Hematology

Abu Ata, N; Hammill, AM; Merrow, AC. Neonatal vascular anomalies manifesting as soft-tissue masses. Pediatric Radiology. 2021.

Antoniak, S; Tatsumi, K; Schmedes, CM; Egnatz, GJ; Auriemma, AC; Bharathi, V; Stokol, T; Beck, MA; Griffin, JH; Palumbo, JS; et al. PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus. Journal of Thrombosis and Haemostasis. 2021; 19:1103-1111.

Avila, L; Cullinan, N; White, M; Gaballah, M; Cahill, AM; Warad, D; Rodriguez, V; Tarango, C; Hoppmann, A; Nelson, S; et al. Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis. Journal of Thrombosis and Haemostasis. 2021; 19:1283-1293.

Bajorek, K; Martin, M; Palumbo, JS; Tarango, C; Mullins, ES; Luchtman-Jones, L. Do Family History Questions Improve the Predictive Value of a Standardized Pediatric Bleeding Assessment Tool?. Blood. 2021; 138:2111-2111.

Bartlett, AL; Romick-Rosendale, L; Nelson, A; Abdullah, S; Luebbering, N; Bartlett, J; Brusadelli, M; Palumbo, JS; Lake, K; Litts, B; et al. Tryptophan metabolism is dysregulated in individuals with Fanconi anemia. Blood Advances. 2021; 5:250-261.

Bode, MF; Schmedes, CM; Egnatz, GJ; Bharathi, V; Hisada, YM; Martinez, D; Kawano, T; Weithauser, A; Rosenfeldt, L; Rauch, U; et al. Cell type-specific roles of PAR1 in Coxsackievirus B3 infection. Scientific Reports. 2021; 11.

Boucher, AA; Bedel, A; Jones, S; Lenahan, SF; Geer, R; McGann, PT. A retrospective study of the safety and efficacy of low molecular weight iron dextran for children with iron deficiency anemia. Pediatric Blood and Cancer. 2021; 68.

Boucher, AA; Dong, M; Vinks, AA; Marahatta, A; Howard, TA; Ware, RE; Nathan, JD; Abu-El-Haija, M; Luchtman-Jones, L. Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation. Journal of Clinical Pharmacology. 2021; 61:547-554.

Brindley, EC; Papoin, J; Kennedy, L; Robledo, RF; Ciciotte, SL; Kalfa, TA; Peters, LL; Blanc, L. Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis. Blood Cells, Molecules, and Diseases. 2021; 87.

Brown, RC C; Saraf, SL; Cruz, K; Idowu, M; Kalfa, TA; Geib, J; Forsyth, S; Schroeder, P; Wu, E; Kelly, P; et al. Activation of Pyruvate Kinase-R with Etavopivat (FT-4202) Is Well Tolerated, Improves Anemia, and Decreases Intravascular Hemolysis in Patients with Sickle Cell Disease Treated for up to 12 Weeks. Blood. 2021; 138:9-9.

Canaud, G; Hammill, AM; Adams, D; Vikkula, M; Keppler-Noreuil, KM. A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations. Orphanet Journal of Rare Diseases. 2021; 16.

Casella, JF; Barton, BA; Kanter, J; Black, LV; Majumdar, S; Inati, A; Wali, Y; Drachtman, RA; Abboud, MR; Kilinc, Y; et al. Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial. JAMA - Journal of the American Medical Association. 2021; 325:1513-1523.

Cazelles, R; Shukla, RP; Ware, RE; Vinks, AA; Ben-Yoav, H. Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS2-Modified Electrodes and Chemometrics. Biomedicines. 2021; 9.

Davidson, A; Maria, N; Papoin, J; Raparia, C; Sun, Z; Zhang, W; Kalfa, TA; Paulson, R; Blanc, L. Overexpression of Human TLR8 Causes Fatal Anemia in SLE-Prone Mice By Altering the Bone Marrow Erythropoietic Niche. Blood. 2021; 138:1989-1989.

Davis, G; York, AJ; Bacon, WC; Lin, SC; McNeal, MM; Yarawsky, AE; Maciag, JJ; Miller, JL C; Locker, KC S; Bailey, M; et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. PLoS ONE. 2021; 16.

