Jain Lab

Publications

Chen, X; Ruiz-Gonzalez, CE; Masias-Leon, Y; Singh, M; Peloquin, CA; Jain, SK. Addition of Clofazimine Enhances the Activity of Standard Treatment Regimen in a Mouse Model of Tuberculous Meningitis. Journal of Infectious Diseases. 2026.

Chen, X; Ruiz-Gonzalez, CE; Masias-Leon, Y; Singh, M; Nino-Meza, OJ; Peloquin, CA; Artemov, D; Jain, SK. Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for TB Meningitis. Journal of Infectious Diseases. 2026.

Donovan, J; Cresswell, FV; Tucker, EW; Davis, AG; Rohlwink, UK; Huynh, J; Solomons, R; Seddon, JA; Bahr, NC; Van Laarhoven, A; Rogozińska, E; Misra, UK; Figaji, A; Thwaites, GE. A clinical practice guideline for tuberculous meningitis. The Lancet Infectious Diseases. 2026; 26(2):e96-e111.

Llamas-Lopez, A; Seddon, JA; Chow, FC; Upton, CM; Jain, SK; Alffenaar, J-W; Grint, DJ; Dooley, K; Aarnoutse, R; Cresswell, FV. Intensified Treatment of Tuberculous Meningitis in Adults: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases. 2025; 12(10):ofaf503.

Sarhan, M; Shelke, AM; Mane, K; Jadhav, R; Jeon, B; Nino-Meza, O; Chen, X; Freundlich, JS; Jain, SK; Carroll, L. Improved Radiosynthesis of [18F]-Labeled Oxazolidinone Antibiotics for Future Clinical Translation. ACS Infectious Diseases. 2025; 11(7):2009-2017.

Ruiz-Gonzalez, CE; Nino-Meza, OJ; Singh, M; Masias-Leon, Y; Kronenberg, A; Shambles, M; Chen, X; Tucker, EW; Lodge, MA; Carroll, LS; Cooke, KR; Kates, OS; Shoham, S; Zhang, SX; Jain, SK. 18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies. Nature Communications. 2025; 16(1):6395.

Masias-Leon, Y; Ruiz-Gonzalez, CE; Nino-Meza, OJ; Singh, M; Sarhan, MO; Chen, X; Flavahan, K; Kronenberg, A; Tucker, EW; Freundlich, JS; Lodge, MA; Carroll, LS; Parrish, N; Lechtzin, N; Jain, SK. Dynamic 11C-Para-Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections. American Journal of Respiratory and Critical Care Medicine. 2025; 211(7):1253-1263.

Singh, M; Sarhan, MO; Damiba, NNL; Singh, AK; Villabona-Rueda, A; Nino-Meza, OJ; Chen, X; Masias-Leon, Y; Ruiz-Gonzalez, CE; Ordonez, AA; D'alessio, FR; Aboagye, EO; Carroll, LS; Jain, SK. Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis. Nature Communications. 2025; 16(1):3003.

Palestro, CJ; Abikhzer, G; Bar-Sever, Z; Bartel, T; Brady, R; Grady, EE; Israel, O; Jain, SK; Kandiah, S; Sathekge, MM; Shulkin, BL. Summary: Appropriate Use Criteria for the Use of Nuclear Medicine in Fever of Unknown Origin. Journal of Nuclear Medicine. 2024; 65(11):1786-1788.

Chen, X; Arun, B; Nino-Meza, OJ; Sarhan, MO; Singh, M; Jeon, B; Mane, K; Shah, M; Tucker, EW; Carroll, LS; Freundlich, JS; Peloquin, CA; Ivaturi, VD; Jain, SK. Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs. Nature Communications. 2024; 15(1):6657.

Adilbay, D; Gonzales, J; Zazhytska, M; Demetrio De Souza Franca, P; Roberts, S; Viray, TD; Artschwager, R; Patel, S; Kodra, A; Overdevest, JB; Carroll, LS; Lomvardas, S; Reiner, T; Pillarsetty, N. Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent. Journal of Nuclear Medicine. 2024; 65(8):1293-1300.

Wright, WF; Kandiah, S; Brady, R; Shulkin, BL; Palestro, CJ; Jain, SK. Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria. Clinical Infectious Diseases. 2024; 78(5):1148-1153.

Tucker, EW; Ruiz-Bedoya, CA; Mota, F; Erice, C; Kim, J; De Jesus, P; Jahdav, R; Bahr, M; Flavahan, K; Chen, X; Peloquin, CA; Freundlich, JS; Jain, SK. Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis. International Journal of Antimicrobial Agents. 2024; 63(1):107048.

Namasivayam, S; Tilves, C; Ding, H; Wu, S; Domingue, JC; Ruiz-Bedoya, C; Shah, A; Bohrnsen, E; Schwarz, B; Bacorn, M; Jain, SK; Sears, CL; Mueller, NT; Hourigan, SK. Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice. Gut Microbes. 2024; 16(1):2353394.

Signore, A; Ordonez, AA; Arjun, C; Aulakh, GK; Beziere, N; Dadachova, E; Ebenhan, T; Granados, U; Korde, A; Jalilian, A; Welling, MM; Zeevaart, JR; Jain, SK; Wilson, DM. The Development and Validation of Radiopharmaceuticals Targeting Bacterial Infection. Journal of Nuclear Medicine. 2023; 64(11):1676-1682.

Singh, AK; Wang, R; Lombardo, KA; Praharaj, M; Bullen, CK; Um, P; Gupta, M; Srikrishna, G; Davis, S; Komm, O; Jain, SK; Bivalacqua, TJ; Yegnasubramanian, S; Bishai, WR. Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells. iScience. 2023; 26(10):107733.

