disease in an era of universal prenatal ultrasound screening in southwest Ohio. Cardiol Young. 2015 Jan;25(1):35-41.

Marx GR, Shirali G, Levine JC, Guey LT, Cnota JF, Baffa JM, Border WL, Colan S, Ensing G, Friedberg MK, Goldberg DJ, Idriss SF, John JB, Lai WW, Lu M, Menon SC, Ohye RG, Saudek D, Wong PC, Pearson GD, Pediatric Heart Network Investigators. Multicenter study comparing shunt type in the norwood procedure for single-ventricle lesions: three-dimensional echocardiographic analysis. Circ Cardiovasc Imaging. 2013 Nov;6(6):934-42.

Michelfelder E, Tan X, Cnota J, Divanovic A, Statile C, Lim FY, Crombleholme T. Prevalence, Spectrum, and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-twin Transfusion Syndrome: A Large, Single-center Experience. Congenit Heart Dis. 2014 Aug 25.

Cnota JF, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB. Somatic growth trajectory in the fetus with hypoplastic left heart syndrome. Pediatr Res. 2013 Sep;74(3):284-9.

Allison A. Divanovic, MD Associate Director, Fetal Heart Program

Allison A. Divanovic, MD, is interested in improving the pre- and postnatal outcomes of infants with congenital heart disease. Her research has evaluated factors that increase risk of intrauterine fetal demise in fetuses with congenital heart disease. She has also conducted research to improve prenatal diagnosis of coarctation and HLHS with restrictive atrial septum. Analyzing cost effectiveness of murmur evaluations in kids is also an ongoing interest.

513-636-3867 allison.divanovic@cchmc.org

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Allison A. Divanovic, MD

Associate Director, Fetal Heart Program

Co-director, Medical Student/Resident Education

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-3867

Fax 513-636-9747

Email allison.divanovic@cchmc.org

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Clinical & Research Interests

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Clinical

Pediatric cardiology; fetal and neonatal cardiology; echocardiography

Research

Echocardiographic predictors of cardiac involvement in the fetus with twin-twin transfusion syndrome; risk factors for intrauterine fetal demise in the fetus with congenital heart disease; improvement in the prenatal identification of fetal coarctation; prediction of atrial septal restriction in the fetus with HLHS

Biography

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Allison A. Divanovic, MD, is an assistant professor of pediatrics with the University of Cincinnati College of Medicine and is currently the co-director of Medical Student and Resident Education in the Heart Institute.

A native of Cincinnati, Dr. Divanovic has completed all of her medical training locally, starting with medical school at the University of Cincinnati. She completed both her pediatric residency and cardiology fellowship at Cincinnati Children’s Hospital Medical Center. In addition to her three year cardiology fellowship, she completed a fourth year of training in order to gain further expertise in fetal echocardiography, transthoracic and transesophageal echocardiography, and neonatal cardiology.

Dr. Divanovic has been an attending staff member in the Heart Institute at Cincinnati Children’s Hospital Medical Center since 2009. Her academic interests include identifying factors that affect outcome in the setting of fetal congenital heart disease, improving the diagnosis of coarctation and hypoplastic left heart syndrome with restrictive atrial septum prior to birth and the cost effectiveness of referrals for murmur evaluations in children. In addition, Dr. Divanovic worked with the Ohio State Legislature to help pass into law the bill which led to the requirement for pulse oximetry screening in all Ohio newborns.

Dr. Divanovic has been active in the pediatric and cardiology communities as a member of the American Heart Association, American Society of Echocardiography and the American Academy of Pediatrics.

Education and Training

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MD: Univeristy of Cincinnati, Cincinnati, OH.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Publications

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View PubMed Publications

Michelfelder E, Tan X, Cnota J, Divanovic A, Statile C, Lim FY, Crombleholme T. Prevalence, Spectrum and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-Twin Transfusion Syndrome: A Large, Single-Center Experience. Congenit Heart Dis. 2014 Aug 25.

Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of Fetal Cardiomyopathy in Early Stage Twin-Twin Transfusion Syndrome: Comparison between Commonly Reported Cardiovascular Assessment Scores. Ultrasound Obstet Gynecol. 2014 Jun;43(6):646:51.

Cnota JF, Hangge PT, Wang Y, Woo JG, Hinton AC, Divanovic AA, Michelfelder EC, Hinton RB. Somatic Growth Trajectory in the Fetus with Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Sep;74(3):284-9.

Hangge P, Cnota JF, Woo JG, Hinton AC, Divanovic AA, Manning PB, Ittenbach RF, Hinton RB. Microcephaly is Associated with Early Adverse Neurologic Outcomes in Hypoplastic Left Heart Syndrome. Pediatr Res. 2013 Jul;74(1):61-7.

Statile CJ, Cnota JF, Gomien S, Divanović A, Crombleholme T, Michelfelder E. The Relationship between Estimated Cardiac Output and Cardiovascular Profile Score in High Output Lesions in the Fetus. Ultrasound Obstet Gynecol. 2013 Jan:41(1):54-8.

Divanović A, Witte D, Michelfelder E. A Fetus with Hypoplastic Left Heart Syndrome and Tricuspid Stenosis with Evolving Hydrops Fetalis. Pediatr Cardiol. 2012 Oct;33(7):1210-12.

Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Ware S, Liu C, Stanek JW. Ductus Arteriosus Aneurysm with Massive Thrombosis of Pulmonary Artery. Pediatr Dev Pathol. 2012 Jan-Feb;15(1):79-85.

Divanović A, Cnota J, Ittenbach R, Tan X, Border W, Crombleholme T, Michelfelder E. Characterization of Diastolic Dysfunction in Twin-Twin Transfusion Syndrome: Association between Doppler Findings and Ventricular Hypertrophy. J Am Soc Echocardiogr. 2011 Aug;24(8):834-40.

Divanović A, Hor K, Cnota J, Hirsch R, Kinsel-Ziter M, Michelfelder E. Prediction and Perinatal Management of Severely Restrictive Atrial Septum in Fetuses with Critical Left Heart Obstruction: Clinical Experience Using Pulmonary Venous Doppler Analysis. J Thorac Cardiovasc Surg. 2011 Apr;141(4):988-94.

Stuart L. Goldstein, MD, FAAP, FNKF Director, Center for Acute Care Nephrology

Stuart L. Goldstein, MD, FAAP, FNKF, focuses on all aspects of acute kidney injury (AKI) spanning from translational work in AKI biomarker validation to long-term AKI epidemiology and outcomes. He is specifically interested in improving outcomes in the critically ill child with or at risk for AKI.

513-803-3295 stuart.goldstein@cchmc.org

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Stuart L. Goldstein, MD, FAAP, FNKF

Director, Center for Acute Care Nephrology

Medical Director, Pheresis Service

Co-Medical Director, Heart Institute Research Core

Medical Director, Dialysis Unit

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-3295

Fax 513-636-6407

Email stuart.goldstein@cchmc.org

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Clinical & Research Interests

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Clinical

Acute kidney injury; continuous renal replacement therapy; cardio-renal syndrome; nephrotoxic medication associated morbidity

Research

Acute kidney injury epidemiology and biomarkers; heart failure associated chronic kidney disease; nephrotoxic medication associated acute kidney injury reduction

Biography

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Stuart L. Goldstein, MD, has been an active investigator in the field of pediatric acute kidney injury (AKI) since 2000. Dr. Goldstein’s main research foci include: AKI epidemiology and outcomes, acute renal replacement therapy provision and investigation of novel urinary AKI biomarkers in the pediatric population. Dr. Goldstein has established a strong record of interdisciplinary and inter-institutional collaboration with cardiologists, intensivists and emergency center physicians, which is evidenced by his establishment and directing of the Prospective Pediatric Continuous Renal Replacement Therapy Registry from 2001 to 2012, and the Prospective Pediatric AKI Research Group (ppAKI-RG) in 2012. The ppAKI-RG is comprised of 39 centers from around the world with the goal of improving outcomes for the child with or at-risk for, AKI.

Dr. Goldstein has led initial efforts to develop a standardized definition for pediatric AKI, assess novel AKI biomarkers in heterogeneous populations, and conceiving and validating stratification tools to identify patients at risk for AKI. Building up these findings, Dr. Goldstein embarked on establishing the ppAKI-RG consortium to focus on multi-centered research studies that are dedicated to understanding and treating AKI in pediatric patients. Currently, the ppAKI-RG has initiated three major, and unprecedented, national and international studies (AWARE, NINJA and DIRECT) to reduce AKI and improve patient outcomes. Dr. Goldstein is also a recognized educator; he has developed the only pediatric specific acute care nephrology sub-specialty fellowship with graduates who are now leaders in the field of pediatric AKI.

Education and Training

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MD: Columbia College of Physicians and Surgeons, New York, NY, 1990.

Residency: Baylor College of Medicine, Houston, TX.

Fellowship: Pediatric Nephrology, Children's Hospital, Boston, MA.