Dong, M; McGann, PT. Changing the Clinical Paradigm of Hydroxyurea Treatment for Sickle Cell Anemia Through Precision Medicine. Clinical Pharmacology and Therapeutics. 2021; 109:73-81.

Engel, E; Losos, M; Martin, J; Palumbo, JS; Lorts, A; Geer, R; Luchtman-Jones, L. Use of Bivalirudin-Specific Monitoring Assays in Ventricular Assist Device Patients. Blood. 2021; 138:3236-3236.

Engel, E; Ricci, K; Hammill, AM; Mittermeier, K; LeCras, TD; Luchtman-Jones, L. Use of Serum Antiopoietin-2 Assay for Therapeutic Decision-Making in Patients with Vascular Anomalies. Blood. 2021; 138:4929-4929.

Filuta, A; Amezcua, PK; Ruff, B; He, H; Martin, LJ; Palumbo, JS; Khurana Hershey, GK; Sherenian, MG. Fibrin(ogen) Mechanistically Contributes to Atopic Dermatitis Pathogenesis and Allergic Sensitization. Blood. 2021; 138:2097-2097.

Ghaleb, S; Reagor, JA; Tarango, C; Benscoter, A; Smith, R; Byrnes, JW. Correlation among Hemolysis Biomarkers in Pediatric Patients Undergoing Extracorporeal Membrane Oxygenation. Journal of Extra-Corporeal Technology. 2021; 53:125-129.

Girnius, A; Zentner, D; Valente, AM; Pieper, PG; Economy, KE; Ladouceur, M; Roos-Hesselink, JW; Warshak, C; Partington, SL; Gao, Z; et al. Bleeding and thrombotic risk in pregnant women with Fontan physiology. Heart. 2021; 107:1390-1397.

Grant, N; Taylor, JM; Plummer, Z; Myers, K; Burrow, T; Luchtman-Jones, L; Byars, A; Hammill, A; Wusick, K; Smith, E; et al. Case Report: Cerebral Revascularization in a Child With Mucopolysaccharidosis Type I. Frontiers in Pediatrics. 2021; 9.

Grimley, M; Asnani, M; Shrestha, A; Felker, S; Lutzko, C; Arumugam, PI; Witting, S; Knight-Madden, J; Niss, O; Quinn, CT; et al. Safety and Efficacy of Aru-1801 in Patients with Sickle Cell Disease: Early Results from the Phase 1/2 Momentum Study of a Modified Gamma Globin Gene Therapy and Reduced Intensity Conditioning. Blood. 2021; 138:3970-3970.

Gutierrez, M; Shamoun, M; Seu, KG; Tanski, T; Kalfa, TA; Eniola-Adefeso, O. Characterizing bulk rigidity of rigid red blood cell populations in sickle-cell disease patients. Scientific Reports. 2021; 11.

Hammill, AM; Wusik, K; Kasthuri, RS. Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2021; 2021:469-477.

Hau, DK; Ambrose, EE; Smart, LR; Kayange, NM; Peck, RN. Linkage to Care Intervention to Improve Post-Hospital Outcomes Among Children with Sickle Cell Disease in Tanzania: A Pilot Study. Journal of Pediatrics. 2021; 232:290-293.e1.

Henrici, RC; Sautter, CL; Bond, C; Opoka, RO; Namazzi, R; Datta, D; Ware, RE; Conroy, AL; John, CC. Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria. Blood Advances. 2021; 5:4710-4720.

Hernandez, AG; Kiyaga, C; Howard, TA; Ssewanyana, I; Ndeezi, G; Aceng, JR; Ware, RE. Trends in sickle cell trait and disease screening in the Republic of Uganda, 2014-2019. Tropical Medicine and International Health. 2021; 26:23-32.

Hernandez, AG; Kiyaga, C; Howard, TA; Ssewanyana, I; Ndeezi, G; Aceng, JR; Ware, RE. Operational analysis of the national sickle cell screening programme in the Republic of Uganda. African Journal of Laboratory Medicine. 2021; 10.

Hood, AM; Hildenbrand, AK; Rebitski, J; Stallworth, J; Johnson, Y; Gomes, S; Whitacre, C; Mara, CA; Shook, LM; Quinn, CT; et al. Effects of the COVID-19 Pandemic on Caregivers of Young Children with Sickle Cell Disease Enrolled in the Engage-HU Trial. Blood. 2021; 138:1891-1891.

