Building capacity for sickle cell stroke prevention in low-resource settings. Discover Public Health. 2025; 22(1):881.
Prolonged, Unintentional Overdose of Hydroxyurea in a Child With Sickle Cell Anemia. Pediatric Blood and Cancer. 2025; e70076.
Development of disease-specific growth curves from Kenyan children with sickle cell anemia. Blood Global Hematology. 2025; 1(3):100031.
A New First-Line Option for Pediatric ITP-Incremental Progress or Paradigm Shift? Journal of the American Medical Association (JAMA). 2025; 334(20):1802-1803.
Microsensor Array for the Electrochemical Analysis of Hydroxyurea in Blood Samples of Children Affected by Sickle Cell Anemia. Analytical Chemistry. 2025; 97(44):24399-24414.
Health status of Ugandan children born with sickle cell anemia and congenital HIV identified through newborn screening. Blood. 2025; 146(Supplement 1):2668.
The ASH consa consortium on newborn screening in Africa for sickle cell disease: Interim updates of progress in screening, follow-up and supporting initiatives. Blood. 2025; 146(Supplement 1):944-944.
Benefits of hydroxyurea in hemoglobin SC: Results of the open-label phase of the prospective identification of variables as outcomes for treatment (PIVOT) trial. Blood. 2025; 146(Supplement 1):409.
Biomarkers of ineffective erythropoiesis in patients with sickle cell anemia, at baseline and while treated with hydroxyurea, in comparison to patients with other iron-loading red cell disorders. Blood. 2025; 146(Supplement 1):4686.
Splenomegaly patterns and clinical impact in African children with sickle cell anemia on hydroxyurea treatment. Blood. 2025; 146(Supplement 1):2971-2971.
Pharmacokinetic (PK)-guided vs weight-based dosing of hydroxyurea for tanzanian children with sickle cell anemia. Blood. 2025; 146(Supplement 1):2959-2959.
Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea. Blood. 2025; 146(Supplement 1):7.
Safety and efficacy of ten years of hydroxyurea treatment for young children with sickle cell anemia in Uganda. Blood. 2025; 146(Supplement 1):412.
Measles vaccine-induced sero-protection among children with sickle cell anemia. Blood. 2025; 146(Supplement 1):1168.
Imaging flow cytometry for detection of red blood cell inclusions: A quantitative approach to assess splenic filtration function in sickle cell disease. Blood. 2025; 146(Supplement 1):1188.
Feasibility, reliability, and accuracy of point-of-care measurements of fetal hemoglobin. Blood. 2025; 146(Supplement 1):4739-4739.
Full assessment of clinical transfusion support (FACTS): A prospective Study to determine the burden of sickle cell anemia on pediatric blood transfusion use in a malaria-endemic region in Africa. Blood. 2025; 146(Supplement 1):300-300.
Thirty Years of Hydroxyurea for Sickle Cell Anemia - Scientific Progress, Global Health Gaps. New England Journal of Medicine. 2025; 393(16):1556-1559.
Erythrocyte alloimmunization in children with sickle cell anemia living in Kilifi, Kenya. Blood Global Hematology. 2025; 1(2):100016.
Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria. Journal of Infectious Diseases. 2025; 232(2):285-297.
Malaria prophylaxis in sickle cell anaemia: some answers, more questions. The Lancet Infectious Diseases. 2025; 25(6):601-602.
Hydroxyurea to decrease stroke risk in children with sickle cell anemia: a systematic review and meta-analysis. Blood Global Hematology. 2025; 1(1).
The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91(6):1865-1872.
The modern use of hydroxyurea for children with sickle cell anemia. Haematologica. 2025; 110(5):1061-1073.
Benefits of Hydroxyurea in Mitigating Early Onset Lung Disease in Children With Sickle Cell Anemia. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Abstracts):a1272-a1272.
Stroke prevention in Hispanic children with sickle cell anemia: the SACRED trial. Blood advances. 2025; 9(8):1791-1800.
The feasibility of pharmacokinetic-based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial. British Journal of Clinical Pharmacology. 2025; 91(6):1865-1872.
The Voxelotor Effect: Decreased Affinity for New Drugs for Sickle Cell Disease? Pediatric Blood and Cancer. 2025; 72(3):e31475.
Hydroxyurea for Children and Adults with Hemoglobin SC Disease. NEJM Evid. 2025; 4(2):EVIDoa2400402.