Parker, MFL; López-Álvarez, M; Alanizi, AA; Luu, JM; Polvoy, I; Sorlin, AM; Qin, H; Lee, S; Rabbitt, SJ; Pichardo-González, PA; Engel, J; Jain, SK; Ohliger, MA; Wilson, DM. Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis. Journal of Infectious Diseases. 2023; 228(Suppl 4):S281-S290.

Ordonez, AA; Saupe, F; Kasper, CA; Turner, ML; Parveen, S; Flavahan, K; Shin, H; Artemov, D; Ittig, SJ; Jain, SK. Imaging Tumor-Targeting Bacteria Using 18F-Fluorodeoxysorbitol Positron Emission Tomography. Journal of Infectious Diseases. 2023; 228(Suppl 4):S291-S296.

Hammoud, DA; Clifford Lane, H; Jain, SK. Molecular Imaging of Infections: Advancing the Search for the Hidden Enemy. Journal of Infectious Diseases. 2023; 228(Suppl 4):S233-S236.

Chen, X; Gallagher, F; Sellmyer, MA; Ordonez, AA; Kjaer, A; Ohliger, M; Wilson, DM; Jain, SK. Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches. Journal of Infectious Diseases. 2023; 228(Suppl 4):S249-S258.

Jacquot, C; Gordon, O; Noland, D; Donowitz, JR; Levy, E; Jain, S; Willis, Z; Rimland, C; Loi, M; Arrieta, A; Ardura, MI; Arora, S; Zivick, E; Delaney, M. Multi-institutional experience with COVID-19 convalescent plasma in children. Transfusion. 2023; 63(5):918-924.

Krug, S; Prasad, P; Xiao, S; Lun, S; Ruiz-Bedoya, CA; Klunk, M; Ordonez, AA; Jain, SK; Srikrishna, G; Kramnik, I; Bishai, WR. Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice. mBio. 2023; 14(2):e0349622.

Merino, VF; Yan, Y; Ordonez, AA; Bullen, CK; Lee, A; Saeki, H; Ray, K; Huang, T; Jain, SK; Pomper, MG. Nucleolin mediates SARS-CoV-2 replication and viral-induced apoptosis of host cells. Antiviral Research. 2023; 211:105550.

Jain, SK. New Approaches for Imaging Bacteria. Seminars in Nuclear Medicine. 2023; 53(2):138-141.

Mota, F; Ruiz-Bedoya, CA; Tucker, EW; Holt, DP; De Jesus, P; Lodge, MA; Erice, C; Chen, X; Bahr, M; Flavahan, K; Ordonez, AA; Peloquin, CA; Dannals, RF; Jain, SK. Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies. Nature Communications. 2022; 13(1):7974.

Solis, O; Beccari, AR; Iaconis, D; Talarico, C; Ruiz-Bedoya, CA; Nwachukwu, JC; Cimini, A; Castelli, V; Bertini, R; Montopoli, M; Nettles, KW; Jain, SK; Allegretti, M; Michaelides, M. The SARS-CoV-2 spike protein binds and modulates estrogen receptors. Science Advances. 2022; 8(48):eadd4150.

Foss, CA; Ordonez, AA; Naik, R; Das, D; Hall, A; Wu, Y; Dannals, RF; Jain, SK; Pomper, MG; Horti, AG. PET/CT imaging of CSF1R in a mouse model of tuberculosis. European Journal of Nuclear Medicine and Molecular Imaging. 2022; 49(12):4088-4096.

Ordonez, AA; Bullen, CK; Villabona-Rueda, AF; Thompson, EA; Turner, ML; Merino, VF; Yan, Y; Kim, J; Davis, SL; Komm, O; Powell, JD; D'alessio, FR; Yolken, RH; Jain, SK; Jones-Brando, L. Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice. Communications Biology. 2022; 5(1):242.

Ruiz-Bedoya, CA; Mota, F; Tucker, EW; Mahmud, FJ; Reyes-Mantilla, MI; Erice, C; Bahr, M; Flavahan, K; De Jesus, P; Kim, J; Hammoud, DA; Ordonez, AA; Pardo, CA; Jain, SK. High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis. Journal of Clinical Investigation. 2022; 132(6).

Ruiz-Bedoya, CA; Mota, F; Ordonez, AA; Foss, CA; Singh, AK; Praharaj, M; Mahmud, FJ; Ghayoor, A; Flavahan, K; De Jesus, P; Mankowski, JL; Villano, J; Klein, SL; Jain, SK. 124I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection. Molecular Imaging and Biology. 2022; 24(1):135-143.

Mulka, KR; Beck, SE; Solis, CV; Johanson, AL; Queen, SE; Mccarron, ME; Richardson, MR; Zhou, R; Marinho, P; Jedlicka, A; Tarwater, PM; Pekosz, AS; Villano, JS; Mankowski, JL. Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters. American Journal of Pathology. 2022; 192(2):195-207.

Gordon, O; Brosnan, MK; Yoon, S; Jung, D; Littlefield, K; Ganesan, A; Caputo, CA; Li, M; Morgenlander, WR; Henson, SN; Pekosz, A; Lederman, HM; Klein, SL; Jain, SK. Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children. JCI Insight. 2022; 7(2).

Ordonez, AA; Parker, MF; Miller, RJ; Plyku, D; Ruiz-Bedoya, CA; Tucker, EW; Luu, JM; Dikeman, DA; Lesniak, WG; Holt, DP; Dannals, RF; Miller, LS; Rowe, SP; Wilson, DM; Jain, SK. 11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans. JCI Insight. 2022; 7(1).