Hood, AM; Nwankwo, C; Walton, A; Mctate, E; Joffe, N; Quinn, CT; Britto, MT; Peugh, J; Mara, CA; Crosby, LE. Mobile health use predicts self-efficacy and self-management in adolescents with sickle cell disease. Translational Behavioral Medicine. 2021; 11:1823-1831.

Hood, AM; Strong, H; Nwankwo, C; Johnson, Y; Peugh, J; Mara, CA; Shook, LM; Brinkman, WB; Real, FJ; Klein, MD; et al. Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial. JMIR Research Protocols. 2021; 10.

Juang, LJ; Hur, WS; Silva, LM; Strilchuk, AW; Francisco, B; Leung, J; Robertson, MK; Groeneveld, DJ; La Prairie, B; Chun, EM; et al. Suppression of fibrin(ogen)-driven pathologies through controlled knockdown by lipid nanoparticle delivery of siRNA. Blood. 2021.

Kalfa, TA. Diagnosis and clinical management of red cell membrane disorders. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2021; 2021:331-340.

Kalfa, TA; Telen, MJ; Saraf, SL; Brown, RC C; Giger Seu, K; Larkin, SK; Ribadeneira, MD; Schroeder, P; Wu, E; Kelly, P; et al. Etavopivat, an Allosteric Activator of Pyruvate Kinase-R, Improves Sickle RBC Functional Health and Survival and Reduces Systemic Markers of Inflammation and Hypercoagulability in Patients with Sickle Cell Disease: An Analysis of Exploratory Studies in a Phase 1 Study. Blood. 2021; 138:8-8.

Karkoska, K; Quinn, CT; Niss, O; Pfeiffer, A; Dong, M; Vinks, AA; McGann, PT. Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia. American Journal of Hematology. 2021; 96:538-544.

Karkoska, K; Ricci, K; VandenHeuvel, K; Trout, AT; Smith, EA; Kotagal, M; Weiss, B. Metastatic neuroblastoma masquerading as infantile hemangioma in a 4-month-old child. Pediatric Blood and Cancer. 2021; 68.

Karkoska, K; Todd, K; Niss, O; Clapp, K; Fenchel, L; Kalfa, TA; Malik, P; Quinn, CT; Ware, RE; McGann, PT. Implementation of near-universal hydroxyurea uptake among children with sickle cell anemia: A single-center experience. Pediatric Blood and Cancer. 2021; 68.

Karkoska, KA; Haber, K; Elam, M; Strong, S; McGann, PT. Academic Challenges and School Service Utilization in Children with Sickle Cell Disease. Journal of Pediatrics. 2021; 230:182-190.

Kim, S; Khoriaty, R; Li, L; McClune, M; Kalfa, TA; Wu, J; Peltier, D; Fujiwara, H; Sun, Y; Oravecz-Wilson, K; et al. ER-to-Golgi transport and SEC23-dependent COPII vesicles regulate T cell alloimmunity. Journal of Clinical Investigation. 2021; 131.

Lal, A; Brown, RC C; Coates, TD; Kalfa, TA; Kwiatkowski, JL; Brevard, J; Potter, V; Wood, KW; Sheth, S. Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease. Blood. 2021; 138:4162-4162.

Mullins, ES; Geer, R; Metcalf, M; Piccola, J; Lane, A; Conard, LA E; Kowalczyk Mullins, TL. Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy. Pediatrics. 2021; 147.

Namazzi, R; Conroy, AL; Bond, C; Goings, MJ; Datta, D; Ware, RE; Jang, JH; John, CC; Opoka, RO. Effect of Hydroxyurea Therapy on the Incidence of Infections in Ugandan Children with Sickle Cell Anaemia. Blood. 2021; 138:765-765.

Nayak, RC; Trump, L; Emberesh, S; Lee, Y; Singh, AK; Wellendorf, AM; Horwitz, MS; Kalfa, TA; Lutzko, C; Cancelas, JA. SERF1 Is Required for G-CSF Resistance of Start-Codon Mutant ELANE Granulocytic Precursors. Blood. 2021; 138:433-433.

Newby, GA; Yen, JS; Woodard, KJ; Mayuranathan, T; Lazzarotto, CR; Li, Y; Sheppard-Tillman, H; Porter, SN; Yao, Y; Mayberry, K; et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature: New biology. 2021; 595:295-302.