Pharmacokinetic-Guided Hydroxyurea to Reduce Transfusions in Ugandan Children with Sickle Cell Anemia: Study Design of the Alternative Dosing And Prevention of Transfusions Trial. Acta Haematologica. 2025; 148(2):208-219.
Globalization in clinical drug development for sickle cell disease. American Journal of Hematology. 2025; 100(1):4-9.
Primary Stroke Screening and Hydroxyurea Treatment for Sickle Cell Anemia in Pediatric Healthcare Settings in East and Central Africa: A Narrative Review of Capacity Gaps and Opportunities. Public Health Reviews. 2025; 46:1608359.
Assessing educational needs of sickle cell anemia healthcare providers in sub-Saharan Africa and the Caribbean. Frontiers in Public Health. 2025; 13:1693285.
Baseline characteristics of Ghanaian children and adults enrolled in PIVOT, a randomised clinical trial of hydroxyurea in HbSC disease in sub-Saharan Africa. British Journal of Haematology. 2024; 205(6):2470-2480.
Stroke Training, Research, and Education Toward Capacity with Hydroxyurea (STRETCH) Blood. 2024; 144(Supplement 1):2242-2242.
RED Blood Cell Alloimmunization in Sickle Cell Anaemia Patients in Kilifi, Kenya. Blood. 2024; 144(Supplement 1):5602-5602.
Pharmacokinetic (PK)-Guided Dosing of Hydroxyurea for Tanzanian Children with Sickle Cell Anemia. Blood. 2024; 144(Supplement 1):289-289.
Newborn Screening for Sickle Cell Disease in Sub-Saharan Africa: Initial Results of the ASH Consortium on Newborn Screening in Africa (CONSA) Program. Blood. 2024; 144(Supplement 1):541-541.
Low Rate of Red Blood Cell Alloimmunization Among Transfused Children with Sickle Cell Anemia in Malawi without Pre-Transfusion Screening or Antigen Matching. Blood. 2024; 144(Supplement 1):4032.
Hydroxyurea Pharmacokinetics in Children with Sickle Cell Anemia: Comparison of Global Cohorts. Blood. 2024; 144(Supplement 1):542-542.
Growth Curves for Children Living with Sickle Cell Anemia in Kilifi County, Kenya, Do Not Follow Who Curves for Normal Children. Blood. 2024; 144(Supplement 1):5315-5315.
Effects of Splenomegaly in Children with Sickle Cell Anemia Treated with Hydroxyurea: Secondary Analysis of the Sphere Trial. Blood. 2024; 144(Supplement 1):2495-2495.
Building Capacity in Sub-Saharan Africa to Address Sickle Cell Disease: The Consortium on Newborn Screening in Africa (CONSA) Blood. 2024; 144(Supplement 1):520-520.
Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical Pharmacology and Therapeutics. 2024; 116(3):670-677.
A pharmacokinetic-pharmacodynamic analysis of l-glutamine for the treatment of sickle cell disease: Implications for understanding the mechanism of action and evaluating response to therapy. British Journal of Haematology. 2024; 205(3):1147-1158.
Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial. The Lancet Haematology. 2024; 11(6):e425-e435.
Successes and pitfalls in orphan drug development for sickle cell disease. Blood advances. 2024; 8(10):2455-2465.
Hydroxyurea reduces infections in children with sickle cell anemia in Uganda. Blood. 2024; 143(14):1425-1428.
Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial. American Journal of Hematology. 2024; 99(4):625-632.
Angiopoietin-2 is associated with sickle cell complications, including stroke risk, and decreases with hydroxyurea therapy. Blood Vessels, Thrombosis & Hemostasis. 2024; 1(1):100001.
A Population Pharmacokinetic Analysis of L-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects. Clinical Pharmacokinetics. 2024; 63(3):357-365.
The bold promise of gene therapy for sickle cell disease. British Journal of Haematology. 2024; 204(2):381-382.
Screening for haemoglobin disorders: One size may not fit all. British Journal of Haematology. 2024; 204(1):26-28.
Cost-Effectiveness of Hydroxyurea for Sickle Cell Anemia in a Low-Income African Setting: A Model-Based Evaluation of Two Dosing Regimens. PharmacoEconomics (Auckland). 2023; 41(12):1603-1615.
A Novel, Rapid, and Accurate Quantitative Hydroxyurea Assay. Blood. 2023; 142(Supplement 1):2530.