Publications

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Grants

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Inflammation, malnutrition and cardiac calcification in pediatric ESRD patients receiving dialysis. Principal Investigator. Casey Lee Ball Foundation. Jan 2010–Dec 2020.

Use of NGAL to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury. Principal Investigator. Gambro Renal Products. Nov 2011-Jan 2017.

Clinical Evaluation of the Prismaflex™ HF20 Set and Prismaflex™Control Unit Version 5.10 Software for Acute Continuous Renal Replacement Therapy (CRRT) in Children. Principal Investigator. Gambro Renal Products, Inc. Mar 2014–Mar 2016.

Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care. Principal Investigator. NICHD Pediatric Trials Network-POPS. Feb 2013–Feb 2017.

Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP Trial). Principal Investigator. NICHD-2013-ABS01 Pediatric Trials Network. May 2014–Sep 2017.

Recombinant Erythropoietin Protects Against Kidney Disease. Principal Investigator. National Institutes of Health. Sep 2014–Aug 2019.

Reduction of Nephrotoxic Medication Associated Acute Kidney Injury in Children: Dissemination of a Successful Quality Improvement Project. Principal Investigator. Agency for Healthcare Research and Quality. Apr 2015–Mar 2018.

James D. Gulick, MS

James D. Gulick, MS, is a member of the Robbins Lab, studying cardiac structure and function. His interest lies primarily in understanding how certain mutations in contractile protein genes are able to alter the function of the heart.
Visit the Robbins Lab.

513-803-0994 james.gulick@cchmc.org

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James D. Gulick, MS

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-803-0994

Fax 513-636-5958

Email james.gulick@cchmc.org

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Research Interests

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Understanding how certain mutations in contractile protein genes are able to alter the function of the heart

Education and Training

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MS: University of Missouri-Columbia, Columbia, Mo, 1983

Publications

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View PubMed Publications

Michalek AJ, Howarth JW, Gulick J, Previs MJ, Robbins J, Rosevear PR, Warshaw DM. Phosphorylation modulates the mechanical stability of the cardiac Myosin-binding protein C motif. Biophys J. 2013 Jan 22;104(2):442-52.

Bhuiyan MS, Gulick J, Osinska H, Gupta M, Robbins J. Determination of the critical residues responsible for cardiac myosin binding protein C's interactions. J Mol Cell Cardiol. 2012 Dec;53(6):838-47.

Weith AE, Previs MJ, Hoeprich GJ, Previs SB, Gulick J, Robbins J, Warshaw DM. The extent of cardiac myosin binding protein-C phosphorylation modulates actomyosin function in a graded manner. J Muscle Res Cell Motil. 2012 Dec;33(6):449-59.

Previs MJ, Previs SB, Gulick J, Robbins J, Warshaw DM. Molecular mechanics of cardiac myosin binding protein C in native thick filaments. Science. 2012 Sept 7; 337 (6099): 1215-8.

Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. J Mol Cell Cardiol. 2012 Jan;52(1):219-27.

Tranter M, Liu Y, He S, Gulick J, Ren X, Robbins J, Jones WK, Reineke TM. In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. Mol Ther. 2012 Mar;20(3):601-8.

Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Mar 1;483(7387):96-9.

John L. Jefferies, MD, MPH, FAAP, FACC Co-Director, Advanced Heart Failure and Cardiomyopathy

John Lynn Jefferies, MD, MPH, FAAP, FACC, is a clinical cardiologist who has translational and clinical research programs. His research involves cardiomyopathy and cardiovascular genetics with specific interest in dystrophinopathies and aortopathies in children and adults. He also has clinical research projects investigating novel biomarkers of heart failure, chemotherapy induced cardiotoxicity, and the cardiorenal syndrome.

513-803-2913 john.jefferies@cchmc.org

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John L. Jefferies, MD, MPH, FAAP, FACC

Co-Director, Advanced Heart Failure and Cardiomyopathy

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-2913

Email john.jefferies@cchmc.org

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Clinical & Research Interests

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Clinical

Advanced heart failure; cardiomyopathy; mechanical circulatory support and transplant

Research

Heritable causes of vascular disease; novel drug therapies for advanced heart failure; novel gene discovery in cardiomyopathy; characterization and management of left ventricular noncompaction (LVNC); early diagnosis and management of chemotherapy induced cardiotoxicity.

Biography

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Dr. Jefferies, a professor of pediatric cardiology and adult cardiovascular diseases within the University of Cincinnati College of Medicine, is the director of Advanced Heart Failure / Cardiomyopathy in the Heart Institute at Cincinnati Children's Hospital Medical Center.

He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 120 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.

His current research interests include heritable causes of cardiovascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.

He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organizations, including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association. He is the lead editor for two textbooks that focus on the management of heart disease in children and young adults entitled “Heart Failure in the Child and Young Adult: From Bench to Bedside” and “Cardioskeletal Myopathies in Children and Young Adults.”

Education and Training

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BS: University of Tennessee, Knoxville, TN, 1992.

MD: University of Tennessee, Knoxville, TN, 1996.

Residency: University of Kentucky, Lexington, KY, 2000.

MPH: University of Kentucky, Lexington, KY, 2001.

Fellowship: Baylor College of Medicine, Houston, TX, 2006.

Certification: Pediatrics, Internal Medicine, Cardiology, Advanced Heart Failure, Cardiac Transplant.

Publications

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View PubMed Publications

Towbin JA, Lorts A, Jefferies JL. Left ventricular noncompaction cardiomyopathy. Lancet. 2015;Apr 9. Epub ahead of print.

McCullough PA, Jefferies JL. Novel Markers And Therapies For Patients With Acute Heart Failure And Renal Dysfunction. Am J Med. 2015 Mar;128(3):312.e1-22.

Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.

Raman SV, Hor KN, Halnon NJ, Kissel JT, He X, Tran T, Smart S, McCarthy B, Taylor MD, Jefferies JL, Rafael-Fortney JA, Lowe J, Roble SL, Cripe LH. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Feb;14(2):153-61.

Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205.

Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.

Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.

Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.

Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.

Jefferies JL, Towbin JA. Dilated cardiomyopathy. Lancet. 2010 Feb;375(9716):752-62.

Zaza Khuchua, PhD

Zaza Khuchua, PhD, research interests are mitochondrial structure, function, biogenesis and recycling in normal and pathological heart muscle. More specifically we are interested in defects in cardiac lipid and phospholipid metabolism. We employ genetically engineered mice to model human genetic disorders.

513-636-1340 zaza.khuchua@cchmc.org

Thomas R. Kimball, MD Medical Director, Heart Institute

Thomas R. Kimball, MD, is a clinical cardiologist who has clinical research interests in the impact of systemic diseases (including renal, pulmonary and hematologic) on cardiovascular structure and function. He has studied the impact of pediatric obesity on both cardiac and arterial anatomy and physiology and directs the Cardiovascular Imaging Core Research Laboratory which is active in using echocardiography to cardiac phenotype transgenic mice models.

513-636-8270 tom.kimball@cchmc.org

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Thomas R. Kimball, MD

Medical Director, Heart Institute

Director, Cardiology Consult Service

Director, Coronary Artery Clinic

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8270

Fax 513-636-3952

Email tom.kimball@cchmc.org

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Clinical & Research Interests

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Clinical

Congenital heart disease; echocardiography; cardiac imaging; Cardiology Consult Service; Cardiac Step-Down Unit; General Cardiology Outpatient Clinic; Coronary Artery Clinic

Research

Ventricular function; transgenic mice phenotyping; cardiovascular changes with obstructive sleep apnea; cardiovascular changes with renal disease; pediatric obesity; cardiovascular changes in fit and unfit children; echocardiography quality assurance; coronary artery anomalies and disease in children

Biography

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Thomas R. Kimball, MD, is a professor of pediatrics with the University of Cincinnati College of Medicine and is currently the medical director of the Heart Institute at Cincinnati Children's Hospital Medical Center.

A native of California, Dr. Kimball graduated with distinction and honors from Stanford University. He earned his medical degree from New York University, New York, NY. He completed his pediatric internship and residency at Children's Hospital of Los Angeles and his pediatric cardiology fellowship at Cincinnati Children's Hospital Medical Center.

Dr. Kimball has been an attending staff member of the Division of Cardiology at Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine since 1988.

Dr. Kimball's academic interests relate to echocardiography and he has made numerous scholarly contributions in the field of ventricular function utilizing echocardiography, particularly in the field of hypertension and obesity.

He has established collaborative relationships with basic scientists at the University of Cincinnati College of Medicine using echocardiography to evaluate phenotypes of transgenic mice, including embryonic mice.

Dr. Kimball has been active in the cardiology community. He is a member of the American Society of Echocardiography, American Heart Association, American Academy of Pediatrics, American College of Cardiology and an investigator in the NIH Pediatric Heart Network.

He was also a member of the first Family Advisory Council at Cincinnati Children's and received the 2006 Family Advisory Council Award of Excellence.

In 2016, he received an Endowed Chair from the Cincinnati Children's Research Foundation for Clinical/Educational Achievements and Major Institutional Contributions. In 2016 he used the funds provided by this Chair to start a Coronary Artery Clinic which evaluates and manages children with coronary artery disease and anomalies.