Niss, O; Lorsbach, RB; Berger, M; Chonat, S; McLemore, M; Buchbinder, D; McCavit, T; Shaffer, LG; Simpson, J; Schwartz, JH; et al. Congenital dyserythropoietic anemia type I: First report from the Congenital Dyserythropoietic Anemia Registry of North America (CDAR). Blood Cells, Molecules, and Diseases. 2021; 87.

O'Brien, SH; Badawy, SM; Rotz, SJ; Shah, MD; Makarski, J; Bercovitz, RS; Hogan, MJ S; Luchtman-Jones, L; Panepinto, JA; Priola, GM; et al. The ASH-ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question. Pediatric Blood and Cancer. 2021; 68.

Pecker, LH; Sharma, D; Nero, A; Paidas, MJ; Ware, RE; James, AH; Smith-Whitley, K. Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease. British Journal of Haematology. 2021; 194:970-979.

Power-Hays, A; Tomlinson, GA; Tshilolo, L; Santos, B; Williams, TN; Olupot-Olupot, P; McGann, PT; Aygun, B; Lane, A; Stuber, SE; et al. Hydroxyurea Reduces the Transfusion Burden in Children with Sickle Cell Anemia: The Reach Experience. Blood. 2021; 138:11-11.

Prasad, JM; Negron, O; Du, X; Mullins, ES; Palumbo, JS; Gilbertie, JM; Hook, M; Grover, SP; Pawlinski, R; Mackman, N; et al. Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Quinn, CT; Niss, O; Dong, M; Pfeiffer, A; Korpik, J; Reynaud, M; Bonar, H; Kalfa, TA; Smart, LR; Malik, P; et al. Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. British Journal of Haematology. 2021; 194:617-625.

Quinn, CT; Ware, RE. Increased oxygen affinity: to have and to hold. Blood. 2021; 138:1094-1095.

Rankine-Mullings, A; Reid, M; Soares, D; Taylor-Bryan, C; Wisdom-Phipps, M; Aldred, K; Latham, T; Schultz, WH; Knight-Madden, J; Badaloo, A; et al. Hydroxycarbamide treatment reduces transcranial Doppler velocity in the absence of transfusion support in children with sickle cell anaemia, elevated transcranial Doppler velocity, and cerebral vasculopathy: the EXTEND trial. British Journal of Haematology. 2021; 195:612-620.

Real, FJ; Hood, AM; Davis, D; Cruse, B; Klein, M; Johnson, Y; McTate, E; Brinkman, WB; Hackworth, R; Hackworth, K; et al. An Immersive Virtual Reality Curriculum for Pediatric Hematology Clinicians on Shared Decision-making for Hydroxyurea in Sickle Cell Anemia. Journal of Pediatric Hematology/Oncology. 2021; Publish Ahead of Print.

Ricci, KW; Iacobas, I. How we approach the diagnosis and management of complex lymphatic anomalies. Pediatric Blood and Cancer. 2021.

Ross, JE; Zhang, BM; Lee, K; Mohan, S; Branchford, BR; Bray, P; Dugan, SN; Freson, K; Heller, PG; Kahr, WH A; et al. Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel. Blood Advances. 2021; 5:414-431.

Sadaf, A; Dong, M; Pfeiffer, A; Latham, T; Vinks, AA; Ware, RE; Quinn, CT. Pharmacokinetics of L-Glutamine (Endari) in Pediatric and Adult Sickle Cell Disease Patients: A Phase 4, Open-Label, Single-Center Study. Blood. 2021; 138:980-980.

Sadaf, A; Quinn, CT; Korpik, JB; Pfeiffer, A; Reynaud, M; Niss, O; Malik, P; Ware, RE; Kalfa, TA; McGann, PT. Rapid and automated quantitation of dense red blood cells: A robust biomarker of hydroxyurea treatment response. Blood Cells, Molecules, and Diseases. 2021; 90.

Sadaf, A; Seu, KG; Thaman, E; Fessler, R; Konstantinidis, DG; Bonar, HA; Korpik, J; Ware, RE; McGann, PT; Quinn, CT; et al. Automated Oxygen Gradient Ektacytometry: A Novel Biomarker in Sickle Cell Anemia. Frontiers in Physiology. 2021; 12.