Effects of L-Glutamine on Biomarkers of Response in Sickle Cell Disease: A Pharmacokinetics-Pharmacodynamics Analysis. Blood. 2023; 142(Supplement 1):1145.
Hydroxyurea Improves Intelligence Quotient Scores in Children with Sickle Cell Anemia and Elevated Transcranial Doppler Velocity. Blood. 2023; 142(Supplement 1):797.
Codetection of Plasmodium falciparum in Children Hospitalized With Dengue Fever in the Dominican Republic. Pediatric Infectious Disease Journal. 2023; 42(11):965-968.
Simultaneous adjunctive treatment of malaria and its coevolved genetic disorder sickle cell anemia. Blood advances. 2023; 7(19):5970-5981.
Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease. Trials. 2023; 24(1):603.
Efficacy, safety, and pharmacokinetics of a new, ready-to-use, liquid hydroxyurea in children with sickle cell anemia. Blood advances. 2023; 7(16):4319-4322.
Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission. The Lancet Haematology. 2023; 10(8):e633-e686.
Sustained and Boosted Antibody Responses in Breast Milk After Maternal SARS-CoV-2 Vaccination. Breastfeeding Medicine. 2023; 18(8):612-620.
Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial. Blood advances. 2023; 7(13):3023-3031.
Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination. Vaccine. 2023; 41(28):4183-4189.
Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps. Pharmacotherapy. 2023; 43(5):419-429.
Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci. British Journal of Haematology. 2023; 201(2):343-352.
Hydroxyurea with dose escalation for primary stroke risk reduction in children with sickle cell anaemia in Tanzania (SPHERE): an open-label, phase 2 trial. The Lancet Haematology. 2023; 10(4):e261-e271.
Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa. Blood. 2023; 141(12):1402-1410.
Lack of hydroxyurea-associated mutagenesis in pediatric sickle cell disease patients. Environmental and Molecular Mutagenesis. 2023; 64(3):167-175.
Stroke Prevention with Hydroxyurea Enabled through Research and Education: A Phase 2 Primary Stroke Prevention Trial in Sub-Saharan Africa. Acta Haematologica. 2023; 146(2):95-105.
Hydroxyurea pharmacokinetics and precision dosing in low-resource settings. Frontiers in Molecular Biosciences. 2023; 10:1130206.
The Consortium on Newborn Screening in Africa for sickle cell disease: study rationale and methodology. Blood advances. 2022; 6(24):6187-6197.
Blood diseases in Africa: Redressing unjust disparities is an urgent unmet need. American Journal of Hematology. 2022; 97(12):1505-1506.
Evaluation of Dosage and Food Effect on L-Glutamine Exposure for Sickle Cell Anemia: A Population Pharmacokinetic Analysis. Blood. 2022; 140(Supplement 1):8256-8257.
Hydroxyurea Pharmacokinetics in Young Children with Sickle Cell Anemia: Results from the Therapeutic Response Evaluation and Adherence Trial (TREAT) Blood. 2022; 140(Supplement 1):8168-8169.
US News & World Report and quality metrics: Inclusion of sickle cell disease is a matter of equity. Pediatric Blood and Cancer. 2022; 69(8):e29679.
New therapeutics for children with sickle cell disease: A time for celebration, caution, or both? Pediatric Blood and Cancer. 2022; 69(8):e29805.
PI‐08: HIGH DISEASE BURDEN, MORBIDITY AND MORTALITY AMONG CHILDREN WITH SICKLE CELL ANAEMIA IN UGANDA. HemaSphere. 2022; 6(Suppl):13-13.
O‐12: BUILDING LOCAL CAPACITY FOR HYDROXYUREA PHARMACOKINETICS AND PRECISION DOSING IN LOW‐RESOURCE SETTINGS. HemaSphere. 2022; 6(Suppl):7-8.
O‐01: HYDROXYUREA REDUCES THE TRANSFUSION BURDEN IN CHILDREN WITH SICKLE CELL ANEMIA IN SUB‐SAHARAN AFRICA: THE REACH EXPERIENCE. HemaSphere. 2022; 6(Suppl):1-1.
Assessment of Plasmodium falciparum Artemisinin Resistance Independent of kelch13 Polymorphisms and with Escalating Malaria in Bangladesh. mBio. 2022; 13(1):e0344421.
Reproductive equity: preserve the reserve. Blood. 2022; 139(7):963-965.
Case Report: β-thalassemia major on the East African coast. Wellcome Open Research. 2022; 7:188.