Education and Training

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BS: Stanford University with Honors and Distinction, Stanford, CA, 1978.

MD: New York University School of Medicine, New York City, NY, 1982.

Residency: Children's Hospital of Los Angeles, Los Angeles, CA, 1985.

Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1988.

Certification: Pediatrics, 1986; Pediatric Cardiology, 1991 (recertification, 1997, 2004).

Publications

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Levenson AE, Shah AS, Khoury PR, Kimball TR, Urbina EM, deFerranti SD, Maahs DM, Dolan LM, Wadwa RP, Biddinger SB. Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women. Pediatr Diabetes. 2017.

Ehsan Z, Amin R, Kimball TR, Zhang N, Zou Y. Longitudinal cardiovascular outcomes of sleep disordered breathing in children: A meta-analysis. Sleep. 2017.

Powell AW, Kimball TR. Incorrect ventricular lead placement into the systemic right ventricle of a patient with D-transposition of the great vessels after Mustard procedure. Cardiol Young. 2016 Aug;1-4.

Cohen MS, Eidem BW, Cetta F, Fogel MA, Frommelt PC, Ganame J, Han BK, Kimball TR, Johnson RK, Mertens L, Paridon SM, Powell AJ, Lopez L. Multimodality imaging guidelines of patients with transposition of the great arteries: a report from the American Society of Echocardiography Developed in collaboration with the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography. J Am Soc Echocardiogr. 2016;29(7)571-621.

Niss O, Quinn CT, Lane A, Daily J, Khoury PR, Bakeer N, Kimball TR, Towbin JA, Malik P, Taylor MD. Cardiomyopathy with restrictive physiology in Sickle Cell Disease. The Authors Reply. JACC Cardiovasc Imaging. 2016;9(3)243-52.

Niss O, Quinn CT, Lane A, Daily J, Khoury PR, Bakeer N, Kimball TR, Towbin JA, Malik P, Taylor MD. Cardiomyopathy with restrictive physiology in Sickle Cell Disease. JACC Cardiovasc Imaging. 2016;9(3)243-52.

Foster BJ, Khoury PR, Kimball TR, Mackie AS, Mitsnefes M. New reference centiles for left ventricular mass relative to lean body mass in children. J Am Soc Echocardiogr. 2016;29:441-7.

Flores S, Kimball TR, Nelson DP, Morales DL. Single-stage repair of an unusual association: Congenital Gerbode defect, hypoplastic aortic arch, and partially anomalous pulmonary venous return in an infant. World J Pediatr Congenit Heart Surg. 2016;7(4)502-5.

Shah A, Davidson W, Zhiqian G, Dolan L, Kimball T, Urbina E. Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without pre-diabetes. J Clin Lipidology. 2016;10(3)610-8.

Gao Z, Khoury PR, McCoy CE, Shah AS, Kimball TR, Dolan LM, Urbina EM. Adiposity has no direct effect on carotid intima-media thickness in adolescents and young adults: Use of structural equation modeling to elucidate indirect & direct pathways. Atherosclerosis. 2016;246:29-35.

Shelley Kirk, PhD, RD, LD Director, HealthWorks!, Center for Better Health and Nutrition, Heart Institute

Shelley Kirk, PhD, RD, LD, is a clinical dietitian specializing in the assessment and treatment of obese youth and their families. With her doctorate in epidemiology, her research interests are focused on evaluating the effectiveness and efficacy of the dietary component as part of a comprehensive pediatric weight management intervention offered in a clinical setting.

513-636-4305 shelley.kirk@cchmc.org

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Shelley Kirk, PhD, RD, LD

Director, HealthWorks!, Center for Better Health and Nutrition, Heart Institute

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4305

Fax 513-636-2459

Email shelley.kirk@cchmc.org

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Clinical Interests

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Developing effective interventions for overweight and obese children and adolescents

Biography

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Shelley Kirk, PhD, RD, LD, is director of HealthWorks! and a staff member of the Center for Better Health and Nutrition, the obesity prevention program of the Heart Institute at Cincinnati Children's Hospital Medical Center.

Education and Training

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BS: Rutgers University, New Brunswick, NJ, 1976.

MS: University of Minnesota, St. Paul, MN, 1978; University of Southern California, Los Angeles, CA, 1988.

PhD: University of Cincinnati, Cincinnati, OH, 2003.

Publications

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Hoelscher DM, Kirk S, Cunningham-Sabo L, Ritchie L. Position of the Academy of Nutrition and Dietetics: Interventions for the prevention and treatment of pediatric overweight and obesity. J Acad Nutri. 2013 Oct;113(10):1375-94.

Hampl S, Demeule M, Eneli I, Frank M, Hawkins MJ, Kirk S, Sallinen B, Santos M, Schmidt A, Ward W, Rhodes S. Parent perspectives on attrition from tertiary care pediatric weight management programs. Clin Pediatr (Phila). 2013; 52(6):509-515.

Kirk S, Brehm B, Saelens BE, Woo JG, Kissel E, D’Alessio D, Bolling C, Daniels SR. Role of carbohydrate modification in weight management among obese children: A randomized clinical trial. J Pediatr. 2012; 161(2): 320-327.

Beebe DW, Miller N, Kirk S, Daniels SR, Amin R. The association between obstructive sleep apnea and dietary choices among obese individuals during middle to late childhood. Sleep Medicine. 2011; 12(8):797-799.

Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Amin R, Hiscock H, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross- sectional study. Sleep. 2011; 34(7):891-898.

Siegel RM, Neidhard MS, Kirk S. A comparison of low glycemic index and staged portion-controlled diets in improving BMI of obese children in a pediatric weight management program. Clinical Pediatrics. 2011; 50(5):459-461.

Kirk S, Bolling C. Practical Strategies in a Clinical Setting for Promoting Lifestyle Changes in Overweight Youth. Obesity Management. December 2007; 3(6):272-282.

Lawson ML, Kirk S, Mitchell T, Chen MK, Loux TJ, Daniels SR, Harmon CM, Clements RH. One-year outcomes of Roux-en-Y gastric bypass for morbidly obese adolescents: a multi-center study from the Pediatric Bariatric Study Group. Journal of Pediatric Surgery. 2006; 41(1):137-43.

Kirk S, Scott B, Daniels SR. Supplement to the Journal: Pediatric obesity epidemic: Treatment options. Journal of the American Dietetic Association. 2005; 105(5 Suppl 1):S44-51.

Kirk S, Zeller MH, Claytor R, Santangelo M, Khoury PR, Daniels SR. The relationship of health outcomes to improvement in body mass index in children and adolescents. Obes Res. 2005; 13:876-882.

Timothy K. Knilans, MD Director, Clinical Cardiac Electrophysiology and Pacing

Timothy K. Knilans, MD, is a clinical cardiac electrophysiologist with a large clinical practice in management of arrhythmia and syncope. He has extensive experience in non-invasive electrocardiographic methods and invasive therapeutic modalities including catheter and surgical ablation and implanted electrical device therapy. His research interests center on evaluation and treatment of syncope and prevention of sudden cardiac death.

513-636-7269 timothy.knilans@cchmc.org

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Timothy K. Knilans, MD

Director, Clinical Cardiac Electrophysiology and Pacing

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-7269

Fax 513-636-3952

Email timothy.knilans@cchmc.org

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Clinical & Research Interests

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Clinical

Cardiac electrophysiology and pacing; radio frequency ablation; tilt table testing

Research

Cardiac arrest; sudden cardiac death

Education and Training

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MD: University of Cincinnati, Cincinnati, OH, 1983.

Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1983-1986.

Fellowship (Pediatric Cardiology): Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1989.

Fellowship (Cardiac Electrophysiology): St. Vincent Hospital, Indianapolis, IN, 1990-1991.

Fellowship (Pediatric cardiac Electrophysiology): Texas Children's Hospital, Houston, TX, 1991.

Certification: Pediatrics, 1989 (Recertified 1999); Pediatric Cardiology, 1992 (Recertified 1998).

Publications

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View PubMed Publications

Czosek RJ, Anderson JB, Marino BS, Mellion K, Knilans TK. Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation. Pacing Clin Electrophysiol. 2011 May;34(5):555-62.

Eghtesady P, Michelfelder EC, Knilans TK, Witte DP, Manning PB, Crombleholme TM. Fetal surgical management of congenital heart block in a hydropic fetus: Lessons learned from a clinical experience. J Thorac Cardiovasc Surg. 2011 Mar;141(3):835-7.

Czosek RJ, Anderson J, Marino BS, Connor C, Knilans TK. Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults. Pacing Clin Electrophysiol. 2010 Nov;33(11):1304-11.

Czosek RJ, Anderson JB, Cao J, Knilans TK. Assessment of T-wave oversensing in an infant with an implanted defibrillator. Heart Rhythm. 2010 Oct;7(10):1516-7.