Sadaf, A; Ware, RE. Microscope diagnosis of MYH9-related thrombocytopenia. Blood. 2021; 138.

Schultz, K; Divanovic, A; Towe, C; Miethke, A; Wusik, K; Hammill, A; Brunner, H. Clinicopathologic Conference: A Four-Year-Old Child With Digital Clubbing. Arthritis Care and Research. 2021; 73:1379-1386.

Sebold, AJ; Day, AM; Ewen, J; Adamek, J; Byars, A; Cohen, B; Kossoff, EH; Mizuno, T; Ryan, M; Sievers, J; et al. Sirolimus Treatment in Sturge-Weber Syndrome. Pediatric Neurology. 2021; 115:29-40.

Shapiro, AD; Ragni, MV; Borhany, M; Abajas, YL; Tarantino, MD; Holstein, K; Croteau, SE; Liesner, R; Tarango, C; Carvalho, M; et al. Natural history study of factor IX deficiency with focus on treatment and complications (B-Natural). Haemophilia. 2021; 27:49-59.

Sharma, B; Kudira, R; Rosenfeldt, LA; Gourley, BE; Cantrell, R; Watanabe, M; Edwards, O; Romick-Rosendale, LE; Haslam, D; Flick, MJ; et al. Fibrin(ogen) Promotes Immune Cell Infiltration, Dysbiosis and ROS Production in Experimental Colitis. Blood. 2021; 138:443-443.

Sharma, BK; Mureb, D; Murab, S; Rosenfeldt, L; Francisco, B; Cantrell, R; Karns, R; Romick-Rosendale, L; Watanabe-Chailland, M; Mast, J; et al. Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth. Journal of Thrombosis and Haemostasis. 2021; 19:2480-2494.

Shook, LM; Haygood, D; Quinn, CT. Clinical Utility of the Addition of Molecular Genetic Testing to Newborn Screening for Sickle Cell Anemia. Frontiers in Medicine. 2021; 8.

Shook, LM; Mosley, C; Farrell, CB; Connelly, A; Jones, CL. Educational Needs of School Nurses Regarding the Evidence-Based Management of Sickle Cell Disease. International Journal of Environmental Research and Public Health. 2021; 18.

Smart, LR; Ware, RE. Newborn screening for sickle cell disease in sub-Saharan Africa: Is the glass half-full yet?. Pediatric Blood and Cancer. 2021; 68.

Smegal, LF; Sebold, AJ; Hammill, AM; Juhász, C; Lo, WD; Miles, DK; Wilfong, AA; Levin, AV; Fisher, B; Ball, KL; et al. Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome. Pediatric Neurology. 2021; 119:3-10.

Tegha, G; Topazian, HM; Kamthunzi, P; Howard, T; Tembo, Z; Mvalo, T; Chome, N; Kumwenda, W; Mkochi, T; Hernandez, A; et al. Prospective Newborn Screening for Sickle Cell Disease and Other Inherited Blood Disorders in Central Malawi. Sozial- und Praventivmedizin. 2021; 66.

Thornburg, CD; Todd, KE; Mcgrady, ME; Ignjatovic, V; Jones, S; Rizzi, M; Luchtman-Jones, L. Results of the International Survey on Adherence with Anticoagulation in Children, Adolescents and Young Adults. Blood. 2021; 138:5001-5001.

Tseng, SY; Gao, Z; Kalfa, TA; Ollberding, NJ; Tabbah, S; Keller, R; Cnota, JF. Altered erythropoiesis in newborns with congenital heart disease. Pediatric Research. 2021.

Vadivelu, S; Patel, M; Hammill, A; Abruzzo, T. Vascular Malformations of the Extracranial Head and Neck in Children and Young Adults. Pediatric Vascular Neurosurgery. 2021.

Voulgaridou, A; Kalfa, TA. Autoimmune Hemolytic Anemia in the Pediatric Setting. Journal of Clinical Medicine. 2021; 10.

Ware, RE; Dertinger, SD. There's safety in numbers. Blood. 2021; 137:729-731.

Ware, RE; Dertinger, SD. Absence of hydroxyurea-induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia. British Journal of Haematology. 2021; 194:252-266.

Weyand, AC; McGann, PT. Eliminating race-based reference ranges in haematology: a call to action. The Lancet Haematology. 2021; 8:e462-e466.