Mays WA, Border WL, Knecht SK, Gerdes YM, Pfriem H, Claytor RP, Knilans TK, Hirsch R, Mone SM, Beekman RH 3rd. Exercise capacity improves after transcatheter closure of the Fontan fenestration in children. Congenit Heart Dis. 2008 Jul;3(4):254-61.

Knecht SK, Mays WA, Gerdes YM, Claytor RP, Knilans TK. Exercise evaluation of upper- versus lower-extremity blood pressure gradients in pediatric and young-adult participants. Pediatr Exerc Sci. 2007 Aug;19(3):344-8.

Wright KN, Knilans TK, Irvin HM. When, why, and how to perform cardiac radiofrequency catheter ablation. J Vet Cardiol. 2006 Nov;8(2):95-107.

Knilans TK. Multielectrode coronary artery catheterization: still an effective tool in ablation of right free-wall accessory pathways. J Cardiovasc Electrophysiol. 2004 Nov;15(11):1244-5.

Markham LW, Knecht SK, Daniels SR, Mays WA, Khoury PR, Knilans TK. Development of exercise-induced arm-leg blood pressure gradient and abnormal arterial compliance in patients with repaired coarctation of the aorta. Am J Cardiol. 2004 Nov 1;94(9):1200-2.

Beery TA, Dyment M, Shooner K, Knilans TK, Benson DW. A candidate locus approach identifies a long QT syndrome gene mutation. Biol Res Nurs. 2003 Oct;5(2):97-104.

Andreas W. Loepke, MD, PhD Staff Anesthesiologist, Division of Cardiac Anesthesia

Andreas W. Loepke, MD, PhD, is a pediatric cardiac anesthesiologist and clinician-scientist who directs a research laboratory investigating the effects of anesthetics on the developing brain. He chairs the department’s Data Safety Monitoring Board and serves on the Editorial Advisory Board for the journal Pediatric Anesthesia as well as the SmartTots Affiliate Advisory Council for the International Anesthesia Research Society.
Visit the Loepke Lab.

513-636-4408

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Andreas W. Loepke, MD, PhD

Staff Anesthesiologist, Division of Cardiac Anesthesia

Academic Affiliation

Professor

UC Department of Pediatrics

Phone 513-636-4408

Fax 513-636-7337

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Specialties

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Anesthesia for neonates; congenital heart surgery; single-ventricle physiology

Visit the Loepke Lab.

Biography

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Andreas W. Loepke, MD, PhD, has been practicing pediatric cardiac anesthesiology since 2000, first at the Children's Hospital of Philadelphia, and since 2003 at Cincinnati Children's Hospital Medical Center.

Dr. Loepke’s research laboratory investigates the potential use of anesthetics for neurological protection during brain ischemia as well as their possible adverse effects on brain development. His research group discovered in animals that anesthetics differentially affect brain regions, dependent on the age during exposure. Related to these findings, his lab made the discovery that neurons are susceptible to the anesthetics’ toxic effects during a specifically vulnerable stage of their development.

Education and Training

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MD: University of Dusseldorf, Germany, 1993.

PhD: University of Dusseldorf, Germany, 1995.

Internship: General Surgery, Pennsylvania Hospital, Philadelphia, PA, 1996.

Residency: Anesthesiology, Thomas Jefferson Medical College, Philadelphia, PA, 1999.

Fellowship: Pediatric Anesthesia and Pediatric Cardiac Anesthesia, Children's Hospital of Philadelphia, Philadelphia, PA, 2000.

Certification: Anesthesiology, 2000.

Maintenance of Certification: Anesthesiology, 2010.

Publications

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View PubMed Publications

Hofacer RD, Deng M, Ward CG, Joseph B, Hughes EA, Jiang C, Danzer SC, Loepke AW. Cell-age specific vulnerability of neurons to anesthetic toxicity. Ann Neurol. 2013.

Istaphanous GK, Ward CG, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer, SC, Loepke AW. Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death In Mouse Cerebral Cortex. Anes Analg. 2013; 116(4): 845-54.

Mintz CD, Wagner M, Loepke AW. Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls. J Neurosurg Anesthesiol. 2012; 24(4): 362-7.

Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice. Anesthesiology. 2011; 114(3): 578-87.

Loepke AW. Developmental Neurotoxicity of Sedatives and Anesthetics – A Concern For Neonatal and Pediatric Critical Care Medicine? Pediatr Crit Care Med. 2010; 11(2): 217-226.

McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, Isoflurane and Sevoflurane Provide Limited Neuroprotection Against Neonatal Hypoxia-Ischemia in a Delayed-Preconditioning Paradigm. Anesthesiology. 2009; 111(3): 533-46.

Loepke AW, Istaphanous GK, McAuliffe JJ, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The Effects of Neonatal Isoflurane Exposure in Mice on Brain Cell Viability, Adult Behavior, Learning, and Memory. Anesth Analg. 2009; 108(1): 90-104.

Loepke AW, Soriano SG. An Assessment of the Effects Of General Anesthetics on Developing Brain Structure and Neurocognitive Function. Anesth Analg. 2008; 106: 1681-1707.

Loepke AW, McCann JC, Kurth CD, McAuliffe JJ. Physiologic Effects of Isoflurane Anesthesia in Neonatal Mice. Anesth Analg. 2006; 102: 75-80.

Loepke AW, Priestley MA, Schultz SE, McCann JC, Kurth CD. Desflurane Improves Outcome After Low-Flow Cardiopulmonary Bypass in Newborn Pigs. Anesthesiology. 2002; 97: 1521-7.

Angela Lorts, MD Medical Director, Mechanical Circulatory Support

Angela Lorts, MD, is interested in myocardial remodeling.

513-803-4580 angela.lorts@cchmc.org

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Angela Lorts, MD

Medical Director, Mechanical Circulatory Support

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-4580

Fax 513-636-3952

Email angela.lorts@cchmc.org

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Clinical & Research Interests

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Clinical

Advanced heart failure; cardiopulmonary bypass mediated myocardial dysfunction; novel uses of pediatric VADs; cardiomyopathy; mechanical circulatory support and transplant

Research

Myocardial remodeling

Education and Training

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MD: Creighton University Medical School, Omaha, NE, 1998.

Residency: The Children’s Hospital, Denver, CO, 2001.

Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004; University of Michigan Medical Center, Ann Arbor, MI, 2006.

Certifications: American Board of Pediatrics, 2001; American Board of Pediatrics, Sub-Board of Pediatric Cardiology, 2004; American Board of Pediatrics, Sub-Board of Pediatric Critical Care, 2006.

Publications

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View PubMed Publications

Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet. 2015 Apr 9.

Benoit S, Antommaria AH, Weidner N, Lorts A. Difficult decision: what should we do when a VAD-supported child experiences a severe stroke? Pediatr Transplant. 2015 Mar;19(2):139-43.

Zafar F, Castleberry C, Khan MS, Mehta V, Bryant R 3rd, Lorts A, Wilmot I, Jefferies JL, Chin C, Morales DL. Pediatric heart transplant waiting list mortality in the era of ventricular assist devices. J Heart Lung Transplant. 2015 Jan;34(1):82-8.

Thomas TO, Chandrakasan S, O'Brien M, Jefferies JL, Ryan TD, Wilmot I, Baker ML, Madueme PC, Morales D, Lorts A. The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease. Pediatr Transplant. 2015 Feb;19(1):E15-8.

Thomas TO, Jefferies JL, Lorts A, Anderson JB, Gao Z, Benson DW, Hor KN, Cripe LH, Urbina EM. Autonomic dysfunction: a driving force for myocardial fibrosis in young Duchenne muscular dystrophy patients? Pediatr Cardiol. 2015 Mar;36(3):561-8.

Friess MR, Marino BS, Cassedy A, Wilmot I, Jefferies JL, Lorts A. Health-related quality of life assessment in children followed in a cardiomyopathy clinic. Pediatr Cardiol. 2015 Mar;36(3):516-23.

Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DL. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO J. 2015 Jan-Feb;61(1):8-14.

Moore RA, Madueme PC, Lorts A, Morales DL, Taylor MD. Virtual implantation evaluation of the total artificial heart and compatibility: Beyond standard fit criteria. J Heart Lung Transplant. 2014 Nov;33(11):1180-3.

Lorts A, Zafar F, Adachi I, Morales DL. Mechanical assist devices in neonates and infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2014;17(1):91-5.

Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DL. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with duchenne muscular dystrophy: lessons learned from the first applications. ASAIO J. 2014 Mar-Apr;60(2):246-8.

Marjorie Maillet, PhD

Marjorie Maillet, PhD, is interested in understanding the signaling pathways that lead to cardiac hypertrophy and heart disease. Her current projects aim at defining new signaling pathways that regulate calcineurin and NFAT in the heart as well as characterizing MAP kinases targets associated with cardiac hypertrophy and heart failure.
Visit the Molkentin Lab.

513-636-2467 marjorie.maillet@cchmc.org

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Marjorie Maillet, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-636-2467

Email marjorie.maillet@cchmc.org

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Specialties

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Signaling pathways; cellular biology; cardiac hypertrophy and heart failure

Education and Training

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PhD: Paris XI University, Orsay, France, 2003.

Fellowship: Cincinnati Children’s Hospital, Cincinnati, Ohio.

Publications

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View PubMed Publications

van Berlo JH, Maillet M, Molkentin JD. Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest. 123, 37-45. 2013.

Maillet M, van Berlo JH, Molkentin JD. Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol. 14, 38-48. 2012.

Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 149, 1257-68. 2012.

Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, Maillet M, Pages G, Rudnicki M, Tajbakhsh S, Maire P. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 198, 815-32. 2012.

Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, Sjaastad I, Liu N, Catalucci D, Mikoshiba K, Hisatsune C, Okkenhaug H, Andrews SR, Bootman MD, Roderick HL. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. J Cell Biol. 199, 783-98. 2012.

Davis J, Maillet M, Miano JM, Molkentin JD. Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circ Res. 111, 761-77. 2012.

Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 109, 141-50. 2011.

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 193, 1181-96. 2011.

Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ Res. 2011 Jan 21;108(2):176-83.

Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circ Res. 2010 Sep 3;107(5):659-66

Douglas Millay , PhD

Douglas Millay, PhD, is interested in understanding how precursor cells fuse to form multi-nucleated skeletal muscle. We recently discovered a necessary component (named myomaker) of the muscle fusion machinery. The lab's goal is to delineate the mechanisms by which this multi-pass membrane protein directs cell-cell fusion and manipulate muscle cell fusion as a strategy for in vivo cell therapy.
Visit the Millay Lab.

513-803-7437 douglas.millay@cchmc.org

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Douglas Millay , PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-7437

Email douglas.millay@cchmc.org

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Research Interests

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Visit the Millay Lab.

Education and Training

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BS: Northern Kentucky University, Highland Heights, KY, 2002.

PhD: University of Cincinnati, Cincinnati, OH, 2008.

Fellowship: University of Texas Southwestern, Dallas, TX, 2014.

Publications

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View PubMed Publications

Millay DP, O’Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN. Myomaker is a membrane activator of myoblast fusion and muscle formation. Nature. 2013 Jul 18;499 (7458).

Millay DP, Olson EN. Making muscle or mitochondria by selective splicing of PGC1α. Cell Metab. 2013 Jan 8;17(1):3-4.

Hatley ME, Tang W, Garcia MR, Finkelstein D, Millay DP, Liu N, Graff J, Galindo RL, Olson EN. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell. 2012 Oct 16;22 (4): 536-46.

Zeve D, Seo J, Suh JM, Stenesen D, Tang W, Berglund ED, Wan Y, Williams LJ, Lim A, Martinez MJ, McKay RM, Millay DP, Olson EN, Graff JM. Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab. 2012 Apr 4;15(4):492-504.

Pei J, Millay DP, Olson EN, Grishin NV. CREST--a large and diverse superfamily of putative transmembrane hydrolases. Biol Direct. 2011 Jul 6;6:37.

Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. J Clin Invest. 2011 Mar;121(3):1044-52.

Wissing ER, Millay DP, Vuagniaux G, Molkentin JD. Debio-025 is more effective that prednisone in reducing muscular pathology in mdx mice. Neuromuscul Disord. 2010 Nov;20(11):753-60.

Millay DP, Goonasekera SA, Sargent MA, Molkentin JD. Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proc Natl Acad Sci USA. 2009 Nov 10;106(45)19023-8.

Millay DP, Sargent MA, Roche JA, Maillet M, McNally EM, Bloch RJ, Molkentin JD. Genetic manipulation of dysferlin expression in skeletal muscle: Novel insights into muscular dystrophy. Am J Pathol. 2009 Nov;175(5):1817-23.

Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med. 2008 Apr;14(4):442-7.

Jeffery D. Molkentin, PhD Professor | Howard Hughes Medical Institute Investigator

Jeffery D. Molkentin, PhD, is interested in understanding the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation.
Visit the Molkentin Lab.

513-636-3557 jeff.molkentin@cchmc.org

David L.S. Morales, MD Director, Congential Heart Surgery, The Heart Institute

513-803-9150 david.morales@cchmc.org

Nick Pratap, MB BChir, MRCPCH, FRCA Congenital Cardiac Anesthesiologist, Department of Anesthesia

Nick Pratap, MB BChir, MRCPCH, FRCA, investigates the use of monitoring in the operating room and cardiac intensive care unit. The goal of his research is to improve clinical outcomes after open heart surgery in young infants. He is also working on novel ways of partnering with families to prepare their children for surgery.

513-803-0645 jayant.pratap@cchmc.org

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Nick Pratap, MB BChir, MRCPCH, FRCA

Congenital Cardiac Anesthesiologist, Department of Anesthesia

Attending Cardiac Intensivist, Heart Institute

Academic Affiliation

Assistant Professor

Phone 513-803-0645

Email jayant.pratap@cchmc.org

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Clinical & Research Interests

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Clinical

Congenital cardiac anesthesia; general pediatric anesthesia; pediatric liver transplant anesthesia; cardiac intensive care medicine

Research
Improving outcomes after pediatric cardiac surgery; reducing surgical cancelations; improving safety in pediatric anesthesia using high-fidelity simulation training and checklists

Biography

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Nick Pratap, MB BChir, is an assistant professor of anesthesia and pediatrics with the University of Cincinnati College of Medicine.

A native of England, Dr. Pratap graduated with first class honors from the University of Cambridge. He earned his medical degree from the University of Cambridge, United Kingdom. He undertook pediatric and anesthesia training, along with fellowships in pediatric anesthesia, pediatric critical care and congenital cardiac anesthesia in London, England.

Dr. Pratap has been an attending staff member of the Department of Anesthesia at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine since 2011. He joined the CICU in 2013.

Dr. Pratap's academic interests relate to reducing cancelation on the day of scheduled pediatric surgery and to improving outcomes after pediatric surgery through the use of novel technology.

Dr. Pratap has been active in the pediatric and cardiac anesthesia and pediatric critical care communities. He is a member of the American Society of Anesthesiologists, the Society for Pediatric Anesthesia, the Congenital Cardiac Anesthesia Society and the Society of Cardiovascular Anesthesiologists, as well as the Royal College of Paediatrics & Child Health and the Royal College of Anaesthetists in the United Kingdom.

Dr. Pratap serves on the Society for Pediatric Anesthesia's Quality and Safety Committee and the Sedation Taskforce of the Society for Critical Care Medicine. He is on the faculty for the Master of Science program in perioperative medicine at University College London, contributing to the Quality, Safety and Leadership module.

Dr. Pratap is an instructor and provider in Basic, Advanced Cardiac and Pediatric Advanced Life Support for the American Heart Association.

Education and Training

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MA (Cantab): University of Cambridge, UK, 1998.

MB BChir: University of Cambridge, UK, 1998.

Pediatric Residency: Royal College of Paediatrics and Child Health, London, UK, 2002.

Anesthesia Residency: Royal College of Anaesthetists, London, UK, 2006.

Pediatric Anesthesia Fellowship: Great Ormond Street Hospital, London, UK, 2008.

Congenital Cardiac Anesthesia Fellowship: Royal Brompton Hospital, London, UK, 2009.

Pediatric Intensive Care Fellowship: Birmingham Children's and Great Ormond Street Hospitals, UK, 2010.

Publications

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View PubMed Publications

Pratap JN, Varughese AM, Mercurio P, Lynch T, Lonnemann T, Ellis A, Rugg J, Stone WR, Bedinghaus C. Reducing cancelations on the day of scheduled surgery at a children’s hospital. Pediatrics. 2015;135(5):e1-8.

Pratap JN. Ventilation. In: Skone R, Reynolds F, Bagshaw O, Cray S & Berry K, eds. Managing the Critically Ill Child: A Guide for Anesthetists and Emergency Physicians. Cambridge: Cambridge University Press. 2013.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: psychology and leadership issues in quality improvement. Br J Hosp Med (Lond). 2013 Feb;74(2):104-8.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: the model in practice. Br J Hosp Med (Lond). 2013 Jan;74(1):42-6.

Pratap JN, Varughese AM, Adler E, Kurth CD. Getting started with the model for improvement: introduction and understanding variation. Br J Hosp Med (Lond). 2012 Dec;73(12):701-5.

Pratap JN, Wilmshurst S. Anaesthetic management of children with in situ Berlin Heart EXCOR. Pediatr Anesth. 2010 Sep;20(9):812-20.

Pratap JN, McEwan AI. Failure to wean from cardiopulmonary bypass due to left atrial compression by periaortic hematoma. Anesth Analg. 2009 Jul;109(1):35-7.

Pratap JN, Sekhri C, Lloyd-Thomas AR. Anaesthetic management for adenotonsillectomy of a child with severe obesity due to homozygous melanocortin-4 receptor gene mutations. Paediatr Anaesth. 2009 Feb;19(2):195-6.

Pratap JN, Shankar RK, Goroszeniuk T. Co-injection of clonidine prolongs the analgesic effect of lidocaine skin infiltration by a peripheral action. Anesth Analg. 2007 Apr;104(4):982-3.

Pratap JN, Down JF. Posterior reversible encephalopathy syndrome: a report of a case with atypical features. Anaesthesia. 2008 Nov;63(11):1245-8.

Grants

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Targeting family support to children coming for surgery. Principal Investigator. Place Outcomes Research Award. Jul 2014-Jun 2016.

Robert M. Siegel, MD, FAAP Medical Director, Center for Better Health and Nutrition

Robert M. Siegel, MD, FAAP, is a general pediatrician whose clinical work is focused on pediatric weight management. His research interests are dietary interventions in overweight children, exercise in obese children and training community practitioners in obesity prevention and obesity treatment.

513-636-9420 bob.siegel@cchmc.org

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Robert M. Siegel, MD, FAAP

Medical Director, Center for Better Health and Nutrition

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-9420

Email bob.siegel@cchmc.org

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Specialties

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Pediatric obesity prevention and treatment

Biography

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Robert M. Siegel is a professor of clinical pediatrics at the University of Cincinnati and medical director of the Center for Better Health and Nutrition of the Heart Institute. He graduated magna cum laude from Hunter College of the City University of New York and earned his MD from New York University. Dr. Siegel did his pediatric residency at Cincinnati Children’s Hospital Medical Center. He was a general pediatrician for more than twenty years before joining the Heart Institute and was president of the Medical Staff at Cincinnati Children’s from 2008 to 2010. Dr. Siegel’s research interests include dietary and physical activity interventions in obese children.

Education and Training

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MD: New York University, School of Medicine, New York, NY, 1984.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1984-87.

Fellowship: Infectious Diseases, Cincinnati Children’s Hospital Medical Center, 1992. American Board of Pediatrics, 1988.

Certification: Pediatrics, 1988.

Publications

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View PubMed Publications

Kirk S, Woo J, Jone M, Siegel R. Increased Frequency of Dietitian Visits is Associated with Improved BMI Outcomes in Obese Youth Participating in a Comprehensive Pediatric Weight Management Program. Childhood Obesity. 2015;11:202-207.

Murphy A, Kist C, Gier A, Edwards NM, Gao Z, Siegel RM. The Feasibility of High Intensity Interval Exercise in Obese Adolescents. Clin Ped. 2015;54:87-90.

Inge T, Siegel R, Xanthakos S. Weight loss maintenance: A hard nut to crack. JAMA Pediatr. 2014;168:796-7.

Siegel RM, Pitnar HE, Kist C, Woo JG, Gier A, Sewell M, Lattin B, Rooney A, Kirk S. Obese Children in a Community YMCA “Fun 2B Fit” Program have a reduction in BMI Z-scores. Clin Ped. 2014;53:694-696.

Siegel RM, Kist C, Ingram L, Kirk S. An after hours rapid access pediatric weight management clinic increases show rate. Clin Ped. 2014;53:490-492.

Garbutt JM, Mandrell KM, Allen M, Sterkel R, Epstein J, Stahl K, Kreusser K, Sitrin H, Ariza A, Cohen Reis E, Siegel R, Strunk RC. Pediatric providers experience with retail-based clinics. Journal of Pediatrics. 2013;163:1384-1388.e6.

Berger KA, Lynch J, Prows CA, Siegel RM, Myers MF. Mother’s perceptions of family health history and an online parent-generated family health history tool. Clin Ped. 2012;52:70-77.

Kanetzke EE, Lynch J, Prows CA, Siegel RM, Myers MF. Perceived Utility of Parent-Generated Family Health History as a Health Promotion Tool in Pediatric Practice. Clinical Pediatrics. 2011;50:720-8.

Siegel RM, Neidhard MS, Kirk S. A Comparison of Reduced Glycemic Load and Staged Portion-Controlled Diets in Improving BMI and Other Health Outcomes of Obese Children in a Pediatric Weight Management Program. Clinical Pediatrics. 2011;50:459-461.

Siegel RM, Rich W, Khoury J. An Office-Based Low Carbohydrate Intervention in Teens: One Year Follow-up of a Six-Month Intervention. Clinical Pediatrics. 2011;50:459-461.

James P. Spaeth, MD Director, Cardiac Anesthesia

James P. Spaeth, MD, is a pediatric cardiac anesthesiologist and the director of Cardiac Anesthesia. His clinical research interests include the effect of congenital cardiac disease and cardiac surgery on neurodevelopmental outcomes, and the use of cerebral monitoring during the perioperative period. He is also involved in quality improvement work focused on improving the safety of pediatric anesthesia.

513-636-4408 james.spaeth@cchmc.org

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James P. Spaeth, MD

Director, Cardiac Anesthesia

Staff Anesthesiologist, Department of Anesthesia

Academic Affiliation

Associate Professor

Phone 513-636-4408

Fax 513-636-7337

Email james.spaeth@cchmc.org

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Clinical Interests

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Cardiac anesthesia; neurologic injury in children with congenital heart disease; improving perioperative safety

Education and Training

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MD: University of Virginia School of Medicine, Charlottesville, VA, 1993.

Internship: Internal Medicine, University of Virginia Medical Center, Charlottesville, VA, 1994.

Residency: Anesthesiology, University of California, San Diego Medical Center, San Diego, CA, 1997.

Fellowship: Pediatric Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA, 1998.

Certification: Anesthesiology, 1998.

Publications

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View PubMed Publications

Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006 Nov;16(11):1153-65.

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg. 2006 Jan;131(1):190-7.

Aronson LA, Spaeth JP. Frontiers in pediatric anesthesia: cardiac anesthesia. Int Anesthesiol Clin. 2006 Winter;44(1):33-49.

Loepke AW, Spaeth JP. Glucose and Heart Surgery: Neonates Are Not Just Small Adults. Anesthesiology. 2004 Jun;100(6):1345-52.

Baker RC, Schubert CJ, Kirwan KA, Lenkauskas SM, Spaeth JT. After-hours telephone triage and advice in private and nonprivate pediatric populations. Arch Pediatr Adolesc Med. 1999 Mar;153(3):292-6.

Sandra L. Staveski, PhD, RN, APRN, CPNP-AC Nurse Scientist, Heart Institute

Sandra L. Staveski, PhD, RN, APRN, CPNP-AC, researches ways to improve outcomes of children with congenital heart defects by minimizing the preventable harm they may experience during hospitalization and at home.

513-803-7636 sandra.staveski@cchmc.org

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Sandra L. Staveski, PhD, RN, APRN, CPNP-AC

Nurse Scientist, Heart Institute

Academic Affiliation

Assistant Professor, UC Department of Nursing

Phone 513-803-7636

Email sandra.staveski@cchmc.org

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Clinical Interests

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Pediatric cardiac surgery; cardiovascular nursing care; preventable harm

Biography

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Sandra L. Staveski PhD, RN, APRN, CPNP-AC, is an assistant professor at Cincinnati Children’s Hospital Medical Center within the UC Department of Nursing. She has over 25 years of clinical and teaching experience in cardiac critical care. She is junior faculty in the departments of Research in Patient Services and the Heart Institute.

Dr. Staveski’s research is aimed at improving outcomes of children after cardiac surgery through preventing harm they may experience during hospitalization and at home. Her doctoral work focused on facilitating safe transition from hospital to home care for post-operative pediatric cardiac patients. Specially, it examined the effect of implementing a structured nurse-parent discharge education program in Southern India. The Parent Education Discharge Instruction (PEDI) program was developed to educate nurses on the importance of discharge teaching and to provide them with a structured process for conducting parent teaching for home care of children after cardiac surgery. The PEDI program has been implemented in at least 10 hospitals and in six countries, reaches over 10,000 children and their families annually, and is available open access through the Children’s HeartLink website.

In addition, her research interests include exploring methods for reducing the iatrogenic effects of analgesics and sedatives utilized during recovery from pediatric cardiac surgery. She won the 10th annual nurse scientist award at the Cardiology 2015 conference for her randomized controlled trial on the effects of use of massage therapy and reading on the reduction of pain and anxiety after pediatric cardiac surgery. She is the member of several organizations including American Heart Association, Society of Pediatric Cardiovascular Nurses, Pediatric Cardiac Intensive Care Society, Sigma Theta Tau, the Council for the Advancement of Nursing Science, and the Midwest Nursing Research Society. Currently, Dr. Staveski is a board liaison for the Pediatric Cardiac Intensive Care Society.

Education and Training

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PhD: University of California San Francisco, San Francisco, CA.

MS: University of California San Francisco, San Francisco, CA.

CPNP-AC: PCNB.

Publications

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View PubMed Publications

Staveski SL, Wu M, Tesoro TM, Roth SJ, Cisco MJ. Effects of comfort management standardization on team perception of care delivery. Critical Care Nurse. 2017.

Gilliland J, Donnellan A, Justice L, Moake L, Mauney J, Steadman P, Drajpuch D, Tucker D, Storey J, Roth SJ, Koch J, Checchia P, Cooper DS, Staveski SL. Establishment of Pediatric Cardiac Intensive Care Advanced Practice Provider Services. World Journal of Pediatric Congenital Heart Surgery. 2016;7(1):72-80.

Staveski SL, Parveen VP, Madathil SB, Kools S, Franck LS. Parent education discharge instruction program for care of children at home after cardiac surgery in southern India. Cardiology in the Young. 2015 Nov;17:1-8.

Presnell LB, Blankenship A, Cheatham SL, Owens GE, Staveski SL. An overview of pulmonary atresia and major aorotpulmonary collaterals. World Journal of Pediatric Congenital Heart Surgery. 2015;6(4):630-639.

Staveski SL, Parveen VP, Madathil SB, Kools S, Franck LS. Nurse and parent percpetions associated with the Parent Education Discharge Instruction Programme in southern India. Cardiology in the Young. 2015.

Staveski SL, Zhelva B, Paul R, Conway R, Carlson A, Soma G, Kools S, Franck LS. Pediatric cardiac surgery Parent Education Discharge Instruction (PEDI) program: a pilot study. World J Pediatr Congenit Heart Surg. 2015 Jan;6(1):18-25.

Staveski SL, Lincoln PA, Fineman LD, Asaro LA, Wypij D, Curley MA. Nurse decision making regarding the use of analgesics and sedatives in the pediatric cardiac ICU. Pediatr Crit Care Med. 2014 Oct;15(8):691-7.

Staveski SL, Tesoro TM, Cisco MJ, Roth SJ, Shin AY. Sedative and analgesic use on night and day shifts in a pediatric cardiovascular intensive care unit. AACN Adv Crit Care. 2014 Apr-Jun;25(2):114-8.

Uzark K, Wang Y, Rudd N, Elixson EM, Strawn J, Nieves JA, Smith C, Staveski S, O'Brien P, Tong E, Ittenbach R. Interstage feeding and weight gain in infants following the Norwood operation: can we change the outcome? Cardiol Young. 2012 Oct;22(5):520-7.

Michael D. Taylor, MD Director, Advanced Imaging Innovation

Michael D. Taylor, MD, is a non-invasive cardiologist interested in applications of imaging to problems of congenital and acquired heart disease. His primary research interest is cardiac MRI and its application in evaluating myocardial function and disease. He has a translational program that uses multi-modality imaging to characterize mouse models of inherited and acquired cardiomyopathies.

513-636-9806 michael.taylor1@cchmc.org

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Michael D. Taylor, MD

Director, Advanced Imaging Innovation

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-9806

Email michael.taylor1@cchmc.org

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Clinical & Research Interests

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Clinical

Cardiac MRI; cardiac CT; and echocardiography; Cardiology Consult Service

Research

Myocardial metabolism; animal models of heart failure; positron emission tomography

Biography

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Michael Taylor, MD, joined the Heart Institute in July, 2010 as the director of Advanced Imaging Innovation. He was previously the director of cardiac magnetic resonance at Texas Children’s Hospital in Houston.

Dr. Taylor has expertise in cardiac magnetic resonance imaging, positron emission tomography and computed tomography. He has a dual appointment in the Cincinnati Children's Hospital Medical Center Imaging Research Center, an interdisciplinary facility of advanced imaging faculty with dedicated clinical and pre-clinical imaging equipment.

Dr. Taylor's primary interests include myocardial metabolism in heart failure, animal models of cardiac pathology, and cardiac magnetic resonance imaging of congenital and acquired heart disease.

Education and Training

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MD: University of Wisconsin, Madison, WI, 2001.

PhD: Medical Physics, University of Wisconsin, Madison, WI, 2001.

Residency: Pediatrics, Baylor College of Medicine, Houston, TX, 2003.

Fellowship: Pediatric Cardiology, Baylor College of Medicine, Houston, TX, 2006.

Certification: Pediatrics, 2005.

Certification: Pediatric Cardiology, 2006.

Publications

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Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8.

Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502.

LP Browne, D Kearney, MD Taylor, T Chung, TC Slesnick, AC Nutting, R Krishnamurthy. ALCAPA: the role of myocardial viability studies in determining prognosis. Pediatr Radiol. 2010;40(2):163-167.

JL Jefferies, MD Taylor, J Rossano, JW Belmont, WJ Craigen. Novel cardiac findings in periventricular nodular heterotopia. Am J Med Genet. 2009; 152A(1): 165-8.

JW Rossano, MD Taylor, EO Smith, CD Fraser, ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events. J Thorac Cardiovasc Surg. 2008; 135(4): 739-745.

Elaine M. Urbina, MD, MS Director, Preventive Cardiology

Elaine M. Urbina, MD, MS, is a pediatric preventive cardiologist who is interested in how CV risk factors affect vascular function. Her lab uses a variety of non-invasive techniques to measure how vascular structure (carotid intima-media thickness), arterial stiffness (pulse wave velocity) and endothelial function (brachial flow mediated dilation) are affected by a variety of pediatric diseases.

513-636-8265 lipid_htm@cchmc.org

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Elaine M. Urbina, MD, MS

Director, Preventive Cardiology

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8265

Fax 513-636-0162

Email lipid_htm@cchmc.org

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Clinical Interests

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Pediatric high blood pressure and cholesterol; diet and exercise to prevent adult heart disease; preventative cardiology

Biography

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Elaine M. Urbina, MD, graduated from the Medical College of Georgia in 1988. She subsequently trained in pediatrics at the University of California at San Francisco. She completed her pediatric cardiology fellowship at Tulane University in New Orleans, Louisiana, in 1994 where she accepted an assistant professor position.

In addition to practicing clinical pediatric cardiology at Tulane, she was also director of preventive cardiology and the Pediatric Echocardiography Laboratory. Her research interests led her to join the world-renowned Bogalusa Heart Study, one of the longest running epidemiologic studies of CV risk factors in children. As co-investigator under the tutelage of Dr. Gerald S. Berenson, she initiated the non-invasive imaging program and supervised collection of CV data for over a decade.

Dr. Urbina joined Cincinnati Children's Hospital Medical Center as associate professor within the UC Department of Pediatrics in October of 2003 and became director of preventive cardiology in 2006. This new opportunity allowed her to concentrate her clinical practice on the diagnosis and treatment of high blood pressure and cholesterol. She continues her research studies concentrating on non-invasive imaging methods to measure atherosclerosis with a focus on vascular function abnormalities using the modalities of:

Carotid Ultrasound
Arterial Stiffness
Endothelial Function

Her current research includes the application of these new techniques to study the roles that pre- and post-natal nutrition, overweight, high blood pressure, cholesterol and diabetes play in the development of hardening of the arteries.

Education and Training

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MD: Medical College of Georgia, Augusta, GA, 1988.

Residency: University of California, San Francisco, CA, 1990; Tulane University, New Orleans, LA, 1991 (Pediatrics).

Fellowship: Tulane University, New Orleans, LA, 1994 (Pediatric Cardiology).

Certification: Pediatrics, 1991; Pediatric Cardiology, 1994.

Publications

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Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM. Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens (Greenwich). May 2011;13(5):332-342.

Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR. Relationship between elevated arterial stiffness and increased left ventricle mass in adolescents and young adults. J Pediatr. May 2011;158(5):715-721.

Urbina EM, Kimball TR, Khoury PR, Daniels SR, Dolan LM. Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus. J Hypertens. Aug 2010;28(8):1692-1698.

Urbina EM, Wadwa RP, Davis C, Snively BM, Dolan LM, Daniels SR, Hamman RF, Dabelea D. Prevalence of increased arterial stiffness in children with type 1 diabetes mellitus differs by measurement site and sex. J Pediatr. May 2010;156(5):731-737.

Urbina EM, Kimball TR, McCoy CE, Khoury PR, Daniels SR, Dolan LM. Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation. Jun 2009;119(22):2913-2919.

Urbina EM, Bean JA, Daniels SR, D’Alessio D, Dolan LM. Overweight and hyperinsulinemia provide individual contributions to comprises in brachial artery distensibility in healthy adolescents and young adults: brachial distensibility in children. J Am Soc Hypertens. Jun 2007;1(3):200-207.

Urbina EM, Kieltkya L, Tsai J, Srinivasan SR, Berenson GS. Impact of multiple cardiovascular risk factors on brachial artery distensibility in young adults: The Bogalusa Heart Study. Am J Hypertens. Jun 2005;18:767-771.

Urbina EM, Srinivasan SR, Kieltyka RL, Tang R, Bond MG, Chen W, Berenson GS. Correlates of carotid artery stiffness in young adults: The Bogalusa Heart Study. Atherosclerosis. Sep 2004;176(1):157-164.

Urbina EM, Srinivasan SR, Tang R, Bond MG, Kieltyka L, Berenson GS. Impact of multiple coronary risk factors on the intima-media thickness of different segments of carotid artery in healthy young adults: The Bogalusa Heart Study. Am J Cardiol. Nov 2002;90(9):953-958.

Urbina EM, Gidding SS, Bao W, Pickoff AS, Berdusis K, Berenson GS. Effect of body size, ponderosity and blood pressure of the left ventricular growth in children and young adults in Bogalusa Heart Study. Circulation. May 1995;91(9):2400-2406.

Grants

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Accelerated CV Aging in Youth Related to CV Risk Factor Clusters. Principal Investigator. National Heart, Lung and Blood Institute. Jan 2011-Dec 2016.

Gruschen R. Veldtman, FRCP, MBChB Director of Adult Congenital Heart Disease

Gruschen R. Veldtman, FRCP, MBChB, is a clinician scientist who conducts research in the areas of single ventricle and Fontan physiology and pathophysiology; Eisenmenger syndrome and arrhythmia; contractile reserve in tetralogy of Fallot; and hepatopathy in the Fontan circulation and heart failure.

513-803-2243 gruschen.veldtman@cchmc.org

Joshua S. Waxman, PhD

Joshua S. Waxman, PhD, uses genetic, molecular and cellular biological techniques to understand the underlying mechanisms of congenital heart defects and cardiomyocyte formation during development.
Visit the Waxman Lab.

513-636-7232 joshua.waxman@cchmc.org

Ivan Wilmot, MD Director, Fellowship Program

Ivan Wilmot, MD, focuses on care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant, and mechanical circulatory support (MCS); and advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.

513-803-2913 ivan.wilmot@cchmc.org

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Ivan Wilmot, MD

Director, Fellowship Program

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-803-2913

Email ivan.wilmot@cchmc.org

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Clinical & Research Interests

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Clinical

Advanced heart failure; transplantation; mechanical circulatory support and transplant; cardiomyopathy

Research

Care of children with advanced heart failure requiring mechanical circulatory support bridge to transplant; quality of life in children with heart failure, transplant and mechanical circulatory support (MCS); advanced strain imaging in evaluation of ventricular function in pediatric heart transplant patients.

Biography

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Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor of Science in zoology.

In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.

His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).

Education and Training

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BS: Louisiana State University, Baton Rouge, LA, 1998.

MD: Emory University School of Medicine, Atlanta, GA, 2002.

Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.

Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.

Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.

Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.

Publications

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Ryan T, Jefferies J, Wilmot I. Managing Heart Failure in Adults with Congenital Heart Disease. 2014. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.

Czosek R, Wilmot I, Jefferies J, Spar D, Anderson J, Khoury P, Knilans T. Outcomes, Arrhythmic Burden and Ambulatory Monitoring of Pediatric Patients with Left Ventricular Non-Compaction and Preserved Left Ventricular Function. AJC. 2015 April;115(7);962-6.

Fries M, Marino B, Cassedy A, Wilmot I, Jefferies J, Lorts A. Health-Related Quality of Life Assessment in Children Followed in a Cardiomyopathy Clinic. Pediatric Cardiol. 2014 Oct 7.

Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.

Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.

Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.

Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.

Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.

Jessica G. Woo, MHSA, PhD

Jessica Graus Woo, MHSA, PhD, is a molecular epidemiologist with particular research interest in the developmental pathways leading to pediatric obesity. She is specifically interested in how genetics and early life influences, especially early diet, may impact a child’s likelihood of developing obesity and specific metabolic complications of obesity, such as insulin resistance and dyslipidemia.

513-636-9598 jessica.woo@cchmc.org

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Jessica G. Woo, MHSA, PhD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-9598

Fax 513-636-7509

Email jessica.woo@cchmc.org

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Clinical Interests

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Molecular epidemiology; pediatric obesity; genetics and early life influences on obesity; insulin resistance; dyslipidemia

Education and Training

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BA: Cornell University, Ithaca, NY, 1993.

MHSA: University of Michigan, Ann Arbor, MI, 1995.

PhD: University of Cincinnati, Cincinnati, OH, 2004.

Publications

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Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol. 2010 Sep;5(9):1552-7.

Elder DA, Woo JG, D'Alessio DA. Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. Pediatr Diabetes. 2010 Aug;11(5):314-21.

Martin LJ, Woo JG, Morrison JA. Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels. Obesity (Silver Spring).2010 Jul;18(7):1378-82.

Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 2009 Dec 15;3 Suppl 7:S41.

Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeed Med. 2009 Jun;4(2):101-9.

Lomenick JP, Reifschneider KL, Lucky AW, Adams D, Azizkhan RG, Woo JG, Backeljauw PF. Prevalence of adrenal insufficiency following systemic glucocorticoid therapy in infants with hemangiomas. Arch Dermatol. .2009 Mar;145(3):262-6.

Woo JG, Zeller MH, Wilson K, Inge T. Obesity identified by discharge ICD-9 codes underestimates the true prevalence of obesity in hospitalized children. J Pediatr. 2009 Mar;154(3):327-31.

Martin LJ, Gao G, Kang G, Fang Y, Woo JG. Improving the signal-to-noise ratio in genome-wide association studies. Genet Epidemiol. 2009;33 Suppl 1:S29-32.

Woo JG. Using body mass index Z-score among severely obese adolescents: a cautionary note. Int J Pediatr Obes. 2009;4(4):405-10.

Hugo ER, Brandebourg TD, Woo JG, Loftus J, Alexander JW, Ben-Jonathan N. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environ Health Perspect. 2008 Dec;116(12):1642-7.

Katherine Yutzey, PhD

Katherine Yutzey, PhD, is focused on the molecular mechanisms of heart development and disease. Particular emphasis is on signaling pathways and transcription factors that control heart valve development as well as contribute to pediatric and adult valve disease. Additional projects address the development of coronary vasculature, cardiac fibrosis and maturation of cardiac muscle after birth.

Visit the Yutzey Lab.

513-636-8340 katherine.yutzey@cchmc.org

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Katherine Yutzey, PhD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8340

Fax 513-636-5958

Email katherine.yutzey@cchmc.org

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Specialties

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Molecular regulation of heart development; valve development and disease mechanisms; cardiomyocyte proliferation; cardiac connective tissue lineages.

Visit the Yutzey Lab.

Biography

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Visit Dr. Yutzey's lab website.

Katherine E. Yutzey, PhD, is a professor who joined the Division of Molecular Cardiovascular Biology at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine in 1995.

Dr. Yutzey is the first recipient of the Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Award and was also a recipient of a Children's Hospital Medical Center Trustee Award. Her work is also supported by grants from National Institutes of Health (NIH) and the American Heart Association.

The focus of Dr. Yutzey's research program is the regulation of normal and abnormal heart development. Congenital heart defects represent one of the most common classes of human birth defects. Increasing evidence exists for a genetic basis of certain instances of congenital heart disease.

Dr. Yutzey’s lab also studies molecular mechanisms of cardiac connective tissue cell lineage development and disease. This work focuses on heart valve development and disease as well as mechanisms of cardiac fibrosis.

Education and Training

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BA: Oberlin College, Oberlin, OH, 1986.

PhD: Purdue University, West Lafayette, IN,1992

Fellowship: Cornell University Medical College, New York, NY,1992-1995.

Publications

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Wirrig EE, Hinton RB, Gomez MV, Yutzey KE. Cox2 inhibition reduces aortic valve calcification in vivo. Arterioscler. Thromb Vasc Biol. 2015;35:938-947.

Yutzey KE. Neuregulin1 makes heart muscle. Nature. 2015;520:445-446.

Wirrig EE, Yutzey KE. Conserved transcriptional regulatory mechanisms in aortic valve development and disease. Arterioscler Thromb Vasc Biol. 2014;34:737-741.

Cole CR, Yutzey KE, Brar AK, Goessling LS, vanVickle-Chavez SJ, Cunningham MV, Eghtesady P. Congenital heart disease linked to maternal autoimmunity against cardiac myosin. J Immunol. 2014;192:4074-4082.

Yutzey KE. Cardiovascular Biology: Switched at birth. Nature. 2014;509:572-573.

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: A consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014;34:2387-2393.

Lee MP, Ratner N, Yutzey KE. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds and peripheral nerve sheath tumor cells. BMC Genomics. 2014;15:821.

Godby RC, Munjal C, Opoka AM, Smith JM, Yutzey KE, Narmoneva DA, Hinton RB. Cross talk between NOTCH signaling and biomechanics in human aortic valve disease pathogenesis. J Cardiovasc Dev Dis. 2014;1:237-256.

Fang M, Alfieri CM, Hulin A, Conway SJ, Yutzey KE. Loss of -catenin promotes chondrogenic differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol. 2014;34:2601-2608.

Sengupta A, Kalinichenko VV, Yutzey KE. FoxO and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell cycle withdrawal and IGF1 gene regulation. Circ Res. 2013;112:267-277.

Grants

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Wnt/-catenin signaling and cardiac fibrosis. National Institutes of Health Component Principal Investigator. 2002-2018. P01 HL069779.

Wnt signaling in heart valve development and disease. National Institutes of Health. Principal Investigator. 2012-2016. R01 HL094319.

Cell signaling mechanisms of calcific aortic valve disease. National Institutes of Health. Principal Investigator. 2012-2016. R01 HL114682.